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Volumn 2008, Issue 3, 2008, Pages 81-98

Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis

Author keywords

Apoptosis; Cell growth; Ceramide; Ceramide 1 phosphate; Sphingolipids; Sphingosine 1 phosphate

Indexed keywords

ACYLSPHINGOSINE DEACYLASE; CERAMIDE; CERAMIDE 1 PHOSPHATE; DOXORUBICIN; ETOPOSIDE; F 1209A; FENRETINIDE; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PHOSPHOTRANSFERASE INHIBITOR; SAFINGOL; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 77953405065     PISSN: None     EISSN: 11772727     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (37)

References (232)
  • 1
    • 0026528994 scopus 로고
    • Improved inhibitors of glucosylceramide synthase
    • Abe, A., Inokuchi, J., Jimbo, M. et al. 1992. Improved inhibitors of glucosylceramide synthase. J. Biochem., 111: 191-6.
    • (1992) J. Biochem , vol.111 , pp. 191-196
    • Abe, A.1    Inokuchi, J.2    Jimbo, M.3
  • 2
    • 0033516586 scopus 로고    scopus 로고
    • Differential pharmacological properties and signal transduction ofthe spbingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5
    • Ancellin, N. and Hla, T. 1999. Differential pharmacological properties and signal transduction ofthe spbingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J. Biol. Chem., 274(27):18997-19002.
    • (1999) J. Biol. Chem , vol.274 , Issue.27 , pp. 18997-19002
    • Ancellin, N.1    Hla, T.2
  • 3
    • 0037155259 scopus 로고    scopus 로고
    • Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation
    • Ancellin, N., Colmont, C., Su, J. et al. 2002. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J. Biol. Chem., 277(8):6667-75.
    • (2002) J. Biol. Chem , vol.277 , Issue.8 , pp. 6667-6675
    • Ancellin, N.1    Colmont, C.2    Su, J.3
  • 4
    • 0024373904 scopus 로고
    • Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles
    • Bajalieh, S.M., Martin, T.F. and Floor, E. 1989. Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles. J. Biol. Chem., 264(24):14354-60.
    • (1989) J. Biol. Chem , vol.264 , Issue.24 , pp. 14354-14360
    • Bajalieh, S.M.1    Martin, T.F.2    Floor, E.3
  • 5
    • 0035929583 scopus 로고    scopus 로고
    • Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3
    • Banno, Y., Takuwa, Y., Akao, Y. et al. 2001. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J. Biol. Chem., 276(38):35622-28.
    • (2001) J. Biol. Chem , vol.276 , Issue.38 , pp. 35622-35628
    • Banno, Y.1    Takuwa, Y.2    Akao, Y.3
  • 6
    • 0032514918 scopus 로고    scopus 로고
    • BAD enables ceramide to signal apoptosis via Ras and Raf-1
    • Basu, S., Bayoumy, S., Zhang, Y. et al. 1998. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J. Biol. Chem., 273(46):30419-26.
    • (1998) J. Biol. Chem , vol.273 , Issue.46 , pp. 30419-30426
    • Basu, S.1    Bayoumy, S.2    Zhang, Y.3
  • 7
    • 0037406227 scopus 로고    scopus 로고
    • Characterization of serine palmitoyltransferase in normal human tissues
    • Batheja, A.D., Uhlinger, D.J., Carton, J.M. et al. 2003. Characterization of serine palmitoyltransferase in normal human tissues. J. Histochem. Cytochem., 51(5):687-96.
    • (2003) J. Histochem. Cytochem , vol.51 , Issue.5 , pp. 687-696
    • Batheja, A.D.1    Uhlinger, D.J.2    Carton, J.M.3
  • 8
    • 12444323123 scopus 로고    scopus 로고
    • Sphingosine kinase activity counteracts coramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression
    • Bektas, M., Jolly, P.S., Muller, C. et al. 2005. Sphingosine kinase activity counteracts coramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene., 24(1):178-87.
    • (2005) Oncogene , vol.24 , Issue.1 , pp. 178-187
    • Bektas, M.1    Jolly, P.S.2    Muller, C.3
  • 9
    • 0029810808 scopus 로고    scopus 로고
    • Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity
    • Berger, A., Bittman, R., Schmidt, R.R. et al. 1996. Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. Mol. Pharmacol., 50(3):451-7.
    • (1996) Mol. Pharmacol , vol.50 , Issue.3 , pp. 451-457
    • Berger, A.1    Bittman, R.2    Schmidt, R.R.3
  • 10
    • 13644259069 scopus 로고    scopus 로고
    • Characterization of a ceramide kinase-like protein
    • Bornancin, F., Mechtcheriakova, D., Stora, S. et al. 2005. Characterization of a ceramide kinase-like protein. Biochim Biophys. Acta., 1687(1-3):31-43.
    • (2005) Biochim Biophys. Acta , vol.1687 , Issue.1-3 , pp. 31-43
    • Bornancin, F.1    Mechtcheriakova, D.2    Stora, S.3
  • 11
    • 0027377618 scopus 로고
    • Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane
    • Boudker, O. and Futerman, A.H. 1993. Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane. J. Biol. Chem., 268(29):22150-55.
    • (1993) J. Biol. Chem , vol.268 , Issue.29 , pp. 22150-22155
    • Boudker, O.1    Futerman, A.H.2
  • 12
    • 0029888864 scopus 로고    scopus 로고
    • Phosphatidate phosphohydrolase and signal transduction
    • Brindley, D.N. and Waggoner, D.W. 1996. Phosphatidate phosphohydrolase and signal transduction. Chem. Phys. Lipids, 80(1-2):45-57.
    • (1996) Chem. Phys. Lipids , vol.80 , Issue.1-2 , pp. 45-57
    • Brindley, D.N.1    Waggoner, D.W.2
  • 13
    • 0032544691 scopus 로고    scopus 로고
    • Mammalian lipid phosphate phosphohydrolases
    • Brindley, D.N. and Waggoner, D.W. 1998. Mammalian lipid phosphate phosphohydrolases. J. Biol. Chem., 273(38):24281-84.
    • (1998) J. Biol. Chem , vol.273 , Issue.38 , pp. 24281-24284
    • Brindley, D.N.1    Waggoner, D.W.2
  • 14
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone, M.H., Roy, N., Stennicke, H.R. et al. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science, 282 (5392):1318-21.
    • (1998) Science , vol.282 , Issue.5392 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 15
    • 0033396710 scopus 로고    scopus 로고
    • Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells
    • Nov
    • Carpio, L.C., Stephan, E., Kamer, A. et al. 1999 Nov. Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. Prostaglandins Leukot Essent, Fatty Acids, 61(5):267-73.
    • (1999) Prostaglandins Leukot Essent, Fatty Acids , vol.61 , Issue.5 , pp. 267-273
    • Carpio, L.C.1    Stephan, E.2    Kamer, A.3
  • 16
    • 0035487315 scopus 로고    scopus 로고
    • A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
    • Cazzolli, R., Carpenter, L., Biden, T.J. et al. 2001. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes, 50:2210-18.
    • (2001) Diabetes , vol.50 , pp. 2210-2218
    • Cazzolli, R.1    Carpenter, L.2    Biden, T.J.3
  • 17
    • 0032497841 scopus 로고    scopus 로고
    • Phospholipase D
    • Exton, J.H. 1998. Phospholipase D. Biochim Biophys. Acta., 1436 (1-2):105-15.
    • (1998) Biochim Biophys. Acta , vol.1436 , Issue.1-2 , pp. 105-115
    • Exton, J.H.1
  • 18
    • 0035977067 scopus 로고    scopus 로고
    • FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase
    • Chalfant, C.E., Ogretmen, B., Galadari, S., Kroesen, B.J., Pettus, B.J. and Hannun, Y.A. 2001. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase. J. Biol. Chem., 276(48):44848-55.
    • (2001) J. Biol. Chem , vol.276 , Issue.48 , pp. 44848-44855
    • Chalfant, C.E.1    Ogretmen, B.2    Galadari, S.3    Kroesen, B.J.4    Pettus, B.J.5    Hannun, Y.A.6
  • 20
    • 27844517355 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
    • Chalfant, C.E. and Spiegel, S. 2005. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell. Sci., 118(Pt 20):4605-12.
    • (2005) J. Cell. Sci , vol.118 , Issue.PART 20 , pp. 4605-4612
    • Chalfant, C.E.1    Spiegel, S.2
  • 21
    • 2542495782 scopus 로고    scopus 로고
    • Regulation of phospholipase D2 activity by protein kinase C alpha
    • Chen, J.S. and Exton, J.H. 2004. Regulation of phospholipase D2 activity by protein kinase C alpha. J. Biol. Chem., 279(21):22076-83.
    • (2004) J. Biol. Chem , vol.279 , Issue.21 , pp. 22076-22083
    • Chen, J.S.1    Exton, J.H.2
  • 22
    • 21344450044 scopus 로고    scopus 로고
    • Sites on phospholipase D2 phosphorylated by PKCalpha
    • Chen, J.S. and Exton, J.H. 2005. Sites on phospholipase D2 phosphorylated by PKCalpha. Biochem. Biophys. Res. Commun., 333(4):1322-26.
    • (2005) Biochem. Biophys. Res. Commun , vol.333 , Issue.4 , pp. 1322-1326
    • Chen, J.S.1    Exton, J.H.2
  • 23
    • 0141593615 scopus 로고    scopus 로고
    • Autotaxin hydrolyzes sphingosyl-phosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate
    • Clair, T., Aoki, J., Koh, E. et al. 2003. Autotaxin hydrolyzes sphingosyl-phosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res., 63(17):5446-53.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5446-5453
    • Clair, T.1    Aoki, J.2    Koh, E.3
  • 24
    • 24344495483 scopus 로고    scopus 로고
    • Ceramide-1-phosphate induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation ofa storeoperated calcium channel
    • Colina, C., Flores, A., Castillo, C. et al. 2005. Ceramide-1-phosphate induces Ca2+ mobilization in Jurkat T-cells by elevation of Ins(1,4,5)-P3 and activation ofa storeoperated calcium channel. Biochim. Biophys. Res. Commun., 336:54-60.
    • (2005) Biochim. Biophys. Res. Commun , vol.336 , pp. 54-60
    • Colina, C.1    Flores, A.2    Castillo, C.3
  • 25
    • 0029974372 scopus 로고    scopus 로고
    • Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades
    • Coroneos, E., Wang, Y., Panuska, J.R. et al. 1996. Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. Biochem. J., 316(1):13-17.
    • (1996) Biochem. J , vol.316 , Issue.1 , pp. 13-17
    • Coroneos, E.1    Wang, Y.2    Panuska, J.R.3
  • 26
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • Cuvillier, O., Pirianov, G., Kleuser, B. et al. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 381(6585):800-3.
    • (1996) Nature , vol.381 , Issue.6585 , pp. 800-803
    • Cuvillier, O.1    Pirianov, G.2    Kleuser, B.3
  • 27
    • 15444373345 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate analogs as receptor antagonists
    • Davis, M.D., Clemens, J.J., Macdonald, T.L. et al. 2005. Sphingosine 1-phosphate analogs as receptor antagonists. J. Biol. Chem., 280(11):9833-41.
    • (2005) J. Biol. Chem , vol.280 , Issue.11 , pp. 9833-9841
    • Davis, M.D.1    Clemens, J.J.2    Macdonald, T.L.3
  • 28
    • 0026457994 scopus 로고
    • Sphingosina-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation
    • Desai, N.N., Zhang, H., Olivera, A. et al. 1992. Sphingosina-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation. J. Biol. Chem., 267(32):23122-28.
