Oxidized Low Density Lipoprotein Inhibits Macrophage Apoptosis by Blocking Ceramide Generation, Thereby Maintaining Protein Kinase B Activation, Bcl-X L Levels

Journal of Biological Chemistry

Volumn 278, Issue 27, 2003, Pages 24399-24408

  Hundal, Rajinder S ^a   Gómez Muñoz, Antonio ^b   Kong, Jennifer Y ^a   Salh, Baljinder S ^a   Marotta, Anthony ^a   Duronio, Vincent ^a   Steinbrecher, Urs P ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c Division of Gastroenterology   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; PIGMENTS; PROTEINS; RNA;

BONE MARROW;

BIOCHEMISTRY;

CASPASE 8; CERAMIDE; COLONY STIMULATING FACTOR 1; CYCLINE; DESIPRAMINE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN BCL 10; PROTEIN BCL XL; PROTEIN KINASE B; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; BCL2L1 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FATTY ACID OXIDATION; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; MACROPHAGE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALIA;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELLS, CULTURED; CERAMIDES; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; LIPOPROTEINS, LDL; MACROPHAGES; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 0042090272     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209179200     Document Type: Article

References (73)

1. Ross, R. (1999) N. Engl. J. Med. 340, 115-126
2. Galis, Z. S., Sukhova, G. K., Kranzhofer, R., Clark, S., and Libby, P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 402-406
3. Galis, Z. S., Sukhova, G. K., and Libby, P. (1995) FASEB J. 9, 974-980
4. Brown, D., Hibbs, M., Kearney, M., Loushin, C., and Isner, J. (1995) Circulation 91, 2125-2131
5. Galis, Z. S., Muszynski, M., Sukhova, G. K., Simon-Morrissey, E., and Libby, P. (1995) Ann. N. Y. Acad. Sci. 748, 501-507
6. Sukhova, G. K., Schonbeck, U., Rabkin, E., Schoen, F. J., Poole, A. R., Billinghurst, R. C., and Libby, P. (1999) Circulation 99, 2503-2509
7. Kockx, M. M. (1998) Arterioscler. Thromb. Vasc. Biol. 18, 1519-15122
8. Katsuda, S., Coltrera, M. D., Ross, R., and Gown, A. M. (1993) Am. J. Pathol. 142, 1787-1793
9. Rekhter, M. D., and Gordon, D. (1995) Am. J. Pathol. 147, 668-677
10. Sata, M., and Walsh, K. (1998) J. Clin. Invest. 102, 1682-1689
11. Nagata, S., and Golstein, P. (1995) Science 267, 1449-1456
12. Kockx, M. M., De Meyer, G. R., Buyssens, N., Knaapen, M. W., Bult, H., and Herman, A. G. (1998) Circ. Res. 83, 378-387
13. Quinn, M. T., Parthasarathy, S., and Steinberg, D. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 2995-2998
14. Sakai, M., Miyazaki, A., Hakamata, H., Sasaki, T., Yui, S., Yamazaki, M., Shichiri, M., and Horiuchi, S. (1994) J. Biol. Chem. 269, 31430-31435
15. Biwa, T., Hakamata, H., Sakai, M., Miyazaki, A., Suzuki, H., Kodama, T., Shichiri, M., and Horiuchi, S. (1998) J. Biol. Chem. 273, 28305-28313
16. Martens, J., Reiner, N., Herrera-Velit, P., and Steinbrecher, U. (1998) J. Biol. Chem. 273, 4915-4920
