Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese, non-insulin-resistant fatty liver disease with characteristic fibrosis

Journal of Gastroenterology

Volumn 41, Issue 10, 2006, Pages 971-980

  Kainuma, Mosaburo ^a   Fujimoto, Makoto ^a   Sekiya, Nobuyasu ^b   Tsuneyama, Koichi ^a   Cheng, Chunmei ^c   Takano, Yasuo ^a   Terasawa, Katsutoshi ^a,b   Shimada, Yutaka ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipocyte differentiation related protein; Hepatic stellate cell; Hyperlipidemia; Nonalcoholic fatty liver disease; Oxidative stress

Indexed keywords

CHOLESTEROL; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL ACTIVATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET RESTRICTION; HISTOPATHOLOGY; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIVER FIBROSIS; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; SEROLOGY; STELLATE CELL;

ANIMALS; CHOLESTEROL, DIETARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; LIPID PEROXIDES; LIPIDS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; RABBITS; SEVERITY OF ILLNESS INDEX; TRANSFORMING GROWTH FACTOR BETA;

EID: 33750996121     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-006-1883-1     Document Type: Article

References (39)

1. RA Hegele RL Pollex 2005 Genetic and physiological insights into the metabolic syndrome Am J Physiol Regul Integr Comp Physiol 289 663-9
2. W Bestermann MC Houston J Basile B Egan CM Ferrario D Lackland 2005 Addressing the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the southeastern United States, part II: Treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome Am J Med Sci 329 292-305 15958871 10.1097/ 00000441-200506000-00009
3. OFW James CP Day 1998 Non-alcoholic steatohepatitis (NASH): A disease of emerging identity and importance J Hepatol 29 495-501 9765002 10.1016/ S0168-8278(98)80073-1
4. JM Clark FL Brancati AM Diehl 2002 Nonalcoholic fatty liver disease Gastroenterology 122 1649-57 12016429 10.1053/gast.2002.33573
5. CE Ruhl JE Everhart 2003 Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the Unites States Gastroenterology 124 71-9 12512031 10.1053/gast.2003.50004
6. S Bellentani G Saccoccio F Masutti LS Crocè G Brandi F Sasso 2000 Prevalence of and risk factors for hepatic steatosis in northern Italy Ann Intern Med 132 112-7 10644271
7. H Nomura S Kashiwagi J Hayashi W Kajiyama S Tani M Goto 1988 Prevalence of fatty liver in a general population of Okinawa Japan Jpn J Med 27 142-9 3047469
8. CA Matteoni ZM Younossi T Gramlich N Boparai YC Liu AJ McCullough 1999 Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity Gastroenterology 116 1413-9 10348825 10.1016/ S0016-5085(99)70506-8
9. EE Powell WGE Cooksley R Hanson J Searle JW Halliday LW Powell 1990 The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years Hepatology 11 74-80 2295475
10. BR Bacon MJ Farahvash CG Janney BA Neuschwander-Tetri 1994 Nonalcoholic steatohepatitis: An expanded clinical entity Gastroenterology 107 1103-9 7523217
11. Y Sumida T Nakashima T Yoh M Furutani A Hirohama Y Kakisaka 2003 Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease J Hepatol 38 32-8 12480557 10.1016/ S0168-8278(02)00331-8
12. S Seki T Kitada T Yamada H Sakaguchi K Nakatani K Wasaka 2002 In situ detection of lipid peroxidation and oxidative DNA damage in nonalcoholic fatty liver disease J Hepatol 37 56-62 12076862 10.1016/ S0168-8278(02)00073-9
13. CP Day OFW James 1998 Steatohepatitis: A tale of two "hits"? Gastroenterology 114 842-5 9547102 10.1016/S0016-5085(98)70599-2
14. MD Weltman GC Farrell P Hall M Ingelman-Sundberg C Liddle 1998 Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis Hepatology 27 128-33 9425928 10.1002/hep.510270121
15. IA Leclercq GC Farrell R Schriemer GR Robertson 2002 Leptin is essential for the hepatic fibrogenic response to chronic liver injury J Hepatol 37 206-13 12127425 10.1016/S0168-8278(02)00102-2
16. A Koteish AM Diehl 2001 Animal models of steatosis Semin Liver Dis 21 89-104 11296700 10.1055/s-2001-12932
