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Volumn 6, Issue 6, 2010, Pages 675-687

A role for CYP in the drughormone crosstalk of the brain

Author keywords

Androgen receptor; Brain; CYP; Drug metabolism; Drughormone crosstalk; Endocrine signaling; Neuroactive drug; Steroid hormone; Steroid hormone receptor; Testosterone

Indexed keywords

ANDROSTANOLONE; ANTICONVULSIVE AGENT; CYTARABINE; CYTOCHROME; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B10; CYTOCHROME P450 2C11; CYTOCHROME P450 2C29; CYTOCHROME P450 2D1; CYTOCHROME P450 2D4; CYTOCHROME P450 2D6; CYTOCHROME P450 2D7; CYTOCHROME P450 2E1; CYTOCHROME P450 2G; CYTOCHROME P450 3A11; CYTOCHROME P450 3A13; CYTOCHROME P450 3A4; CYTOCHROME P450 3A9; CYTOCHROME P450 4F; ESTRADIOL; METHOTREXATE; NEUROLEPTIC AGENT; TESTOSTERONE; UNCLASSIFIED DRUG; CYTOCHROME P450; DRUG; SEX HORMONE;

EID: 77952513532     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425251003680791     Document Type: Review
Times cited : (8)

References (130)
  • 1
    • 34249009984 scopus 로고    scopus 로고
    • Expression and function of cytochrome P450 in brain drug metabolism
    • •• A concise review on brain P450 expression and function
    • Meyer RP, Gehlhaus M, Knoth R, Volk B. Expression and function of cytochrome P450 in brain drug metabolism. Curr Drug Metab 2007;8(4):297-306 •• A concise review on brain P450 expression and function.
    • (2007) Curr. Drug. Metab. , vol.8 , Issue.4 , pp. 297-306
    • Meyer, R.P.1    Gehlhaus, M.2    Knoth, R.3    Volk, B.4
  • 4
    • 51649130866 scopus 로고    scopus 로고
    • The alchemy of immune privilege explored from a neuroimmunological perspective
    • Arck PC, Gilhar A, Bienenstock J, Paus R. The alchemy of immune privilege explored from a neuroimmunological perspective. Curr Opin Pharmacol 2008;8(4):480-9
    • (2008) Curr. Opin. Pharmacol. , vol.8 , Issue.4 , pp. 480-489
    • Arck, P.C.1    Gilhar, A.2    Bienenstock, J.3    Paus, R.4
  • 5
    • 60549083987 scopus 로고    scopus 로고
    • The bright side of the glial scar in CNS repair
    • Rolls A, Shechter R, Schwartz M. The bright side of the glial scar in CNS repair. Nat Rev Neurosci 2009;10(3):235-41
    • (2009) Nat. Rev. Neurosci. , vol.10 , Issue.3 , pp. 235-241
    • Rolls, A.1    Shechter, R.2    Schwartz, M.3
  • 6
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9(1):46-56
    • (2008) Nat. Rev. Neurosci. , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3
  • 7
    • 0742321734 scopus 로고    scopus 로고
    • Human drug metabolising cytochrome P450 enzymes: Properties and polymorphisms
    • Ingelman-Sundberg M. Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms. Naunyn Schmiedebergs Arch Pharmacol 2004;369(1):89-104
    • (2004) Naunyn Schmiedebergs Arch. Pharmacol. , vol.369 , Issue.1 , pp. 89-104
    • Ingelman-Sundberg, M.1
  • 8
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005;352(21):2211-21
    • (2005) N Engl. J. Med. , vol.352 , Issue.21 , pp. 2211-2221
    • Wilkinson, G.R.1
  • 9
    • 15944402792 scopus 로고    scopus 로고
    • Self-evaluation of depression by patients and condition identification by primary care physicians-a comparison
    • Bermejo I, Kratz S, Gaebel W, et al. Self-evaluation of depression by patients and condition identification by primary care physicians-a comparison. Med Welt 2005;56(3):73-8
    • (2005) Med. Welt , vol.56 , Issue.3 , pp. 73-78
    • Bermejo, I.1    Kratz, S.2    Gaebel, W.3
  • 10
    • 77952530735 scopus 로고    scopus 로고
    • Deutsche Hauptstelle fuer Suchtfrage
    • Editor, Neuland Verlag, Geesthacht, Germany
    • Jahrbuch S, Deutsche Hauptstelle fuer Suchtfrage, (Editor), Jahrbuch sucht (2004). Neuland Verlag, Geesthacht, Germany
    • (2004) Jahrbuch Sucht
    • Jahrbuch, S.1
  • 11
    • 77952479825 scopus 로고    scopus 로고
    • Angststoerungen. Gesundheitsberichterstattung desBundes
    • Berlin, Germany
    • Wittchen HU, Jacobi F. Angststoerungen. Gesundheitsberichterstattung desBundes. Robert Koch-Institut. Berlin, Germany; 2004. p. 1-16
    • (2004) Robert Koch-Institut , pp. 1-16
    • Wittchen, H.U.1    Jacobi, F.2
  • 12
    • 16444364594 scopus 로고    scopus 로고
    • The epidemiology of epilepsy in Europe-a systematic review
    • Forsgren L, Beghi E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe-a systematic review. Eur J Neurol 2005;12(4):245-53
    • (2005) Eur. J. Neurol. , vol.12 , Issue.4 , pp. 245-253
    • Forsgren, L.1    Beghi, E.2    Oun, A.3    Sillanpaa, M.4
  • 14
    • 84883990627 scopus 로고    scopus 로고
    • Marrow ablative chemotherapy with hematopoetic stem cell rescue
    • Newton HB, editor, Academic Press, Oxford
    • Newton HB. Marrow ablative chemotherapy with hematopoetic stem cell rescue. In: Newton HB, editor, Handbook of brain tumor chemotherapy. Academic Press, Oxford; 2005. p. 305-15
    • (2005) Handbook of Brain Tumor Chemotherapy , pp. 305-15
    • Newton, H.B.1
  • 15
    • 77952472037 scopus 로고    scopus 로고
    • Clinical pharmacology of brain tumor chemotherapy
    • Newton HB, editor, Academic Press, Oxford
    • Newton HB. Clinical pharmacology of brain tumor chemotherapy. In: Newton HB, editor, Handbook of brain tumor chemotherapy. Academic Press, Oxford; 2005. p. 21-42
    • (2005) Handbook of Brain Tumor Chemotherapy , pp. 21-42
    • Newton, H.B.1
  • 16
    • 0023032483 scopus 로고
    • Chronic alcohol consumption induces lipofuscin deposition in the rat hippocampus
    • Borges MM, Paula-Barbosa MM, Volk B. Chronic alcohol consumption induces lipofuscin deposition in the rat hippocampus. Neurobiol Aging 1986;7(5):347-55
    • (1986) Neurobiol. Aging , vol.7 , Issue.5 , pp. 347-355
    • Borges, M.M.1    Paula-Barbosa, M.M.2    Volk, B.3
  • 17
    • 0028009129 scopus 로고
    • Long-term effects of intermittent versus continuous ethanol exposure on hippocampal synapses of the rat
    • Lundqvist C, Volk B, Knoth R, Alling C. Long-term effects of intermittent versus continuous ethanol exposure on hippocampal synapses of the rat. Acta Neuropathol 1994;87(3):242-9
    • (1994) Acta Neuropathol , vol.87 , Issue.3 , pp. 242-249
    • Lundqvist, C.1    Volk, B.2    Knoth, R.3    Alling, C.4
  • 18
    • 0037450449 scopus 로고    scopus 로고
    • Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: Summary and implications
    • Schoedel KA, Tyndale RF. Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. Biochim Biophys Acta 2003;1619(3):283-90
    • (2003) Biochim Biophys. Acta , vol.1619 , Issue.3 , pp. 283-290
    • Schoedel, K.A.1    Tyndale, R.F.2
  • 19
    • 13444263617 scopus 로고    scopus 로고
    • Alcohol and public health
    • Room R, Babor T, Rehm J. Alcohol and public health. Lancet 2005;365(9458):519-30
    • (2005) Lancet , vol.365 , Issue.9458 , pp. 519-530
    • Room, R.1    Babor, T.2    Rehm, J.3
  • 20
    • 58149215663 scopus 로고    scopus 로고
    • Neurocognitive changes in cancer survivors
    • Correa DD, Ahles TA. Neurocognitive changes in cancer survivors. Cancer J 2008;14(6):396-400
    • (2008) Cancer J. , vol.14 , Issue.6 , pp. 396-400
    • Correa, D.D.1    Ahles, T.A.2
  • 21
    • 34249910330 scopus 로고    scopus 로고
    • Antiepileptic drugs and the significance of event-related potentials
    • Sun W, Wang W, Wu X, Wang Y. Antiepileptic drugs and the significance of event-related potentials. J Clin Neurophysiol 2007;24(3):271-6
    • (2007) J. Clin. Neurophysiol. , vol.24 , Issue.3 , pp. 271-276
    • Sun, W.1    Wang, W.2    Wu, X.3    Wang, Y.4
  • 22
    • 16244368450 scopus 로고    scopus 로고
    • Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy
    • DOI 10.2165/00023210-200519030-00003
    • Isojarvi JI, Tauboll E, Herzog AG. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs 2005;19(3):207-23 •• A concise summary of the endocrine disorders in patients taking P450-inducing drugs. (Pubitemid 40460661)
    • (2005) CNS Drugs , vol.19 , Issue.3 , pp. 207-223
    • Isojarvi, J.I.T.1    Tauboll, E.2    Herzog, A.G.3
  • 23
    • 0036225453 scopus 로고    scopus 로고
    • Altered reproductive endocrine regulation in men with epilepsy: Implications for reproductive function and seizures
    • Herzog AG. Altered reproductive endocrine regulation in men with epilepsy: implications for reproductive function and seizures. Ann Neurol 2002;51(5):539-42
    • (2002) Ann. Neurol. , vol.51 , Issue.5 , pp. 539-542
    • Herzog, A.G.1
  • 24
    • 33644874555 scopus 로고    scopus 로고
    • Anti-epileptic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus
    • Meyer RP, Hagemeyer CE, Knoth R, et al. Anti-epileptic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus. J Neurochem 2006;96(2):460-72
    • (2006) J. Neurochem. , vol.96 , Issue.2 , pp. 460-472
    • Meyer, R.P.1    Hagemeyer, C.E.2    Knoth, R.3
  • 25
    • 58149151212 scopus 로고    scopus 로고
    • Sexual quality of life in epilepsy: Correlations with sex hormone blood levels
    • Molleken D, Richter-Appelt H, Stodieck S, Bengner T. Sexual quality of life in epilepsy: correlations with sex hormone blood levels. Epilepsy Behav 2009;14(1):226-31
    • (2009) Epilepsy Behav. , vol.14 , Issue.1 , pp. 226-231
    • Molleken, D.1    Richter-Appelt, H.2    Stodieck, S.3    Bengner, T.4
  • 26
    • 38949103008 scopus 로고    scopus 로고
    • Disorders of reproduction in patients with epilepsy: Primary neurological mechanisms
    • Herzog AG. Disorders of reproduction in patients with epilepsy: primary neurological mechanisms. Seizure 2008;17(2):101-10
    • (2008) Seizure , vol.17 , Issue.2 , pp. 101-110
    • Herzog, A.G.1
  • 27
    • 67349222551 scopus 로고    scopus 로고
    • Epilepsy and hormones: A critical review
    • Luef G, Rauchenzauner M. Epilepsy and hormones: a critical review. Epilepsy Behav 2009;15(1):73-7
    • (2009) Epilepsy Behav. , vol.15 , Issue.1 , pp. 73-77
    • Luef, G.1    Rauchenzauner, M.2
  • 28
    • 9644281626 scopus 로고    scopus 로고
    • Role of neurosteroids in catamenial epilepsy
    • Reddy DS. Role of neurosteroids in catamenial epilepsy. Epilepsy Res 2004;62(2-3):99-118
    • (2004) Epilepsy Res. , vol.62 , Issue.2-3 , pp. 99-118
    • Reddy, D.S.1
  • 29
    • 38949125480 scopus 로고    scopus 로고
    • Disorders of reproduction in patients with epilepsy: Antiepileptic drug related mechanisms
    • Isojarvi J. Disorders of reproduction in patients with epilepsy: antiepileptic drug related mechanisms. Seizure 2008;17(2):111-9
    • (2008) Seizure , vol.17 , Issue.2 , pp. 111-119
    • Isojarvi, J.1
  • 30
    • 68149134517 scopus 로고    scopus 로고
    • Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy
    • •• Demonstrates drug-homone crosstalk AR, ER and P450 in samples from human brain
    • Killer N, Hock M, Gehlhaus M, et al. Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy. Epilepsia 2009;50(8):1875-90 •• Demonstrates drug-homone crosstalk (AR, ER and P450) in samples from human brain.
    • (2009) Epilepsia , vol.50 , Issue.8 , pp. 1875-1890
    • Killer, N.1    Hock, M.2    Gehlhaus, M.3
  • 31
    • 33745965329 scopus 로고    scopus 로고
    • Role of androgens in epilepsy
    • •• A concise overview on steroid hormone action and regulation in epilepsy
    • Frye CA. Role of androgens in epilepsy. Expert Rev Neurother 2006;6(7):1061-75 •• A concise overview on steroid hormone action and regulation in epilepsy.
