The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat

Expert Opinion on Drug Metabolism and Toxicology

Volumn 5, Issue 6, 2009, Pages 631-645

  Wójcikowski, Jacek ^a   Daniel, Władysława Anna ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Brain dopaminergic system; Cytokines; Dopaminemimetics; Liver cytochrome P450; Mesolimbic pathway; Neuroleptics; Pituitary hormones; Regulation; Tuberoinfundibular pathway

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2C11; CYTOCHROME P450 3A; CYTOKINE; DOPAMINE 2 RECEPTOR; GROWTH HORMONE; HYPOPHYSIS HORMONE; LIOTHYRONINE; PROTIRELIN; THYROTROPIN;

CYP GENE; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; ENZYME REGULATION; GENE; HORMONE RELEASE; LIMBIC CORTEX; MESOLIMBIC DOPAMINERGIC SYSTEM; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN EXPRESSION; RAT; REVIEW; THALAMUS MIDLINE NUCLEUS; TUBEROHYPOPHYSEAL TRACT;

ANIMALS; BRAIN; CYTOCHROME P-450 ENZYME SYSTEM; CYTOKINES; DOPAMINE; GONADAL STEROID HORMONES; GROWTH HORMONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; ISOENZYMES; LIVER; NEUROIMMUNOMODULATION; PITUITARY HORMONES; PITUITARY-ADRENAL SYSTEM; RATS; RECEPTORS, DOPAMINE D2; THYROID HORMONES;

RATTUS;

EID: 67649379376     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425250902973703     Document Type: Review

References (118)

1. Honkakoski P, Negishi M. Regulation of cytochrome P450 genes by nuclear receptors. Biochem J 2000;347:321-337 (Pubitemid 30229378)
2. Hines RN, Luo T, Cresteil T, et al. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metab Dispos 2001;29:623-633 (Pubitemid 32374561)
3. Wójcikowski J. Potential role of the brain dopaminergic system in the regulation of cytochrome P450 expression. Pol J Pharmacol 2004;56:701-708 (Pubitemid 40287471)
4. Kretschmer XC, Baldwin WS. CAR and PXR: xenosensors of endocrine disrupters? Chem Biol Interact 2005;155:11-128
5. Pascussi JM, Gerbal-Chaloin S, Duret C, et al. The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences. Annu Rev Pharmacol Toxicol 2008;48:1-32 •• Review on nuclear receptor cross-talk that controls xenobiotic/drug disposition and toxicity. (Pubitemid 351738147)
6. Palkovits M, Leranth C, Zaborszky L, Brownstein MJ. Electron microscopic evidence of direct neuronal connection from the lower brain stem to the median eminence. Brain Res 1977;136:339-344 (Pubitemid 8205708)
7. Simon H, Le Moal M, Calas A. Efferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H] leucine and horseradish peroxidase. Brain Res 1979;178:17-40 (Pubitemid 10241289)
8. Oades RD, Halliday GM. Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity. Brain Res Rev 1987;12:117-165
9. Conrad LCA, Pfaff DW. Autoradiographic tracing of nucleus accumbens efferents in the rat. Brain Res 1976;133:589-596 •• Evidence for neuronal connections from the nucleus accumbens to the paraventricular nucleus of the hypothalamus.
10. Powell EW, Leman RB. Connections of the nucleus accumbens. Brain Res 1976;105:389-403 •• Evidence for neuronal connections from the nucleus accumbens to the medial hypothalamus.
11. Williams DJ, Crossman AR, Slater P. The efferent projections of the nucleus accumbens in the rat. Brain Res 1977;130:217-227 (Pubitemid 8139720)
12. Hokfelt T, Fuxe K, Johansson O, et al. Distribution of thyrotropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistry. Eur J Pharmacol 1975;134:389-392 •• Evidence for liberation of TSH from cells in the paraventricular nucleus of the hypothalamus.
