Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary

Toxicology and Applied Pharmacology

Volumn 169, Issue 2, 2000, Pages 159-167

  Huang, Ping ^a   Rannug, Agneta ^a,b   Ahlbom, Eva ^a   Hakansson, Helen ^a   Ceccatelli, Sandra ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

Author keywords

2, 3, 7, 8 Tetrachlorodibenzo p dioxin (TCDD); Aryl hydrocarbon receptor (AHR); Aryl hydrocarbon receptor nuclear translocator (ARNT); Brain; Cytochrome P450 1A1 (CYP1A1); Gene expression; Pituitary; RT PCR

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CARRIER PROTEIN; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; PHENACETIN O DEETHYLASE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; GENE EXPRESSION; HIPPOCAMPUS; HYPOPHYSIS; HYPOTHALAMUS; MALE; NEUROENDOCRINE SYSTEM; NEUROTOXICITY; NONHUMAN; OLFACTORY BULB; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALIA;

EID: 0034418176     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.9064     Document Type: Article

References (55)

1. Developmental express ion of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo
2. Targeting of NH2-terminal-processed microsomal protein to mitochondria: A novel pathway for the biogenesis of hepatic mitochondrial P450MT2
3. Rat brain cytochromes P-450-catalytic, immunochemical properties and inducibility of multiple forms
4. Pituitary as a target organ for toxic effects of P4501A1 inducing Chemicals
5. TCDD alters pituitary-adrenal function. I: Adrenal responsiveness to exogenous ACTH
6. Evidence for Ah receptor mediation of increased ACTH concentrations in primary cultures of rat anterior pituitary cells exposed to TCDD
7. Constitutive activation of the aromatic hydrocarbon receptor
8. Aryl hydrocarbon hydroxylase of rat brain mitochondria: Properties of, and effect of inhibitors and inducers on, enzyme activity
9. Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localised in situ hybridisation
10. Role of CYP1A2 in hepatic sequestration of dioxin: Studies using CYP1A2 knock-out mice
11. Molecular bases for circadian clocks
12. Neurochemical effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in Wistar and Gunn rats
13. Relationship between acute toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and disturbance of intermediary metabolism in the Long-Evans rat
14. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human kerationocyte cell line involves both transcriptional and post-transcriptional control
15. Exposure to dioxin and dioxin-like compounds as a potential factor in developmental disabilities
16. The effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on the uptake, distribution and excretion of a single oral dose of [11, 12,-3H]retinyl acetate and on the vitamin A status in the rat
17. The aryl hydrocarbon receptor complex
18. Stimulation of calcium uptake in cultured rat hippocampal neurons by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
19. Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
20. Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways
21. Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells
22. The dioxin receptor and its nuclear translocator (Arnt) in the rat brain
23. Immunohistochemical localisation of cytochrome P-450 in rat brain
24. A mechanistic model of effects of dioxin on gene expression in the rat liver
25. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) increases release of luteinizing hormone and follicle-stimulating hormone from the pituitary of immature female rats in vivo and in vitro
26. The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
27. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin phase advances the deer mouse (Peromyscus maniculaturs) circadian rhythm by altering expression of clock proteins
28. Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain
29. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
30. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) increases serum and kidney retinoic acid levels and kidney retinol esterification in the rat
31. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons
32. Mechanism by which 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat
33. Short-term toxicity of 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models
34. The central nervous system may be involved in TCDD toxicity
35. Tissue distribution, metabolism, and excretion of 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain
36. Female Sprague-Dawley rats exposed to a single oral dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin exhibit sustained depletion of aryl hydrocarbon receptor protein in liver, spleen, thymus, and lung
37. Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances
38. Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands
39. Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5, 6 benzoflavone, comparison with liver and lung microsomal activities
40. Is a serotonergic mechanism involved in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced appetite suppression in the Sprague-Dawley rat?
41. Hypothalamic site of action of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
42. Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes
43. Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain
44. Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1 beta
45. Changes in rat brain monoamines, monoamine metabolites and histamine after a single administration of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
46. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) induced ethoxyresorufin-O-deethylase (EROD) and aldehyde dehydrogenase (ALDH3) activities in the brain and liver. A comparison between the most TCDD-susceptible and the most TCDD-resistant rat strain
47. Characterization of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced brain serotonin metabolism in the rat
48. Biochemical effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds on the central nervous system
49. Dioxin-induced perturbations in tryptophan homeostasis in laboratory animals
50. Effect of a single lethal dose of TCDD on the levels of monoamines, their metabolites and tryptophan in discrete brain nuclei and peripheral tissues of Long-Evans rats
51. Regional distribution of cytochrome P-450 in the rat brain: Spectral quantitation and contribution of P-450b, e, and P-450c, d
52. Comparative toxicity of 4 chlorinated dibenzo-p-dioxins (CDDs) and their mixture. 3. Structure-activity relationship with increased plasma tryptophan levels, but no relationship to hepatic ethoxyresorufin O-deethylase activity
53. Regulation of CYP1A1 transcription via the metabolism of the tryptophan-derived 6-formylindolo[3, 2-b]carbazole
54. Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo [3, 2-b] carbazole