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Volumn 60, Issue 6, 2006, Pages 729-739

Simvastatin enhances learning and memory independent of amyloid load in mice

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; SIMVASTATIN;

EID: 33846048569     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.21053     Document Type: Article
Times cited : (129)

References (62)
  • 1
    • 0034518216 scopus 로고    scopus 로고
    • The genetics and molecular pathology of Alzheimer's disease: Roles of amyloid and the presenilins
    • Selkoc DJ. The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins. Neurol Clin 2000;18:903-922.
    • (2000) Neurol Clin , vol.18 , pp. 903-922
    • Selkoc, D.J.1
  • 2
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986;232:34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 1842528400 scopus 로고    scopus 로고
    • Convergence of atherosclerosis and Alzheimer's disease: Inflammation, cholesterol, and misfolded proteins
    • Casserly I, Topol E. Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. Lancet 2004;363:1139-1146.
    • (2004) Lancet , vol.363 , pp. 1139-1146
    • Casserly, I.1    Topol, E.2
  • 4
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruossean P, et al. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000;57:1439-1443.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruossean, P.3
  • 5
    • 0034638746 scopus 로고    scopus 로고
    • Statins and the risk of dementia
    • Jick H, Zornberg GL, Jick SS, et al. Statins and the risk of dementia. Lancet 20000;356:1627-1631.
    • Lancet , vol.20000 , Issue.356 , pp. 1627-1631
    • Jick, H.1    Zornberg, G.L.2    Jick, S.S.3
  • 6
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • Hajjar I, Schumpert J, Hirth V, et al. The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. J Gerontol A Biol Sci Med Sci 2002;57: M414-M418.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3
  • 7
    • 0036842773 scopus 로고    scopus 로고
    • Use of lipid-lowering drugs in older adults with and without dementia: A community-based epidemiological study
    • Rodriguez EG, Dodge HH, Birzescu MA, et al. Use of lipid-lowering drugs in older adults with and without dementia: a community-based epidemiological study. J Am Geriatr Soc 2002;50:1852-1856.
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1852-1856
    • Rodriguez, E.G.1    Dodge, H.H.2    Birzescu, M.A.3
  • 8
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • Rockwood K, Kirkland S, Hogan DH, et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol 2002;59: 223-227.
    • (2002) Arch Neurol , vol.59 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.H.3
  • 9
    • 0942278990 scopus 로고    scopus 로고
    • Association between statin use and Alzheimer's disease
    • Zamrini E, McGwin G, Roseman JM. Association between statin use and Alzheimer's disease. Neuroepidemiology 2004;23: 94-98.
    • (2004) Neuroepidemiology , vol.23 , pp. 94-98
    • Zamrini, E.1    McGwin, G.2    Roseman, J.M.3
  • 10
    • 0036714243 scopus 로고    scopus 로고
    • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
    • Simons M, Schwarzler F, Lutjohann D, et al. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol 2002;52:346-350.
    • (2002) Ann Neurol , vol.52 , pp. 346-350
    • Simons, M.1    Schwarzler, F.2    Lutjohann, D.3
  • 11
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results
    • Sparks DL, Sabbagh MN, Connor DJ, et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 2005;62:753-757.
    • (2005) Arch Neurol , vol.62 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3
  • 12
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancer 2002;360:1623-1630.
    • (2002) Lancer , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 13
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Collins R, Armitage J, Parish S, et al. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
    • Collins, R.1    Armitage, J.2    Parish, S.3
  • 14
    • 0036550239 scopus 로고    scopus 로고
    • Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients
    • Buxbaum JD, Cullen EI, Friedhoff LT. Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Front Biosci 2002;7:a50-a59.
    • (2002) Front Biosci , vol.7
    • Buxbaum, J.D.1    Cullen, E.I.2    Friedhoff, L.T.3
  • 15
    • 0037262480 scopus 로고    scopus 로고
    • Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    • Sjogren M, Gustafsson K, Syversen S, et al. Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein. Dement Geriatr Cogn Disord 2003;16:25-30.