    • (1992) J. Biol. Chem , vol.267 , Issue.32 , pp. 23122-23128
    • Desai, N.N.1    Zhang, H.2    Olivera, A.3
  • 29
    • 0010620607 scopus 로고    scopus 로고
    • Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons
    • De Chaves, E.I., Bussiere, M., Vance, D.E. et al.. 1997. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. J. Biol. Chem., 272(5):3028-35.
    • (1997) J. Biol. Chem , vol.272 , Issue.5 , pp. 3028-3035
    • De Chaves, E.I.1    Bussiere, M.2    Vance, D.E.3
  • 30
    • 0036340284 scopus 로고    scopus 로고
    • Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells
    • De Stefanis, D., Reffo, P., Bonelli, G. et al. 2002. Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells. Biol. Chem., 383(6):989-99.
    • (2002) Biol. Chem , vol.383 , Issue.6 , pp. 989-999
    • De Stefanis, D.1    Reffo, P.2    Bonelli, G.3
  • 31
    • 33845304290 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate regulates cytoscheleton dynamics: Implications in its biological response
    • Donati, C. and Bruni, P. 2006. Sphingosine 1-phosphate regulates cytoscheleton dynamics: Implications in its biological response. Biochim Biophys. Acta., 1758 (12):2037-48.
    • (2006) Biochim Biophys. Acta , vol.1758 , Issue.12 , pp. 2037-2048
    • Donati, C.1    Bruni, P.2
  • 32
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatase
    • Dobrowsky, R.T. and Hannun, Y.A. 1992. Ceramide stimulates a cytosolic protein phosphatase. J. Biol. Chem., 267(8):5048-51.
    • (1992) J. Biol. Chem , vol.267 , Issue.8 , pp. 5048-5051
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 33
    • 33846474121 scopus 로고    scopus 로고
    • G-proteiris coupled receptors and cancer
    • Dorsam, R.T. and Gutkind, J.S. 2007. G-proteiris coupled receptors and cancer. Nat. Rev. Cancer, 7(2):79-94.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 34
    • 33845577788 scopus 로고    scopus 로고
    • Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: Implications for postoperative ileus
    • Dragusin, M., Wehner, S., Kelly, S. et al. 2006. Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. FASEB. J. 20(11):1930-32.
    • (2006) FASEB. J , vol.20 , Issue.11 , pp. 1930-1932
    • Dragusin, M.1    Wehner, S.2    Kelly, S.3
  • 35
    • 0025168334 scopus 로고
    • Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin
    • Dressler, K.A. and Kolesnick, R.N. 1990. Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin. J. Biol. Chem., 265(25):14917-21.
    • (1990) J. Biol. Chem , vol.265 , Issue.25 , pp. 14917-14921
    • Dressler, K.A.1    Kolesnick, R.N.2
  • 36
    • 33646146401 scopus 로고    scopus 로고
    • Alkaline sphingomyelinase: An old enzyme with novel implications
    • Duan, R.D. 2006. Alkaline sphingomyelinase: an old enzyme with novel implications. Biochim. Biophys. Acta., 1761(3):281-91.
    • (2006) Biochim. Biophys. Acta , vol.1761 , Issue.3 , pp. 281-291
    • Duan, R.D.1
  • 37
    • 0022418382 scopus 로고
    • Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines
    • Epand, R.M. 1985. Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines. Biochemistry, 24:7092-95.
    • (1985) Biochemistry , vol.24 , pp. 7092-7095
    • Epand, R.M.1
  • 38
    • 33745964562 scopus 로고    scopus 로고
    • Antitumor Activity of Sphingosine Kinase Inhibitors
    • French, K.J., Upson, U., Keller, S.N. et al. 2006. Antitumor Activity of Sphingosine Kinase Inhibitors. J. Pharmacol. Exp. Ther., 318(2):596-603.
    • (2006) J. Pharmacol. Exp. Ther , vol.318 , Issue.2 , pp. 596-603
    • French, K.J.1    Upson, U.2    Keller, S.N.3
  • 39
    • 0141507968 scopus 로고    scopus 로고
    • Discovery and evaluation of inhibitors of human sphingosine kinase
    • French, K.J., Schrecengost, R.S., Lee, B.D. et al. 2003. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res., 63(18):5962-69.
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5962-5969
    • French, K.J.1    Schrecengost, R.S.2    Lee, B.D.3
  • 40
    • 0032794361 scopus 로고    scopus 로고
    • N-acetylsphingenine-1-phosphate is a potent calcium mobilizing agent
    • Gijsbers, S., Mannaerts, G.P., Himpens, B. et al. 1999. N-acetylsphingenine-1-phosphate is a potent calcium mobilizing agent. FEBS Lett, 453:269-72.
    • (1999) FEBS Lett , vol.453 , pp. 269-272
    • Gijsbers, S.1    Mannaerts, G.P.2    Himpens, B.3
  • 41
    • 33745442062 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
    • Giussani, P., Maceyka, M., Le Stunff, H. et al. 2006. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell. Biol., 26(13):5055-69.
    • (2006) Mol. Cell. Biol , vol.26 , Issue.13 , pp. 5055-5069
    • Giussani, P.1    Maceyka, M.2    Le Stunff, H.3
  • 42
    • 0026654779 scopus 로고
    • Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes
    • Gómez-Muñoz, A., Haniza, E.H. and Brindley, D.N. 1992. Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes. Biochim. Biophys. Acta., 1127(1):49-56.
    • (1992) Biochim. Biophys. Acta , vol.1127 , Issue.1 , pp. 49-56
    • Gómez-Muñoz, A.1    Haniza, E.H.2    Brindley, D.N.3
  • 43
    • 0028339322 scopus 로고
    • Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts
    • Gómez-Muñoz, A., Martin, A., O'Brien, L. et al. 1994. Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J. Biol. Chem., 269(12):8937-43.
    • (1994) J. Biol. Chem , vol.269 , Issue.12 , pp. 8937-8943
    • Gómez-Muñoz, A.1    Martin, A.2    O'Brien, L.3
  • 44
    • 0029014026 scopus 로고
    • Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: Antagonism by cell-permeable ceramides
    • Gómez-Muñoz, A., Duffy, P.A., Martin, A. et al. 1995. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol. Pharmacol., 47(5):883-9.
    • (1995) Mol. Pharmacol , vol.47 , Issue.5 , pp. 883-889
    • Gómez-Muñoz, A.1    Duffy, P.A.2    Martin, A.3
  • 45
    • 0028825719 scopus 로고
    • Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity
    • Gómez-Muñoz, A., Waggoner, D.W., O'Brien, et al. 1995. Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J. Biol. Chem., 270(44):26318-25.
    • (1995) J. Biol. Chem , vol.270 , Issue.44 , pp. 26318-26325
    • Gómez-Muñoz, A.1    Waggoner, D.W.2    O'Brien3
  • 46
    • 0030788162 scopus 로고    scopus 로고
    • Stimulation of DNA synthesis by natural ceramide 1-phosphate
    • Gómez-Muñoz, A., Frago, L.M., Alvarez, L. et al. 1997. Stimulation of DNA synthesis by natural ceramide 1-phosphate. Biochem. J., 235:435-40.
    • (1997) Biochem. J , vol.235 , pp. 435-440
    • Gómez-Muñoz, A.1    Frago, L.M.2    Alvarez, L.3
  • 47
    • 0032489435 scopus 로고    scopus 로고
    • Modulation of cell signalling by ceramides
    • Gómez-Muñoz, A. 1998. Modulation of cell signalling by ceramides. Biochim Biophys. Acta., 1391(1):92-109.
    • (1998) Biochim Biophys. Acta , vol.1391 , Issue.1 , pp. 92-109
    • Gómez-Muñoz, A.1
  • 48
    • 0037878774 scopus 로고    scopus 로고
    • Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages
    • Gómez-Muñoz, A., Martens, J.S. and Steinbrecher, U.P. 2000. Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages. Arterioscler Thromb Vasc. Biol., 20(1):135-43.
    • (2000) Arterioscler Thromb Vasc. Biol , vol.20 , Issue.1 , pp. 135-143
    • Gómez-Muñoz, A.1    Martens, J.S.2    Steinbrecher, U.P.3
  • 49
    • 0037468614 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages
    • Gómez-Muñoz, A., Kong, J., Salh, B. et al. 2003. Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. FEBS Lett, 539(1-3):56-60.
    • (2003) FEBS Lett , vol.539 , Issue.1-3 , pp. 56-60
    • Gómez-Muñoz, A.1    Kong, J.2    Salh, B.3
  • 50
    • 1642403610 scopus 로고    scopus 로고
    • Ceramide-1-phosphate: A novel regulator of cell activation
    • Gómez-Muñoz, A. 2004. Ceramide-1-phosphate: a novel regulator of cell activation. FEBS Lett, 562(1-3):5-10.
    • (2004) FEBS Lett , vol.562 , Issue.1-3 , pp. 5-10
    • Gómez-Muñoz, A.1
  • 51
    • 0842282983 scopus 로고    scopus 로고
    • Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
    • Gómez-Muñoz, A., Kong, J.Y., Salh, B. et al. 2004. Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. J. Lipid Res., 45(1):99-105.
    • (2004) J. Lipid Res , vol.45 , Issue.1 , pp. 99-105
    • Gómez-Muñoz, A.1    Kong, J.Y.2    Salh, B.3
  • 52
    • 21244479753 scopus 로고    scopus 로고
    • Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Gómez-Muñoz, A., Kong, J.Y., Parhar, K. et al. 2005. Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway. FEBS Lett, 579(17):3744-50.
    • (2005) FEBS Lett , vol.579 , Issue.17 , pp. 3744-3750
    • Gómez-Muñoz, A.1    Kong, J.Y.2    Parhar, K.3
  • 53
    • 33845292007 scopus 로고    scopus 로고
    • Ceramide 1-phosphate/ceramide, a switch between life and death
    • Gómez Muñoz, A. 2006. Ceramide 1-phosphate/ceramide, a switch between life and death. Biochim. Biophys. Acta., 1758(12):2049-56.
    • (2006) Biochim. Biophys. Acta , vol.1758 , Issue.12 , pp. 2049-2056
    • Gómez Muñoz, A.1
  • 54
    • 33746206286 scopus 로고    scopus 로고
    • Sphingomyelinases and the regulation of cell death and survival
    • Gómez-Muñoz, A. 2006. Sphingomyelinases and the regulation of cell death and survival. Curr Enzyme Inhibition, 2:125-34.
    • (2006) Curr Enzyme Inhibition , vol.2 , pp. 125-134
    • Gómez-Muñoz, A.1
  • 55
    • 33845346790 scopus 로고    scopus 로고
    • Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids
    • Gohi, F.M. and Alonso, A. 2006. Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. Biochim. Biophys. Acta., 1758(12):1902-21.
    • (2006) Biochim. Biophys. Acta , vol.1758 , Issue.12 , pp. 1902-1921
    • Gohi, F.M.1    Alonso, A.2
  • 56
    • 0037201939 scopus 로고    scopus 로고
    • Sphingomyelinases: Enzymology and membrane activity
    • Gofti, F.M. and Alonso, A. 2002. Sphingomyelinases: enzymology and membrane activity. FEBS Lett, 531(1):38-46.
    • (2002) FEBS Lett , vol.531 , Issue.1 , pp. 38-46
    • Gofti, F.M.1    Alonso, A.2
  • 57
    • 33845346454 scopus 로고    scopus 로고
    • Glycosphingolipids and drug resistance
    • Gouaze-Andersson, V. and Cabot, M.C. 2006. Glycosphingolipids and drug resistance. Biochim Biophys. Acta., 1758(12):2096-103.