13. Sawchenko PE. Evidence for differential regulation of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory and autonomic-related projections of the paraventricular nucleus. Brain Res 1987;437:253-263 •• Evidence for liberation of CRH from cells in the paraventricular nucleus of the hypothalamus. (Pubitemid 18016213)
14. Sonderfan AJ, Arlotto MP, Dutton DR, et al. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch Biochem Biophys 1987;255:27-41
15. Waxman DJ. Interactions of hepatic cytochromes P450 with steroid hormones. Biochem Pharmacol 1988;37:71-84
16. Wolterboer HM, De Kruif CA, van Iersel AAJ, et al. Comparison of cytochrome P-450 isoenzyme profiles in rat liver and hepatocyte cultures. Biochem Pharmacol 1991;42:381-390
17. Chinta SJ, Andersen JK. Dopaminergic neurons. Int J Biochem Cell Biol 2005;37:942-946 •• Description of the main dopaminergic pathways in the brain. (Pubitemid 40311737)
18. Goudreau JL, Falls WM, Lookingland KJ, Moore KE. Periventricular- hypophysial dopaminergic neurons innervate the intermediate but not the neural lobe of the rat pituitary gland. Neuroendocrinology 1995;62:147-154
19. Seeman P, van Tol HHM. Dopamine receptor pharmacology. Trends Pharmacol Sci 1994;15:264-267 • Classification of dopaminergic receptors. (Pubitemid 24210734)
20. Boyson SJ, McGonigle P, Molinoff PB. Quantitative autoradiographic localization of D1 and D2 subtypes of dopamine receptors in rat brain. J Neurosci 1986;6:3177-3188 • Distribution of dopaminergic receptors in rat brain. (Pubitemid 17186043)
21. Meador-Woodruff JH, Mansour A, Healy DJ, et al. Comparison of the distributions of D1 and D2 dopamine receptors mRNAs in rat brain. Neuropsychopharmacology 1991;5:231-242
22. De Souza EB. Serotonin and dopamine receptors in the rat pituitary gland: autoradiographic identification, characterization, and localization. Endocrinology 1986;119:1534-1542 •• Direct evidence for localization of dopaminergic D2 receptors in the anterior lobe of pituitary. (Pubitemid 17170517)
23. Wamsley JK, Gehlert DR, Filloux FM, Dawson TM. Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain. J Chem Neuroanat 1989;2:119-137 (Pubitemid 19157683)
24. Levant B, Grigoriadis DE, De Souza EB. [3H]quinpirole binding to putative D2 and D3 dopamine receptors in rat brain and pituitary gland: a quantitative autoradiographic study. J Pharmacol Exp Ther 1993;264:991-1001 • Evidence for the distribution of dopaminergic receptors in rat brain and the pituitary.
25. Fuller RW, Snoddy HD. Elevation of serum corticosterone concentrations in rats by pergolide and other dopamine agonists. Endocrinology 1981;109:1026-1032 • Evidence for positive regulation of corticosterone level by dopamine agonists in rats. (Pubitemid 11008277)
26. Je ova D, Jurcovicova J, Vigas M, et al. Increase in plasma ACTH after dopaminergic stimulation in rats. Psychopharmacology 1985;85:201-203 • Evidence for positive regulation of ACTH level by dopamine agonists in rats.
27. Fuller RW, Snoddy HD, Mason NR, et al. Elevation of serum corticosterone in rats by dopamine agonists related in structure to pergolide. Neuroendocrinology 1983;36:285-290
28. Je ova D, Vigas M. Apomorphine injection stimulates b-endorphin, adrenocorticotropin, and cortisol release in healthy man. Psychoneuroendocrinology 1988;13:479-485
29. Prough RA, Linder MW, Pinairen JA, et al. Hormonal regulation of hepatic enzymes involved in foreign compound metabolism. FASEB 1996;10:1369-1377 (Pubitemid 26347871)
30. Quatrochi LC, Guzelian PS. CYP3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos 2001;29:615-622 (Pubitemid 32374560)
31. Lal S, De La Vega C, Sourkes TL, Friesen HG. Effect of apomorphine on growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone levels in human serum. J Clin Edocrinol Metab 1973;37:719-724 • Evidence for positive regulation of GH level by dopamine agonists in humans.
