-
1
-
-
0037115049
-
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not plaque formation
-
Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not plaque formation. J Neurosci 22: 10539-10548
-
(2002)
J Neurosci
, vol.22
, pp. 10539-10548
-
-
Buttini, M.1
Yu, G.Q.2
Shockley, K.3
Huang, Y.4
Jones, B.5
Masliah, E.6
Mallory, M.7
Yeo, T.8
Longo, F.M.9
Mucke, L.10
-
2
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R, Yan SD, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9: 907-913
-
(2003)
Nat Med
, vol.9
, pp. 907-913
-
-
Deane, R.1
Yan, S.D.2
Submamaryan, R.K.3
LaRue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
Zhu, H.11
Ghiso, J.12
Frangione, B.13
Stern, A.14
Schmidt, A.M.15
Armstrong, D.L.16
Arnold, B.17
Liliensiek, B.18
Nawroth, P.19
Hofman, F.20
Kindy, M.21
Stern, D.22
Zlokovic, B.23
more..
-
3
-
-
0032491398
-
A redox-triggered Ras-effector interaction: Recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress
-
Deora A, Win T, Vanhaesebroeck B, Lander H (1998) A redox-triggered Ras-effector interaction: recruitment of phosphatidylinositol 3′-kinase to Ras by redox stress. J Biol Chem 273: 29923-29928
-
(1998)
J Biol Chem
, vol.273
, pp. 29923-29928
-
-
Deora, A.1
Win, T.2
Vanhaesebroeck, B.3
Lander, H.4
-
4
-
-
0032737316
-
Exposing rats to a predator impairs spatial working-memory in the radial arm water maze
-
Diamond D, Park C, Herman K, Rose G (1999) Exposing rats to a predator impairs spatial working-memory in the radial arm water maze. Hippocampus 9: 542-552
-
(1999)
Hippocampus
, vol.9
, pp. 542-552
-
-
Diamond, D.1
Park, C.2
Herman, K.3
Rose, G.4
-
5
-
-
16044366039
-
Increased amyloid-Beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon M, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S (1996) Increased amyloid-Beta42(43) in brains of mice expressing mutant presenilin 1. Nature 83: 710-713
-
(1996)
Nature
, vol.83
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
6
-
-
0031904324
-
Abnormalities of neuronal circuitry in Alzheimer's disease: Hippocampus and cortical cholinergic innervation
-
Geula C (1998) Abnormalities of neuronal circuitry in Alzheimer's disease: hippocampus and cortical cholinergic innervation. Neurology 51: S18-S29
-
(1998)
Neurology
, vol.51
-
-
Geula, C.1
-
7
-
-
0033603241
-
RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides
-
Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM (1999) RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 97: 889-901
-
(1999)
Cell
, vol.97
, pp. 889-901
-
-
Hofmann, M.A.1
Drury, S.2
Fu, C.3
Qu, W.4
Taguchi, A.5
Lu, Y.6
Avila, C.7
Kambham, N.8
Bierhaus, A.9
Nawroth, P.10
Neurath, M.F.11
Slattery, T.12
Beach, D.13
McClary, J.14
Nagashima, M.15
Morser, J.16
Stern, D.17
Schmidt, A.M.18
-
8
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon J, McGowan E, Yu X, Benkovic S, Jantzen P, Wrighi K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada C-M, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97-100
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, J.2
McGowan, E.3
Yu, X.4
Benkovic, S.5
Jantzen, P.6
Wrighi, K.7
Saad, I.8
Mueller, R.9
Morgan, D.10
Sanders, S.11
Zehr, C.12
O'Campo, K.13
Hardy, J.14
Prada, C.-M.15
Eckman, C.16
Younkin, S.17
Hsiao, K.18
Duff, K.19
-
9