    • (2006) Biochim Biophys. Acta , vol.1758 , Issue.12 , pp. 2096-2103
    • Gouaze-Andersson, V.1    Cabot, M.C.2
  • 58
    • 18144371163 scopus 로고    scopus 로고
    • Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    • Gouaze, V., Liu, Y.Y., Prickett, C.S. et al. 2005. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res., 65(9):3861-7.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3861-3867
    • Gouaze, V.1    Liu, Y.Y.2    Prickett, C.S.3
  • 59
    • 0242574357 scopus 로고    scopus 로고
    • Raft ceramide in molecular medicine
    • Gulbins, E. and Kolesnick, R. 2003. Raft ceramide in molecular medicine. Oncogene, 22(45):7070-77.
    • (2003) Oncogene , vol.22 , Issue.45 , pp. 7070-7077
    • Gulbins, E.1    Kolesnick, R.2
  • 60
    • 33845291120 scopus 로고    scopus 로고
    • Sphingosine kinase, sphingosine 1-phosphate, apoptosis and diseases
    • Hait, N.C., Oskeiritzian, C.A., Paugh, S.W. et al. 2006. Sphingosine kinase, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta., 1758(12):2116-2026.
    • (2006) Biochim. Biophys. Acta , vol.1758 , Issue.12 , pp. 2116-2026
    • Hait, N.C.1    Oskeiritzian, C.A.2    Paugh, S.W.3
  • 61
    • 0035896366 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt)-a key regulator of glucose transport?
    • Hajduch, E., Litherland, G.J. and Hundal, H.S. 2001. Protein kinase B (PKB/Akt)-a key regulator of glucose transport? FEBS Lett, 492(3):199-203.
    • (2001) FEBS Lett , vol.492 , Issue.3 , pp. 199-203
    • Hajduch, E.1    Litherland, G.J.2    Hundal, H.S.3
  • 62
    • 33646227441 scopus 로고    scopus 로고
    • Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide
    • Hanada, K. 2006. Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide. Mol. Cell. Biochem., 286(1-2):23-31.
    • (2006) Mol. Cell. Biochem , vol.286 , Issue.1-2 , pp. 23-31
    • Hanada, K.1
  • 63
    • 0347611095 scopus 로고    scopus 로고
    • Molecular machinery for non-vesicular trafficking of ceramide
    • Hanada, K., Kumagai, K., Yasuda, S. et al. 2003. Molecular machinery for non-vesicular trafficking of ceramide. Nature, 426(6968):803-9.
    • (2003) Nature , vol.426 , Issue.6968 , pp. 803-809
    • Hanada, K.1    Kumagai, K.2    Yasuda, S.3
  • 64
    • 0022876160 scopus 로고
    • Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies
    • Hannun, YA., Loomis, C.R. and Bell, R-M. 1986. Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J. Biol. Chem., 261(16):7184-90.
    • (1986) J. Biol. Chem , vol.261 , Issue.16 , pp. 7184-7190
    • Hannun, Y.A.1    Loomis, C.R.2    Bell, R.-M.3
  • 65
    • 0022974603 scopus 로고
    • Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
    • Hannun, Y.A., Loomis, C.R., Merrill, A.H. Jr et al. 1986. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem., 261(27):12604-9.
    • (1986) J. Biol. Chem , vol.261 , Issue.27 , pp. 12604-12609
    • Hannun, Y.A.1    Loomis, C.R.2    Merrill Jr, A.H.3
  • 66
    • 0027994349 scopus 로고
    • The sphingomyelin cycle and the second messenger function of ceramide
    • Hannun, Y.A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem., 269(5):3125-8.
    • (1994) J. Biol. Chem , vol.269 , Issue.5 , pp. 3125-3128
    • Hannun, Y.A.1
  • 67
    • 0028855405 scopus 로고
    • Ceramide: Intracellular signal for apoptosis
    • Hannun, Y.A. and Obeid, L.M. 1995. Ceramide: intracellular signal for apoptosis. Trends Biochem. Sci., 20:73-9.
    • (1995) Trends Biochem. Sci , vol.20 , pp. 73-79
    • Hannun, Y.A.1    Obeid, L.M.2
  • 68
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science, 274(5294):1855-9.
    • (1996) Science , vol.274 , Issue.5294 , pp. 1855-1859
    • Hannun, Y.A.1
  • 69
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun, Y.A. and Obeid, L.M. 2002. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem., 277(29):25847-50.
    • (2002) J. Biol. Chem , vol.277 , Issue.29 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 70
    • 0030965154 scopus 로고    scopus 로고
    • Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer
    • Heasley, L.E., Thaler, S., Nicks, M. et al. 1997. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. J B.iol. Chem., 272(23):14501-4.
    • (1997) J B.iol. Chem , vol.272 , Issue.23 , pp. 14501-14504
    • Heasley, L.E.1    Thaler, S.2    Nicks, M.3
  • 71
    • 0242266384 scopus 로고    scopus 로고
    • Purified intestinal alkaline sphingoinyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells
    • Hertervig, E., Nilsson, A., Cheng, Y. et al. 2003. Purified intestinal alkaline sphingoinyelinase inhibits proliferation without inducing apoptosis in HT-29 colon carcinoma cells. J. Cancer Res. Clin. Oncol., 129(10):577-82.
    • (2003) J. Cancer Res. Clin. Oncol , vol.129 , Issue.10 , pp. 577-582
    • Hertervig, E.1    Nilsson, A.2    Cheng, Y.3
  • 72
    • 0032509523 scopus 로고    scopus 로고
    • The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion
    • Hinkovska-Galcheva, V.T., Boxer, L.A., Mansfield, P.J. et al. 1998. The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion. J. Biol. Chem., 273(50):33203-9.
    • (1998) J. Biol. Chem , vol.273 , Issue.50 , pp. 33203-33209
    • Hinkovska-Galcheva, V.T.1    Boxer, L.A.2    Mansfield, P.J.3
  • 73
    • 22544464177 scopus 로고    scopus 로고
    • Ceramide 1-phosphate, a mediator of phagocytosis
    • Hinkovska-Galcheva, V.T., Boxer, L.A., Kindzelskii, A. et al. 2005. Ceramide 1-phosphate, a mediator of phagocytosis. J. Biol. Chem., 280 (28):26612-21.
    • (2005) J. Biol. Chem , vol.280 , Issue.28 , pp. 26612-26621
    • Hinkovska-Galcheva, V.T.1    Boxer, L.A.2    Kindzelskii, A.3
  • 74
    • 0037401876 scopus 로고    scopus 로고
    • Signaling and biological actions of sphingosine 1-phosphate
    • Hla, T. 2003. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res., 47(5):401-7.
    • (2003) Pharmacol. Res , vol.47 , Issue.5 , pp. 401-407
    • Hla, T.1
  • 75
    • 0035957326 scopus 로고    scopus 로고
    • Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis
    • Hong, K.H., Bonventre, J.C., O'Leary, E. et al. 2001. Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. Proc. Natl. Acad Sci. U.S.A., 98(7):3935-9.
    • (2001) Proc. Natl. Acad Sci. U.S.A , vol.98 , Issue.7 , pp. 3935-3939
    • Hong, K.H.1    Bonventre, J.C.2    O'Leary, E.3
  • 76
    • 0242501551 scopus 로고    scopus 로고
    • Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: Evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate
    • Hogback, S., Leppimaki, P., Rudnas, B. et al. 2003. Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. Biochem. J., 370(Pt 1): 111-9.
    • (2003) Biochem. J , vol.370 , Issue.PART 1 , pp. 111-119
    • Hogback, S.1    Leppimaki, P.2    Rudnas, B.3
  • 77
    • 0037462741 scopus 로고    scopus 로고
    • Mechanisms of regulation of phospholipase D1 by protein kinase Calpha
    • Hu, T. and Exton, J.H. 2003. Mechanisms of regulation of phospholipase D1 by protein kinase Calpha. J. Biol. Chem., 278(4):2348-55.
    • (2003) J. Biol. Chem , vol.278 , Issue.4 , pp. 2348-2355
    • Hu, T.1    Exton, J.H.2
  • 78
    • 0042090272 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels
    • Hundal, R.S., Gomez-Munoz, A., Kong, J.Y. et al. 2003. Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J .Biol. Chem., 278(27):24399-408.
    • (2003) J .Biol. Chem , vol.278 , Issue.27 , pp. 24399-24408
    • Hundal, R.S.1    Gomez-Munoz, A.2    Kong, J.Y.3
  • 79
    • 0035654579 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits macrophage apaptosis through activation of the PI 3 -kinase/PKB pathway
    • Hundal, R.S., Salh, B.S., Schrader, J.W. et al. 2001. Oxidized low density lipoprotein inhibits macrophage apaptosis through activation of the PI 3 -kinase/PKB pathway. J. Lipid Res., 42(9):1483-91.
    • (2001) J. Lipid Res , vol.42 , Issue.9 , pp. 1483-1491
    • Hundal, R.S.1    Salh, B.S.2    Schrader, J.W.3
  • 80
    • 0031967883 scopus 로고    scopus 로고
    • Common Regions of Deletion on Chromosomes 5q, 6q, and 10q in Renal Cell Carcinoma
    • Ichimura, K., Schmidt, E., Miyakopwa, A. et al. 1998. Common Regions of Deletion on Chromosomes 5q, 6q, and 10q in Renal Cell Carcinoma. Genes Chromosomes Cancer, 22:9-15.
    • (1998) Genes Chromosomes Cancer , vol.22 , pp. 9-15
    • Ichimura, K.1    Schmidt, E.2    Miyakopwa, A.3
  • 81
    • 0025027772 scopus 로고
    • Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action
    • Inokuchi, J., Jimbo, M., Mimosaki, K. et al. 1990: Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. Cancer Res., 50(20):6731-9.
    • (1990) Cancer Res , vol.50 , Issue.20 , pp. 6731-6739
    • Inokuchi, J.1    Jimbo, M.2    Mimosaki, K.3
  • 82
    • 0041344688 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry
    • Itagaki, K. and Hauser, C.J. 2003. Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. J Biol. Chem., 278(30):27540-47.
    • (2003) J Biol. Chem , vol.278 , Issue.30 , pp. 27540-27547
    • Itagaki, K.1    Hauser, C.J.2
  • 83
    • 0025774977 scopus 로고
    • Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol
    • Jamal, Z., Martin, A., Gómez-Munoz, A. et al. 1991. Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol. J. Biol. Chem., 266(5):2988-96.
    • (1991) J. Biol. Chem , vol.266 , Issue.5 , pp. 2988-2996
    • Jamal, Z.1    Martin, A.2    Gómez-Munoz, A.3
  • 84
    • 0033591231 scopus 로고    scopus 로고
    • Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal
    • Jaworowski, A., Wilson, N.J., Christy, E. et al. 1999. Roles of the mitogen-activated protein kinase family in macrophage responses to colony stimulating factor-1 addition and withdrawal. J. Biol. Chem., 274(21):15127-33.
    • (1999) J. Biol. Chem , vol.274 , Issue.21 , pp. 15127-15133
    • Jaworowski, A.1    Wilson, N.J.2    Christy, E.3
  • 85
    • 0037144434 scopus 로고    scopus 로고
    • PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)
    • Johnson, K.R., Becker, K.P., Facchinetti, M.M. et al. 2002. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J. Biol. Chem., 277(38):35257-62.