32. Nair NP, Lal S, Iskandar HI, et al. Effect of sulpiride, an atypical neuroleptic, on apomorphine-induced growth hormone secretion. Brain Res Bull 1982;8:587-591 (Pubitemid 13240599)
33. Sherman GP, Kim S, Benjamin F, Kolodny KD. Effect of chlorpromazine on serum growth hormone concentration in man. N Engl J Med 1971;284:72 • Evidence for negative regulation of GH level by dopamine-receptor blocking neuroleptic chlorpromazine in humans.
34. Hanev K, Sasaki A, Yoshinaga K. Evidence for endogenous dopaminergic control of GH release in man. Tohoku J Exp Med 1981;135:103-108 (Pubitemid 12234435)
35. Müller EE, Pecile A, Felici M, Cocchi D. Norepinephrine and dopamine injection into lateral brain ventricle of the rat and growth hormone-releasing activity in the hypothalamus and plasma. Endocrinology 1970;86:1376-1382 •• Showing positive regulation of GH level by a local injection of dopamine into rat brain.
36. Mueller GP, Simpkins J, Meites J, Moore KE. Differential effects of dopamine agonists and haloperidol on the release of prolactin, thyroid stimulating hormone, growth hormone, and luteinizing hormone in rats. Neuroendocrinology 1976;20:121-135 • Evidence for different effects of dopaminemimetics on GH and TSH levels in rats.
37. Vijayan E, Krulich L, McCann SM. Catecholamic regulation of TSH and growth hormone release in ovariectomized and steroid-primed rats. Neuroendocrinology 1978;26:174-185 • Evidence for negative regulation of TSH and positive regulation of GH levels by dopamine in rats. (Pubitemid 8364062)
38. Onaya T, Hashizume K. Effects of drugs that modify brain biogenic amine concentrations on thyroid activation induced by exposure to cold. Neuroendocrinology 1976;20:47-52
39. Männistö PT, Mattila J, Kaakkola S. Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat. Eur J Pharmacol 1981;76:403-409 (Pubitemid 12253537)
40. Morley JE, Brammer GL, Sharp B, et al. Neurotransmitter control of hypothalamic-pituitary-thyroid function in rats. Eur J Pharmacol 1981;70:263-271 • Evidence for negative regulation of TSH level by dopamine in rats. (Pubitemid 11149318)
41. Schuetz EG, Wrighton SA, Barwick JL, Guzelian PS. Induction of cytochrome P450 by glucocorticoids in rat liver. J Biol Chem 1984;259:1999-2006
42. Monostory K, Kohalmy K, Prough RA, et al. The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes. FEBS Lett 2005;579:229-235 (Pubitemid 40023401)
43. Vrzal R, Stejskalova L, Monostory K, et al. Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact 2009;179:288-296
44. Bergeron RM, Serron SC, Rinehart JJ, et al. Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11. Xenobiotica 1988;28:303-312
45. Gibson GG, Plant NJ, Swales K, et al. Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 2002;32:165-206 • Review on the regulation of CYP3A. (Pubitemid 34267348)
46. Dvorak Z, Modriansky M, Pichard-Garcia L, et al. Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9 and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol Pharmacol 2003;64:160-169 (Pubitemid 36759828)
47. Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003;1619:243-253
48. Burk O, Wojnowski L. Cytochrome P450 3A and their regulation. Naunyn Schmieebergs Arch Pharmacol 2004;369:105-124 • Review on the regulation of CYP3A. (Pubitemid 38161227)
49. Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. Cross-talk between xenobiotic detoxication and other signaling pathways: clinical and toxicological consequences. Xenobiotica 2004;34:633-664 (Pubitemid 39486045)
50. Pascussi JM, Drocourt L, Fabre JM, et al. Dexamethasone induces pregnane X receptor and retinoid X receptor-a expression in human hepatocytes: synergistic increaseof CYP3A4 induction by pregnane X receptor. Mol Pharmacol 2000;58:361-372 (Pubitemid 30497480)
51. Pascussi JM, Gerbal-Chaloin S, Fabre JM, et al. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 2000;58:1441-1450
52. Hukkanen J, Lassila A, Paivarinta K, et al. Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 2000;22:360-366 (Pubitemid 30343363)
53. Hukkanen J, Vaisanen T, Lassila A, et al. Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther 2003;304:745-752 (Pubitemid 36152353)
54. Pereira TM, Carlstedt-Duke J, Lechner MC, Gustafsson JA. Identification of a functional glucocorticoid response element in the CYP3A1/igc2 gene. DNA Cell Biol 1998;17:39-49 (Pubitemid 28084082)
55. Telhada MB, Pereira TM, Lechner MC. Effect of dexamethasone and Phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development. Arch Biochem Biophys 1992;298:715-725
56. Zaphiropoulos PG, Mode A, Norstedt G, Gustafsson JA. Regulation of sexual differentiation in drug and steroid metabolism. TIPS 1989;10:149-153 (Pubitemid 19106306)
57. Waxman DJ, Ram PA, Pampori NA, Shapiro BH. Growth hormone regulation of male-specific rat liver P450 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol Pharmacol 1995;48:790-797 • Showing positive regulation of the adult male-specific isoenzymes CYP2A2 and CYP3A2 by intermittent GH pulsation.
