Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice

European Journal of Neuroscience

Volumn 12, Issue 12, 2000, Pages 4541-4546

  Veinbergs, Isaac ^a   Mallory, Margaret ^a   Sagara, Yutaka ^a   Masliah, Eliezer ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ageing; Alzheimer's disease; Antioxidants; Gene knock out; Neurodegeneration

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN E; GLUTATHIONE;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITE; DIET SUPPLEMENTATION; FEMALE; HYPERLIPOPROTEINEMIA TYPE 3; LIPID PEROXIDATION; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TASK PERFORMANCE; VITAMIN SUPPLEMENTATION;

ANIMALS; APOLIPOPROTEINS E; CEREBRAL CORTEX; DENDRITES; DIETARY SUPPLEMENTS; FEMALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEUROPROTECTIVE AGENTS; REFERENCE VALUES; SPACE PERCEPTION; VITAMIN E;

EID: 0034513572     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.01308.x     Document Type: Article

References (44)

1. -/- mice: Isoform-specific effects on neurodegeneration
2. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells
3. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydro-xynonenal
4. M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice
5. Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
6. Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: Implications for early treatment of Alzheimer's disease
7. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
8. Increased plasma and lipoprotein lipid peroxidation in apoE-deficient mice
9. Antiatherosclerotic and antioxidative effects of captopril in apolipoprotein E-deficient mice
10. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
11. Lipoprotein uptake by neuronal growth cones in vitro
12. Time-dependent changes to lipids and antioxidants in plasma and aortas of apolipoprotein E knockout mice
13. Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury
14. Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury
15. Neurodegeneration in the CNS of apoE-deficient mice
16. Abnormal synaptic regeneration in hAPP. 695 transgenic and APOE knockout mice
17. Apolipoprotein E role in maintaining the integrity of the aging central nervous system
18. Alterations in apolipoprotein expression during aging and neurodegeneration
19. Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE
20. Increased 3-nitrotyrosine in brains of apoE-deficient mice
21. Glutathione-ascorbic acid antioxidant system in animals
22. Glutathione metabolism
23. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
24. Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice. Possible mechanisms of action
25. Crosslinking of apolipoprotein E by products of lipid peroxidation
26. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice
27. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
28. Severe learning deficits in apolipoprotein E-knockout mice in a water maze task
29. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum
30. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
31. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
32. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
33. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation
34. Isoform-specific effects of human apolipoprotein E on brain function revealed in APOE knockout mice: Increased susceptibility of females
35. Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype
36. Induction of reactive oxygen species in neurons by haloperidol
37. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease
38. Dietary β-carotene and alpha-tocopherol combination does not inhibit atherogenesis in and apoE-deficient mouse model
39. Effect of the antioxidant N,N'-diphenyl 1,4-phenylendiamine (DPPD) on atherosclerosis in apoE-deficient mice
40. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
41. In vivo uptake of radiolabeled MDA2 an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in axidized LDL and is highly sensative to their regression
42. Altered long term potentiation in the hippocampus of apolipoprotein E-deficient mice
43. Frequency of the apolipoprotein E E2 allele is diminished in sporadic Alzheimer's disease
44. Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice