Anti-epileptic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus

Journal of Neurochemistry

Volumn 96, Issue 2, 2006, Pages 460-472

  Meyer, Ralf Peter ^a,c   Hagemeyer, Christoph Eugen ^a   Knoth, Rolf ^a   Kaufmann, Michel Rene ^b   Volk, Benedikt ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Androgen receptor; Anti epileptic drugs; Cytochrome P450; Endocrine system; Hippocampus; Phenytoin

Indexed keywords

2BETA HYDROXYTESTOSTERONE; 6BETA HYDROXYTESTOSTERONE; ANDROGEN RECEPTOR; ANTICONVULSIVE AGENT; AROMATASE; CYTOCHROME; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; ESTRADIOL; PHENYTOIN; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; ANDROGEN; CYP2C29 PROTEIN, MOUSE; CYP3A11 PROTEIN, MOUSE; CYP3A13 PROTEIN, MOUSE; CYTOCHROME P450; MEMBRANE PROTEIN; MESSENGER RNA; OXYGENASE;

ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; EPILEPSY; ESTROGEN BLOOD LEVEL; GENE EXPRESSION; HIPPOCAMPUS; HORMONE METABOLISM; MALE; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BLOOD; C57BL MOUSE; CELL NUCLEUS; GENETICS; HYDROXYLATION; METABOLISM; PYRAMIDAL NERVE CELL; TISSUE DISTRIBUTION;

ANIMALIA; MURINAE;

ANDROGENS; ANIMALS; ANTICONVULSANTS; AROMATASE; CELL NUCLEUS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ESTRADIOL; HIPPOCAMPUS; HYDROXYLATION; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; OXYGENASES; PHENYTOIN; PYRAMIDAL CELLS; RECEPTORS, ANDROGEN; RNA, MESSENGER; TESTOSTERONE; TISSUE DISTRIBUTION;

EID: 33644874555     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03555.x     Document Type: Article

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