    • (2002) J. Biol. Chem , vol.277 , Issue.38 , pp. 35257-35262
    • Johnson, K.R.1    Becker, K.P.2    Facchinetti, M.M.3
  • 86
    • 0141445962 scopus 로고    scopus 로고
    • Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability
    • Johnson, K.R., Johnson, K.Y., Becker, K.P. et al. 2003. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol. Chem., 278(36):34541-7.
    • (2003) J Biol. Chem , vol.278 , Issue.36 , pp. 34541-34547
    • Johnson, K.R.1    Johnson, K.Y.2    Becker, K.P.3
  • 87
    • 24344501665 scopus 로고    scopus 로고
    • Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue
    • Johnson, K.R., Johnson, K.Y., Crellin, H.G. et al. 2005. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J. Histochem. Cytochem., 53(9):1159-66.
    • (2005) J. Histochem. Cytochem , vol.53 , Issue.9 , pp. 1159-1166
    • Johnson, K.R.1    Johnson, K.Y.2    Crellin, H.G.3
  • 88
    • 31044449986 scopus 로고    scopus 로고
    • Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1
    • Kim, J.W., Inagaki, Y., Mitsutake, S. et al. 2005. Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1. Biochim. Biophys. Acta., 1738(1-3):82-90.
    • (2005) Biochim. Biophys. Acta , vol.1738 , Issue.1-3 , pp. 82-90
    • Kim, J.W.1    Inagaki, Y.2    Mitsutake, S.3
  • 89
    • 0030586198 scopus 로고    scopus 로고
    • On the molecular level mechanisms of peripheral protein/membrane interactions induced by lipids forming non-lamellar phases
    • Kinnunen, PKJ. 1996. On the molecular level mechanisms of peripheral protein/membrane interactions induced by lipids forming non-lamellar phases. Chem. Phys. Lipids, 81:151-66.
    • (1996) Chem. Phys. Lipids , vol.81 , pp. 151-166
    • Kinnunen, P.K.J.1
  • 90
    • 34547122771 scopus 로고    scopus 로고
    • Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alphalbetaII
    • Kitatani, K., Idkowiak-Baldys, J. and Hannun, Y.A. 2007. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alphalbetaII. J. Biol. Chem., 282(28):20647-56.
    • (2007) J. Biol. Chem , vol.282 , Issue.28 , pp. 20647-20656
    • Kitatani, K.1    Idkowiak-Baldys, J.2    Hannun, Y.A.3
  • 91
    • 0035839128 scopus 로고    scopus 로고
    • Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor
    • Kleuser, B., Maceyka, M., Milstien, S. et al. 2001. Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor. FEBS Lett, 503(1):85-90.
    • (2001) FEBS Lett , vol.503 , Issue.1 , pp. 85-90
    • Kleuser, B.1    Maceyka, M.2    Milstien, S.3
  • 92
    • 0023555012 scopus 로고
    • 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells
    • Kolesnick, R.N. 1987. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J. Biol. Chem., 262(35):16759-62.
    • (1987) J. Biol. Chem , vol.262 , Issue.35 , pp. 16759-16762
    • Kolesnick, R.N.1
  • 93
    • 0025185675 scopus 로고
    • Characterization ofa ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity
    • Kolesnick, R.N. and Hemer, M.R. 1990. Characterization ofa ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. J. Biol. Chem., 265(31):18803-08.
    • (1990) J. Biol. Chem , vol.265 , Issue.31 , pp. 18803-18808
    • Kolesnick, R.N.1    Hemer, M.R.2
  • 94
    • 0028352908 scopus 로고
    • Signal transduction through the sphingomyelin pathway
    • Kolesnick, R.N. 1994. Signal transduction through the sphingomyelin pathway. Mot. Chem. Neuropathol., 21(2-3):287-97.
    • (1994) Mot. Chem. Neuropathol , vol.21 , Issue.2-3 , pp. 287-297
    • Kolesnick, R.N.1
  • 95
    • 0028297068 scopus 로고
    • The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
    • Kolesnick, R.N. and Golde, D.W. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell., 77(3):325-8.
    • (1994) Cell , vol.77 , Issue.3 , pp. 325-328
    • Kolesnick, R.N.1    Golde, D.W.2
  • 96
    • 0033884050 scopus 로고    scopus 로고
    • Compartmentalization of ceramide signaling: Physical foundations and biological effects
    • Kolesnick, R.N., Goni, F.M. and Alonso, A. 2000. Compartmentalization of ceramide signaling: physical foundations and biological effects. J. Cell. Physiol., 184(3):285-300.
    • (2000) J. Cell. Physiol , vol.184 , Issue.3 , pp. 285-300
    • Kolesnick, R.N.1    Goni, F.M.2    Alonso, A.3
  • 97
    • 0036303786 scopus 로고    scopus 로고
    • The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    • 3-8
    • Kolesnick, R.N. 2002. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J. Clin. Invest., 110(1)-3-8.
    • (2002) J. Clin. Invest , vol.110 , Issue.1
    • Kolesnick, R.N.1
  • 98
    • 33749185077 scopus 로고    scopus 로고
    • Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    • Kohno, M., Momoi, M., Oo, M.L. et al. 2006. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell. Biol., 26(19):7211-23.
    • (2006) Mol. Cell. Biol , vol.26 , Issue.19 , pp. 7211-7223
    • Kohno, M.1    Momoi, M.2    Oo, M.L.3
  • 99
    • 0033588370 scopus 로고    scopus 로고
    • Comparison of intrinsic activities of the putative sphingosine1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells
    • Kon, J., Sato, K., Watanabe, T. et al. 1999. Comparison of intrinsic activities of the putative sphingosine1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. J. Biol. Chem., 274:23940-7.
    • (1999) J. Biol. Chem , vol.274 , pp. 23940-23947
    • Kon, J.1    Sato, K.2    Watanabe, T.3
  • 100
    • 7244244035 scopus 로고    scopus 로고
    • Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
    • Koybasi, S., Senkal, C.E., Sundararaj, K. et al. 2004. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J. Biol. Chem., 279(43):44311-9.
    • (2004) J. Biol. Chem , vol.279 , Issue.43 , pp. 44311-44319
    • Koybasi, S.1    Senkal, C.E.2    Sundararaj, K.3
  • 101
    • 30344435318 scopus 로고    scopus 로고
    • Ceramide-1-phosphate: The "missing" link in eicosanoid biosynthesis and inflammation
    • Lamour, N.F. and Chalfant, C.E. 2005. Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation. Mol. Interv., 5(6):358-67.
    • (2005) Mol. Interv , vol.5 , Issue.6 , pp. 358-367
    • Lamour, N.F.1    Chalfant, C.E.2
  • 102
    • 14644391944 scopus 로고    scopus 로고
    • Generation and metabolism of bioactive sphingosine-1-phosphate
    • Le Stunff, H., Milstien, S. and Spiegel, S. 2004. Generation and metabolism of bioactive sphingosine-1-phosphate. J. Cell. Biochem., 92(5):882-99.
    • (2004) J. Cell. Biochem , vol.92 , Issue.5 , pp. 882-899
    • Le Stunff, H.1    Milstien, S.2    Spiegel, S.3
  • 103
    • 0037119991 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
    • Le Stunff, H., Galve-Roperh, I., Peterson, C. et al. 2002. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J. Cell. Biol., 158(6):1039-49.
    • (2002) J. Cell. Biol , vol.158 , Issue.6 , pp. 1039-1049
    • Le Stunff, H.1    Galve-Roperh, I.2    Peterson, C.3
  • 104
    • 27444432178 scopus 로고    scopus 로고
    • Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA)
    • Lee, S. and Lynch, K.R. 2005. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem. J., 391:317-23.
    • (2005) Biochem. J , vol.391 , pp. 317-323
    • Lee, S.1    Lynch, K.R.2
  • 105
    • 15844387528 scopus 로고    scopus 로고
    • Ceramide inactivates cellular protein kinase Calpha
    • Lee, J.Y., Hannun, Y.A. and Obeid, L.M. 1996. Ceramide inactivates cellular protein kinase Calpha. J. Biol. Chem., 271(22):13169-74.
    • (1996) J. Biol. Chem , vol.271 , Issue.22 , pp. 13169-13174
    • Lee, J.Y.1    Hannun, Y.A.2    Obeid, L.M.3
  • 106
    • 0027968517 scopus 로고
    • Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase
    • Liu, J., Mathias, S., Yang, Z. et al. 1994. Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase. J. Biol. Chem., 269(4):3047-52.
    • (1994) J. Biol. Chem , vol.269 , Issue.4 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3
  • 107
    • 0034629305 scopus 로고    scopus 로고
    • Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin, resistance
    • Liu, Y.Y., Han, T.Y., Giuliano, A.E. et al. 2000. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin, resistance. J. Biol. Chem., 275:7138-43.
    • (2000) J. Biol. Chem , vol.275 , pp. 7138-7143
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3
  • 108
    • 0141924852 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 is aputative BH3-only protein that induces apoptosis
    • Liu, H., Toman, R.E., Goparaju, S.K. et al. 2003. Sphingosine kinase type 2 is aputative BH3-only protein that induces apoptosis. J. Biol. Chem., 278(41):40330-6.
    • (2003) J. Biol. Chem , vol.278 , Issue.41 , pp. 40330-40336
    • Liu, H.1    Toman, R.E.2    Goparaju, S.K.3
  • 109
    • 26844442547 scopus 로고    scopus 로고
    • Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
    • Long, J., Darroch, P., Wan, K.F. et al. 2005. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem. J., 391(Pt 1):25-32.
    • (2005) Biochem. J , vol.391 , Issue.PART 1 , pp. 25-32
    • Long, J.1    Darroch, P.2    Wan, K.F.3
  • 110
    • 0027965006 scopus 로고
    • Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingemyelinase
    • Lozano, J., Berra, E., Municio, M.M. et al. 1994. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingemyelinase. J. Biol. Chem., 269(30):19200-2.
    • (1994) J. Biol. Chem , vol.269 , Issue.30 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Municio, M.M.3
  • 111
    • 0032486257 scopus 로고    scopus 로고
    • Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
    • Luberto, C. and Hannun, Y.A. 1998. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem., 273(23):14550-59.
    • (1998) J. Biol. Chem , vol.273 , Issue.23 , pp. 14550-14559
    • Luberto, C.1    Hannun, Y.A.2
  • 112
    • 1642336218 scopus 로고    scopus 로고
    • Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity
    • Lu, F.G., Wong, C.S. et al. 2004. Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity. Int. J. Radiat. Biol., 80(1):39-51.
    • (2004) Int. J. Radiat. Biol , vol.80 , Issue.1 , pp. 39-51
    • Lu, F.G.1    Wong, C.S.2
  • 113
    • 0037203305 scopus 로고    scopus 로고
    • Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
    • Maceyka, M., Payne, S.G., Milstien, S. et al. 2002. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys. Acta., 1585(2-3):193-201.
    • (2002) Biochim Biophys. Acta , vol.1585 , Issue.2-3 , pp. 193-201
    • Maceyka, M.1    Payne, S.G.2    Milstien, S.3
  • 114
    • 27744547965 scopus 로고    scopus 로고
    • SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
    • Maceyka, M., Sankala, H., Hait, N.C. et al. 2005. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J. Biol. Chem., 280(44):37118-19.
    • (2005) J. Biol. Chem , vol.280 , Issue.44 , pp. 37118-37119
    • Maceyka, M.1    Sankala, H.2    Hait, N.C.3
  • 115
    • 3242788127 scopus 로고    scopus 로고
    • Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes
    • Mackintosh, C. 2004. Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem. J., 381(Pt 2):329-42.