    • (2006) Expert Rev. Neurother , vol.6 , Issue.7 , pp. 1061-1075
    • Frye, C.A.1
  • 32
    • 70649110724 scopus 로고    scopus 로고
    • Available from:, Last accessed 13 January
    • Flockhart DA. P450-Drug interaction table. Available from: http://medicine. iupui.edu/clinpharm/ddis/. [Last accessed 13 January 2010]
    • (2010) P450-Drug Interaction Table
    • Flockhart, D.A.1
  • 33
    • 52249086496 scopus 로고    scopus 로고
    • Available from:, Last accessed 14 January
    • Nelson DR. P450 nomenclature and overview. Available from: http://drnelson. utmem.edu/CytochromeP450.html. [Last accessed 14 January 2010]
    • (2010) P450 Nomenclature and Overview
    • Nelson, D.R.1
  • 34
    • 0141706810 scopus 로고    scopus 로고
    • Genomic characterization and regulation of CYP3a13: Role of xenobiotics and nuclear receptors
    • Anakk S, Kalsotra A, Shen Q, et al. Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors. FASEB J 2003;17(12):1736-8
    • (2003) FASEB J. , vol.17 , Issue.12 , pp. 1736-1738
    • Anakk, S.1    Kalsotra, A.2    Shen, Q.3
  • 35
    • 0344740559 scopus 로고    scopus 로고
    • Induction of drug metabolism: The role of nuclear receptors
    • Handschin C, Meyer UA. Induction of drug metabolism: the role of nuclear receptors. Pharmacol Rev 2003;55(4):649-73
    • (2003) Pharmacol. Rev. , vol.55 , Issue.4 , pp. 649-673
    • Handschin, C.1    Meyer, U.A.2
  • 36
    • 2942640266 scopus 로고    scopus 로고
    • Cognitive impairment associated with chemotherapy for cancer: Report of a workshop
    • Tannock IF, Ahles TA, Ganz PA, Van Dam FS. Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol 2004;22(11):2233-9
    • (2004) J. Clin. Oncol. , vol.22 , Issue.11 , pp. 2233-2239
    • Tannock, I.F.1    Ahles, T.A.2    Ganz, P.A.3    Van Dam, F.S.4
  • 37
    • 0344692063 scopus 로고    scopus 로고
    • Breast cancer chemotherapy-related cognitive dysfunction
    • Ahles TA, Saykin AJ. Breast cancer chemotherapy-related cognitive dysfunction. Clin Breast Cancer 2002;3(Suppl 3):S84-90
    • (2002) Clin. Breast Cancer , vol.3 , Issue.3 SUPPL.
    • Ahles, T.A.1    Saykin, A.J.2
  • 38
    • 33847195328 scopus 로고    scopus 로고
    • Candidate mechanisms for chemotherapy-induced cognitive changes
    • •• Gives a good overview on the current discussion concernng mechanisms in CHT induced cogitive changes
    • Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 2007;7(3):192-201 •• Gives a good overview on the current discussion concernng mechanisms in CHT induced cogitive changes.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.3 , pp. 192-201
    • Ahles, T.A.1    Saykin, A.J.2
  • 39
    • 2142816687 scopus 로고    scopus 로고
    • What is the effect of systemic anticancer treatment on cognitive function?
    • Minisini A, Atalay G, Bottomley A, et al. What is the effect of systemic anticancer treatment on cognitive function? Lancet Oncol 2004;5(5):273-82
    • (2004) Lancet Oncol. , vol.5 , Issue.5 , pp. 273-282
    • Minisini, A.1    Atalay, G.2    Bottomley, A.3
  • 40
    • 70450241056 scopus 로고    scopus 로고
    • Polymorphisms in methotrexate pathways: What is clinically relevant, what is not, and what is promising
    • Gervasini G. Polymorphisms in methotrexate pathways: what is clinically relevant, what is not, and what is promising. Curr Drug Metab 2009;10(6):547-66
    • (2009) Curr. Drug. Metab. , vol.10 , Issue.6 , pp. 547-566
    • Gervasini, G.1
  • 41
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006;7(1):41-53
    • (2006) Nat. Rev. Neurosci. , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 42
    • 4944230477 scopus 로고    scopus 로고
    • Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
    • Bauer B, Hartz AM, Fricker G, Miller DS. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol 2004;66(3):413-9
    • (2004) Mol. Pharmacol. , vol.66 , Issue.3 , pp. 413-419
    • Bauer, B.1    Hartz, A.M.2    Fricker, G.3    Miller, D.S.4
  • 43
    • 68949192657 scopus 로고    scopus 로고
    • Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
    • Stanley LA, Horsburgh BC, Ross J, et al. Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior. Drug Metab Rev 2009;41(1):27-65
    • (2009) Drug. Metab. Rev. , vol.41 , Issue.1 , pp. 27-65
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3
  • 44
    • 0036007742 scopus 로고    scopus 로고
    • St Johns wort increases expression of P-glycoprotein: Implications for drug interactions
    • Hennessy M, Kelleher D, Spiers JP, et al. St Johns wort increases expression of P-glycoprotein: implications for drug interactions. Br J Clin Pharmacol 2002;53(1):75-82
    • (2002) Br. J. Clin. Pharmacol. , vol.53 , Issue.1 , pp. 75-82
    • Hennessy, M.1    Kelleher, D.2    Spiers, J.P.3
  • 45
    • 0036304016 scopus 로고    scopus 로고
    • Pharmacokinetic interactions between herbal remedies and medicinal drugs
    • Ioannides C. Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica 2002;32(6):451-78
    • (2002) Xenobiotica , vol.32 , Issue.6 , pp. 451-478
    • Ioannides, C.1
  • 46
    • 0036874345 scopus 로고    scopus 로고
    • Drug-metabolizing cytochrome P450s in the brain
    • Miksys SL, Tyndale RF. Drug-metabolizing cytochrome P450s in the brain. J Psychiatry Neurosci 2002;27(6):406-15
    • (2002) J. Psychiatry Neurosci. , vol.27 , Issue.6 , pp. 406-415
    • Miksys, S.L.1    Tyndale, R.F.2
  • 47
    • 58149475254 scopus 로고    scopus 로고
    • Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition
    • •• Gives an overview on recent methodology to access brain drug metabolism
    • Miksys S, Tyndale RF. Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition. Neuropsychopharmacology 2009;34(3):634-40 •• Gives an overview on recent methodology to access brain drug metabolism.
