Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition

Cardiovascular Research

Volumn 45, Issue 2, 2000, Pages 360-369

  Javadov, Sabzali A ^a   Lim, Kelvin H H ^b   Kerr, Paul M ^c   Suleiman, M Saadah ^b   Angelini, Gianni D ^b   Halestrap, Andrew P ^b  

^a AZERBAIJAN MEDICAL UNIVERSITY   (Azerbaijan)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cardioplegia; Free radicals; Ischaemia; Mitochondria; Reperfusion; Ventricular function

Indexed keywords

CARDIOPLEGIC AGENT; INTRALIPID; PROPOFOL;

ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE FUNCTION; ISOLATED HEART; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANALYSIS OF VARIANCE; ANIMALS; FAT EMULSIONS, INTRAVENOUS; FREE RADICAL SCAVENGERS; HEART ARREST, INDUCED; MALE; MITOCHONDRIA, HEART; MYOCARDIAL REPERFUSION INJURY; PERFUSION; PROPOFOL; RATS; RATS, WISTAR;

EID: 0033969964     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00365-X     Document Type: Article

References (48)

1. Bryson H.M., Fulton B.R., Faulds D. Propofol: an update of its use in anesthesia and conscious sedation. Drugs. 50:1995;513-559.
2. Kokita N., Hara A. Propofol attenuates hydrogen-peroxide induced mechanical and metabolic derangements in the isolated rat heart. Anesthesiology. 84:1996;117-127.
3. Kokita N., Hara A., Abiko Y., et al. Propofol improves functional and metabolic recovery in ischemic reperfused isolated rat hearts. Anesth Analg. 86:1998;252-258.
4. Ko S.H., Yu C.W., Choe H., et al. Propofol attenuates ischaemic-reperfusion injury in the isolated rat heart. Anesth Analg. 85:1997;719-724.
5. Eriksson O., Pollesello P., Saris N.E. Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anaesthetic propofol. Biochem Pharmacol. 44:1992;391-393.
6. Murphy P.G., Myers D.S., Davies W.J., Webster N.R.J.J.G. The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth. 68:1992;616-618.
7. Murphy P.G., Bennett J.R., Myers D.S., Davies M.J., Jones J.G. The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes. Eur J Anaesth. 10:1993;261-266.
8. Green T.R., Bennett S.R., Nelson V.M. Specificity and properties of propofol as an antioxidant free radical scavenger. Toxicol Appl Pharmacol. 129:1994;163-169.
9. Buljubasic N., Marijic J., Berczi V., Supan D.F., Kampine J.P., Bosnjak Z.J. Differential effects of etomidate, propofol, and midazolam on calcium and potassium channel currents in canine myocardial cells. Anesthesiology. 85:1996;1092-1099.
10. Li Y.C., Ridefelt P., Wiklund L., Bjerneroth G. Propofol induces a lowering of free cytosolic calcium in myocardial cells. Acta Anaesth Scand. 41:1997;633-638.
11. Reimer K.A., Jennings R.B. Myocardial ischemia, hypoxia and infarction. Fozzard H.A., Haber E., Jennings R.B., Katz A.M., Morgan H.E. The heart and cardiovascular system. 2nd ed Scientific foundations. 1992;1875-1973 Raven Press, New York.
12. Halestrap A.P. Interactions between oxidative stress and calcium overload on mitochondrial function. Darley-Usmar V., Schapira A.H.V. Mitochondria: DNA, proteins and disease. 1994;113-142 Portland Press, London.
13. Lemasters J.J., Thurman R.G. The many facets of reperfusion injury. Gastroenterology. 108:1995;1317-1320.
14. Halestrap A.P., Kerr P.M., Javadov S., Woodfield K.Y. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta: Bioenerg. 1366:1998;79-94.
15. Griffiths E.J., Halestrap A.P. Protection by cyclosporin a of ischemia reperfusion-induced damage in isolated rat hearts. J Mol Cell Cardiol. 25:1993;1461-1469.
16. Griffiths E.J., Halestrap A.P. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J. 307:1995;93-98.
17. Halestrap A.P., Connern C.P., Griffiths E.J., Kerr P.M. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury. Mol Cell Biochem. 174:1997;167-172.
18. Kerr P.M., Suleiman M.-. S, Halestrap A.P. Recovery of rat hearts reperfused after a period of ischemia is accompanied by reversal of the mitochondrial permeability transition and is enhanced by pyruvate. Am J Physiol. 276:1999;H496-502.
19. 2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J. 255:1988;357-360.