58. Waxman DJ, O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 2006;20:2613-2629 •• Detailed review on GH regulation of sex-dependent liver CYP isoforms in different species. (Pubitemid 44833525)
59. Legraverend C, Mode A, Westin S, et al. Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion. Mol Endocrinol 1992;6:259-266
60. Sundseth SS, Alberta JA, Waxman DJ. Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J Biol Chem 1992;267:3907-3914
61. Pampori NA, Shapiro BH. Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile. Mol Pharmacol 1996;50:1148-1156 (Pubitemid 26384853)
62. Shimada M, Murayama N, Nagata K, et al. A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in rats: reversal of the profiles by growth hormone-treatment. Arch Biochem Biophys 1997;337:34-42 (Pubitemid 27198052)
63. Pampori NA, Agrawal AK, Shapiro BH. Infusion of gender-dependent plasma growth hormone profiles into intact rats: effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms. Drug Metab Dispos 2001;29:8-16 (Pubitemid 32042156)
64. Schuetz EG, Schuetz JD, May B, Guzelian PS. Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem 1990;265:1188-1192 (Pubitemid 20048916)
65. Liddle C, Mode A, Legraverend C, Gustafsson JA. Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes. Arch Biochem Biophys 1992;298:159-166
66. Choi HK, Waxman DJ. Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression. Endocrinology 2000;141:3245-3255 (Pubitemid 32269012)
67. Gonzalez FJ, Lee YH. Constitutive expression of hepatic cytochrome P-450 genes. FASEB 1996;10:1112-1117 (Pubitemid 26276953)
68. Jaffe CA, Turgeon DK, Lown K, et al. Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. Am J Physiol Endocrinol Metab 2002;283:E1008-15 (Pubitemid 35216960)
69. Dhir R, Dworakowski W, Tangavel C, Shapiro BH. Sexual dimorphic regulation of hepatic isoforms of human cytochrome P450by growth hormone. J Pharmacol Exp Ther 2006;316:87-94 (Pubitemid 41832584)
70. Lamba V, Lamba J, Yasuda K, et al. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 2003;307:906-922 (Pubitemid 37494207)
71. Swales K, Kakizaki S, Yamamoto Y, et al. Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells. J Biol Chem 2005;280:3458-3466 (Pubitemid 40223810)
72. Devesa J, Barros MG, Gondar M, et al. Regulation of hypothalamic somatostatin by glucocorticoids. J Steroid Biochem Mol Biol 1995;53:277-282
73. Iber H, Chen Q, Sewer M, Morgan ET. Regulation of hepatic cytochrome P450 2C11 by glucocorticoids. Arch Biochem Biophys 1997;343:305-310 (Pubitemid 27400624)
74. Miller TL, Mayo KE. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression. Endocrinology 1997;138:2458-2465 (Pubitemid 27215250)
75. Ohyama T, Sato M, Ohye H, et al. Effects of adrenalectomy and glucocorticoid receptor antagonist, RU38486, on pituitary growth hormone-releasing hormone receptor gene expression in rats. Peptides 1998;19:1063-1067 (Pubitemid 28383804)
76. Gehlhaus M, Schmitt N, Volk B, Meyer RP. Antiepileptics drugs affect neuronal androgen signaling via a cytochrome P45-dependent pathway. J Pharmacol Exp Ther 2007;322:550-559
77. Meyer RP, Gehlhaus M, Schwab R, et al. Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment. J Neurochem 2009;109:670-681 •• Evidence for neuroactive drugs-steroid hormone cross-talk in mouse brain.