    • (2009) Neuropsychopharmacology , vol.34 , Issue.3 , pp. 634-640
    • Miksys, S.1    Tyndale, R.F.2
  • 48
    • 55549140837 scopus 로고    scopus 로고
    • CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury
    • Wang Y, Zhao J, Kalsotra A, et al. CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury. J Neurotrauma 2008;25(10):1187-94
    • (2008) J. Neurotrauma , vol.25 , Issue.10 , pp. 1187-1194
    • Wang, Y.1    Zhao, J.2    Kalsotra, A.3
  • 50
    • 61649098367 scopus 로고    scopus 로고
    • Astrocytes and the regulation of cerebral blood flow
    • Koehler RC, Roman RJ, Harder DR. Astrocytes and the regulation of cerebral blood flow. Trends Neurosci 2009;32(3):160-9
    • (2009) Trends Neurosci. , vol.32 , Issue.3 , pp. 160-169
    • Koehler, R.C.1    Roman, R.J.2    Harder, D.R.3
  • 51
    • 0031025257 scopus 로고    scopus 로고
    • Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-alpha/beta induction
    • Delaporte E, Renton KW. Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-alpha/beta induction. J Pharm Biomed Anal 1997;60(10):787-96
    • (1997) J. Pharm. Biomed. Anal. , vol.60 , Issue.10 , pp. 787-796
    • Delaporte, E.1    Renton, K.W.2
  • 52
    • 0043233001 scopus 로고    scopus 로고
    • Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism
    • Tindberg N. Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. J Neurochem 2003;86(4):888-95
    • (2003) J. Neurochem. , vol.86 , Issue.4 , pp. 888-895
    • Tindberg, N.1
  • 53
    • 0034418176 scopus 로고    scopus 로고
    • Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary
    • Huang P, Rannug A, Ahlbom E, et al. Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary. Toxicol Appl Pharmacol 2000;169(2):159-67
    • (2000) Toxicol. Appl. Pharmacol. , vol.169 , Issue.2 , pp. 159-167
    • Huang, P.1    Rannug, A.2    Ahlbom, E.3
  • 54
    • 0031862390 scopus 로고    scopus 로고
    • Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: Role in metabolic activation of acetaminophen and 2, 6-dichlorobenzonitrile in mouse olfactory mucosal microsomes
    • Gu J, Zhang QY, Genter MB, et al. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2, 6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. J Pharm Exp Ther 1998;285(3):1287-95
    • (1998) J. Pharm. Exp. Ther. , vol.285 , Issue.3 , pp. 1287-1295
    • Gu, J.1    Zhang, Q.Y.2    Genter, M.B.3
  • 55
    • 0036839755 scopus 로고    scopus 로고
    • Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme
    • •• Basic paper on the regulation of brain P450 by heme
    • Meyer RP, Podvinec M, Meyer UA. Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Mol Pharmacol 2002;62(5):1061-7 •• Basic paper on the regulation of brain P450 by heme.
    • (2002) Mol. Pharmacol. , vol.62 , Issue.5 , pp. 1061-1067
    • Meyer, R.P.1    Podvinec, M.2    Meyer, U.A.3
  • 56
    • 0027359523 scopus 로고
    • Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain
    • Schilter B, Omiecinski CJ. Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. Mol Pharmacol 1993;44(5):990-6
    • (1993) Mol. Pharmacol. , vol.44 , Issue.5 , pp. 990-996
    • Schilter, B.1    Omiecinski, C.J.2
  • 58
    • 0034869539 scopus 로고    scopus 로고
    • Progesterone oxidation by cytochrome P450 2D isoforms in the brain
    • Hiroi T, Kishimoto W, Chow T, et al. Progesterone oxidation by cytochrome P450 2D isoforms in the brain. Endocrinology 2001;142(9):3901-8
    • (2001) Endocrinology , vol.142 , Issue.9 , pp. 3901-3908
    • Hiroi, T.1    Kishimoto, W.2    Chow, T.3
  • 59
    • 0842313073 scopus 로고    scopus 로고
    • Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain
    • Kishimoto W, Hiroi T, Shiraishi M, et al. Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology 2004;145(2):699-705
    • (2004) Endocrinology , vol.145 , Issue.2 , pp. 699-705
    • Kishimoto, W.1    Hiroi, T.2    Shiraishi, M.3
  • 60
    • 0037475157 scopus 로고    scopus 로고
    • Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain
    • Hagemeyer CE, Rosenbrock H, Ditter M, et al. Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. Neuroscience 2003;117(3):521-9
    • (2003) Neuroscience , vol.117 , Issue.3 , pp. 521-529
    • Hagemeyer, C.E.1    Rosenbrock, H.2    Ditter, M.3
  • 61
    • 62649093460 scopus 로고    scopus 로고
    • Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment
    • Meyer RP, Gehlhaus M, Schwab R, et al. Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment. J Neurochem 2009;109(2):670-81
    • (2009) J. Neurochem. , vol.109 , Issue.2 , pp. 670-681
    • Meyer, R.P.1    Gehlhaus, M.2    Schwab, R.3
  • 62
    • 0033656861 scopus 로고    scopus 로고
    • Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones
    • Wang H, Napoli KL, Strobel HW. Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. Mol Cell Biochem 2000;213(1-2):127-35
    • (2000) Mol. Cell. Biochem. , vol.213 , Issue.1-2 , pp. 127-135
    • Wang, H.1    Napoli, K.L.2    Strobel, H.W.3
  • 63
    • 32144443980 scopus 로고    scopus 로고
    • CYP2B6 is expressed in African green monkey brain and is induced by chronic nicotine treatment
    • Lee AM, Miksys S, Palmour R, Tyndale RF. CYP2B6 is expressed in African green monkey brain and is induced by chronic nicotine treatment. Neuropharmacology 2006;50(4):441-50
    • (2006) Neuropharmacology , vol.50 , Issue.4 , pp. 441-450
    • Lee, A.M.1    Miksys, S.2    Palmour, R.3    Tyndale, R.F.4
  • 64
    • 0037739660 scopus 로고    scopus 로고
    • Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics
    • Howard LA, Miksys S, Hoffmann E, et al. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. Br J Pharmacol 2003;138(7):1376-86
    • (2003) Br. J. Pharmacol. , vol.138 , Issue.7 , pp. 1376-1386
    • Howard, L.A.1    Miksys, S.2    Hoffmann, E.3
  • 65
    • 0001469981 scopus 로고    scopus 로고
    • Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis
    • Jover R, Hoffmann K, Meyer UA. Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis. Biochem Biophys Res Commun 1996;226(1):152-7
    • (1996) Biochem. Biophys. Res. Commun. , vol.226 , Issue.1 , pp. 152-157
    • Jover, R.1    Hoffmann, K.2    Meyer, U.A.3
  • 66
    • 0008881566 scopus 로고    scopus 로고
    • The heme oxygenase system and its functions in the brain
    • Maines MD. The heme oxygenase system and its functions in the brain. Cell Mol Biol 2000;46(3):573-85
    • (2000) Cell. Mol. Biol. , vol.46 , Issue.3 , pp. 573-585
    • Maines, M.D.1
  • 67
    • 0030069657 scopus 로고    scopus 로고
    • Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria
    • Lindberg RLP, Porcher C, Grandchamp B, et al. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nat Genet 1996;12(2):195-9
    • (1996) Nat. Genet. , vol.12 , Issue.2 , pp. 195-199
    • Lindberg, R.L.P.1    Porcher, C.2    Grandchamp, B.3
  • 68
    • 28244437193 scopus 로고    scopus 로고
    • Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency
    • Meyer RP, Lindberg RL, Hoffmann F, Meyer UA. Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency. Biol Chem 2005;386(11):1157-64
    • (2005) Biol. Chem. , vol.386 , Issue.11 , pp. 1157-1164
    • Meyer, R.P.1    Lindberg, R.L.2    Hoffmann, F.3    Meyer, U.A.4
  • 69
    • 0018910365 scopus 로고
    • Activators of cytochrome P-450 dependent monooxygenation reactions
    • • One of the first papers demonstrating the heme effect on extrahepatic P450s
    • Omiecinski CJ, Juchau MR. Activators of cytochrome P-450 dependent monooxygenation reactions. Proc West Pharmacol Soc 1980;23:9-10 • One of the first papers demonstrating the heme effect on extrahepatic P450s.