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia A, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka R, Nicoll R, Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 96: 3228-3233
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3228-3233
-
-
Hsia, A.1
Masliah, E.2
McConlogue, L.3
Yu, G.Q.4
Tatsuno, G.5
Hu, K.6
Kholodenko, D.7
Malenka, R.8
Nicoll, R.9
Mucke, L.10
-
10
-
-
0029742199
-
Correlative memory deficits. Aβ elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274: 99-102
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
11
-
-
0035096603
-
Role of RAGE and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells
-
Huang J, Guh J, Chen H, Hung W, Lai Y, Chuang L (2001) Role of RAGE and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells. J Cell Biochem 81: 102-113
-
(2001)
J Cell Biochem
, vol.81
, pp. 102-113
-
-
Huang, J.1
Guh, J.2
Chen, H.3
Hung, W.4
Lai, Y.5
Chuang, L.6
-
12
-
-
0033538569
-
RAGE-mediated neunte outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways
-
Huttunen H, Fages C, Rauvala H (1999) RAGE-mediated neunte outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J Biol Chem 274: 19919-19924
-
(1999)
J Biol Chem
, vol.274
, pp. 19919-19924
-
-
Huttunen, H.1
Fages, C.2
Rauvala, H.3
-
13
-
-
0030983079
-
Transcription factor NF-κB is activated in primary neurons by Aβ and in neurons surrounding early plaques from patients with Alzheimer disease
-
Kaltschmidt B, Uherek M, Volk B, Baeuerle P, Kaltschmidt C (1997) Transcription factor NF-κB is activated in primary neurons by Aβ and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94: 2642-2647
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2642-2647
-
-
Kaltschmidt, B.1
Uherek, M.2
Volk, B.3
Baeuerle, P.4
Kaltschmidt, C.5
-
14
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
Kyriakis J, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869
-
(2001)
Physiol Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.1
Avruch, J.2
-
15
-
-
0030859290
-
Activation of RAGE triggers a MAP kinase pathway regulated by oxidant stress
-
Lander H, Tauras J, Ogiste J, Moss R, Schmidt AM (1997) Activation of RAGE triggers a MAP kinase pathway regulated by oxidant stress. J Biol Chem 272: 17810-17814
-
(1997)
J Biol Chem
, vol.272
, pp. 17810-17814
-
-
Lander, H.1
Tauras, J.2
Ogiste, J.3
Moss, R.4
Schmidt, A.M.5
-
16
-
-
0034840664
-
Involvement of RAGE-microglial interactions in Alzheimer's disease: In vivo and in vitro studies
-
Lue LF, Walker D, Brachova L, Rogers J, Shen Y, Schmidt AM, Stern DM, Yan SD (2001) Involvement of RAGE-microglial interactions in Alzheimer's disease: in vivo and in vitro studies. Exp Neurol 171: 29-45
-
(2001)
Exp Neurol
, vol.171
, pp. 29-45
-
-
Lue, L.F.1
Walker, D.2
Brachova, L.3
Rogers, J.4
Shen, Y.5
Schmidt, A.M.6
Stern, D.M.7
Yan, S.D.8
-
17
-
-
0024364877
-
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
-
Masliah E, Terry R, DeTeresa R, Hansen L (1989) Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 103: 234-239
-
(1989)
Neurosci Lett
, vol.103
, pp. 234-239
-
-
Masliah, E.1
Terry, R.2
DeTeresa, R.3
Hansen, L.4
-
18
-
-
0022519298
-
Regulation of brain type II calcium calmodulin-dependent protein kinase by autophosphorylation by calcium-triggered molecular switch
-
Miller S, Kennedy M (1986) Regulation of brain type II calcium calmodulin-dependent protein kinase by autophosphorylation by calcium-triggered molecular switch. Cell 44: 861-870
