Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice

Journal of Immunology

Volumn 159, Issue 5, 1997, Pages 2452-2461

  Labow, Mark ^a   Shuster, David ^a   Zetterstrom, Maria ^b   Nunes, Perla ^a   Terry, Robert ^a   Cullinan, Emily B ^c   Bartfai, Tamas ^b   Solorzano, Carmen ^d   Moldawer, Lyle L ^d   Chizzonite, Richard ^a   Mclntyre, Kim W ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 6; TURPENTINE;

ACUTE PHASE RESPONSE; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DELAYED HYPERSENSITIVITY; DISEASE PREDISPOSITION; DRUG EFFECT; FEMALE; FEVER; FIBROBLAST; GENE TARGETING; GENETICS; IMMUNOLOGY; INFLAMMATION; LISTERIOSIS; MALE; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACUTE-PHASE REACTION; ANIMALS; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; E-SELECTIN; FEMALE; FEVER; FIBROBLASTS; GENE TARGETING; HYPERSENSITIVITY, DELAYED; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; LISTERIA INFECTIONS; MALE; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-1 TYPE I; SIGNAL TRANSDUCTION; TURPENTINE;

EID: 0031227868     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Dinarello, C. A. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627.
2. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095.
3. Rothwell, N. J. 1990. Mechanisms of the pyrogenic actions of cytokines. Eur. Cytokine Netw. 1:211.
4. Kent, S., R.-M. Bluthe, K. W. Kelley, and R. Dantzer. 1992. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 131:24.
5. Geiger, T., H. Towbin, A. Cosenti-Vargas, O. Zingel, J. Arnold, C. Rordorf, M. Galtt, and K. Vosbeck. 1993. Neutralization of interleukin-1β activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response. Clin. Exp. Rheumatol. 11:515.
6. Jacobs, C. A., P. E. Baker, E. R. Roux, K. S. Picha, B. Toivola, S. Waugh, and M. K. Kennedy. 1991. Experimental autoimmune encephalomyelitis is exacerbated by IL-1α and suppressed by soluble IL-1 receptor. J. Immunol. 146:2983.
7. Ohlsson, K., P. Bjork, M. Bergenfeildt, R. Hageman, and R. C. Thompson. 1990. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550.
8. Van Den Berg, W. B., L. A. B. Joosten, M. Helsen, and F. A. J. Van De Loo. 1994. Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin. Exp. Immunol. 95:237.
9. Farrar, W. L., P. L. Kilian, M. R. Ruff, J. M. Hill, and C. B. Pert. 1987. Visualization and characterization of interleukin 1 receptors in brain. J. Immunol. 139:459.
10. Breder, C. D., C. A. Dinarello, and C. B. Saper. 1988. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240:321.
11. Wong, M. L., and J. Licinio. 1994. Localization of interleukin 1 type I receptor mRNA in rat brain. Neuroimmunomodulation 1:110.