    • (2003) Dement Geriatr Cogn Disord , vol.16 , pp. 25-30
    • Sjogren, M.1    Gustafsson, K.2    Syversen, S.3
  • 16
    • 0037159224 scopus 로고    scopus 로고
    • Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide
    • Fassbender K, Stroick M, Bertsch T, et al. Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide. Neurology 2002;59:1257-1258.
    • (2002) Neurology , vol.59 , pp. 1257-1258
    • Fassbender, K.1    Stroick, M.2    Bertsch, T.3
  • 17
    • 12144290725 scopus 로고    scopus 로고
    • Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins
    • Hoglund K, Wiklund O, Vanderstichele H, et al. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol 2004;61: 333-337.
    • (2004) Arch Neurol , vol.61 , pp. 333-337
    • Hoglund, K.1    Wiklund, O.2    Vanderstichele, H.3
  • 18
    • 23744516018 scopus 로고    scopus 로고
    • Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease
    • Hoglund K, Syversen S, Lewczuk P, et al. Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease. Exp Brain Res 2005;164:205-214.
    • (2005) Exp Brain Res , vol.164 , pp. 205-214
    • Hoglund, K.1    Syversen, S.2    Lewczuk, P.3
  • 19
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    • Fassbender K, Simons M, Bergmann C, et al. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A 2001;98:5856-5861.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3
  • 20
    • 0035826909 scopus 로고    scopus 로고
    • Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
    • Kojro E, Gimpl G, Lammich S, et al. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc Natl Acad Sci U S A 2001;98: 5815-5820.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5815-5820
    • Kojro, E.1    Gimpl, G.2    Lammich, S.3
  • 21
    • 0036672689 scopus 로고    scopus 로고
    • Statin therapy for Alzheimer's disease: Will it work?
    • Petanceska SS, DeRosa S, Olm V, et al. Statin therapy for Alzheimer's disease: will it work? J Mol Neurosci 2002;19: 155-161.
    • (2002) J Mol Neurosci , vol.19 , pp. 155-161
    • Petanceska, S.S.1    DeRosa, S.2    Olm, V.3
  • 22
    • 0041382978 scopus 로고    scopus 로고
    • Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice
    • Park IH, Hwang EM, Hong HS, et al. Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging 2003;24:637-643.
    • (2003) Neurobiol Aging , vol.24 , pp. 637-643
    • Park, I.H.1    Hwang, E.M.2    Hong, H.S.3
  • 23
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficit's, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficit's, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 24
    • 0345275964 scopus 로고    scopus 로고
    • Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    • Li L, Cao D, Garber DW, et al. Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease. Am J Pathol 2003;163: 2155-2164.
    • (2003) Am J Pathol , vol.163 , pp. 2155-2164
    • Li, L.1    Cao, D.2    Garber, D.W.3
  • 25
    • 33748431934 scopus 로고    scopus 로고
    • Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    • Cao D, Fukuchi KI, Wan H, et al. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol Aging 2006;27:1632-1643.
    • (2006) Neurobiol Aging , vol.27 , pp. 1632-1643
    • Cao, D.1    Fukuchi, K.I.2    Wan, H.3
  • 26
    • 0141552123 scopus 로고    scopus 로고
    • Aging of the brain and dementia of the Alzheimer type
    • Kandel ER, Schwartz JH, Jessell TM, eds, 4th ed. New York: McGraw-Hill
    • Price DL. Aging of the brain and dementia of the Alzheimer type. In: Kandel ER, Schwartz JH, Jessell TM, eds. Principles of neural science. 4th ed. New York: McGraw-Hill, 2000.
    • (2000) Principles of neural science
    • Price, D.L.1
  • 27
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982;297: 681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 28
    • 0038022595 scopus 로고    scopus 로고
    • Transgenic mice expressing the betaAPP695SWE mutation: Effects on exploratory activity, anxiety, and motor coordination
    • Lalonde R, Lewis TL, Strazielle C, et al. Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination. Brain Res 2003;977: 38-45.
    • (2003) Brain Res , vol.977 , pp. 38-45
    • Lalonde, R.1    Lewis, T.L.2    Strazielle, C.3
  • 29
    • 0037456569 scopus 로고    scopus 로고
    • Prevention of stroke and dementia with statins: Effects beyond lipid lowering
    • Vaughan CJ. Prevention of stroke and dementia with statins: effects beyond lipid lowering. Am J Cardiol 2003;91:23B-29B.