17. Martens, J., Lougheed, M., Gomez-Muñoz, A., and Steinbrecher, U. (1999) J. Biol. Chem. 274, 10903-10910
18. Hamilton, J. A., Myers, D., Jessup, W., Cochrane, F., Byrne, R., Whitty, G., and Moss, S. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 98-105
19. Hundal, R., Salh, B., Schrader, J., Gómez-Muñoz, A., Duronio, V., and Steinbrecher, U. (2001) J. Lipid Res. 42, 1483-1491
20. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Cell 96, 857-868
21. Kops, G. J., de Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. M. (1999) Nature 398, 630-634
22. Tang, E. D., Nunez, G., Barr, F. G., and Guan, K. L. (1999) J. Biol. Chem. 274, 16741-16746
23. Chen, C., Edelstein, L. C., and Gelinas, C. (2000) Mol. Cell. Biol. 20, 2687-2695
24. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. (1997) Cell 91, 479-489
25. Tepper, A. D., Cock, J. G., de Vries, E., Borst, J., and van Blitterswijk, W. J. (1997) J. Biol. Chem. 272, 24308-24312
26. Huang, C., Ma, W., Ding, M., Bowden, G. T., and Dong, Z. (1997) J. Biol. Chem. 272, 27753-27757
27. Havel, R. J., Eder, H. A., and Bragdon, J. H. (1955) J. Clin. Invest. 43, 1345-1353
28. Steinbrecher, U. P., Witztum, J. L., Parthasarathy, S., and Steinberg, D. (1987) Arteriosclerosis 7, 135-143
29. Bielawska, A., Perry, D. K., and Hannun, Y. A. (2001) Anal. Biochem. 298, 141-150
30. Ogretmen, B., Pettus, B. J., Rossi, M. J., Wood, R., Usta, J., Szulc, Z., Bielawska, A., Obeid, L. M., and Hannun, Y. A. (2002) J. Biol. Chem. 277, 12960-12969
31. Liu, B., and Hannun, Y. A. (2000) Methods Enzymol. 311, 164-167
32. Jaworowski, A., Wilson, N. J., Christy, E., Byrne, R., and Hamilton, J. A. (1999) J. Biol. Chem. 274, 15127-15133
33. Nicholson, D. W., and Thornberry, N. A. (1997) Trends Biochem. Sci. 22, 299-306
34. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
35. Hannun, Y. (1994) J. Biol. Chem. 269, 3125-3128
36. Mathias, S., Pena, L. A., and Kolesnick, R. N. (1998) Biochem. J. 335, 465-480
37. Basu, S., Bayoumy, S., Zhang, Y., Lozano, J., and Kolesnick, R. (1998) J. Biol. Chem. 273, 30419-30426
38. Gamard, C. J., Dbaibo, G. S., Liu, B., Obeid, L. M., and Hannun, Y. A. (1997) J. Biol. Chem. 272, 16474-16481
39. Higuchi, M., Singh, S., Jaffrezou, J. P., and Aggarwal, B. B. (1996) J. Immunol. 157, 297-304
40. Haimovitz-Friedman, A., Kan, C. C., Ehleiter, D., Persaud, R. S., McLoughlin, M., Fuks, Z., and Kolesnick, R. N. (1994) J. Exp. Med. 180, 525-535
41. Bose, R., Verheij, M., Haimovitz-Friedman, A., Scotto, K., Fuks, Z., and Kolesnick, R. (1995) Cell 82, 405-414
42. Hurwitz, R., Ferlinz, K., and Sandhoff, K. (1994) Biol. Chem. Hoppe-Seyler 375, 447-450
43. Kelley, T. W., Graham, M. M., Doseff, A. I., Pomerantz, R. W., Lau, S. M., Ostrowski, M. C., Franke, T. F., and Marsh, C. B. (1999) J. Biol. Chem. 274, 26393-26398
44. Zhou, H., Summers, S. A., Birnbaum, M. J., and Pittman, R. N. (1998) J. Biol. Chem. 273, 16568-16575
45. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
46. Yui, S., Sasaki, T., Miyazaki, A., Horiuchi, S., and Yamazaki, M. (1993) Arterioscler. Thromb. 13, 331-337
