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Volumn 18, Issue 3, 2006, Pages 363-370

Programming CD8+ T cells for effective immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYTOKINE RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 33646149184     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2006.03.009     Document Type: Review
Times cited : (61)

References (71)
  • 4
    • 14244260068 scopus 로고    scopus 로고
    • DNA methylation and the expanding epigenetics of T cell lineage commitment
    • Wilson C.B., Makar K.W., Shnyreva M., and Fitzpatrick D.R. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin Immunol 17 (2005) 105-119
    • (2005) Semin Immunol , vol.17 , pp. 105-119
    • Wilson, C.B.1    Makar, K.W.2    Shnyreva, M.3    Fitzpatrick, D.R.4
  • 5
    • 33644646837 scopus 로고    scopus 로고
    • Chromatin structure and gene regulation in T cell development and function
    • Wilson C.B., and Merkenschlager M. Chromatin structure and gene regulation in T cell development and function. Curr Opin Immunol 18 (2006) 143-151
    • (2006) Curr Opin Immunol , vol.18 , pp. 143-151
    • Wilson, C.B.1    Merkenschlager, M.2
  • 9
    • 19344370239 scopus 로고    scopus 로고
    • + T-cell differentiation towards senescence in HIV-1 infection
    • + T cells in vitro and in vivo based on expression of the molecules CD27 and CD28. Furthermore the loss of proliferative capacity associated with this process is firmly established in this work.
    • + T cells in vitro and in vivo based on expression of the molecules CD27 and CD28. Furthermore the loss of proliferative capacity associated with this process is firmly established in this work.
    • (2004) PLoS Biol , vol.2
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3    Salio, M.4    Rufer, N.5    Little, S.6    Dong, T.7    Chesney, G.8    Waters, A.9    Easterbrook, P.10
  • 10
    • 27744450650 scopus 로고    scopus 로고
    • Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy
    • Zhou J., Shen X., Huang J., Hodes R.J., Rosenberg S.A., and Robbins P.F. Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J Immunol 175 (2005) 7046-7052
    • (2005) J Immunol , vol.175 , pp. 7046-7052
    • Zhou, J.1    Shen, X.2    Huang, J.3    Hodes, R.J.4    Rosenberg, S.A.5    Robbins, P.F.6
  • 11
    • 22344434167 scopus 로고    scopus 로고
    • Differential contributions of central and effector memory T cells to recall responses
    • Roberts A.D., Ely K.H., and Woodland D.L. Differential contributions of central and effector memory T cells to recall responses. J Exp Med 202 (2005) 123-133
    • (2005) J Exp Med , vol.202 , pp. 123-133
    • Roberts, A.D.1    Ely, K.H.2    Woodland, D.L.3
  • 12
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • Sallusto F., Geginat J., and Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22 (2004) 745-763
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 13
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation
    • Kaech S.M., Hemby S., Kersh E., and Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111 (2002) 837-851
    • (2002) Cell , vol.111 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 14
    • 2342570341 scopus 로고    scopus 로고
    • Lessons from the study of T-cell differentiation in persistent human virus infection
    • Appay V., and Rowland-Jones S.L. Lessons from the study of T-cell differentiation in persistent human virus infection. Semin Immunol 16 (2004) 205-212
    • (2004) Semin Immunol , vol.16 , pp. 205-212
    • Appay, V.1    Rowland-Jones, S.L.2
  • 15
    • 18844372332 scopus 로고    scopus 로고
    • Understanding the generation and function of memory T cell subsets
    • Lanzavecchia A., and Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 17 (2005) 326-332
    • (2005) Curr Opin Immunol , vol.17 , pp. 326-332
    • Lanzavecchia, A.1    Sallusto, F.2
  • 17
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 18
    • 0037369590 scopus 로고    scopus 로고
    • + memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers
    • + memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers. J Immunol 170 (2003) 2461-2468
    • (2003) J Immunol , vol.170 , pp. 2461-2468
    • Ravkov, E.V.1    Myrick, C.M.2    Altman, J.D.3
  • 20
    • 0035412370 scopus 로고    scopus 로고
    • CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection
    • Chen G., Shankar P., Lange C., Valdez H., Skolnik P.R., Wu L., Manjunath N., and Lieberman J. CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood 98 (2001) 156-164
    • (2001) Blood , vol.98 , pp. 156-164
    • Chen, G.1    Shankar, P.2    Lange, C.3    Valdez, H.4    Skolnik, P.R.5    Wu, L.6    Manjunath, N.7    Lieberman, J.8
  • 21
    • 0036919199 scopus 로고    scopus 로고
    • Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections
    • Ellefsen K., Harari A., Champagne P., Bart P.A., Sekaly R.P., and Pantaleo G. Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections. Eur J Immunol 32 (2002) 3756-3764
    • (2002) Eur J Immunol , vol.32 , pp. 3756-3764
    • Ellefsen, K.1    Harari, A.2    Champagne, P.3    Bart, P.A.4    Sekaly, R.P.5    Pantaleo, G.6
  • 24
    • 14244259568 scopus 로고    scopus 로고
    • Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo
    • Bouneaud C., Garcia Z., Kourilsky P., and Pannetier C. Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo. J Exp Med 201 (2005) 579-590
    • (2005) J Exp Med , vol.201 , pp. 579-590
    • Bouneaud, C.1    Garcia, Z.2    Kourilsky, P.3    Pannetier, C.4
  • 25
    • 23944461953 scopus 로고    scopus 로고
    • + T cell lineage commitment
    • + T cells whereas low precursor frequency leads to an effector memory phenotype. Because competition for antigen by T cells might limit antigenic stimulation, the author's findings might instead stem from differences in the strength and duration of TCR signaling.
