Sphinoosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

Biochemical Journal

Volumn 374, Issue 3, 2003, Pages 715-722

  Yamaguchi, Hironori ^a   Kitayama, Joji ^a   Takuwa, Noriko ^b   Arikawa, Kayo ^b   Inoki, Isao ^b   Takehara, Kazuhiko ^b   Nagawa, Hirokazu ^a   Takuwa, Yoh ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

B16 melanoma cells; Metastasis; Rac; S1P Edg receptor; Sphingosine 1 phosphate

Indexed keywords

BIOCHEMISTRY; PHOSPHATES;

METASTASIS;

GENES;

ADENOVIRUS VECTOR; RAC PROTEIN; RECEPTOR PROTEIN; RECEPTOR SUBTYPE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DRUG DERIVATIVE; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHOLIPID; LYSOPHOSPHOLIPID RECEPTOR; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC TRANSDUCTION; LUNG METASTASIS; MELANOMA CELL; METASTASIS INHIBITION; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CALCIUM SIGNALING; CANCER TRANSPLANTATION; CELL CULTURE; CHO CELL; DOWN REGULATION; DRUG ANTAGONISM; EXPERIMENTAL MELANOMA; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; LEUKOCYTE MIGRATION INHIBITION TEST; MALE; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGY; TUMOR EMBOLISM; UPREGULATION;

ADENOVIRIDAE; ANIMALIA; CRICETINAE;

ANIMALS; CALCIUM SIGNALING; CELL MIGRATION INHIBITION; CHO CELLS; CRICETINAE; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; LYSOPHOSPHOLIPIDS; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM CIRCULATING CELLS; NEOPLASM TRANSPLANTATION; RAC GTP-BINDING PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHOLIPID; SPHINGOSINE; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0141679087     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030381     Document Type: Article

References (36)