47. Hu, Y., Benedict, M. A., Wu, D., Inohara, N., and Nunez, G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 4386-4391
48. Pan, G., O'Rourke, K., and Dixit, V. M. (1998) J. Biol. Chem. 273, 5841-5845
49. Reid, V. C., Hardwick, S. J., and Mitchinson, M. J. (1993) FEBS Lett. 332, 218-220
50. Hardwick, S. J., Hegyi, L., Clare, K., Law, N. S., Carpenter, K. L., Mitchinson, M. J., and Skepper, J. N. (1996) J. Pathol. 179, 294-302
51. Sata, M., and Walsh, K. (1998) J. Biol. Chem. 273, 33103-33106
52. Kinscherf, R., Claus, R., Wagner, M., Gehrke, C., Kamencic, H., Hou, D., Nauen, O., Schmiedt, W., Kovacs, G., Pill, J., Metz, J., and Deigner, H. P. (1998) FASEB J. 12, 461-467
53. Asmis, R., and Wintergerst, E. S. (1998) Eur. J. Biochem. 255, 147-155
54. Han, C. Y., and Pak, Y. K. (1999) Exp. Mol. Med. 31, 165-173
55. Farber, A., Kitzmiller, T., Morganelli, P. M., Pfeiffer, J., Groveman, D., Wagner, R. J., Cronenwett, J. L., and Powell, R. J. (1999) J. Surg. Res. 85, 323-330
56. Harada-Shiba, M., Kinoshita, M., Kamido, H., and Shimokado, K. (1998) J. Biol. Chem. 273, 9681-9687
57. Dimmeler, S., Haendeler, J., Galle, J., and Zeiher, A. M. (1997) Circulation 95, 1760-1763
58. Escargueil-Blanc, I., Meilhac, O., Pieraggi, M.-T., Arnal, J.-F., Salvayre, R., and Nègre-Salvayre, A. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 331-339
59. Escargueil-Blanc, I., Andrieu-Abadie, N., Caspar-Bauguil, S., Brossmer, R., Levade, T., Negre-Salvayre, A., and Salvayre, R. (1998) J. Biol. Chem. 273, 27389-27395
60. Li, D., Yang, B., and Mehta, J. L. (1998) Am. J. Physiol. 275, H568-H576
61. Galle, J., Schneider, R., Heinloth, A., Wanner, C., Galle, P. R., Conzelmann, E., Dimmeler, S., and Heermeier, K. (1999) Kidney Int. 55, 1450-1461
62. Nishio, E., Arimura, S., and Watanabe, Y. (1996) Biochem. Biophys. Res. Commun. 223, 413-418
63. Bachem, M. G., Wendelin, D., Schneiderhan, W., Haug, C., Zorn, U., Gross, H. J., Schmid-Kotsas, A., and Grunert, A. (1999) Clin. Chem. Lab. Med. 37, 319-326
64. Langheed, M., Zhang, H., and Steinbrecher, U. (1991) J. Biol. Chem. 266, 14519-14525
65. Hoppe, G., O'Neil, J., and Hoff, H. (1994) J. Clin. Invest. 94, 1506-1512
66. O'Neil, J., Hoppe, G., Sayre, L. M., and Hoff, H. F. (1997) Free Radic. Biol. Med. 23, 215-225
67. Maor, I., Mandel, H., and Aviram, M. (1995) Arterioscler. Thromb. Vasc. Biol. 15, 1378-1387
68. Goswami, R., Kilkus, J., Dawson, S. A., and Dawson, G. (1999) J. Neurosci. Res. 57, 884-893
69. Sambrano, G., Parthasarathy, S., and Steinberg, D. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3265-3269
70. Shiratsuchi, A., Osada, S., Kanazawa, S., and Nakanishi, Y. (1998) Biochem. Biophys. Res. Commun. 246, 549-555
71. Sambrano, G., and Steinberg, D. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1396-1400
72. Fadok, V. A., Bratton, D. L., Frasch, S. C., Warner, M. L., and Henson, P. M. (1998) Cell Death Differ. 5, 551-562
73. Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A., Ezekewitz, R. A., and Henson, P. M. (2000) Nature 405, 85-90