    • (2004) Biochem. J , vol.381 , Issue.PART 2 , pp. 329-342
    • Mackintosh, C.1
  • 116
    • 0031841493 scopus 로고    scopus 로고
    • Vitamin D metabolites activate the sphingomyelin pathway and induce death of glioblastoma cells
    • Magrassi, L., Adorni, L., Montorfano, G. et al. 1998. Vitamin D metabolites activate the sphingomyelin pathway and induce death of glioblastoma cells. Acta. Neurochir., 140(7):707-14.
    • (1998) Acta. Neurochir , vol.140 , Issue.7 , pp. 707-714
    • Magrassi, L.1    Adorni, L.2    Montorfano, G.3
  • 117
    • 0032993377 scopus 로고    scopus 로고
    • Lipid signaling in CD95-mediated apoptosis
    • Malisan, F. and Testi, R. 1999. Lipid signaling in CD95-mediated apoptosis. FEBS Lett, 452(1-2):100-3.
    • (1999) FEBS Lett , vol.452 , Issue.1-2 , pp. 100-103
    • Malisan, F.1    Testi, R.2
  • 118
    • 0030942087 scopus 로고    scopus 로고
    • Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts
    • Martin, A., Duffy, P.A., Liossis, C. et al. 1997. Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts. Oncogene, 14(13):1571-80.
    • (1997) Oncogene , vol.14 , Issue.13 , pp. 1571-1580
    • Martin, A.1    Duffy, P.A.2    Liossis, C.3
  • 119
    • 0027488403 scopus 로고
    • Ceramide: A novel second messenger
    • Mathias, S. and Kolesnick, R.N. 1993. Ceramide: a novel second messenger. Adv. Lipid Res., 25:65-90.
    • (1993) Adv. Lipid Res , vol.25 , pp. 65-90
    • Mathias, S.1    Kolesnick, R.N.2
  • 120
    • 0027991078 scopus 로고
    • Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an mositol trisphosphate-independent pathway
    • Mattie, M., Brooker, G. and Spiegel, S. 1994. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an mositol trisphosphate-independent pathway. J. Biol. Chem., 269(5):3181-8.
    • (1994) J. Biol. Chem , vol.269 , Issue.5 , pp. 3181-3188
    • Mattie, M.1    Brooker, G.2    Spiegel, S.3
  • 121
    • 0034614095 scopus 로고    scopus 로고
    • Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxypheny)retinamide and modulators of ceramide metabolism
    • Mauret, B.J., Melton, L., Billups, C. et al. 2000. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxypheny)retinamide and modulators of ceramide metabolism. J. Natl. Cancer Inst., 92:1897-909.
    • (2000) J. Natl. Cancer Inst , vol.92 , pp. 1897-1909
    • Mauret, B.J.1    Melton, L.2    Billups, C.3
  • 122
    • 33847055467 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
    • Mechtcheriakova, D., Wlachos, A., Sobanov, J. et al. 2007. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell. Signal, 19(4):748-60.
    • (2007) Cell. Signal , vol.19 , Issue.4 , pp. 748-760
    • Mechtcheriakova, D.1    Wlachos, A.2    Sobanov, J.3
  • 123
    • 0025283928 scopus 로고
    • An update of the enzymology and regulation of sphingomyelin metabolism
    • Merrill, A.H. Jr and Jones, P.D. 1990. An update of the enzymology and regulation of sphingomyelin metabolism. Biochim. Biophys. Acta., 1044(1):1-12.
    • (1990) Biochim. Biophys. Acta , vol.1044 , Issue.1 , pp. 1-12
    • Merrill Jr, A.H.1    Jones, P.D.2
  • 124
    • 0242710592 scopus 로고    scopus 로고
    • Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors
    • Meyer zu Heringdorf, D., Liliom, K., Schaefer, M. et al. 2003. Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors, FEBS Lett, 554(3):443-9.
    • (2003) FEBS Lett , vol.554 , Issue.3 , pp. 443-449
    • Meyer zu Heringdorf, D.1    Liliom, K.2    Schaefer, M.3
  • 125
    • 33644832772 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics
    • Mar
    • Milstien, S. and Spiegel, S. 2006 Mar. Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell., 9(3):148-50.
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 148-150
    • Milstien, S.1    Spiegel, S.2
  • 126
    • 33846889954 scopus 로고    scopus 로고
    • Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells
    • Mitra, P., Maceyka, M., Payne, S.G. et al. 2007. Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells. FEBS Lett, 581(4):735-40.
    • (2007) FEBS Lett , vol.581 , Issue.4 , pp. 735-740
    • Mitra, P.1    Maceyka, M.2    Payne, S.G.3
  • 127
    • 1642491745 scopus 로고    scopus 로고
    • Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases
    • Miura, Y., Gotoh, E., Nara, F. et al. 2004. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. FEBS Lett, 557 (1-3):288-92.
    • (2004) FEBS Lett , vol.557 , Issue.1-3 , pp. 288-292
    • Miura, Y.1    Gotoh, E.2    Nara, F.3
  • 129
    • 34047146501 scopus 로고    scopus 로고
    • 4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bel-2
    • Morales, M.C., Perez-Yarza, G., Rementeria, N.N. et al. 2007. 4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bel-2. Free Radic. Res., 41(5):591-601.
    • (2007) Free Radic. Res , vol.41 , Issue.5 , pp. 591-601
    • Morales, M.C.1    Perez-Yarza, G.2    Rementeria, N.N.3
  • 130
    • 33747880401 scopus 로고    scopus 로고
    • Curcumin mediates ceramide generation vis the de novo pathway in colon cancer cells
    • Moussavi, M., Assi, K., Gómez-Muñoz, et al. 2006. Curcumin mediates ceramide generation vis the de novo pathway in colon cancer cells. Carcinogenesis, 27(8):1636-44.
    • (2006) Carcinogenesis , vol.27 , Issue.8 , pp. 1636-1644
    • Moussavi, M.1    Assi, K.2    Muñoz, G.3
  • 131
    • 0029003788 scopus 로고
    • PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
    • Muller, G., Ayoub, M., Storz, P. et al. 1995. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 14(9):1961-9.
    • (1995) EMBO J , vol.14 , Issue.9 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3
  • 132
    • 0036436697 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
    • Nava, V.E., Hobson, J.P., Murthy, S. et al. 2002. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell. Res., 281:115-27.
    • (2002) Exp. Cell. Res , vol.281 , pp. 115-127
    • Nava, V.E.1    Hobson, J.P.2    Murthy, S.3
  • 133
    • 0028486763 scopus 로고
    • Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate
    • Natarajan, V, Jayaram, H.N., Scribner, W.M. et al. 1994. Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. Am. J. Respir. Cell. Mol. Biol., 11(2):221-9.
    • (1994) Am. J. Respir. Cell. Mol. Biol , vol.11 , Issue.2 , pp. 221-229
    • Natarajan, V.1    Jayaram, H.N.2    Scribner, W.M.3
  • 134
    • 0037428384 scopus 로고    scopus 로고
    • Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2
    • Ogawa, C., Kihara, A., Gokoh, M. et al. 2003. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem., 278(2):1268-72.
    • (2003) J. Biol. Chem , vol.278 , Issue.2 , pp. 1268-1272
    • Ogawa, C.1    Kihara, A.2    Gokoh, M.3
  • 135
    • 0037066756 scopus 로고    scopus 로고
    • Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide
    • Ogretmen, B., Pettus, B.J., Rossi, M.J. et al. 2002. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J. Biol. Chem., 277(15):12960-9.
    • (2002) J. Biol. Chem , vol.277 , Issue.15 , pp. 12960-12969
    • Ogretmen, B.1    Pettus, B.J.2    Rossi, M.J.3
  • 136
    • 0032538463 scopus 로고    scopus 로고
    • EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition
    • Okamoto, H., Takuwa, N., Gonda, K. et al. 1998. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J. Biol. Chem., 273(42):27104-10.
    • (1998) J. Biol. Chem , vol.273 , Issue.42 , pp. 27104-27110
    • Okamoto, H.1    Takuwa, N.2    Gonda, K.3
  • 137
    • 0024795059 scopus 로고
    • Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
    • Okazaki, T., Bell, R.M. and Hannun, Y.A. 1989. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem., 264:19076-80.
    • (1989) J. Biol. Chem , vol.264 , pp. 19076-19080
    • Okazaki, T.1    Bell, R.M.2    Hannun, Y.A.3
  • 138
    • 0025003424 scopus 로고
    • Role of ceramide as a lipio mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation
    • Okazaki, T., Bielawska, A., Bell, R.M. et al. 1990. Role of ceramide as a lipio mediator of 1 alpha, 25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J. Biol. Chem., 265(26):15823-31.
    • (1990) J. Biol. Chem , vol.265 , Issue.26 , pp. 15823-15831
    • Okazaki, T.1    Bielawska, A.2    Bell, R.M.3
  • 139
    • 0027371722 scopus 로고
    • Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
    • Olivera, A. and Spiegel, S. 1993. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature, 365:557-60.
    • (1993) Nature , vol.365 , pp. 557-560
    • Olivera, A.1    Spiegel, S.2
  • 140
    • 0035399943 scopus 로고    scopus 로고
    • TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes
    • Osawa, Y., Banno, Y., Nagaki, M. et al. 2001. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J. Immunol., 167(1):173-80.
    • (2001) J. Immunol , vol.167 , Issue.1 , pp. 173-180
    • Osawa, Y.1    Banno, Y.2    Nagaki, M.3
  • 141
    • 33751225686 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate lyase potentiates apoptosis via p53 and p38 dependent pathways and is down-regulated in colon cancer
    • Oskouian, B., Sooriyakumaran, P., Borowsky, A.D. et al. 2006. Sphingosine 1-phosphate lyase potentiates apoptosis via p53 and p38 dependent pathways and is down-regulated in colon cancer. PNAS, 13(46):17384-9.
    • (2006) PNAS , vol.13 , Issue.46 , pp. 17384-17389
    • Oskouian, B.1    Sooriyakumaran, P.2    Borowsky, A.D.3
  • 142
    • 0037190128 scopus 로고    scopus 로고
    • Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas
    • Osterstrom, A., Dimberg, J., Fransen, K. et al. 2002. Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas. Cancer Lett, 182(2):175-82.
    • (2002) Cancer Lett , vol.182 , Issue.2 , pp. 175-182
    • Osterstrom, A.1    Dimberg, J.2    Fransen, K.3
  • 143
    • 34247379074 scopus 로고    scopus 로고
    • Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
    • Pappu, R., Schwab, S.R., Cornelissen, I. et al. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science, 316(5822):295-8.
    • (2007) Science , vol.316 , Issue.5822 , pp. 295-298
    • Pappu, R.1    Schwab, S.R.2    Cornelissen, I.3
  • 144
    • 0037201970 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Dual messenger function s
    • Payne, S.G., Milstien, S. and Spiegel, S. 2002. Sphingosine-1-phosphate: dual messenger function s. FEBS Lett, 531(1):54-7.
    • (2002) FEBS Lett , vol.531 , Issue.1 , pp. 54-57
    • Payne, S.G.1    Milstien, S.2    Spiegel, S.3
  • 145
    • 0036689367 scopus 로고    scopus 로고
    • Activation of phospholipase D-2 by P2X(7) agonists in rat submandibular gland acini
    • Perez-Andres, E., Fernandez-Rodriguez, M., Gonzalez, M. et al. 2002. Activation of phospholipase D-2 by P2X(7) agonists in rat submandibular gland acini. J. Lipid Res., 43(8):1244-55.