    • (2003) Am J Cardiol , vol.91
    • Vaughan, C.J.1
  • 30
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999;13:2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 31
    • 0036580702 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
    • Sanna PP, Cammalleri M, Berton F, et al. Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. J Neurosci 2002;22:3359-3365.
    • (2002) J Neurosci , vol.22 , pp. 3359-3365
    • Sanna, P.P.1    Cammalleri, M.2    Berton, F.3
  • 32
    • 0037219345 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase: A molecule mediating BDNF-dependent spatial memory formation
    • Mizuno M, Yamada K, Takei N, et al. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Mol Psychiatry 2003;8:217-224.
    • (2003) Mol Psychiatry , vol.8 , pp. 217-224
    • Mizuno, M.1    Yamada, K.2    Takei, N.3
  • 33
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998;273:24266-24271.
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 34
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • Endres M, Laufs U, Huang Z, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 1998;95:8880-8885.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3
  • 35
    • 0033800718 scopus 로고    scopus 로고
    • Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice
    • Laufs U, Gertz K, Huang P, et al. Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke 2000;31:2442-2449.
    • (2000) Stroke , vol.31 , pp. 2442-2449
    • Laufs, U.1    Gertz, K.2    Huang, P.3
  • 36
    • 0033578855 scopus 로고    scopus 로고
    • Long-term potentiation-a decade of progress?
    • Malenka RC, Nicoll RA. Long-term potentiation-a decade of progress? Science 1999;285:1870-1874.
    • (1999) Science , vol.285 , pp. 1870-1874
    • Malenka, R.C.1    Nicoll, R.A.2
  • 37
    • 0035798238 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialogue between genes and synapses
    • Kandel ER. The molecular biology of memory storage: a dialogue between genes and synapses. Science 2001;294: 1030-1038.
    • (2001) Science , vol.294 , pp. 1030-1038
    • Kandel, E.R.1
  • 38
    • 0034840227 scopus 로고    scopus 로고
    • Calcineurin inhibitors and post-transplant hyperlipidaemias
    • Moore R, Hernandez D, Valantine H. Calcineurin inhibitors and post-transplant hyperlipidaemias. Drug Saf 2001;24: 755-766.
    • (2001) Drug Saf , vol.24 , pp. 755-766
    • Moore, R.1    Hernandez, D.2    Valantine, H.3
  • 39
    • 0141568813 scopus 로고    scopus 로고
    • Sinivastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A
    • Inman SR, Davis NA, Olson KM, Lukaszek VA. Sinivastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A. Am J Med Sci 2003;326:117-121.
    • (2003) Am J Med Sci , vol.326 , pp. 117-121
    • Inman, S.R.1    Davis, N.A.2    Olson, K.M.3    Lukaszek, V.A.4
  • 40
    • 0042122374 scopus 로고    scopus 로고
    • Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression
    • Balduini W, Mazzoni E, Carloni S, et al. Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression. Stroke 2003; 34:2007-2012.
    • (2003) Stroke , vol.34 , pp. 2007-2012
    • Balduini, W.1    Mazzoni, E.2    Carloni, S.3
  • 41
    • 0942290538 scopus 로고    scopus 로고
    • Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury
    • Lu D, Goussev A, Chen J, et al. Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma 2004;21:21-32.
    • (2004) J Neurotrauma , vol.21 , pp. 21-32
    • Lu, D.1    Goussev, A.2    Chen, J.3
  • 42
    • 32044440770 scopus 로고    scopus 로고
    • Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury
    • Qu C, Lu D, Goussev A, et al. Effect of atorvastatin on spatial memory, neuronal survival, and vascular density in female rats after traumatic brain injury. J Neurosurg 2005;103:695-701.
    • (2005) J Neurosurg , vol.103 , pp. 695-701
    • Qu, C.1    Lu, D.2    Goussev, A.3
  • 43
    • 27644517404 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    • Li W, Cui Y, Kushner SA, et al. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol 2005; 15:1961-1967.