    • (1980) Proc. West Pharmacol. Soc. , vol.23 , pp. 9-10
    • Omiecinski, C.J.1    Juchau, M.R.2
  • 70
    • 0017087792 scopus 로고
    • Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity
    • Bissell DM, Hammaker LE. Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity. Arch Biochem Biophys 1976;176(1):91-102
    • (1976) Arch. Biochem. Biophys. , vol.176 , Issue.1 , pp. 91-102
    • Bissell, D.M.1    Hammaker, L.E.2
  • 71
    • 0021109198 scopus 로고
    • Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture
    • Giger U, Meyer UA. Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture. FEBS Lett 1983;153(2):335-8
    • (1983) FEBS Lett. , vol.153 , Issue.2 , pp. 335-338
    • Giger, U.1    Meyer, U.A.2
  • 72
    • 0141925798 scopus 로고    scopus 로고
    • Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene
    • Fraser DJ, Zumsteg A, Meyer UA. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J Biol Chem 2003;278(41):39392-401
    • (2003) J. Biol. Chem. , vol.278 , Issue.41 , pp. 39392-39401
    • Fraser, D.J.1    Zumsteg, A.2    Meyer, U.A.3
  • 73
    • 0024725051 scopus 로고
    • Drug-induced protoporphyria in the olfactory mucosa of the hamster
    • Reed CJ, van den Broeke LT, De Matteis F. Drug-induced protoporphyria in the olfactory mucosa of the hamster. J Biochem Toxicol 1989;4(3):161-4
    • (1989) J. Biochem. Toxicol. , vol.4 , Issue.3 , pp. 161-164
    • Reed, C.J.1    Van Den Broeke, L.T.2    De Matteis, F.3
  • 74
    • 0019410148 scopus 로고
    • Brain 5-aminolaevulinate synthase. Developmental aspects and evidence for regulatory role
    • De Matteis F, Zetterlund P, Wetterberg L. Brain 5-aminolaevulinate synthase. Developmental aspects and evidence for regulatory role. Biochem J 1981;196(3):811-7
    • (1981) Biochem. J. , vol.196 , Issue.3 , pp. 811-817
    • De Matteis, F.1    Zetterlund, P.2    Wetterberg, L.3
  • 75
    • 0029830910 scopus 로고    scopus 로고
    • The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons
    • Ingi T, Chiang G, Ronnett GV. The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons. J Neurosci 1996;16(18):5621-8
    • (1996) J. Neurosci. , vol.16 , Issue.18 , pp. 5621-5628
    • Ingi, T.1    Chiang, G.2    Ronnett, G.V.3
  • 76
    • 0034533523 scopus 로고    scopus 로고
    • Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital
    • Jover R, Hoffmann F, Scheffler-Koch V, Lindberg RL. Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital. Eur J Biochem 2000;267(24):7128-37
    • (2000) Eur. J. Biochem. , vol.267 , Issue.24 , pp. 7128-7137
    • Jover, R.1    Hoffmann, F.2    Scheffler-Koch, V.3    Lindberg, R.L.4
  • 77
    • 0035072428 scopus 로고    scopus 로고
    • Heme oxygenase isoformspecific expression and distribution in the rat kidney
    • da Silva JL, Zand BA, Yang LM, et al. Heme oxygenase isoformspecific expression and distribution in the rat kidney. Kidney Int 2001;59(4):1448-57
    • (2001) Kidney Int. , vol.59 , Issue.4 , pp. 1448-1457
    • Da Silva, J.L.1    Zand, B.A.2    Yang, L.M.3
  • 78
    • 0021229577 scopus 로고
    • Biosynthesis of rat liver cytochrome P-450 in mitochondria-associated rough endoplasmic reticulum and in rough microsomes in vivo
    • Meier PJ, Gasser R, Hauri HP, et al. Biosynthesis of rat liver cytochrome P-450 in mitochondria-associated rough endoplasmic reticulum and in rough microsomes in vivo. J Biol Chem 1984;259(16):10194-200
    • (1984) J. Biol. Chem. , vol.259 , Issue.16 , pp. 10194-10200
    • Meier, P.J.1    Gasser, R.2    Hauri, H.P.3
  • 79
    • 0029873802 scopus 로고    scopus 로고
    • Cytochrome P450 and its interactions with the heme biosynthetic pathway
    • De Matteis F, Marks GS. Cytochrome P450 and its interactions with the heme biosynthetic pathway. Can J Physiol Pharmacol 1996;74(1):1-8
    • (1996) Can J. Physiol. Pharmacol. , vol.74 , Issue.1 , pp. 1-8
    • De Matteis, F.1    Marks, G.S.2
  • 80
    • 39749106099 scopus 로고    scopus 로고
    • Influence of protein-protein interactions on the cellular localization of cytochrome P450
    • Szczesna-Skorupa E, Kemper B. Influence of protein-protein interactions on the cellular localization of cytochrome P450. Expert Opin Drug Metab Toxicol 2008;4(2):123-36
    • (2008) Expert Opin. Drug. Metab. Toxicol. , vol.4 , Issue.2 , pp. 123-136
    • Szczesna-Skorupa, E.1    Kemper, B.2
  • 81
    • 53049108739 scopus 로고    scopus 로고
    • Proteasome inhibition compromises direct retention of cytochrome P450 2C2 in the endoplasmic reticulum
    • Szczesna-Skorupa E, Kemper B. Proteasome inhibition compromises direct retention of cytochrome P450 2C2 in the endoplasmic reticulum. Exp Cell Res 2008;314(17):3221-31
    • (2008) Exp. Cell. Res. , vol.314 , Issue.17 , pp. 3221-3231
    • Szczesna-Skorupa, E.1    Kemper, B.2
  • 82
    • 73849151743 scopus 로고    scopus 로고
    • 7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver
    • Hagemeyer CE, Burck C, Schwab R, et al. 7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver. Anal Biochem 2010;398(1):104-11
    • (2010) Anal. Biochem. , vol.398 , Issue.1 , pp. 104-111
    • Hagemeyer, C.E.1    Burck, C.2    Schwab, R.3
  • 83
    • 34447321555 scopus 로고    scopus 로고
    • An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites
    • Kommaddi RP, Turman CM, Moorthy B, et al. An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites. J Neurochem 2007;102(3):867-77