17. J George N Pera N Phung I Leclercq Hou J Yun G Farrell 2003 Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis J Hepatol 39 756-64 14568258 10.1016/ S0168-8278(03)00376-3
18. CS Lieber MA Leo KM Mak Y Xu Q Cao C Ren 2004 Model of nonalcoholic steatohepatitis Am J Clin Nutr 79 502-9 14985228
19. JG Fan L Zhong ZJ Xu LY Tia XD Ding MS Li 2003 Effects of low-calorie diet on steatohepatitis in rats with obesity and hyperlipidemia World J Gastroenterol 9 2045-9 12970903
20. G Finking H Hanke 1997 Nikolaj Nikolajewitsch Antischkow (1885-1964) established the cholesterol-fed rabbit as a model for atherosclerosis research Atherosclerosis 135 1-7 9395267 10.1016/S0021-9150(97)00161-5
21. PP Gupta HD Tandon V Ramalingaswami 1976 Cirrhosis of the liver in rabbits induced by a high cholesterol diet: An experimental model Indian J Med Res 64 1516-26 1017865
22. N Buyssens MM Kockx AG Herman JM Lazou K Van den Berg E Wisse 1996 Centrolobular liver fibrosis in the hypercholesterolemic rabbit Hepatology 24 939-46 8855202 10.1002/hep.510240431
23. IR Wanless J Belgiorno PM Huet 1996 Hepatic sinusoidal fibrosis induced by cholesterol and stilbesterol in the rabbit: 1. morphology and inhibition of fibrogenesis by dipyridamole Hepatology 24 855-64 8855188 10.1002/hep.510240417
24. N Sekiya N Tanaka T Itoh Y Shimada H Goto K Terasawa 1999 Keishi-bukuryo-gan prevents the progression of atherosclerosis in cholesterol-fed rabbit Phytother Res 13 192-6 10353155 10.1002/ (SICI)1099-1573(199905)13:3<192::AID-PTR412>3.0.CO;2-2
25. H Yoshiji S Kuriyama J Yoshii Y Ikenaka R Noguchi T Nakatani 2001 Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats Hepatology 34 745-50 11584371
26. S Saadeh ZM Younossi EM Remer T Gramlich JP Ong M Hurley 2002 The utility of radiological imaging in nonalcoholic fatty liver disease Gastroenterology 123 745-50 12198701 10.1053/gast.2002.35354
27. K Washington K Wright Y Shyr EB Hunter S Olson DS Raiford 2000 Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver Hum Pathol 31 822-8 10923919 10.1053/hupa.2000.8440
28. H Kasai 1997 Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis Mutat Res 387 147-63 9439711 10.1016/ S1383-5742(97)00035-5
29. DE Kleiner EM Brunt M Van Natta C Behling MJ Contos OW Cummings 2005 Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 1313-21 15915461 10.1002/hep.20701
30. B Fromenty D Pessayre 1995 Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity Pharmacol Ther 67 101-54 7494860 10.1016/ 0163-7258(95)00012-6
31. S Chitturi S Abeygunasekera GC Farrell J Holmes-Walker JM Hui C Fung 2002 NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome Hepatology 35 373-9 11826411 10.1053/jhep.2002.30692
32. G Pagano G Pacini G Musso R Gambino F Mecca N Depetris 2002 Non-alcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association Hepatology 35 367-72 11826410 10.1053/jhep.2002.30690
33. AJ Sanyal C Campbell-Sargent F Mirshahi WB Rizzo MJ Contos RK Sterling 2001 Non-alcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 1183-92 11266382 10.1053/gast.2001.23256
34. ME Rinella RM Green 2004 The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance J Hepatol 40 47-51 14672613 10.1016/j.jhep.2003.09.020
35. A Chen L Zhang J Xu J Tang 2002 The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression Biochem J 368 695-704 12223099 10.1042/BJ20020894
36. A Pietrangelo 1996 Metals, oxidative stress, and hepatic fibrogenesis Semin Liver Dis 16 13-30 8723320
37. P Stärkel C Sempoux I Leclercq M Herin C Deby JP Desager 2003 Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats J Hepatol 39 538-46 12971963 10.1016/S0168-8278(03)00360-X
38. M Matsuoka H Tsukamoto 1990 Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: implication for a pathogenetic role in alcoholic liver fibrogenesis Hepatology 11 599-605 2328954
39. H Nakatsukasa P Nagy RP Everts CC Hsia E Marsden SS Thorgeirsson 1990 Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis J Clin Invest 85 1833-43 1693377