    • (2005) Curr Biol , vol.15 , pp. 1961-1967
    • Li, W.1    Cui, Y.2    Kushner, S.A.3
  • 44
    • 19944432452 scopus 로고    scopus 로고
    • Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
    • Johnson-Anuna LN, Eckert GP, Keller JH, et al. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther 2005;312:786-793.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 786-793
    • Johnson-Anuna, L.N.1    Eckert, G.P.2    Keller, J.H.3
  • 45
    • 3042640736 scopus 로고    scopus 로고
    • High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
    • Lutjohann D, Stroick M, Bertsch T, et al. High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids 2004;69:431-438.
    • (2004) Steroids , vol.69 , pp. 431-438
    • Lutjohann, D.1    Stroick, M.2    Bertsch, T.3
  • 46
  • 47
    • 0035901715 scopus 로고    scopus 로고
    • Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice
    • Eckert GP, Kirsch C, Mueller WE. Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice. Neuroreport 2001;12:883-887.
    • (2001) Neuroreport , vol.12 , pp. 883-887
    • Eckert, G.P.1    Kirsch, C.2    Mueller, W.E.3
  • 48
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol micro-domains in brain plasma membranes
    • Kirsch C, Eckert GP, Mueller WE. Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem Pharmacol 2003;65:843-856.
    • (2003) Biochem Pharmacol , vol.65 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 49
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    • Simons M, Keller P, De Strooper B, et al. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A 1998;95:6460-6464.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3
  • 50
    • 0034053890 scopus 로고    scopus 로고
    • Non-lipid-related effects of statins
    • Bellosta S, Ferri N, Bernini F, et al. Non-lipid-related effects of statins. Ann Med 2000;32:164-176.
    • (2000) Ann Med , vol.32 , pp. 164-176
    • Bellosta, S.1    Ferri, N.2    Bernini, F.3
  • 51
    • 0035572718 scopus 로고    scopus 로고
    • Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
    • Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001;21:1712-1719.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1712-1719
    • Takemoto, M.1    Liao, J.K.2
  • 52
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 53
    • 33745215607 scopus 로고    scopus 로고
    • Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
    • Horwood JM, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 2006;23:3375-3384.
    • (2006) Eur J Neurosci , vol.23 , pp. 3375-3384
    • Horwood, J.M.1    Dufour, F.2    Laroche, S.3    Davis, S.4
  • 54
    • 4344586929 scopus 로고    scopus 로고
    • Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway
    • Wolfrum S, Dendorfer A, Schutt M, et al. Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol 2004;44:348-355.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 348-355
    • Wolfrum, S.1    Dendorfer, A.2    Schutt, M.3
  • 55
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 56
    • 0028059637 scopus 로고
    • Endothelial NOS and the blockade of LIP by NOS inhibitors in mice lacking neuronal NOS
    • O'Dell TJ, Huang PL, Dawson TM, et al. Endothelial NOS and the blockade of LIP by NOS inhibitors in mice lacking neuronal NOS. Science 1994;265:542-546.
    • (1994) Science , vol.265 , pp. 542-546
    • O'Dell, T.J.1    Huang, P.L.2    Dawson, T.M.3
  • 57
    • 0033542414 scopus 로고    scopus 로고
    • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601.
    • Fulton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999;399:597-601.
  • 58
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3
  • 59
    • 0346749450 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
    • Zacco A, Togo J, Spence K, et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 2003;23:11104-11111.
    • (2003) J Neurosci , vol.23 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3
  • 60
    • 20144385721 scopus 로고    scopus 로고
    • Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones
    • Bosel J, Gandor F, Harms C, et al. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem 2005;92:1386-1398.
    • (2005) J Neurochem , vol.92 , pp. 1386-1398
    • Bosel, J.1    Gandor, F.2    Harms, C.3
  • 61
    • 0035875462 scopus 로고    scopus 로고
    • Use of statins in CNS disorders
    • Cucchiara B, Kasner SE. Use of statins in CNS disorders. J Neurol Sci 2001;187:81-89.
    • (2001) J Neurol Sci , vol.187 , pp. 81-89
    • Cucchiara, B.1    Kasner, S.E.2
  • 62
    • 0038443056 scopus 로고    scopus 로고
    • Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    • Chen J, Zhang ZG, Li Y, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 2003;53:745-751.
    • (2003) Ann Neurol , vol.53 , pp. 745-751
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.