78. Yamazoe Y, Murayama N, Shimada M, Kato R. Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e, and other neonatal P-450s in hypophysectomized rats. Biochem Biophys Res Commun 1989;160:609-614 (Pubitemid 19140583)
79. Waxman DJ, Ram PA, Notani G, et al. Pituitary regulation of the male-specific steroid 6b-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level. Mol Endocrinol 1990;4:447-454
80. Yamazoe Y, Ling X, Murayama N, et al. Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. J Biochem 1990;108:599-603 (Pubitemid 20336673)
81. Liddle C, Goodwin BJ, George J, et al. Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 1998;83:2411-2416 (Pubitemid 28503039)
82. Ram PA, Waxman DJ. Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem 1990;265:19223-19229 (Pubitemid 20378594)
83. Basu S, Dasgupta PS. Dopamine, a neurotransmitter, influences the immune system. J Neuroimmunol 2000;102:113-124
84. Castano A, Herrera AJ, Cano J, Machado A. The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma. J Neurochem 2002;81:150-157 (Pubitemid 34808862)
85. Stypula G, Kunert-Radek J, Stepien H, et al. Evaluation of interleukins, ACTH, cortisol and prolactin concentration in the blood of patients with Parkinson's disease. Neuroimmunomodulation 1996;3:131-134 (Pubitemid 26373868)
86. Ganguli R, Yang ZW, Shurin G, et al. Serum interleukin-6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Res 1994;51:1-10 (Pubitemid 24056866)
87. Maes M, Bosmans E, Calabrese J, et al. Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers. J Psychiatr Res 1995;29:141-152
88. Jankovic BD, Maric D. In vivo modulation of immune system by encephalin. Int J Neurosci 1990;51:167-169
89. Matera L. Endocrine, paracrine and autocrine actions of prolactin on immune cells. Life Sci 1996;59:599-614 (Pubitemid 26274402)
90. Khan ZU, Koulen P, Rubinstein M, et al. An astroglia-linked dopamine D2-receptor action in prefrontal cortex. PNAS 2001;98:1964-1969 (Pubitemid 32165606)
91. Voltera A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 2005;6:626-640 (Pubitemid 41059337)
92. Gutierrez EG, Banks WA, Kastin AJ. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J Neuroimmunol 1993;47:169-176 (Pubitemid 23284281)
93. Moreau A, Vilarem MJ, Maurel P, Pascussi JM. Xenoreceptors CAR and PXR activation and consequence on lipid metabolism, glucose homeostasis, and inflammatory response. Mol Pharm 2008;5:35-41 (Pubitemid 351300032)
94. Warren GW, Poloyac SM, Gary DS, et al. Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/ p75) knockout mice after endotoxin administration. J Pharmacol Exp Ther 1999;288:945-950 (Pubitemid 29254130)
95. Siewert E, Bort R, Kluge R, et al. Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent. Hepatology 2000;32:49-55 (Pubitemid 30432365)
96. Tinel M, Elkahwaji J, Robin MA, et al. Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes. J Pharmacol Exp Ther 1999;289:649-655 (Pubitemid 29191214)
97. Bleu AM, Maurel P, Pichette V, et al. Interleukin-1b, interleukin-6, tumor necrosis factor-a and interferon-g released by viral infection and aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes. Eur J Pharmacol 2003;473:197-206 (Pubitemid 36929885)
98. Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, et al. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 2000;274:707-713 (Pubitemid 30663683)
99. Assenat E, Gerbal-Chaloin S, Larrey D, et al. Interleukin 1b inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 2004;40:951-960 (Pubitemid 39288129)
100. Beigneux AP, Moser AH, Shigenaga JK, et al. The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem 2000;275:16390-16399 (Pubitemid 30366957)
101. Fang C, Yoon S, Tinberg N, et al. Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure. Biochem Pharmacol 2004;67:1389-1397 (Pubitemid 38315104)
102. Wójcikowski J, Gołembiowska K, Daniel WA. The regulation of liver cytochrome P450 by the brain dopaminergic system. Curr Drug Metab 2007;8:631-638 •• First direct evidence for the influence of lesions of brain dopaminergic pathways on the level and activity of liver CYP isoforms. (Pubitemid 47209100)
103. Wójcikowski J, Daniel WA. Identification of factors mediating the effects of the brain dopaminergic system on the expression of cytochrome P450 in the liver. Pharmacol Rep 2008;60:966-971 •• Indicating hormones mediating the effect of the brain dopaminergic system on the liver CYP expression.