-
(1986)
Cell
, vol.44
, pp. 861-870
-
-
Miller, S.1
Kennedy, M.2
-
19
-
-
0034213718
-
1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20: 4050-4058
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
20
-
-
0030248270
-
Microglial cells internalize aggregates of the Alzhsimer's disease amyloid β-protein via a scavenger receptor
-
Paresce D, Ghosh R, Maxfield F (1996) Microglial cells internalize aggregates of the Alzhsimer's disease amyloid β-protein via a scavenger receptor. Neuron 17: 553-565
-
(1996)
Neuron
, vol.17
, pp. 553-565
-
-
Paresce, D.1
Ghosh, R.2
Maxfield, F.3
-
21
-
-
0042466644
-
Receptor protein tyrosine phosphatase alpha (RPTPα) is essential for hippocampal neuronal migration, long-term potentiation, and working memory
-
Petrone A, Battaglia F, Wang C, Dusa A, Su J, Zagzag D, Bianchi R, Casaccia-Bonnefil P, Arancio O, Sap J (2003) Receptor protein tyrosine phosphatase alpha (RPTPα) is essential for hippocampal neuronal migration, long-term potentiation, and working memory. EMBO J 22: 4121-4131
-
(2003)
EMBO J
, vol.22
, pp. 4121-4131
-
-
Petrone, A.1
Battaglia, F.2
Wang, C.3
Dusa, A.4
Su, J.5
Zagzag, D.6
Bianchi, R.7
Casaccia-Bonnefil, P.8
Arancio, O.9
Sap, J.10
-
22
-
-
0034795140
-
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
-
Schmidt AM, Yan SD, Yan SF, Stern DM (2001) The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 108: 949-955
-
(2001)
J Clin Invest
, vol.108
, pp. 949-955
-
-
Schmidt, A.M.1
Yan, S.D.2
Yan, S.F.3
Stern, D.M.4
-
23
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298: 789-791
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
24
-
-
0029047722
-
Differential binding of vascular cell-derived proteoglycans (perIecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease
-
Snow A, Kinsella M, Parks E, Sekiguchi R, Miller J, Kimata K, Wight T (1995) Differential binding of vascular cell-derived proteoglycans (perIecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease. Arch Biochem Biophys 320: 84-95
-
(1995)
Arch Biochem Biophys
, vol.320
, pp. 84-95
-
-
Snow, A.1
Kinsella, M.2
Parks, E.3
Sekiguchi, R.4
Miller, J.5
Kimata, K.6
Wight, T.7
-
25
-
-
0035166616
-
The neuronal MAP kinase cascade: A biochemical signal integration system subserving synaptic plasticity and memory
-
Sweatt J (2001) The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76: 1-10
-
(2001)
J Neurochem
, vol.76
, pp. 1-10
-
-
Sweatt, J.1
-
26
-
-
0034682315
-
Blockade of RAGE/amphoterin suppresses tumor growth and metastases
-
Taguchi A, DelToro G, Canet A, Lee D, Tanji N, Lu Y, Ingram M, Lalla E, Hofmann M, Fu J, Kislinger T, Lu A, Stern DM, Schmidt A-M (2000) Blockade of RAGE/amphoterin suppresses tumor growth and metastases. Nature 405: 354-360
-
(2000)
Nature
, vol.405
, pp. 354-360
-
-
Taguchi, A.1
DelToro, G.2
Canet, A.3
Lee, D.4
Tanji, N.5
Lu, Y.6
Ingram, M.7
Lalla, E.8
Hofmann, M.9
Fu, J.10
Kislinger, T.11
Lu, A.12
Stern, D.M.13
Schmidt, A.-M.14
-
27
-
-
2542584749
-
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
-
Trinchese F, Liu S, Battaglia F, Walter S, Mathews P, Arancio O (2004) Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Ann Neurol 55: 801-814
-
(2004)
Ann Neurol
, vol.55
, pp. 801-814
-
-
Trinchese, F.1
Liu, S.2
Battaglia, F.3
Walter, S.4