1. Spiegel, S. and Milstien, S. (2000) Sphingosine-1-phosphate: signaling inside and out. FEBS Lett. 476, 55-57
2. Igarashi, Y. (1998) Sphingosine-1-phosphate as an intercellular signaling molecule. Ann. N. Y. Acad. Sci. 845, 19-31
3. Takuwa, Y. (2002) Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. Biochim. Biophys. Acta 1582, 112-120
4. Hla, T., Lee, M. J., Ancellin, N., Paik, J. H. and Kluk, M. J. (2001) Lysophospholipids-receptor revelations. Science 294, 1875-1878
5. Fukushima, N., Ishii, I., Contos, J. J. A., Weiner, J. A. and Chun, J. (2001) Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol. 41, 507-534
6. Tigyi, G. (2001) Physiological responses to lysophosphatidic acid and related glycero-phospholipids. Prostaglandins Other Lipid Mediators 64, 47-62
7. Sadahira, Y., Ruan, F., Hakomori, S. and Igarashi, Y. (1992) Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. U.S.A. 89, 9686-9690
8. Yamamura, S., Yatomi, Y., Ruan, F., Sweeney, E. A., Hakomori, S. and Igarashi, Y. (1997) Sphingosine 1-phosphate regulates melanoma cell motility through a receptor-coupled extracellular action and in a pertussis toxin-insensitive manner. Biochemistry 36, 10751-10759
9. Wang, F., Van Brocklyn, J. R., Edsall, L., Nava, V. E. and Spiegel, S. (1999) Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. Cancer Res. 59, 6185-6191
10. Okamoto, H., Takuwa, N., Yokomizo, T., Sugimoto, N., Sakurada, S., Shigematsu, H. and Takuwa, Y. (2000) Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell. Biol. 20, 9247-9261
11. Paik, J. H., Chae, S. S., Lee, M. J., Thangada, S. and Hla, T. (2001) Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of αvβ3- and β1-containing integrins. J. Biol. Chem. 276, 11830-11837
12. Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V. (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (London) 390, 632-636
13. Shaw, L. M., Rabinovitz, I., Wang, H. H.-F., Toker, A. and Mercurio, A. M. (1997) Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion. Cell 91, 949-960
14. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science 279, 509-514
15. Yoshioka, K., Matsumura, F., Akedo, H. and Itoh, K. (1998) Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J. Biol. Chem. 273, 5146-5154
16. Banyard, J., Anand-Apte, B., Symons, M. and Zetter, B. R. (2000) Motility and invasion are differentially modulated by Rho family GTPases. Oncogene 19, 580-591
17. Whitehead, I. P., Zohn, I. E. and Der, C. J. (2001) Rho GTPase-dependent transformation by G protein-coupled receptors. Oncogene 20, 1547-1555
18. Ryu, Y., Takuwa, N., Sugimoto, N., Sakurada, S., Usui, S., Okamoto, H., Matsui, O. and Takuwa, Y. (2002) Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Circ. Res. 90, 325-332
19. 2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J. Biol. Chem. 273, 27104-27110
20. Gonda, K., Okamoto, H., Takuwa, N., Yatomi, Y., Okazaki, H., Sakurai, T., Kimura, S., Sillard, R., Harii, K. and Takuwa, Y. (1999) The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. Biochem J. 337, 67-75
21. S6K-independent signaling in growth factor-stimulated NIH3T3 fibroblasts. Mol. Cell. Biol. 19, 1346-1358
22. Poste, G., Doll, J., Hart, I. R. and Fidler, I. J. (1980) In vitro selection of mouse B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res. 40, 1636-1644
23. 2 system. Clin. Exp. Metastasis 1, 103-114
24. Cory, A. H., Owen, T. C., Barltrop, J. A. and Cory, J. G. (1991) Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Comm. 3, 207-212
25. Clark, E. A., Golub, T. R., Lander, E. S. and Hynes, R. O. (2000) Genomic analysis of metastasis reveals an essential role for RhoC. Nature (London) 406, 532-535
26. Tamama, K., Kon, J., Sato, K., Tomura, H., Kuwabara, A., Kimura, T., Kanda, T., Ohta, H., Ui, M., Kobayashi, I. and Okajima, F. (2001) Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. Biochem J. 353, 139-146
27. i-pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol. Cell. Biol. 23, 1534-1545
28. Crissman, J. D., Hatfield, J., Schaldenbrand, M., Sloane, B. F. and Hon, K. V. (1985) Arrest and extravasation of B16 amelanotic melanoma in murine lungs. Lab. Invest. 53, 470-478
29. 2 G protein-coupled receptor: requirement of inhibition of cellular Rac activity. J. Biol. Chem., DOI 10.1074/jbc.M305024200
30. Bouzahzah, B., Albanese, C., Ahmed, F., Pixley, F., Lisanti, M. P., Segall, J. D., Condeelis, J., Joyce, D., Minden, A., Der, C. J. et al. (2001) Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol. Med. 7, 816-830
31. del Peso, L., Hernandez-Alcoceba, R., Embade, N., Carnero, A., Esteva, P., Paje, C. and Lacal, J. C. (1997) Rho proteins induce metastatic properties in vivo. Oncogene 15, 3047-3057
32. Van Aelst, L. and D'Souza-Schorey, C. (1997) Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322
33. Yatomi, Y., Ozaki, Y., Ohmori, T. and Igarashi, Y. (2001) Sphingosine 1-phosphate, synthesis and release. Prostaglandins Other Lipid Mediators 64, 107-122
34. Murata, N., Sato, K., Kon, J., Tomura, H., Yanagita, M., Kuwabara, A., Ui, M. and Okajima, F. (2000) Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem. J. 352, 809-815
35. Olivera, A. and Spiegel, S. (2001) Sphingosine kinase: a mediator of vital cellular functions. Prostaglandins Other Lipid Mediators 64, 123-134
36. Xia, P., Wang, L., Gamble, J. R. and Vadas, M. A. (1999) Activation of sphingosine kinase by tumor necrosis factor-α inhibits apoptosis in human endothelial cells. J. Biol. Chem. 274, 34499-34505