Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2α and enhances the interaction of the enzyme with phosphatidylcholine

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 17601-17607

  Subramanian, Preeti ^a   Stahelin, Robert V ^b   Szulc, Zdzislaw ^c   Bielawska, Alicja ^c   Cho, Wonhwa ^b   Chalfant, Charles E ^a,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOASSAY; BIOCHEMICAL ENGINEERING; DISSOCIATION; MICELLES; REACTION KINETICS; SURFACE PLASMON RESONANCE;

DISSOCIATION RATES; MICELLE ASSAYS; SURFACE-DILUTION KINETICS;

ENZYMES;

CERAMIDE 1 PHOSPHATE; CERAMIDE DERIVATIVE; PHOSPHATE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE; PHOSPHOLIPASE A2 ALPHA; SPHINGOLIPID; UNCLASSIFIED DRUG; CERAMIDE; CERAMIDE 1-PHOSPHATE; ISOENZYME; PHOSPHOLIPASE A; PHOSPHOLIPASE A2 IV; PHOSPHOLIPASE A2-ALPHA;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; DILUTION; DISSOCIATION CONSTANT; ENZYME ACTIVITY; INTRACELLULAR MEMBRANE; MEMBRANE BINDING; MICELLE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; ANIMAL; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; INSECT; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

ANIMALIA;

ALLOSTERIC REGULATION; ANIMALS; CERAMIDES; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; INSECTS; ISOENZYMES; PHOSPHATIDYLCHOLINES; PHOSPHOLIPASES A; PROTEIN BINDING;

EID: 20444371635     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414173200     Document Type: Article

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