    • (2007) J. Neurochem. , vol.102 , Issue.3 , pp. 867-877
    • Kommaddi, R.P.1    Turman, C.M.2    Moorthy, B.3
  • 84
    • 33750343237 scopus 로고    scopus 로고
    • Unique cytochromes P450 in human brain: Implication in disease pathogenesis
    • Ravindranath V, Kommaddi RP, Pai HV. Unique cytochromes P450 in human brain: implication in disease pathogenesis. J Neural Transm Suppl 2006;70:167-71
    • (2006) J. Neural Transm. Suppl. , vol.70 , pp. 167-171
    • Ravindranath, V.1    Kommaddi, R.P.2    Pai, H.V.3
  • 85
    • 3042641834 scopus 로고    scopus 로고
    • A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine
    • Pai HV, Kommaddi RP, Chinta SJ, et al. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. J Biol Chem 2004;279(26):27383-9
    • (2004) J. Biol. Chem. , vol.279 , Issue.26 , pp. 27383-27389
    • Pai, H.V.1    Kommaddi, R.P.2    Chinta, S.J.3
  • 86
    • 64549154408 scopus 로고    scopus 로고
    • Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake
    • Yue J, Khokhar J, Miksys S, Tyndale RF. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. Eur J Pharmacol 2009;609(1-3):88-95
    • (2009) Eur. J. Pharmacol. , vol.609 , Issue.1-3 , pp. 88-95
    • Yue, J.1    Khokhar, J.2    Miksys, S.3    Tyndale, R.F.4
  • 87
    • 24944592412 scopus 로고    scopus 로고
    • Human CYP2D6 and mouse CYP2Ds: Organ distribution in a humanized mouse model
    • Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF. Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model. Drug Metab Dispos 2005;33(10):1495-502
    • (2005) Drug. Metab. Dispos , vol.33 , Issue.10 , pp. 1495-1502
    • Miksys, S.L.1    Cheung, C.2    Gonzalez, F.J.3    Tyndale, R.F.4
  • 88
    • 33645211926 scopus 로고    scopus 로고
    • Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
    • Joshi M, Tyndale RF. Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine. Neuropharmacology 2006;50(5):568-75
    • (2006) Neuropharmacology , vol.50 , Issue.5 , pp. 568-575
    • Joshi, M.1    Tyndale, R.F.2
  • 89
    • 0038119910 scopus 로고    scopus 로고
    • Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
    • Miksys S, Lerman C, Shields PG, et al. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology 2003;45(1):122-32
    • (2003) Neuropharmacology , vol.45 , Issue.1 , pp. 122-132
    • Miksys, S.1    Lerman, C.2    Shields, P.G.3
  • 90
    • 1942421701 scopus 로고    scopus 로고
    • Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
    • Ingelman-Sundberg M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 2004;25(4):193-200
    • (2004) Trends Pharmacol. Sci. , vol.25 , Issue.4 , pp. 193-200
    • Ingelman-Sundberg, M.1
  • 91
    • 0029118238 scopus 로고
    • Cytochrome P450 in the brain: Neuroendocrine functions
    • Warner M, Gustafsson JA. Cytochrome P450 in the brain: neuroendocrine functions. Frontiers Neuroendocrinol 1995;16:224-36
    • (1995) Frontiers Neuroendocrinol , vol.16 , pp. 224-236
    • Warner, M.1    Gustafsson, J.A.2
  • 93
    • 34547652315 scopus 로고    scopus 로고
    • The regulation of liver cytochrome p450 by the brain dopaminergic system
    • Wojcikowski J, Golembiowska K, Daniel WA. The regulation of liver cytochrome p450 by the brain dopaminergic system. Curr Drug Metab 2007;8(6):631-8
    • (2007) Curr. Drug. Metab. , vol.8 , Issue.6 , pp. 631-638
    • Wojcikowski, J.1    Golembiowska, K.2    Daniel, W.A.3
  • 94
    • 67649379376 scopus 로고    scopus 로고
    • The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat
    • Wojcikowski J, Daniel WA. The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat. Expert Opin Drug Metab Toxicol 2009;5(6):631-45
    • (2009) Expert Opin. Drug. Metab. Toxicol. , vol.5 , Issue.6 , pp. 631-645
    • Wojcikowski, J.1    Daniel, W.A.2
  • 95
    • 4344568973 scopus 로고    scopus 로고
    • Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: Modulation by endogenous compounds
    • Gervasini G, Carrillo JA, Benitez J. Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds. Clin Pharmacokinet 2004;43(11):693-706
    • (2004) Clin. Pharmacokinet , vol.43 , Issue.11 , pp. 693-706
    • Gervasini, G.1    Carrillo, J.A.2    Benitez, J.3
  • 96
    • 33644804671 scopus 로고    scopus 로고
    • Treatment with anti-epileptic drugs
    • Berkovic SF. Treatment with anti-epileptic drugs. Aust Fam Physician 2005;34(12):1017-20
    • (2005) Aust Fam. Physician , vol.34 , Issue.12 , pp. 1017-1020
    • Berkovic, S.F.1
  • 97
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004;5(7):553-64
    • (2004) Nat. Rev. Neurosci. , vol.5 , Issue.7 , pp. 553-564
    • Rogawski, M.A.1    Loscher, W.2
  • 98
    • 0026644032 scopus 로고
    • Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice
    • Voigt JP, Morgenstern E. Comparative effects of carbamazepine, phenytoin, diazepam and clonazepam on inhibitory avoidance learning in mice. Psychopharmacology 1992;108(1-2):131-5
    • (1992) Psychopharmacology , vol.108 , Issue.1-2 , pp. 131-135
    • Voigt, J.P.1    Morgenstern, E.2
  • 99
    • 34547094821 scopus 로고    scopus 로고
    • Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway
    • •• Mechanistic aspects of the drug hormone crosstalk
    • Gehlhaus M, Schmitt N, Volk B, Meyer RP. Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway. J Pharm Exp Ther 2007;322(2):550-9 •• Mechanistic aspects of the drug hormone crosstalk.