104. Wójcikowski J, Gołembiowska K, Daniel WA. Regulation of liver cytochrome P450 by activation of brain dopaminergic system: physiological and pharmacological implications. Biochem Pharmacol 2008;76:258-267 •• First evidence for the contribution of dopaminergic D2 receptors of the pituitary (activated by the tuberoinfundibular pathway) and D2 receptors of the nucleus accumbens (activated by the mesolimbic pathway) to the regulation of liver CYP.
105. Murayama N, Shimada M, Yamazoe Y, Kato R. Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbitalinducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. Mol Pharmacol 1991;39:811-817
106. Vrzal R, Ulrichova J, Dvorak Z. Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions. Biomed Pap 2004;148:3-10
107. Sérée E, Villard P-H, Pascussi J-M, et al. Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology 2004;127:1436-1445 • First evidence for the contribution of PPAR-a to the regulation of human CYP1A1. (Pubitemid 39457770)
108. Hunter J, Kassam A, Winrow CJ, et al. Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes. Mol Cell Endocrinol 1996;116:213-221 (Pubitemid 26052798)
109. Miller RT, Scappino LA, Long SM, Corton JC. Role of thyroid hormones in hepatic effects of peroxisome proliferators. Toxicol Pathol 2001;29:149-155 (Pubitemid 32127334)
110. Baum LO, Strobel HW. Regulation of expression of cytochrome P-450 2D mRNA in rat brain with steroid hormones. Brain Res 1997;765:67-73 (Pubitemid 27374915)
111. Rane A, Liu Z, Levol R, et al. Differential effects of neuroleptic agents on hepatic cytochrome P-450 isoenzymes in the male rat. Biochem Biophys Acta 1996;1291:60-66 •• Suggestion of the involvement of GH in the downregulation of CYP2C11 and CYP3A during treatment of male rats with selective and non-selective dopamine receptor-blocking neuroleptics. (Pubitemid 26284326)
112. Daniel WA. The influence of the long-term treatment with psychotropic drugs on cytochrome P450: the involvement of different mechanisms. Expert Opin Drug Metab Toxicol 2005;1:203-217 •• Review on the direct and indirect mechanisms of CYP-psychotropic drug interactions.
113. Haduch A, Wójcikowski J, Daniel WA. The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment. Pharmacol Rep 2007;59:606-612
114. Murray M. Inhibition and induction of cytochrome P450 2B1 in rat liver by promazine and chlorpromazine. Biochem Pharmacol 1992;44:1219-1222 • Showing in vivo and in vitro effects of phenothiazine neuroleptics on CYP2C11 and CYP2B1 expression in rats.
115. Honkakoski P, Jaaskelainen I, Kortelahti M, Urtti A. A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR). Pharm Res 2001;18:146-150 (Pubitemid 32592592)
116. Cheung C, Yu AM, Chen CS, et al. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther 2006;316:1328-1334 (Pubitemid 43345309)
117. Meltzer HY. Long-term effects of neuroleptic drugs on the neuroendocrine system. Adv Biochem Psychopharmacol 1985;40:59-68
118. Kot M, Daniel WA. The brain noradrenergic and serotonergic systems as unknown factors regulating the activity of cytochrome P450. Eur Neuropsychopharmacol 2009;19(Suppl 1):S17 •• First suggestions for the contribution of the brain noradrenergic and serotonergic system to the regulation of liver CYP expression.