Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

Cell Death and Differentiation

Volumn 9, Issue 5, 2002, Pages 505-512

  Puthalakath, H ^a   Strasser, A ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Apoptosis; Bcl 2; BH3 only proteins; Programmed cell death; Signal transduction

Indexed keywords

BH3 PROTEIN; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; CAENORHABDITIS ELEGANS; CELL STIMULATION; CONTROLLED STUDY; GENE TARGETING; GENETIC ANALYSIS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SOMATIC CELL; TRANSCRIPTION REGULATION;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0036097786     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400998     Document Type: Review

References (72)

1. Apoptosis signaling
2. Death receptors: Signaling and modulation
3. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
4. A dominant interfering mutant of FADD/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
5. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
6. Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2
7. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
8. The Bcl-2 protein family: Arbiters of cell survival
9. Bcl-2 family members and the mitochondria in apoptosis
10. The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane
11. Immunohistochemical analysis of in vivo patterns of Bcl-X expression
12. Tissue expression and subcellular localization of the pro-survival molecule Bcl-w
13. Mitochondria and apoptosis
14. Bcl-2 family members do not inhibit apoptosis by binding the caspase-activator Apaf-1
15. L
16. Structure of Bax: Coregulation of dimer formation and intracellular localization
17. BH3-only proteins - Essential initiators of apoptotic cell death
18. BID: A novel BH3 domain-only death agonist
19. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
20. The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene
21. Mechanisms and functions of cell death
22. A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans
23. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
24. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
25. L and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
26. L
27. Fas ligand, Bcl-2, G-CSF and p38 MAPK: Regulators of distinct cell death and survival pathways in granulocytes
28. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
29. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
30. Bcl-2, bcl-x(l) sequester bh3 domain-only molecules preventing bax-and bak-mediated mitochondrial apoptosis
31. L, an inhibitor of programmed cell death
32. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2
33. Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
34. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein
35. L
36. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death
37. The cell death-promoting gene DP5, which interacts with the Bcl-2 family, is induced during neuronal apoptosis following exposure to amyloid β protein
38. Noxa, a BH3-only member of the bcl-2 family and candidate mediator of p53-induced apoptosis
39. PUMA, a novel proapoptotic gene, is induced by p53
40. PUMA induces the rapid apoptosis of colorectal cancer cells
41. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
42. Induction of Bim, a proapoptotic BH3-only Bcl-2 family member, is critical for neuronal apoptosis
43. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
44. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
45. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
46. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors
47. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis
48. Thymocyte apoptosis induced by p53-dependent and independent pathways
49. p53 is required for radiation-induced apoptosis in mouse thymocytes
50. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
51. Bim: A novel member of the Bcl-2 family that promotes apoptosis
52. L
53. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
54. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
55. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
56. Bcl-2 targets the protein kinase Raf-1 to mitochondria
57. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
58. 2+-induced apoptosis through calcineurin dephosphorylation of BAD
59. Phosphorylation of the pro-apoptotic protein bik. mapping of phosphorylation sites and effect on apoptosis
60. Phosphorylation of bid by casein kinases i and ii regulates its cleavage by caspase 8
61. Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis
62. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
63. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
64. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
65. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
66. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
67. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
68. Bmf: A pro-apoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
69. The pro-apoptotic BH3-only protein Bim is expressed in hemopoietic, epithelial, neuronal and germ cells
70. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer
71. Anchorage dependence, integrins, and apoptosis
72. Degenerative disorders caused by Bcl-2 deficiency are prevented by loss of its BH3-only antagonist Bim