20. 2+-induced large amplitude swelling of liver and heart mitochondria by cyclosporin A is probably caused by the inhibitor binding to mitochondrial matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem J. 268:1990;153-160.
21. Nazareth W., Yafei N., Crompton M. Inhibition of anoxia-induced injury in heart myocytes by cyclosporin-A. J Mol Cell Cardiol. 23:1991;1351-1354.
22. Reed J.C. Cytochrome c: can't live with it - can't live without it. Cell. 91:1997;559-562.
23. Green D.R., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
24. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol. 60:1998;619-642.
25. Olivetti G., Abbi R., Quaini F., et al. Apoptosis in the failing human heart. N Engl J Med. 336:1997;1131-1141.
26. Umansky S.R., Tomei L.D. Apoptosis in the heart. Adv Pharmacol. 41:1997;383-407.
27. Fliss H., Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res. 79:1996;949-956.
28. Gottlieb R.A., Burleson K.O., Kloner R.A., Babior B.M., Engler R.L. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest. 94:1994;1621-1628.
29. Black S.C., Huang J.Q., Rezaiefar P., et al. Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat. J Mol Cell Cardiol. 30:1998;733-742.
30. Yaoita H., Ogawa K., Maehara K., Maruyama Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation. 97:1998;276-281.
31. 2+-induced permeabilization of rat liver mitochondria. FEBS Lett. 279:1991;45-48.
32. Sztark F., Ichas F., Ouhabi R., Dabadie P., Mazat J.P. Effects of the anaesthetic propofol on the calcium-induced permeability transition of rat heart mitochondria: direct pore inhibition and shift of the gating potential. FEBS Lett. 368:1995;101-104.
33. 2+. Biochem J. 244:1987;159-164.
34. Halestrap A.P., Woodfield K.Y., Connern C.P. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J Biol Chem. 272:1997;3346-3354.
35. Servin F., Desmonts J.M., Haberer J.P., Cockshott I.D., Plummer G.F., Farinotti R. Pharmacokinetics and protein binding of propofol in patients with cirrhosis. Anesthesiology. 69:1988;887-891.
36. Cockshott I.D. Propofol ('Diprivan') pharmacokinetics and metabolism - an overview. Postgrad Med J. 61:1985;45-50.
37. Branca D., Vincenti E., Scutari G. Influence of the anesthetic 2,6-diisopropylphenol (propofol) on isolated rat heart mitochondria. Comp Biochem Physiol C: Pharmacol Toxicol Endocrinol. 110:1995;41-45.
38. Rigoulet M., Devin A., Averet N., Vandais B., Guerin B. Mechanisms of inhibition and uncoupling of respiration in isolated rat liver mitochondria by the general anesthetic 2,6-diisopropylphenol. Eur J Biochem. 241:1996;280-285.
39. Mayer N., Legat K., Weinstabl C., Zimpfer M. Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium. Anesth Analg. 76:1993;33-39.
40. Coetzee A. Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury. Afr Med J. 86:1996;C85-C90.
41. Park K.W., Dai H.B., Lowenstein E., Sellke F.W. Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide. Anesth Analg. 81:1995;1191-1196.
42. Yoo K.Y., Yang S.Y., Lee J., et al. Intracoronary propofol attenuates myocardial but not coronary endothelial dysfunction after brief ischaemia and reperfusion in dogs. Br J Anaesth. 82:1999;90-96.
43. Humphrey C.B., Gibbons J.A., Folkerth T.L., Shapiro A.R., Fosburg R.G. An analysis of direct and indirect measurements of left atrial filling pressure. J Thorac Cardiovasc Surg. 71:1976;643-647.
44. Matsuda Y., Toma Y., Matsuzaki M., et al. Change of left atrial systolic pressure waveform in relation to left ventricular end-diastolic pressure. Circulation. 82:1990;1659-1667.
45. Stewart J.T., Grbic M., Sigwart U. Left atrial and left ventricular diastolic function during acute myocardial ischaemia. Br Heart J. 68:1992;377-381.
46. Mankad P.S., Yacoub M.H. Systolic and diastolic function of both ventricles after prolonged cardioplegic arrest. Ann Thorac Surg. 55:1993;933-939.
47. Marsch S.C., Dalmas S., Philbin D.M., Ryder W.A., Foex P. Myocardial ischemia and reperfusion are associated with an increased stiffness of remote nonischemic myocardium. Anesth Analg. 82:1996;695-701.
48. DeLaCruz J.P., Villalobos M.A., Sedeno G., DeLaCuesta F.S. Effect of propofol on oxidative stress in an in vitro model of anoxia-reoxygenation in the rat brain. Brain Res. 800:1998;136-144.