    • (2007) J. Pharm. Exp. Ther. , vol.322 , Issue.2 , pp. 550-559
    • Gehlhaus, M.1    Schmitt, N.2    Volk, B.3    Meyer, R.P.4
  • 100
    • 53049108463 scopus 로고    scopus 로고
    • Hormonal influences on seizures: Basic neurobiology
    • Frye CA. Hormonal influences on seizures: basic neurobiology. Int Rev Neurobiol 2008;83:27-77
    • (2008) Int. Rev. Neurobiol. , vol.83 , pp. 27-77
    • Frye, C.A.1
  • 101
    • 0025017646 scopus 로고
    • Autologous down-regulation of androgen receptor messenger ribonucleic acid
    • Quarmby VE, Yarbrough WG, Lubahn DB, et al. Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol Endocrinol 1990;4(1):22-8
    • (1990) Mol. Endocrinol. , vol.4 , Issue.1 , pp. 22-28
    • Quarmby, V.E.1    Yarbrough, W.G.2    Lubahn, D.B.3
  • 102
    • 0025982059 scopus 로고
    • Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells
    • Krongrad A, Wilson CM, Wilson JD, et al. Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Mol Cell Endocrinol 1991;76(1-3):79-88
    • (1991) Mol. Cell. Endocrinol. , vol.76 , Issue.1-3 , pp. 79-88
    • Krongrad, A.1    Wilson, C.M.2    Wilson, J.D.3
  • 103
    • 3042606867 scopus 로고    scopus 로고
    • Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain
    • Kumar RC, Thakur MK. Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain. Neurobiol Aging 2004;25(7):925-33
    • (2004) Neurobiol. Aging , vol.25 , Issue.7 , pp. 925-933
    • Kumar, R.C.1    Thakur, M.K.2
  • 104
    • 33744905825 scopus 로고    scopus 로고
    • Functional neuroimaging of emotional learning and autonomic reactions
    • Peper M, Herpers M, Spreer J, et al. Functional neuroimaging of emotional learning and autonomic reactions. J Physiol Paris 2006;99(4-6):342-54
    • (2006) J. Physiol. Paris , vol.99 , Issue.4-6 , pp. 342-354
    • Peper, M.1    Herpers, M.2    Spreer, J.3
  • 105
    • 33748950454 scopus 로고    scopus 로고
    • In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    • Bauer B, Yang X, Hartz AM, et al. In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol Pharmacol 2006;70(4):1212-9
    • (2006) Mol. Pharmacol. , vol.70 , Issue.4 , pp. 1212-1219
    • Bauer, B.1    Yang, X.2    Hartz, A.M.3
  • 106
    • 7044237266 scopus 로고    scopus 로고
    • CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11
    • Anakk S, Kalsotra A, Kikuta Y, et al. CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. Pharmacogenomics J 2004;4(2):91-101
    • (2004) Pharmacogenomics J. , vol.4 , Issue.2 , pp. 91-101
    • Anakk, S.1    Kalsotra, A.2    Kikuta, Y.3
  • 107
    • 0242522148 scopus 로고    scopus 로고
    • Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum
    • Iba MM, Storch A, Ghosal A, et al. Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum. ArchToxicol 2003;77(10):547-54
    • (2003) ArchToxicol , vol.77 , Issue.10 , pp. 547-554
    • Iba, M.M.1    Storch, A.2    Ghosal, A.3
  • 108
    • 34250754487 scopus 로고    scopus 로고
    • Cytochrome P450 1B1 expression in glial cell tumors: An immunotherapeutic target
    • Barnett JA, Urbauer DL, Murray GI, et al. Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target. Clin Cancer Res 2007;13(12):3559-67
    • (2007) Clin. Cancer Res. , vol.13 , Issue.12 , pp. 3559-3567
    • Barnett, J.A.1    Urbauer, D.L.2    Murray, G.I.3
  • 109
    • 0033988383 scopus 로고    scopus 로고
    • Human brain cytochrome P450 1B1: Immunohistochemical localization in human temporal lobe and induction by dimethylbenz (a) anthracene in astrocytoma cell line (MOG-G-CCM)
    • Rieder CR, Parsons RB, Fitch NJ, et al. Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz (a) anthracene in astrocytoma cell line (MOG-G-CCM). Neurosci Lett 2000;278(3):177-80
    • (2000) Neurosci. Lett. , vol.278 , Issue.3 , pp. 177-180
    • Rieder, C.R.1    Parsons, R.B.2    Fitch, N.J.3
  • 110
    • 0033947897 scopus 로고    scopus 로고
    • Regional and cellular distribution of CYP2D subfamily members in rat brain
    • Miksys S, Rao Y, Sellers EM, et al. Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica 2000;30(6):547-64
    • (2000) Xenobiotica , vol.30 , Issue.6 , pp. 547-564
    • Miksys, S.1    Rao, Y.2    Sellers, E.M.3
  • 111
    • 0029583277 scopus 로고
    • Localization and characterization of cytochrome P450 in the brain. In vivo and in vitro investigations on phenytoin- and phenobarbital-inducible isoforms
    • Volk B, Meyer RP, von Lintig F, et al. Localization and characterization of cytochrome P450 in the brain. In vivo and in vitro investigations on phenytoin- and phenobarbital-inducible isoforms. Toxicol Lett 1995;83:655-62
    • (1995) Toxicol. Lett. , vol.83 , pp. 655-662
    • Volk, B.1    Meyer, R.P.2    Von Lintig, F.3
  • 112
    • 0030835966 scopus 로고    scopus 로고
    • Possible role of cytochrome P450 in inactivation of testosterone in immortalized hippocampal neurons
    • Thuerl C, Otten U, Knoth R, et al. Possible role of cytochrome P450 in inactivation of testosterone in immortalized hippocampal neurons. Brain Res 1997;762(1-2):47-55
    • (1997) Brain Res. , vol.762 , Issue.1-2 , pp. 47-55
    • Thuerl, C.1    Otten, U.2    Knoth, R.3
  • 113
    • 0035130457 scopus 로고    scopus 로고
    • Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: In vitro studies on murine astrocyte primary cultures
    • Meyer RP, Knoth R, Schiltz E, Volk B. Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary cultures. Exp Neurol 2001;167(2):376-84
    • (2001) Exp. Neurol. , vol.167 , Issue.2 , pp. 376-384
    • Meyer, R.P.1    Knoth, R.2    Schiltz, E.3    Volk, B.4
  • 114
    • 0032809128 scopus 로고    scopus 로고