    • (2002) J. Lipid Res , vol.43 , Issue.8 , pp. 1244-1255
    • Perez-Andres, E.1    Fernandez-Rodriguez, M.2    Gonzalez, M.3
  • 146
    • 0033946582 scopus 로고    scopus 로고
    • Chromosomal imbalances in brain metastases of solid tumors
    • Petersen, I., Hidalgo, A., Petersen, S. et al. 2000. Chromosomal imbalances in brain metastases of solid tumors. Brain Pathol., 10(3):395-401.
    • (2000) Brain Pathol , vol.10 , Issue.3 , pp. 395-401
    • Petersen, I.1    Hidalgo, A.2    Petersen, S.3
  • 147
    • 0031974485 scopus 로고    scopus 로고
    • Allelic loss on chromosome 10q in human lung cancer: Association with tumour progression and metastatic phenotype
    • Petersen, S., Wolf, G., Bockmühl, U. et al. 1998. Allelic loss on chromosome 10q in human lung cancer: association with tumour progression and metastatic phenotype. Br. J. Cancer, 77(2):270-6.
    • (1998) Br. J. Cancer , vol.77 , Issue.2 , pp. 270-276
    • Petersen, S.1    Wolf, G.2    Bockmühl, U.3
  • 148
    • 23044459004 scopus 로고    scopus 로고
    • The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate
    • Pettus, B.J., Kitatani, K., Chalfant, C.E. et al. 2005. The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol. Pharmacol., 68(2):330-5.
    • (2005) Mol. Pharmacol , vol.68 , Issue.2 , pp. 330-335
    • Pettus, B.J.1    Kitatani, K.2    Chalfant, C.E.3
  • 149
    • 12144287654 scopus 로고    scopus 로고
    • Ceramide 1-phos-phate is a direct activator of cytosolic phospholipase A2
    • Pettus, B.J., Bielawska, A., Subramanian, P. et al. 2004. Ceramide 1-phos-phate is a direct activator of cytosolic phospholipase A2. J. Biol. Chem., 279(12):11320-6.
    • (2004) J. Biol. Chem , vol.279 , Issue.12 , pp. 11320-11326
    • Pettus, B.J.1    Bielawska, A.2    Subramanian, P.3
  • 150
    • 0141755365 scopus 로고    scopus 로고
    • Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release
    • Pettus, B.J., Bielawska, A., Spiegel, S. et al. 2003. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J. Biol. Chem., 278(40):38206-13.
    • (2003) J. Biol. Chem , vol.278 , Issue.40 , pp. 38206-38213
    • Pettus, B.J.1    Bielawska, A.2    Spiegel, S.3
  • 151
    • 0037203342 scopus 로고    scopus 로고
    • Ceramide in apoptosis: An overview and current perspectives
    • Pettus, B.J., Chalfant, C.E. and Hannun, Y.A. 2002. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys. Acta., 1585(2-3):114-25.
    • (2002) Biochim Biophys. Acta , vol.1585 , Issue.2-3 , pp. 114-125
    • Pettus, B.J.1    Chalfant, C.E.2    Hannun, Y.A.3
  • 152
    • 13444274563 scopus 로고    scopus 로고
    • Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons
    • Plummer, G., Perreault, K.R., Holmes, C.F. et al. 2005. Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons. Biochem. J., 385(3):685-93.
    • (2005) Biochem. J , vol.385 , Issue.3 , pp. 685-693
    • Plummer, G.1    Perreault, K.R.2    Holmes, C.F.3
  • 153
    • 0034661482 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate signalling in mammalian cells
    • Pyne, S. and Pyne, N.J. 2000. Sphingosine 1-phosphate signalling in mammalian cells. Biochem. J., 349:395-402.
    • (2000) Biochem. J , vol.349 , pp. 395-402
    • Pyne, S.1    Pyne, N.J.2
  • 154
    • 18344394549 scopus 로고    scopus 로고
    • Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes
    • Raisova, M., Goltz, G., Bektas, M. et al. 2002. Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. FEBS Lett, 516(1-3):47-52.
    • (2002) FEBS Lett , vol.516 , Issue.1-3 , pp. 47-52
    • Raisova, M.1    Goltz, G.2    Bektas, M.3
  • 155
    • 0030891014 scopus 로고    scopus 로고
    • Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling
    • Rani, C.S., Wang, F., Fuior, E. et al. 1997. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. J. Biol. Chem., 272(16):10777-83.
    • (1997) J. Biol. Chem , vol.272 , Issue.16 , pp. 10777-10783
    • Rani, C.S.1    Wang, F.2    Fuior, E.3
  • 156
    • 0346463027 scopus 로고    scopus 로고
    • Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis
    • Reiss, U., Oskouian, B., Zhou, J. et al. 2004. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J. Biol. Chem., 279(2):1281-90.
    • (2004) J. Biol. Chem , vol.279 , Issue.2 , pp. 1281-1290
    • Reiss, U.1    Oskouian, B.2    Zhou, J.3
  • 157
    • 0029834974 scopus 로고    scopus 로고
    • c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells
    • Reyes, J.G., Robayna, J.G., Delgado, P.S. et al. 1996. c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells. J. Biol. Chem., 271(35):21375-80.
    • (1996) J. Biol. Chem , vol.271 , Issue.35 , pp. 21375-21380
    • Reyes, J.G.1    Robayna, J.G.2    Delgado, P.S.3
  • 158
    • 1542358155 scopus 로고    scopus 로고
    • Ceramide synthesis and metabolism as a target for cancer therapy
    • Reynolds, C.P., Maurer, B.J. and Kolesnick, R.N. 2004. Ceramide synthesis and metabolism as a target for cancer therapy. Cancer Lett, 206(2):169-80.
    • (2004) Cancer Lett , vol.206 , Issue.2 , pp. 169-180
    • Reynolds, C.P.1    Maurer, B.J.2    Kolesnick, R.N.3
  • 159
    • 0038782392 scopus 로고    scopus 로고
    • Fenretinide as an antiangiogenic agent in neuroblastoma
    • Ribatti, D., Raffaghello, L., Marimpietri, D. et al. 2003. Fenretinide as an antiangiogenic agent in neuroblastoma. Cancer Lett, 197(1-2):181-4.
    • (2003) Cancer Lett , vol.197 , Issue.1-2 , pp. 181-184
    • Ribatti, D.1    Raffaghello, L.2    Marimpietri, D.3
  • 160
    • 0036695440 scopus 로고    scopus 로고
    • Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: Evidence for the phosphorylation of ceramide by different metabolic pathways
    • Riboni, L., Bassi, R., Anelli, V. et al. 2002. Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: evidence for the phosphorylation of ceramide by different metabolic pathways. Neurochem. Res., 27(7-8):711-6.
    • (2002) Neurochem. Res , vol.27 , Issue.7-8 , pp. 711-716
    • Riboni, L.1    Bassi, R.2    Anelli, V.3
  • 161
    • 0035983292 scopus 로고    scopus 로고
    • Ceramide levels are inversely associated with malignant progression of human glial tumors
    • Riboni, L., Campanella, R., Bassi, R. et al. 2002. Ceramide levels are inversely associated with malignant progression of human glial tumors. Glia, 39(2):105-13.
    • (2002) Glia , vol.39 , Issue.2 , pp. 105-113
    • Riboni, L.1    Campanella, R.2    Bassi, R.3
  • 162
    • 0037219462 scopus 로고    scopus 로고
    • Ceramide 1-phosphate formation in neutrophils
    • Rile, G., Yatomi, Y., Takafuta, T. et al. 2003. Ceramide 1-phosphate formation in neutrophils. Acta. Haematol., 109:76-83.
    • (2003) Acta. Haematol , vol.109 , pp. 76-83
    • Rile, G.1    Yatomi, Y.2    Takafuta, T.3
  • 163
    • 0035196711 scopus 로고    scopus 로고
    • EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    • Rosenfeldt, H.M., Hobson, J.P., Maceyka, M. et al. 2001. EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB. J., 15(14):2649-59.
    • (2001) FASEB. J , vol.15 , Issue.14 , pp. 2649-2659
    • Rosenfeldt, H.M.1    Hobson, J.P.2    Maceyka, M.3
  • 164
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • Ruvolo, P.P., Deng, X., Ito, T. et al. 1999. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem., 274(29):20296-300.
    • (1999) J. Biol. Chem , vol.274 , Issue.29 , pp. 20296-20300
    • Ruvolo, P.P.1    Deng, X.2    Ito, T.3
  • 165
    • 0032566717 scopus 로고    scopus 로고
    • A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
    • Ruvolo, P.P., Deng, X., Carr, B.K. et al. 1998. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem., 273(39):25436-42.
    • (1998) J. Biol. Chem , vol.273 , Issue.39 , pp. 25436-25442
    • Ruvolo, P.P.1    Deng, X.2    Carr, B.K.3
  • 166
    • 0032150716 scopus 로고    scopus 로고
    • Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary
    • Rylova, S.N., Somova, O.G. and Dyatlovitskaya, E.V. 1998. Comparative investigation of sphingoid bases and fatty acids in ceramides and sphingomyelins from human ovarian malignant tumors and normal ovary. Biochemistry (Mosc), 63(9):1057-60.
    • (1998) Biochemistry (Mosc) , vol.63 , Issue.9 , pp. 1057-1060
    • Rylova, S.N.1    Somova, O.G.2    Dyatlovitskaya, E.V.3
  • 167
    • 1842455323 scopus 로고    scopus 로고
    • Point-counterpoint of sphingosine 1-phosphate metabolism
    • Saba, J.D. and Hla, T. 2004. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ. Res., 94(6):724-34.
    • (2004) Circ. Res , vol.94 , Issue.6 , pp. 724-734
    • Saba, J.D.1    Hla, T.2
  • 168
    • 33750456153 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate for cancer therapy
    • Sabbadini, R.A. 2006. Targeting sphingosine-1-phosphate for cancer therapy. Br. J. Cancer, 95(9):1131-35.
    • (2006) Br. J. Cancer , vol.95 , Issue.9 , pp. 1131-1135
    • Sabbadini, R.A.1
  • 169
    • 0024412757 scopus 로고
    • Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol
    • Sakane, F., Yamada, K. and Kanoh, H. 1989. Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol. FEBS Lett, 255(2):409-13.
    • (1989) FEBS Lett , vol.255 , Issue.2 , pp. 409-413
    • Sakane, F.1    Yamada, K.2    Kanoh, H.3
  • 170
    • 0342980927 scopus 로고    scopus 로고
    • Inhibition of PKB/ Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
    • Salinas, M., Lopez-Valdaliso, R., Martin, D. et al. 2000. Inhibition of PKB/ Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Mol. Cell. Neurosci, 15(2):156-69.
    • (2000) Mol. Cell. Neurosci , vol.15 , Issue.2 , pp. 156-169
    • Salinas, M.1    Lopez-Valdaliso, R.2    Martin, D.3
  • 171
    • 0005226914 scopus 로고    scopus 로고
    • Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells
    • Samet, D. and Barenholz, Y. 1999. Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells. Chem. Phys. Lipids, 102(1-2):65-77.
    • (1999) Chem. Phys. Lipids , vol.102 , Issue.1-2 , pp. 65-77
    • Samet, D.1    Barenholz, Y.2
  • 172
    • 16044364385 scopus 로고    scopus 로고
    • Acid sphingo-myelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
    • Santana, P., Pena, L.A., Haimovitz-Friedman, A. et al. 1996. Acid sphingo-myelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell., 86(2):189-99.
    • (1996) Cell , vol.86 , Issue.2 , pp. 189-199
    • Santana, P.1    Pena, L.A.2    Haimovitz-Friedman, A.3
  • 173
    • 25844457390 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
    • Sarkar, S., Maceyka, M., Hait, N.C. et al. 2005. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett, 579(24):5313-17.