    • + T cells whereas low precursor frequency leads to an effector memory phenotype. Because competition for antigen by T cells might limit antigenic stimulation, the author's findings might instead stem from differences in the strength and duration of TCR signaling.
    • (2005) Nat Immunol , vol.6 , pp. 793-799
    • Marzo, A.L.1    Klonowski, K.D.2    Le Bon, A.3    Borrow, P.4    Tough, D.F.5    Lefrancois, L.6
  • 27
    • 27144467425 scopus 로고    scopus 로고
    • Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets
    • Willinger T., Freeman T., Hasegawa H., McMichael A.J., and Callan M.F. Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets. J Immunol 175 (2005) 5895-5903
    • (2005) J Immunol , vol.175 , pp. 5895-5903
    • Willinger, T.1    Freeman, T.2    Hasegawa, H.3    McMichael, A.J.4    Callan, M.F.5
  • 28
    • 0035854521 scopus 로고    scopus 로고
    • Arrested differentiation, the self-renewing memory lymphocyte, and vaccination
    • Fearon D.T., Manders P., and Wagner S.D. Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science 293 (2001) 248-250
    • (2001) Science , vol.293 , pp. 248-250
    • Fearon, D.T.1    Manders, P.2    Wagner, S.D.3
  • 29
    • 22344449965 scopus 로고    scopus 로고
    • Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease
    • Sacre K., Carcelain G., Cassoux N., Fillet A.M., Costagliola D., Vittecoq D., Salmon D., Amoura Z., Katlama C., and Autran B. Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease. J Exp Med 201 (2005) 1999-2010
    • (2005) J Exp Med , vol.201 , pp. 1999-2010
    • Sacre, K.1    Carcelain, G.2    Cassoux, N.3    Fillet, A.M.4    Costagliola, D.5    Vittecoq, D.6    Salmon, D.7    Amoura, Z.8    Katlama, C.9    Autran, B.10
  • 31
    • 0037058993 scopus 로고    scopus 로고
    • + T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells
    • + T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci USA 99 (2002) 16168-16173
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3    Riddell, S.R.4    Roche, P.5    Celis, E.6    Greenberg, P.D.7
  • 33
    • 10344261422 scopus 로고    scopus 로고
    • Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy
    • Robbins P.F., Dudley M.E., Wunderlich J., El-Gamil M., Li Y.F., Zhou J., Huang J., Powell Jr. D.J., and Rosenberg S.A. Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J Immunol 173 (2004) 7125-7130
    • (2004) J Immunol , vol.173 , pp. 7125-7130
    • Robbins, P.F.1    Dudley, M.E.2    Wunderlich, J.3    El-Gamil, M.4    Li, Y.F.5    Zhou, J.6    Huang, J.7    Powell Jr., D.J.8    Rosenberg, S.A.9
  • 34
    • 11144241310 scopus 로고    scopus 로고
    • + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
    • + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy. Blood 105 (2005) 241-250
    • (2005) Blood , vol.105 , pp. 241-250
    • Powell Jr., D.J.1    Dudley, M.E.2    Robbins, P.F.3    Rosenberg, S.A.4
  • 35
    • 21644453108 scopus 로고    scopus 로고
    • Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination
    • Wherry E.J., Blattman J.N., and Ahmed R. Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. J Virol 79 (2005) 8960-8968
    • (2005) J Virol , vol.79 , pp. 8960-8968
    • Wherry, E.J.1    Blattman, J.N.2    Ahmed, R.3
  • 37
    • 0642377166 scopus 로고    scopus 로고
    • Immunology. T-bet or not T-bet
    • Hatton R.D., and Weaver C.T. Immunology. T-bet or not T-bet. Science 302 (2003) 993-994
    • (2003) Science , vol.302 , pp. 993-994
    • Hatton, R.D.1    Weaver, C.T.2
  • 38
    • 0037236203 scopus 로고    scopus 로고
    • Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    • Messi M., Giacchetto I., Nagata K., Lanzavecchia A., Natoli G., and Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 4 (2003) 78-86
    • (2003) Nat Immunol , vol.4 , pp. 78-86
    • Messi, M.1    Giacchetto, I.2    Nagata, K.3    Lanzavecchia, A.4    Natoli, G.5    Sallusto, F.6
  • 39
    • 1442281449 scopus 로고    scopus 로고
    • Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation
