Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: Time-course analysis

Neurochemical Research

Volumn 23, Issue 5, 1998, Pages 627-634

  Yehuda, Shlomo ^a   Rabinovitz, Sharon ^a   Mostofsky, David I ^b  

^a BAR ILAN UNIVERSITY   (Israel)

^b BOSTON UNIVERSITY   (United States)

Author keywords

linolenic acid; Cholesterol; Linoleic acid; Morris Water tank; Rat cortex

Indexed keywords

CHOLESTEROL; ESSENTIAL FATTY ACID; LINOLEIC ACID; LINOLENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN CORTEX; BRAIN SYNAPTOSOME; COGNITION; CONTROLLED STUDY; LEARNING; MALE; MAZE TEST; MEMBRANE FLUIDITY; NERVE CELL MEMBRANE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SEIZURE; THERMOREGULATION;

ALPHA-LINOLENIC ACID; ANIMALS; CHOLESTEROL; FATTY ACIDS; FATTY ACIDS, ESSENTIAL; FRONTAL LOBE; LINOLEIC ACID; LINOLENIC ACIDS; MALE; MAZE LEARNING; MINERAL OIL; RATS; REGRESSION ANALYSIS; SWIMMING; SYNAPTOSOMES; TIME FACTORS;

EID: 0031922472     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022430620205     Document Type: Article

References (38)

