Extract isolated from Angelica hirsutiflora with insulin secretagogue activity

Journal of Ethnopharmacology

Volumn 123, Issue 2, 2009, Pages 208-212

  Leu, Yann Lii ^a   Chen, Ya Wen ^b,c   Yang, Ching Yao ^d   Huang, Chun Fa ^b   Lin, Guan Hong ^a   Tsai, Keh Sung ^b   Yang, Rong Sen ^b   Liu, Shing Hwa ^b,d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cells; Angelica hirsutiflora; Diabetes; Insulin secretagogue; Islets

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGELICA HIRSUTIFLORA EXTRACT; ANTIDIABETIC AGENT; CALCIUM; GLIBENCLAMIDE; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; STARCH; UNCLASSIFIED DRUG;

ANGELICA; ANGELICA HIRSUTIFLORA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG DOSE COMPARISON; DRUG ISOLATION; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID DIET; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION;

ANGELICA; ANIMALS; BLOOD GLUCOSE; CALCIUM; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, INBRED ICR; PLANT EXTRACTS; TAIWAN;

APIACEAE; MUS;

EID: 67349091433     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.03.027     Document Type: Article

References (20)

1. Arnette D., Gibson T.B., Lawrence M.C., January B., Khoo S., McGlynn K., Vanderbilt C.A., and Cobb M.H. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. Journal of Biological Chemistry 278 (2003) 32517-32525
2. Benes C., Roisin M.P., Van Tan H., Creuzet C., Miyazaki J., and Fagard R. Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line. Journal of Biological Chemistry 273 (1998) 15507-15513
3. Benes C., Poitout V., Marie J.C., Martin-Perez J., Roisin M.P., and Fagard R. Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription. Biochemical Journal 340 (1999) 219-225
4. Bensky D., Gamble A., and Kaptchuk T. Chinese Herbal Medicine: Materia Medica, Revised edition (1993), Eastland Press, Seattle pp. 34-35
5. Briaud I., Lingohr M.K., Dickson L.M., Wrede C.E., and Rhodes C.J. Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells. Diabetes 52 (2003) 974-983
6. Carroll M.F., Izard A., Riboni K., Burge M.R., and Schade D.S. Control of postprandial hyperglycemia: optimal use of short-acting insulin secretagogues. Diabetes Care 25 (2002) 2147-2152
7. Chen Y.W., Huang C.F., Tsai K.S., Yang R.S., Yen C.C., Yang C.Y., Lin-Shiau S.Y., and Liu S.H. The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo. Diabetes 55 (2006) 1614-1624
8. Enoki T., Ohnogi H., Nagamine K., Kudo Y., Sugiyama K., Tanabe M., Kobayashi E., Sagawa H., and Kato I. Antidiabetic activities of chalcones isolated from a Japanese herb, Angelica keiskei. Journal of Agricultural and Food Chemistry 55 (2007) 6013-6017
9. Garber A.J. The importance of early insulin secretion and its impact on glycaemic regulation. International Journal of Obesity and Relative Metabolic Disorders 24 (2000) S32-37
10. Giorgino F., Laviola L., Leonardini A., and Natalicchio A. GLP-1 a new approach for type 2 diabetes therapy. Diabetes Research and Clinical Practice 74 (2006) S152-155
11. Henquin J.C. Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues. Diabetes 53 (2004) S48-58
12. Kang S.Y., Lee K.Y., Sung S.H., and Kim Y.C. Four new neuroprotective dihydropyranocoumarins from Angelica gigas. Journal of Natural Products 68 (2005) 56-59
13. Krentz A.J., and Bailey C.J. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65 (2005) 385-411
14. Lacroix A., and Hontela A. Role of calcium channels in cadmium-induced disruption of cortisol synthesis in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology 144 (2006) 141-147
15. Lee Y.Y., Lee S., Jin J.L., and Yun-Choi H.S. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of Pharmacological Research 26 (2003) 723-726
16. Li W.L., Zheng H.C., Bukuru J., and De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology 92 (2004) 1-21
17. Longuet C., Broca C., Costes S., Hani E.H., Bataille D., and Dalle S. Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans. Endocrinology 146 (2005) 643-654
18. 2+ channels. The Journal of Membrane Biology 200 (2004) 57-66
19. Oh H., Lee H.S., Kim T., Chai K.Y., Chung H.T., Kwon T.O., Jun J.Y., Jeong O.S., Kim Y.C., and Yun Y.G. Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. Planta Medica 68 (2002) 463-464
20. Schaeffer H.J., and Weber M.J. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Molecular and Cellular Biology 19 (1999) 2435-2444