Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital

European Journal of Biochemistry

Volumn 267, Issue 24, 2000, Pages 7128-7137

  Jover, Ramiro ^a,b,c   Hoffmann, Francine ^a,b   Scheffler Koch, Valeria ^a,b   Lindberg, Raija L P ^a,b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

aminolevulinic acid synthase; Cyp2a5; Cytochrome P450; Heme regulation; Porphobilinogen deaminase deficient mouse

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; CYTOCHROME P450; CYTOCHROME P450 2A5; CYTOCHROME P450 ISOENZYME; GUANYLATE CYCLASE; HEME; HEMOPROTEIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PHENOBARBITAL; PORPHOBILINOGEN DEAMINASE; UNCLASSIFIED DRUG;

ACUTE INTERMITTENT PORPHYRIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEME SYNTHESIS; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME; HYDROXYMETHYLBILANE SYNTHASE; LIVER; MALE; MICE; MICE, INBRED C57BL; PHENOBARBITAL; TRANS-ACTIVATION (GENETICS);

EID: 0034533523     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01815.x     Document Type: Article

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