    • Zhou W., Chang S., and Aune T.M. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Proc Natl Acad Sci USA 101 (2004) 2440-2445
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2440-2445
    • Zhou, W.1    Chang, S.2    Aune, T.M.3
  • 40
    • 0036305450 scopus 로고    scopus 로고
    • T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    • Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol 3 (2002) 643-651
    • (2002) Nat Immunol , vol.3 , pp. 643-651
    • Avni, O.1    Lee, D.2    Macian, F.3    Szabo, S.J.4    Glimcher, L.H.5    Rao, A.6
  • 41
    • 0141920622 scopus 로고    scopus 로고
    • Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation
    • Sundrud M.S., Grill S.M., Ni D., Nagata K., Alkan S.S., Subramaniam A., and Unutmaz D. Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol 171 (2003) 3542-3549
    • (2003) J Immunol , vol.171 , pp. 3542-3549
    • Sundrud, M.S.1    Grill, S.M.2    Ni, D.3    Nagata, K.4    Alkan, S.S.5    Subramaniam, A.6    Unutmaz, D.7
  • 42
    • 30044440799 scopus 로고    scopus 로고
    • + T cell fate coupled by T-bet and eomesodermin
    • This publication offers new insight into how the transcriptional master regulators T-bet and Eomes redundantly determine not only effector lineage commitment but also survival of committed lineages. Mice that have compound mutations in the genes that encode these transcription factors were nearly devoid of several IL-15-dependent lineages. T-bet and Eomes were found to be responsible for enhanced expression of the IL-2/IL-15 receptor β-chain.
    • + T cell fate coupled by T-bet and eomesodermin. Nat Immunol 6 (2005) 1236-1244. This publication offers new insight into how the transcriptional master regulators T-bet and Eomes redundantly determine not only effector lineage commitment but also survival of committed lineages. Mice that have compound mutations in the genes that encode these transcription factors were nearly devoid of several IL-15-dependent lineages. T-bet and Eomes were found to be responsible for enhanced expression of the IL-2/IL-15 receptor β-chain.
    • (2005) Nat Immunol , vol.6 , pp. 1236-1244
    • Intlekofer, A.M.1    Takemoto, N.2    Wherry, E.J.3    Longworth, S.A.4    Northrup, J.T.5    Palanivel, V.R.6    Mullen, A.C.7    Gasink, C.R.8    Kaech, S.M.9    Miller, J.D.10
  • 46
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 47
    • 31144450253 scopus 로고    scopus 로고
    • Human naïve CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T Cell Factor-1) following antigen encounter in vitro and in vivo
    • Willinger T., Freeman T., Herbert M., Hasegawa H., McMichael A.J., and Callan M.F. Human naïve CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T Cell Factor-1) following antigen encounter in vitro and in vivo. J Immunol 176 (2006) 1439-1446
    • (2006) J Immunol , vol.176 , pp. 1439-1446
    • Willinger, T.1    Freeman, T.2    Herbert, M.3    Hasegawa, H.4    McMichael, A.J.5    Callan, M.F.6
  • 50
    • 0035348175 scopus 로고    scopus 로고
    • + T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
    • + T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol 2 (2001) 415-422
    • (2001) Nat Immunol , vol.2 , pp. 415-422
    • Kaech, S.M.1    Ahmed, R.2
  • 51
    • 0035348246 scopus 로고    scopus 로고
    • Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • van Stipdonk M.J., Lemmens E.E., and Schoenberger S.P. Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol 2 (2001) 423-429
    • (2001) Nat Immunol , vol.2 , pp. 423-429
    • van Stipdonk, M.J.1    Lemmens, E.E.2    Schoenberger, S.P.3
  • 53
    • 0032143421 scopus 로고    scopus 로고
    • Mice with a fluorescent marker for interleukin 2 gene activation
    • Naramura M., Hu R.J., and Gu H. Mice with a fluorescent marker for interleukin 2 gene activation. Immunity 9 (1998) 209-216
    • (1998) Immunity , vol.9 , pp. 209-216
    • Naramura, M.1    Hu, R.J.2    Gu, H.3
  • 54
    • 17044410174 scopus 로고    scopus 로고
    • Signals from CD28 induce stable epigenetic modification of the IL-2 promoter
    • Thomas R.M., Gao L., and Wells A.D. Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol 174 (2005) 4639-4646