    • (2005) FEBS Lett , vol.579 , Issue.24 , pp. 5313-5317
    • Sarkar, S.1    Maceyka, M.2    Hait, N.C.3
  • 174
    • 0034718540 scopus 로고    scopus 로고
    • Modulation of Akt kinase activity by binding to Hsp90
    • Sato, S., Fujita, N. and Tsuruo, T. 2000. Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl. Acad. Sci. U.S.A, 97(20):10832-37.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , Issue.20 , pp. 10832-10837
    • Sato, S.1    Fujita, N.2    Tsuruo, T.3
  • 175
    • 0028846952 scopus 로고
    • Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells
    • Sawai, H., Okazaki, T., Yamamoto, H. et al. 1995. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem., 270:27326-31.
    • (1995) J. Biol. Chem , vol.270 , pp. 27326-27331
    • Sawai, H.1    Okazaki, T.2    Yamamoto, H.3
  • 176
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • Scheid, M.P., Marignani, P.A. and Woodgett, J.R. 2002. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol. Cell. Biol., 22(17):6247-60.
    • (2002) Mol. Cell. Biol , vol.22 , Issue.17 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 177
    • 0037862006 scopus 로고    scopus 로고
    • Unravelling the activation mechanisms of protein kinase B/Akt
    • Scheid, M.P. and Woodgett, J.R. 2003. Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett, 546(1):108-12.
    • (2003) FEBS Lett , vol.546 , Issue.1 , pp. 108-112
    • Scheid, M.P.1    Woodgett, J.R.2
  • 178
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer, C., Craig, D.L. and Biden, T.J. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem., 274(34):24202-10.
    • (1999) J. Biol. Chem , vol.274 , Issue.34 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 179
    • 0025819971 scopus 로고
    • Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
    • Schuchman, E.H., Suchi, M., Takahashi, T. et al. 1991. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem., 266(13):8531-9.
    • (1991) J. Biol. Chem , vol.266 , Issue.13 , pp. 8531-8539
    • Schuchman, E.H.1    Suchi, M.2    Takahashi, T.3
  • 180
    • 0033839592 scopus 로고    scopus 로고
    • Human acid ceramidase is overexpressed but not mutated in prostate cancer
    • Seelan, R.S., Qian, C., Yokomizo, A. et al. 2000. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer, 29(2):137-46.
    • (2000) Genes Chromosomes Cancer , vol.29 , Issue.2 , pp. 137-146
    • Seelan, R.S.1    Qian, C.2    Yokomizo, A.3
  • 181
    • 33845291121 scopus 로고    scopus 로고
    • Sphingolipids as modulators of cancer cell death: Potential therapeutic targets
    • Ségui, B., Andrieu-Abbadie, N., Jaffrézou, J-P. et al. 2006. Sphingolipids as modulators of cancer cell death: Potential therapeutic targets. Biochim Biophys. Acta., 1758 (12):2104-20.
    • (2006) Biochim Biophys. Acta , vol.1758 , Issue.12 , pp. 2104-2120
    • Ségui, B.1    Andrieu-Abbadie, N.2    Jaffrézou, J.-P.3
  • 182
    • 0035114217 scopus 로고    scopus 로고
    • Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
    • Selzner, M., Bielawska, A., Morse, M.A. et al. 2001. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res., 61(3):1233-40.
    • (2001) Cancer Res , vol.61 , Issue.3 , pp. 1233-1240
    • Selzner, M.1    Bielawska, A.2    Morse, M.A.3
  • 183
    • 0035819885 scopus 로고    scopus 로고
    • Targeting ceramide metabolism-a strategy for overcoming drug resistance
    • Senchenkov, A., Litvak, D.A. and Cabot, M.C. 2001. Targeting ceramide metabolism-a strategy for overcoming drug resistance. J. Natl. Cancer Inst., 93:347-57.
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 347-357
    • Senchenkov, A.1    Litvak, D.A.2    Cabot, M.C.3
  • 184
    • 0027430787 scopus 로고
    • Ceramide-1-phosphate phosphatase activity in brain
    • Shinghal, R., Scheller, R.H. and Bajjalieh, S.M. 1993. Ceramide-1-phosphate phosphatase activity in brain. J. Neurochem., 61:2279-85.
    • (1993) J. Neurochem , vol.61 , pp. 2279-2285
    • Shinghal, R.1    Scheller, R.H.2    Bajjalieh, S.M.3
  • 185
    • 0027434784 scopus 로고
    • The role of sphingosine in cell growth regulation and transmembrane signaling
    • Spiegel, S., Olivera, A. and Carlson, R.O. 1993. The role of sphingosine in cell growth regulation and transmembrane signaling. Adv Lipid Res., 25:105-29.
    • (1993) Adv Lipid Res , vol.25 , pp. 105-129
    • Spiegel, S.1    Olivera, A.2    Carlson, R.O.3
  • 186
    • 0029996139 scopus 로고    scopus 로고
    • Signal transduction through lipid second messengers
    • Spiegel, S., Foster, D. and Kolesnick, R. 1996. Signal transduction through lipid second messengers. Curr. Opin. Cell. Biol., 8:159-67.
    • (1996) Curr. Opin. Cell. Biol , vol.8 , pp. 159-167
    • Spiegel, S.1    Foster, D.2    Kolesnick, R.3
  • 187
    • 0029862561 scopus 로고    scopus 로고
    • Sphingolipid metabolism and cell growth regulation
    • Spiegel, S. and Merrill, A.H. Jr. 1996. Sphingolipid metabolism and cell growth regulation. FASEB. J., 10(12):1388-97.
    • (1996) FASEB. J , vol.10 , Issue.12 , pp. 1388-1397
    • Spiegel, S.1    Merrill Jr., A.H.2
  • 188
    • 0034733910 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: Signaling inside and out
    • Spiegel, S. and Milstien, S. 2000. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett, 476:55-67.
    • (2000) FEBS Lett , vol.476 , pp. 55-67
    • Spiegel, S.1    Milstien, S.2
  • 189
    • 0034630127 scopus 로고    scopus 로고
    • Functions of a new family of sphingosine-1-phosphate receptors
    • Spiegel, S. and Milstien, S. 2000. Functions of a new family of sphingosine-1-phosphate receptors. Biochim Biophys. Acta., 1484(2-3):107-16.
    • (2000) Biochim Biophys. Acta , vol.1484 , Issue.2-3 , pp. 107-116
    • Spiegel, S.1    Milstien, S.2
  • 190
    • 0037135572 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a key cell signaling molecule
    • Spiegel, S. and Milstien, S. 2002. Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem., 77(29):25851-54.
    • (2002) J. Biol. Chem , vol.77 , Issue.29 , pp. 25851-25854
    • Spiegel, S.1    Milstien, S.2
  • 191
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signalling lipid
    • Spiegel, S. and Milstien, S. 2003. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell. Biol., 4(5):397-407.
    • (2003) Nat. Rev. Mol. Cell. Biol , vol.4 , Issue.5 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 192
    • 20444371635 scopus 로고    scopus 로고
    • Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine
    • Subramaman, P., Stahelin, R.V., Szulc, Z., et al. 2005. Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine. J. Biol. Chem., 280(18):17601-7.
    • (2005) J. Biol. Chem , vol.280 , Issue.18 , pp. 17601-17607
    • Subramaman, P.1    Stahelin, R.V.2    Szulc, Z.3
  • 193
    • 0037307483 scopus 로고    scopus 로고
    • Cyclooxygenase 2: A molecular target for cancer prevention and treatment
    • Subbaramaiah, K. and Dannenberg, A.J. 2003. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol. Sci., 24(2):96-102.
    • (2003) Trends Pharmacol. Sci , vol.24 , Issue.2 , pp. 96-102
    • Subbaramaiah, K.1    Dannenberg, A.J.2
  • 194
    • 0026458406 scopus 로고
    • TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyclin breakdown
    • Schẗze, S., Potthoff, K., Machleidt, T. et al. 1992. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyclin breakdown. Cell., 71:765-76.
    • (1992) Cell , vol.71 , pp. 765-776
    • Schẗze, S.1    Potthoff, K.2    Machleidt, T.3
  • 195
    • 0037189475 scopus 로고    scopus 로고
    • Ceramide kinase, a novel lipid kinase. Molecular cloning and characterization
    • Sugiura, M., Kono, K., Liu, H. et al. 2002. Ceramide kinase, a novel lipid kinase. Molecular cloning and characterization. J. Biol. Chem., 277:23294-300.
    • (2002) J. Biol. Chem , vol.277 , pp. 23294-23300
    • Sugiura, M.1    Kono, K.2    Liu, H.3
  • 196
    • 2442699980 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptors: Receptor specificity versus functional redundancy
    • Taha, T.A., Argraves, K.M. and Obeid, L.M. 2004. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim. Biophys. Acta., 1682(1-3):48-55.
    • (2004) Biochim. Biophys. Acta , vol.1682 , Issue.1-3 , pp. 48-55
    • Taha, T.A.1    Argraves, K.M.2    Obeid, L.M.3
  • 197
    • 2442494074 scopus 로고    scopus 로고
    • Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53, 279(l9):20546-52054
    • Taha, T.A., Osta, W., Kozhaya, L. et al. 2004. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J. Biol. Chem., 279(l9):20546-52054.
    • (2004) J. Biol. Chem
    • Taha, T.A.1    Osta, W.2    Kozhaya, L.3
  • 198
    • 33845294390 scopus 로고    scopus 로고
    • A house divided: Ceramide, sphingosine, and Sphingosine-1-phosphate in programmed cell death
    • Taha, T.A., Mullen, T.D. and Obeid, L.M. 2006. A house divided: Ceramide, sphingosine, and Sphingosine-1-phosphate in programmed cell death. Biochim. Biophys. Acta., 1758(12):2027-36.
    • (2006) Biochim. Biophys. Acta , vol.1758 , Issue.12 , pp. 2027-2036
    • Taha, T.A.1    Mullen, T.D.2    Obeid, L.M.3
  • 199
    • 0032556188 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors in tumorigenesis (part I)
    • Taketo, M.M. 1998. Cyclooxygenase-2 inhibitors in tumorigenesis (part I). J. Natl. Cancer Inst., 90:1529-36.
    • (1998) J. Natl. Cancer Inst , vol.90 , pp. 1529-1536
    • Taketo, M.M.1
  • 200
    • 27444446836 scopus 로고    scopus 로고
    • Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets
    • Tani, M., Sano, T., Ito, M. et al. 2005. Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. J. Lipid Res., 46(11):2458-67.
    • (2005) J. Lipid Res , vol.46 , Issue.11 , pp. 2458-2467
    • Tani, M.1    Sano, T.2    Ito, M.3
  • 201
    • 2042499658 scopus 로고    scopus 로고
    • Acid sphingomyelinase and inhibition by phosphate ion: Role of inhibition by phosphatidyl-myo-inositol 3, 4, 5-triphosphate in oligodendrocyte cell signaling
    • Testai, F.D., Landek, M.A., Goswami, R. et al. 2004. Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3, 4, 5-triphosphate in oligodendrocyte cell signaling. J. Neurochem., 89(3):636-44.
    • (2004) J. Neurochem , vol.89 , Issue.3 , pp. 636-644
    • Testai, F.D.1    Landek, M.A.2    Goswami, R.3
  • 202
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science, 267(5203):1456-62.
    • (1995) Science , vol.267 , Issue.5203 , pp. 1456-1462
    • Thompson, C.B.1
  • 203
    • 3042737630 scopus 로고    scopus 로고
    • Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH4C1 rat pituitary cells
    • Tornquist, K., Blom, T., Shariatmadari, R. et al. 2004. Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH4C1 rat pituitary cells. Biochem. J., 380(3):661-8.