1. Holman, R. T., Johnson, S. B., and Hatch, T. F. 1982. A case of human linolenic and deficiency involving neurological abnormalities. American Journal of Clinical Nutrition, 35:617-623.
2. Wainwright, P. E. 1991. Do essential fatty acids play a role in brain and behavioral development? Neuroscience & Biobehavioral Reviews 16:193-205.
3. Coscina, D. V., Yehuda, S., Dixon, L. M., Kish, S. I., and Leprohon-Greenwood, C. E. 1985. Learning is improved by asybean oil diet in rats. Life Science, 38:1789-1794.
4. Yehuda, S. 1989. Behavioral effects of dietary fats. In: Health Effects of Fish and Fish Oils (Chandra RK, ed), pp. 327-335. Canada: ARTS, St John's, NF.
5. Yehuda, S., and Carasso, R. L. 1987. Effects if dietary fats on learning pain threshold, thermoregulation and motor activity in rats: interaction with the length of feeding period. International Journal of Neuroscience, 32:919-925.
6. Yehuda, S., Leprohon-Greenwood, C. E., Dixon, L. M., and Coscina, D. V. 1986. Effects of dietary fat on pain threshold, thermoregulation and motor activity in rats. Pharmacology Biochemistry and Behavior, 24:1775-1777.
7. Bourre, J. M., Dumont, O., Piciotti, M., Clement, M., Chaudiere, J., Bonneil, M., Halbone, G., Lafont, H., Pascal, G., and Durand, G. 1991. Essentiality of w3 fatty acids for brain structure and function. World Review of Nutrition, 66:103-117.
8. Bourre, J. M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G., and Durand, G. 1989. The effect of dietary α-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. Journal of Nutrition, 119:1880-1892.
9. Bourre, J. M., Pascal, G., Durand, G., Masson, M., Dumont, O., and Piciotti, M. 1984. Alternations in the fatty acid composition of rat brain cells (neurons, astrocytes, and oligodenrocytes) and of subcellular fractions (myelin and synaptosomes) induced by a diet devoid of n-3 fatty-acids. Journal of Neurochemistry, 43:342-348.
10. Claninin, M. T., Cheema, S., Field, C. J., Garg, L., Venkatraman, J., and Clandinin, T. R. 1991. Dietary fat: exogenous determination of membrane structure and cell function. FASEB 5:2701-2709.
11. Enslen, M., Milon, H., and Malone, A. 1991. Effects of low intake of n-3 fatty acids during development on brain phospholipid fatty acid composition and exploratory behavior in rats. Lipids, 26:203-208.
12. Hargreaves, K., and Clandinin, M. T. 1990. Dietary lipids in relation to postnatal development of the brain. Uppsala Journal of Medical Sciences S, 48:79-95.
13. Salvati, S., Campeggi, L. M., Sorcinni, M., Olivieri, A., and DiBase, A. 1993. Effects of propylthiouracial-induced hypothyroidism on membranes of adult rat brain. Lipids 28:1075-1078.
14. Thompson, A. B. R., Keelan, M., and Clandinin, M. T. 1991. Feeding rats a diet enriched with saturated fatty acids presents the inhibitory effects of acute and chromic etharol exposure on the in vitro uptake ofhexoses and lipids. Biochemical ET Biophysical Acta, 1084:122-128.
15. Bazan, N. G., Birkle, D. L., Targ, W., and Reddy, T. S. 1986. The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimented epilepsy. Advanced Neurology, 44:879-902.
16. Visioli, F., Rihn, L. L., Rodriguez de Turco, E. B., Kreisman, N. R., and Bazan, N. G. 1993. Free fatty acid and diacylglycerol accumulation in the rat brain during recurrent seizures in related to cortial oxygenation. Journal of Neurochemistry, 61:1835-1842.
17. Farooqui, A. A., and Horrocks, L. A. 1991. Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders. Brain Research Reviews, 16:171-191.
18. Ellis, E., Police, R. J., Dodson, L. Y., McKinney, J. C., and Holt, S. A. 1992. Effect of dietary n-3 fatty acids on cerebral microcirculation. American Journal of Physiology, 262:H1379-1386.
19. Spector, A. A. 1989. Polyunsaturated fatty acids and membrane function. In: Biomembrane and Nutrition (Leger CL, Bereziat G, ed), 195:11-20. Paris:Colloque INSERM.
20. Zachowski, A. 1993. Phospholipids in animal eukaryotic membranes: transference asymmetry and movement. Biochemistry Journal, 294:1-14.
21. Houslay, M. D., and Stanley, K. K. 1982. Dynamics of Biological Membrane. pp. 135-137. New York: J. Wiley.
22. Davis, P. J. 1992. n-3 and n-6 polyunsaturated fatty acids have different effects on acyl-CoA:cholesterol acyltransfered in fatty macrophages. Biochemistry and Cell Biology, 70:1313-1318.
23. Garg, M. L., and Clandinin, M. T. 1992. α-linolenic acid and metabolism of cholesterol and long-chain fatty acids. Nutrition, 8: 208-210.
24. Horrocks, L. A., and Harder, H. W. 1983. Fatty acids and cholesterol. Pages 1-16, in Lajtha A., (ed) vol. 3 Handbook of Neurochemistry New York: Plenum.
25. Huang, Y. S., Koba, K., Horrobin, D. F., and Sugano, M. 1993. Interrelationship between dietary protein, cholesterol and nj-6 polyunsaturated fatty acid metabolism. Progress in Lipid Research, 32:123-137.
26. Kessler, A., and Yehuda, S. 1985. Learning-induced changes in brain membrane cholesterol and fluidity: Implications for brain aging. International Journal of Neuroscience, 28:73-82.
27. McGee, C. D., and Greenwood, C. E. 1990. Effects of dietary fatty acid composition on micronutrient selection and synaptosomal fatty acid composition in rats. Life Science, 47:933-937.
28. Yehuda, S., and Carraso, R. L. 1993. Modulation of learning pain thresholds, and thermoregulation in the rat by preparations of frepurified α-linolenic and linoleic acids: Determination of the optimal w3-to w6 ratio. Proceedings of the National Academy of Sciences of the USA, 90:10345-10349.
29. Yehuda, S., Carraso, R. L., and Mostofsky, D. I. 1995. Essential fatty acid preparation (SR-3) rehabilitates learning deficits induced by AF64A and 5,7-DHT. NeuroReport, 6:511-515.
30. Yehuda, S., Carasso, R. L., and Mostofsky, D. I. 1994. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. European Journal of Pharmacology, 254:193-198.
31. Yehuda, S., Rabinovitz, S., Mostofsky, D. I., Huberman, M., Carraso, R. L., and Sredni, B. 1995. Neuroreport, in press.
32. Whittaker, V. P., and Barker, L. A. 1972. The subcellular fraction of brain tissue with special reference to the preparation of synaptosomes and their component organelles. In: Methods in Neurochemistry (Fried R, ed), 1-52. New York: Marcel Dekker.
33. Folch-Pi, J., Lees, M., and Sloane-Stanley, G. M. 1957. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry, 226:497-509.
34. Reeves, P. G., Nielsen, F. H., and Fahey, G. C. 1993. AIN-93 prifled diets for laboratory rodents: final report of the american institute of nutrition ad hoc writing committee on the reformation of the AIN-76A rodent diet. Journal of Nutrition, 123:1939-1951.
35. Joo, F. 1993. Brain microvascular cyclic nucleotides and protein phosphorylation. In: Blood Brain Barrier: Cellular and Molecular Biology (Pardridge WM, ed), pp. 267-287. New York: Raven Press.
36. Dhopeshwarkar, G. A. 1983. Nutrition and Brain Development. pp. 35-37. New York: Plenum.
37. Finch, C. E. 1994. Biochemistry of aging in the Mammalian Brain. Pages 627-644, in Siegel GJ, Agranoff BW, Albers RW, Molinoff PB, (ed), Basic neurochemistry: molecular, cellular, and medical aspects, 5th Edition, New York: Raven Press.
38. Yehuda, S., Rabinovitz, S., and Mostofsky, D.I. 1997. Effects of essential fatty acid preparation (SR-3) on brain lipids, biochemistry and behavioral cognitive functions. Pages 427-452, in Yehuda, S., and Mostofsky, D.I. (eds.) Handbook of Essential Fatty Acid Biology: Biochemistry, Physiology, and behavioral neurobiology. New York Humana Press