    • (2005) J Immunol , vol.174 , pp. 4639-4646
    • Thomas, R.M.1    Gao, L.2    Wells, A.D.3
  • 56
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 57
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells
    • Weiner H.L. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol Rev 182 (2001) 207-214
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 59
    • 0031859293 scopus 로고    scopus 로고
    • In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines
    • Cerwenka A., Carter L.L., Reome J.B., Swain S.L., and Dutton R.W. In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. J Immunol 161 (1998) 97-105
    • (1998) J Immunol , vol.161 , pp. 97-105
    • Cerwenka, A.1    Carter, L.L.2    Reome, J.B.3    Swain, S.L.4    Dutton, R.W.5
  • 61
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns K.S., and Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3 (2003) 269-279
    • (2003) Nat Rev Immunol , vol.3 , pp. 269-279
    • Schluns, K.S.1    Lefrancois, L.2
  • 65
    • 23444445913 scopus 로고    scopus 로고
    • IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
    • •].
    • •].
    • (2005) J Immunol , vol.175 , pp. 2261-2269
    • Li, Y.1    Bleakley, M.2    Yee, C.3
  • 66
    • 17844402285 scopus 로고    scopus 로고
    • TGF-β 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells
    • Ahmadzadeh M., and Rosenberg S.A. TGF-β 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells. J Immunol 174 (2005) 5215-5223
    • (2005) J Immunol , vol.174 , pp. 5215-5223
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 67
    • 17844381070 scopus 로고    scopus 로고
    • + T cell primary responses and inhibition of secondary responses
    • + T cell primary responses and inhibition of secondary responses. J Immunol 174 (2005) 5382-5389
    • (2005) J Immunol , vol.174 , pp. 5382-5389
    • Kang, S.S.1    Allen, P.M.2
  • 70
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • This work shows that it might be possible in one model (lymphocytic choriomeningitis virus) to reverse T-cell 'exhaustion' by blocking negative regulatory signals sent by way of PD-1. These findings vividly illustrate the kind of maneuver that might enable vaccines and immunotherapies for cancer and chronic infectious disease to overcome effector exhaustion associated with terminal differentiation.
    • Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., Freeman G.J., and Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439 (2006) 682-687. This work shows that it might be possible in one model (lymphocytic choriomeningitis virus) to reverse T-cell 'exhaustion' by blocking negative regulatory signals sent by way of PD-1. These findings vividly illustrate the kind of maneuver that might enable vaccines and immunotherapies for cancer and chronic infectious disease to overcome effector exhaustion associated with terminal differentiation.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masopust, D.3    Zhu, B.4    Allison, J.P.5    Sharpe, A.H.6    Freeman, G.J.7    Ahmed, R.8
  • 71
    • 5344280456 scopus 로고    scopus 로고
    • MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation
    • This study describes how the manipulation of key transcriptional factors might be used to reprogram the lymphocyte fate. The authors were able to de-differentiate plasma cells into less differentiated B cells by forcing the expression of BCL-6 and MTA-3.
    • Fujita N., Jaye D.L., Geigerman C., Akyildiz A., Mooney M.R., Boss J.M., and Wade P.A. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119 (2004) 75-86. This study describes how the manipulation of key transcriptional factors might be used to reprogram the lymphocyte fate. The authors were able to de-differentiate plasma cells into less differentiated B cells by forcing the expression of BCL-6 and MTA-3.
    • (2004) Cell , vol.119 , pp. 75-86
    • Fujita, N.1    Jaye, D.L.2    Geigerman, C.3    Akyildiz, A.4    Mooney, M.R.5    Boss, J.M.6    Wade, P.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.