Sphingolipids, apoptosis, cancer treatments and the ovary: Investigating a crime against female fertility

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1585, Issue 2-3, 2002, Pages 135-138

  Tilly, Jonathan L ^a   Kolesnick, Richard N ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Apoptosis; Cell death; Ceramide; Fertility; Oocyte; Ovary; Sphingosine 1 phosphate

Indexed keywords

ANTINEOPLASTIC AGENT; CERAMIDE; DOXORUBICIN; FUMONISIN B1; N,N DIMETHYLSPHINGOSINE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE;

APOPTOSIS; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER THERAPY; CELL DEATH; CELL POPULATION; CHRONIC TOXICITY; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; EARLY MENOPAUSE; FEMALE INFERTILITY; GONAD; HUMAN; MEDIATOR; NONHUMAN; OOCYTE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; TARGET ORGAN;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CERAMIDES; FEMALE; HUMANS; INFERTILITY; MEMBRANE PROTEINS; OOCYTES; OVARY; PHOSPHORIC MONOESTER HYDROLASES; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; SPHINGOLIPIDS;

EID: 0037203319     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(02)00333-5     Document Type: Review

References (32)

1. Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr. Rev. 17:1996;121-155.
2. Tilly J.L. Commuting the death sentence: how oocytes strive to survive. Nat. Rev., Mol. Cell Biol. 2:2001;838-848.
3. Baker T.G. A quantitative and cytological study of germ cells in human ovaries. Proc. R. Soc. Lond., B. 158:1963;417-433.
4. Forabosco A., Sforza C., De Pol A., Vizzotto L., Marzona L., Ferrario V.F. Morphometric study of the human neonatal ovary. Anat. Rec. 231:1991;201-208.
5. Faddy M.J., Gosden R.G., Gougeon A., Richardson S.J., Nelson J.F. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum. Reprod. 7:1992;1342-1346.
6. Pru J.K., Tilly J.L. Programmed cell death in the ovary: insights and future prospects using genetic technologies. Mol. Endocrinol. 15:2001;845-853.
7. Morita Y., Perez G.I., Paris F., Miranda S., Ehleiter D., Haimovitz-Friedman A., Fuks Z., Xie Z., Reed J.C., Schuchman E.H., Kolesnick R.N., Tilly J.L. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat. Med. 6:2000;1109-1114.
8. Cuvillier O., Pirianov G., Kleuser B., Vanek P.G., Coso O.A., Gutkind S., Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 381:1996;800-803.
9. Spiegel S., Milstien S. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett. 476:2000;55-57.
10. Solary E., Plenchette S., Sordet O., Rebe C., Ducoroy P., Filomenko R., Bruey J.M., Droin N., Corcos L. Modulation of apoptotic pathways triggered by cytotoxic agents. Therapie. 56:2001;511-518.
11. Verheij M.J., Bartelink H. Radiation-induced apoptosis. Cell Tissue Res. 301:2000;133-142.
12. Briggs D., Miller D., Gosden R.G. Molecular biology of female gametogenesis. Fauser B.C.J.M. Molecular Biology in Reproductive Medicine. 1999;251-269 Parthenon, New York.
13. Perez G.I., Knudson C.M., Leykin L., Korsmeyer S.J., Tilly J.L. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat. Med. 3:1997;1228-1232.
14. Kolesnick R.N., Kronke M. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60:1998;643-665.
15. Senchenkov A., Litvak D.A., Cabot M.C. Targeting ceramide metabolism - a strategy for overcoming drug resistance. J. Natl. Cancer Inst. 93:2001;347-357.
16. Nava V.E., Cuvillier O., Edsall L.C., Kimura K., Milstien S., Gelmann E.P., Spiegel S. Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. Cancer Res. 60:2000;4468-4474.
17. Cuvillier O., Nava V.E., Murthy S.K., Edsall L.C., Levade T., Milstien S., Spiegel S. Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ. 8:2001;162-171.
18. Paris F., Perez G.I., Haimovitz-Friedman A., Nguyen H., Fuks Z., Bose M., Ilagan A., Hunt P.A., Morgan W.F., Tilly J.L., Kolesnick R. Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat. Med. 8:2002;901-902.
19. Pyne S., Pyne N.J. Sphingosine 1-phosphate signaling in mammalian cells. Biochem. J. 349:2000;385-402.
20. Olivera A., Spiegel S. Sphingosine kinase: a mediator of vital cellular functions. Prostaglandins Other Lipid Mediat. 64:2001;123-134.
21. Takuwa Y., Okamoto H., Takuwa N., Gonda K., Sugimoto N., Sakurada S. Suptype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. Mol. Cell. Endocrinol. 177:2001;3-11.
22. Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat. 64:2001;135-142.
23. Fukushima N., Chun J. The LPA receptors. Prostaglandins Other Lipid Mediat. 64:2001;21-32.
24. Goetzl E.J., Kong Y., Mei B. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with a suppression of Bax. J. Immunol. 162:1999;2049-2056.
25. Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1999;1899-1911.
26. Cuvillier O., Rosenthal D.S., Smulson M.E., Spiegel S. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. J. Biol. Chem. 273:1998;2910-2916.
27. Bergeron L., Perez G.I., Mcdonald G., Shi L., Sun Y., Jurisicova A., Varmuza S., Latham K.E., Flaws J.A., Salter J., Hara H., Moskowitz M.A., Li E., Greenberg A.H., Tilly J.L., Yuan J. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 12:1998;1304-1314.
28. Cuvillier O., Levade T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood. 98:2001;2828-2836.
29. Pastorino J.G., Tafani M., Rothman R.J., Marcinkeviciute A., Hoek J.B., Farber J.L. Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J. Biol. Chem. 274:1999;31734-31739.
30. Lantz M.E. Childbearing after cancer treatment. Trimble E.L., Trimble C.L. Cancer Obstetrics and Gynecology. 1999;87-98 Lippincott Williams and Wilkins, Philadelphia.
31. Weissman A., Gotlieb L., Colgan T., Jurisicova A., Greenblatt E.M., Casper R.F. Preliminary experience with subcutaneous human ovarian cortex transplantation in the NOD-SCID mouse. Biol. Reprod. 60:1999;1462-1467.
32. Matikainen T., Perez G.I., Jurisicova A., Schlezinger J.J., Ryu H.-Y., Pru J.K., Sakai T., Korsmeyer S.J., Casper R.F., Sherr D.H., Tilly J.L. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat. Genet. 28:2001;355-360.