    • Characterization of cytochrome P-450 2D1 activity in rat brain: High-affinity kinetics for dextromethorphan
    • Tyndale RF, Li Y, Li NY, et al. Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Drug Metab Dispos 1999;27(8):924-30
    • (1999) Drug. Metab. Dispos , vol.27 , Issue.8 , pp. 924-930
    • Tyndale, R.F.1    Li, Y.2    Li, N.Y.3
  • 115
    • 0029788829 scopus 로고    scopus 로고
    • Cytochrome P4502D4 in the brain: Specific neuronal regulation by clozapine and toluene
    • Hedlund E, Wyss A, Kainu T, et al. Cytochrome P4502D4 in the brain: specific neuronal regulation by clozapine and toluene. Mol Pharm 1996;50:342-50
    • (1996) Mol. Pharm. , vol.50 , pp. 342-350
    • Hedlund, E.1    Wyss, A.2    Kainu, T.3
  • 116
    • 0035049437 scopus 로고    scopus 로고
    • Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
    • Siegle I, Fritz P, Eckhardt K, et al. Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 2001;11(3):237-45
    • (2001) Pharmacogenetics , vol.11 , Issue.3 , pp. 237-245
    • Siegle, I.1    Fritz, P.2    Eckhardt, K.3
  • 117
    • 0028118901 scopus 로고
    • Effect of ethanol on cytochrome P450 in the rat brain
    • Warner M, Gustafsson JA. Effect of ethanol on cytochrome P450 in the rat brain. Proc Natl Acad Sci USA 1994;91(3):1019-23
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.3 , pp. 1019-1023
    • Warner, M.1    Gustafsson, J.A.2
  • 118
    • 0024602373 scopus 로고
    • Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception
    • Nef P, Heldman J, Lazard D, et al. Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. J Biol Chem 1989;264:6780-5
    • (1989) J. Biol. Chem. , vol.264 , pp. 6780-6785
    • Nef, P.1    Heldman, J.2    Lazard, D.3
  • 119
    • 0034645927 scopus 로고    scopus 로고
    • Cytochrome P-450 activities in human and rat brain microsomes
    • Voirol P, Jonzier-Perey M, Porchet F, et al. Cytochrome P-450 activities in human and rat brain microsomes. Brain Res 2000;855(2):235-43
    • (2000) Brain Res. , vol.855 , Issue.2 , pp. 235-243
    • Voirol, P.1    Jonzier-Perey, M.2    Porchet, F.3
  • 120
    • 0031571662 scopus 로고    scopus 로고
    • Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli
    • Wang H, Strobel HW. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Arch Biochem Biophys 1997;344(2):365-72
    • (1997) Arch. Biochem. Biophys. , vol.344 , Issue.2 , pp. 365-372
    • Wang, H.1    Strobel, H.W.2
  • 122
    • 0028142645 scopus 로고
    • Cytochrome P450s of the 4A subfamily in the brain
    • Stromstedt M, Warner M, Gustafsson JA. Cytochrome P450s of the 4A subfamily in the brain. J Neurochem 1994;63(2):671-6
    • (1994) J. Neurochem. , vol.63 , Issue.2 , pp. 671-676
    • Stromstedt, M.1    Warner, M.2    Gustafsson, J.A.3
  • 123
    • 0029610431 scopus 로고
    • C3DNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily
    • Kawashima H, Strobel HW. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Biochem Biophys Res Commun 1995;217(3):1137-44
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , Issue.3 , pp. 1137-1144
    • Kawashima, H.1    Strobel, H.W.2
  • 124
    • 50549083650 scopus 로고    scopus 로고
    • Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide
    • Stark K, Dostalek M, Guengerich FP. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J 2008;275(14):3706-17
    • (2008) FEBS J. , vol.275 , Issue.14 , pp. 3706-3717
    • Stark, K.1    Dostalek, M.2    Guengerich, F.P.3
  • 125
    • 0036384287 scopus 로고    scopus 로고
    • Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain
    • Bylund J, Zhang C, Harder DR. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem Biophys Res Commun 2002;296(3):677-84
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , Issue.3 , pp. 677-684
    • Bylund, J.1    Zhang, C.2    Harder, D.R.3
  • 126
    • 33644941615 scopus 로고    scopus 로고
    • Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain
    • Al Anizy M, Horley NJ, Kuo CW, et al. Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. FEBS J 2006;273(5):936-47
    • (2006) FEBS J. , vol.273 , Issue.5 , pp. 936-947
    • Anizy, M.A.1    Horley, N.J.2    Kuo, C.W.3
  • 127
    • 0042668350 scopus 로고    scopus 로고
    • 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro
    • Pringle AK, Schmidt W, Deans JK, et al. 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro. Eur J Neurosci 2003;18(1):117-24
    • (2003) Eur. J. Neurosci. , vol.18 , Issue.1 , pp. 117-124
    • Pringle, A.K.1    Schmidt, W.2    Deans, J.K.3
  • 128
    • 0141533183 scopus 로고    scopus 로고
    • Dehydroepiandrosterone 7-hydroxylase CYP7B: Predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    • Yau JL, Rasmuson S, Andrew R, et al. Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. Neuroscience 2003;121(2):307-14
    • (2003) Neuroscience , vol.121 , Issue.2 , pp. 307-314
    • Yau, J.L.1    Rasmuson, S.2    Andrew, R.3
  • 129
    • 12644253822 scopus 로고    scopus 로고
    • Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone
    • Rose KA, Stapleton G, Dott K, et al. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci USA 1997;94(10):4925-30
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.10 , pp. 4925-4930
    • Rose, K.A.1    Stapleton, G.2    Dott, K.3
  • 130
    • 16444374659 scopus 로고    scopus 로고
    • Sexual hormones and epilepsy: Threat and opportunities
    • Herzog AG, Fowler KM. Sexual hormones and epilepsy: threat and opportunities. Curr Opin Neurol 2005;18(2):167-72
    • (2005) Curr. Opin. Neurol. , vol.18 , Issue.2 , pp. 167-172
    • Herzog, A.G.1    Fowler, K.M.2


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