Mathews, P.5
Arancio, O.6
-
28
-
-
0032897760
-
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
-
Usdin M, Shelbourne P, Myers R, Madison D (1999) Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. Hum Mol Genet 8: 839-846
-
(1999)
Hum Mol Genet
, vol.8
, pp. 839-846
-
-
Usdin, M.1
Shelbourne, P.2
Myers, R.3
Madison, D.4
-
29
-
-
0034006944
-
Aβ(1-42) binds to α7 nicotinic acetylcholine receptor with high affinity
-
Wang HY, Lee D, D'Andrea M, Peterson P, Shank R, Reitz A (2000) Aβ(1-42) binds to α7 nicotinic acetylcholine receptor with high affinity. J Biol Chem 275: 5626-5632
-
(2000)
J Biol Chem
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.2
D'Andrea, M.3
Peterson, P.4
Shank, R.5
Reitz, A.6
-
30
-
-
0034996659
-
Activation of NADPH oxidase by AGEs links oxidant stress to altered gene expression via RAGE
-
Wautier MP, Chappey O, Corda S, Stern D, Schmidt A-M, Wautier JL (2001) Activation of NADPH oxidase by AGEs links oxidant stress to altered gene expression via RAGE. Am J Physiol 280: E685-E694
-
(2001)
Am J Physiol
, vol.280
-
-
Wautier, M.P.1
Chappey, O.2
Corda, S.3
Stern, D.4
Schmidt, A.-M.5
Wautier, J.L.6
-
31
-
-
0013615899
-
RAGE and Aβ peptide neurotoxicity in Alzheimer's disease
-
Yan SD, Chen X, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern DM, Schmidt A-M (1996) RAGE and Aβ peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Chen, M.3
Zhu, H.4
Roher, A.5
Slattery, T.6
Zhao, L.7
Nagashima, M.8
Morser, J.9
Migheli, A.10
Nawroth, P.11
Stern, D.M.12
Schmidt, A.-M.13
-
32
-
-
0029076397
-
Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of Aβ
-
Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith M, Perry G, Godman G, Nawroth P, Zweier J, Stern DM (1995) Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of Aβ. Nat Med 1: 693-699
-
(1995)
Nat Med
, vol.1
, pp. 693-699
-
-
Yan, S.D.1
Yan, S.F.2
Chen, X.3
Fu, J.4
Chen, M.5
Kuppusamy, P.6
Smith, M.7
Perry, G.8
Godman, G.9
Nawroth, P.10
Zweier, J.11
Stern, D.M.12
-
33
-
-
0000920292
-
RAGE-Aβ interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease
-
Yan SD, Zhu H, Fu J, Yan SF, Roher A, Tourtellotte WW, Rajavashisth T, Chen X, Godman GC, Stern D, Schmidt AM (1997) RAGE-Aβ interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc Natl Acad Sci USA 94: 5296-5301
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5296-5301
-
-
Yan, S.D.1
Zhu, H.2
Fu, J.3
Yan, S.F.4
Roher, A.5
Tourtellotte, W.W.6
Rajavashisth, T.7
Chen, X.8
Godman, G.C.9
Stern, D.10
Schmidt, A.M.11
-
34
-
-
0001358519
-
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
-
Yan SD, Zhu H, Zhu A, Golabek A, Roher A, Yu J, Soto C, Schmidt AM, Stern DM, Kindy M (2000) Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat Med 6: 643-651
-
(2000)
Nat Med
, vol.6
, pp. 643-651
-
-
Yan, S.D.1
Zhu, H.2
Zhu, A.3
Golabek, A.4
Roher, A.5
Yu, J.6
Soto, C.7
Schmidt, A.M.8
Stern, D.M.9
Kindy, M.10
-
36
-
-
0030991201
-
The transcriptional activity of NF-κB is regulated by IkB-associated PKAc subunit through a cyclic AMP-independent mechanism
-
Zhong H, SuYang H, Bromage H, Tempst P, Ghosh S (1997) The transcriptional activity of NF-κB is regulated by IkB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89: 413-424
-
(1997)
Cell
, vol.89
, pp. 413-424
-
-
Zhong, H.1
SuYang, H.2
Bromage, H.3
Tempst, P.4
Ghosh, S.5
|