    • (2004) Biochem. J , vol.380 , Issue.3 , pp. 661-668
    • Tornquist, K.1    Blom, T.2    Shariatmadari, R.3
  • 204
    • 0027350613 scopus 로고
    • Sphingomyelinase D: A pathogenic agent produced by bacteria and arthropods
    • Truett, A.P. 3rd and King, L.E. Jr. 1993. Sphingomyelinase D: a pathogenic agent produced by bacteria and arthropods. Adv. Lipid Res., 26:275-91.
    • (1993) Adv. Lipid Res , vol.26 , pp. 275-291
    • Truett 3rd, A.P.1    King Jr., L.E.2
  • 205
    • 0346373649 scopus 로고    scopus 로고
    • Mutation of CERKL, a novel human ceramide-kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)
    • Tuson, M., Marfany, G. and Gonzalez-Duarte, R. 2004. Mutation of CERKL, a novel human ceramide-kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am. J. Hum. Genet., 74(1):128-38.
    • (2004) Am. J. Hum. Genet , vol.74 , Issue.1 , pp. 128-138
    • Tuson, M.1    Marfany, G.2    Gonzalez-Duarte, R.3
  • 206
    • 0037066688 scopus 로고    scopus 로고
    • Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells
    • Vann, L.R., Payne, S.G., Edsall, L.C. et al. 2002. Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. J. Biol. Chem., 277(15):12649-56.
    • (2002) J. Biol. Chem , vol.277 , Issue.15 , pp. 12649-12656
    • Vann, L.R.1    Payne, S.G.2    Edsall, L.C.3
  • 207
    • 0033593572 scopus 로고    scopus 로고
    • Cell death in development
    • Vaux, D.L. and Korsmeyer, S.J. 1999. Cell death in development. Cell., 96(2):245-54.
    • (1999) Cell , vol.96 , Issue.2 , pp. 245-254
    • Vaux, D.L.1    Korsmeyer, S.J.2
  • 208
    • 0038167025 scopus 로고    scopus 로고
    • Characterisation of a sphingosine 1 -phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells
    • Villullas, I.R., Smith, A.J., Heavens, R.P. et al. 2003. Characterisation of a sphingosine 1 -phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells. J. Neurosci. Res., 73(2):215-26.
    • (2003) J. Neurosci. Res , vol.73 , Issue.2 , pp. 215-226
    • Villullas, I.R.1    Smith, A.J.2    Heavens, R.P.3
  • 209
    • 33644830810 scopus 로고    scopus 로고
    • Validation of an anti-sphingosine-1-pbosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
    • Visentin, B., Vekich, J.A., Sibbald, B.J. et al. 2006. Validation of an anti-sphingosine-1-pbosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell., 9(3):225-38.
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 225-238
    • Visentin, B.1    Vekich, J.A.2    Sibbald, B.J.3
  • 210
    • 0019003203 scopus 로고
    • Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain
    • Vunnam, R.R. and Radin, N.S. 1980. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain. Chem. Phys. Lipids, 26:265-78.
    • (1980) Chem. Phys. Lipids , vol.26 , pp. 265-278
    • Vunnam, R.R.1    Radin, N.S.2
  • 211
    • 0029904257 scopus 로고    scopus 로고
    • Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate
    • Waggoner, D.W., Gomez-Munoz, A., Dewald, J. et al. 1996. Phosphatidate phosphohydrolase catalyzes the hydrolysis of ceramide 1-phosphate, lysophosphatidate, and sphingosine 1-phosphate. J. Biol. Chem., 271(28):16506-9.
    • (1996) J. Biol. Chem , vol.271 , Issue.28 , pp. 16506-16509
    • Waggoner, D.W.1    Gomez-Munoz, A.2    Dewald, J.3
  • 212
    • 0033544870 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis
    • Wang, F., Van Brocklyn, J.R., Hobson, J.P. et al. 1999. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J. Biol. Chem., 274:35343-50.
    • (1999) J. Biol. Chem , vol.274 , pp. 35343-35350
    • Wang, F.1    Van Brocklyn, J.R.2    Hobson, J.P.3
  • 213
    • 34250683438 scopus 로고    scopus 로고
    • Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway
    • Wang, S.W., Parhar,,K., Chiu, K.J. et al. 2007, Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. Cell. Signal, 19(8):1772-83.
    • (2007) Cell. Signal , vol.19 , Issue.8 , pp. 1772-1783
    • Wang, S.W.1    Parhar, K.2    Chiu, K.J.3
  • 214
    • 0037411237 scopus 로고    scopus 로고
    • Pleiotropic actions of sphingosinc-1-phosphate
    • Watterson, K., Sankala, H., Milstien, S. et al. 2003. Pleiotropic actions of sphingosinc-1-phosphate. Prog. Lipid Res., 42(4):344-57.
    • (2003) Prog. Lipid Res , vol.42 , Issue.4 , pp. 344-357
    • Watterson, K.1    Sankala, H.2    Milstien, S.3
  • 216
    • 30344439710 scopus 로고    scopus 로고
    • Substrate specificity of human ceramide kinase
    • Wijesinghe, D.S., Massiello, A., Subramanian, P. et al. 2005. Substrate specificity of human ceramide kinase. J. Lipid Res., 46(12):2706-16.
    • (2005) J. Lipid Res , vol.46 , Issue.12 , pp. 2706-2716
    • Wijesinghe, D.S.1    Massiello, A.2    Subramanian, P.3
  • 217
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff, R.A., Dobrowsky, R.T., Bielawska, A. et al. 1994. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J. Biol. Chem., 269(30):19605-9.
    • (1994) J. Biol. Chem , vol.269 , Issue.30 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, R.T.2    Bielawska, A.3
  • 218
    • 4344656249 scopus 로고    scopus 로고
    • Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells
    • Wu, J., Cheng, Y., Nilsson, A. et al. 2004. Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells. Carcinogenesis, 25(8):1327-33.
    • (2004) Carcinogenesis , vol.25 , Issue.8 , pp. 1327-1333
    • Wu, J.1    Cheng, Y.2    Nilsson, A.3
  • 219
    • 0029079324 scopus 로고
    • Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G proteindependent mechanism
    • Wu, J., Spiegel, S. and Sturgill, T. W. 1995. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G proteindependent mechanism. J. Biol. Chem., 270:11484-8.
    • (1995) J. Biol. Chem , vol.270 , pp. 11484-11488
    • Wu, J.1    Spiegel, S.2    Sturgill, T.W.3
  • 220
    • 0034735916 scopus 로고    scopus 로고
    • An oncogenic role of sphingosine kinase
    • Xia, P., Gamble, J.R., Wang, L. et al. 2000. An oncogenic role of sphingosine kinase. Curr. Biol., 10: 1527-30.
    • (2000) Curr. Biol , vol.10 , pp. 1527-1530
    • Xia, P.1    Gamble, J.R.2    Wang, L.3
  • 221
    • 0037040908 scopus 로고    scopus 로고
    • Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling
    • Xia, P., Wang, L., Moretti, P.A. et al. 2002. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J. Biol. Chem., 277(10):7996-8003.
    • (2002) J. Biol. Chem , vol.277 , Issue.10 , pp. 7996-8003
    • Xia, P.1    Wang, L.2    Moretti, P.A.3
  • 222
    • 0037162029 scopus 로고    scopus 로고
    • Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction
    • Xu, Y. 2002. Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim. Biophys. Acta., 1582(1-3):81-8.
    • (2002) Biochim. Biophys. Acta , vol.1582 , Issue.1-3 , pp. 81-88
    • Xu, Y.1
  • 223
    • 0027302925 scopus 로고
    • Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line
    • Yamada, K., Sakane, F., Imai, S. et al. 1993. Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line. Biochim. Biophys. Acta., 1169(3):217-24.
    • (1993) Biochim. Biophys. Acta , vol.1169 , Issue.3 , pp. 217-224
    • Yamada, K.1    Sakane, F.2    Imai, S.3
  • 224
    • 1642302305 scopus 로고    scopus 로고
    • Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells
    • Yamada, M., Banno, Y., Takuwa, Y. et al. 2004. Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells. Biochem. J., 378(2):649-56.
    • (2004) Biochem. J , vol.378 , Issue.2 , pp. 649-656
    • Yamada, M.1    Banno, Y.2    Takuwa, Y.3
  • 225
    • 0028838235 scopus 로고
    • Phosphorylation of Raf by ceramide-activated protein kinase
    • Yao, B., Zhang, Y., Delikat, S. et al. 1995. Phosphorylation of Raf by ceramide-activated protein kinase. Nature, 378(6554):307-10.
    • (1995) Nature , vol.378 , Issue.6554 , pp. 307-310
    • Yao, B.1    Zhang, Y.2    Delikat, S.3
  • 226
    • 34249657837 scopus 로고    scopus 로고
    • Activation of acid sphingomyetinase by protein kinase Cγ mediated phosphorylation
    • Zeidan, Y.H. and Hannun, Y.A. 2007. Activation of acid sphingomyetinase by protein kinase Cγ mediated phosphorylation. J. Lipid Res., 282(15):11549-6l.
    • (2007) J. Lipid Res , vol.282 , Issue.15
    • Zeidan, Y.H.1    Hannun, Y.A.2
  • 227
    • 19944432760 scopus 로고    scopus 로고
    • Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
    • Zhao, Y, Usatyuk, P.V., Cummings, R. et al. 2005. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. Biochem. J., 385(Pt 2):493-502.
    • (2005) Biochem. J , vol.385 , Issue.PART 2 , pp. 493-502
    • Zhao, Y.1    Usatyuk, P.V.2    Cummings, R.3
  • 228
    • 0025021423 scopus 로고
    • Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway
    • Zhang, H., Buckley, N.E., Gibson, K. et al. 1990. Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. J. Biol. Chem., 265(1):76-81.
    • (1990) J. Biol. Chem , vol.265 , Issue.1 , pp. 76-81
    • Zhang, H.1    Buckley, N.E.2    Gibson, K.3
  • 229
    • 0029391135 scopus 로고
    • Signaling through the sphingomyelin pathway
    • Zhang, Y. and Kolesnick, R. 1995. Signaling through the sphingomyelin pathway. Endocrinology, 136(10):4157-60.
    • (1995) Endocrinology , vol.136 , Issue.10 , pp. 4157-4160
    • Zhang, Y.1    Kolesnick, R.2
  • 230
    • 0343742670 scopus 로고    scopus 로고
    • Kinase suppressor of Ras is ceramide-activated protein kinase
    • Zhang, Y, Yao, B., Delikat, S. et al. 1997. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell., 89(1):63-72.
    • (1997) Cell , vol.89 , Issue.1 , pp. 63-72
    • Zhang, Y.1    Yao, B.2    Delikat, S.3
  • 231
    • 0036469777 scopus 로고    scopus 로고
    • Apoptotic DNA fragmentation and tissue homeostasis
    • Zhang, J. and Xu, M. 2002. Apoptotic DNA fragmentation and tissue homeostasis. Trends Cell. Biol., 12(2):84-9.
    • (2002) Trends Cell. Biol , vol.12 , Issue.2 , pp. 84-89
    • Zhang, J.1    Xu, M.2
  • 232
    • 0032569026 scopus 로고    scopus 로고
    • Zhou, H., Summers, S.A., Birnbaum, M.J. et al. 1998. N. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem., 273(26):16568-75.
    • Zhou, H., Summers, S.A., Birnbaum, M.J. et al. 1998. N. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem., 273(26):16568-75.


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