Scutellaria baicalensis: Enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic wistar rats

American Journal of Chinese Medicine

Volumn 36, Issue 3, 2008, Pages 517-540

  Waisundara, Viduranga Y ^a   Hsu, Annie ^b   Huang, Dejian ^a   Tan, Benny Kwong Huat ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antioxidant enzymes; Diabetes; Metformin; Oxidative stress; Streptozotocin

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; METFORMIN; SCUTELLARIA BAICALENSIS EXTRACT; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID LIVER LEVEL; MALE; MONOTHERAPY; NONHUMAN; OXIDATIVE STRESS; RAT; SCUTELLARIA BAICALENSIS; STREPTOZOCIN DIABETES; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; HYPOGLYCEMIC AGENTS; INSULIN; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; METFORMIN; OXIDATIVE STRESS; PANCREAS; PLANT EXTRACTS; RATS; RATS, WISTAR; SCUTELLARIA BAICALENSIS; STREPTOZOCIN;

EID: 44949212949     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X08005953     Document Type: Article

References (53)

1. Bailey, C.J. and R.C. Turner. Metformin. N. Engl. J. Med. 334: 574-579, 1996.
2. Brown, J.B., K.L. Pedula and K.H. Summers. Diabetic retinopathy. Diabetes Care 26: 2631-2642, 2003.
3. Brownlee, A Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
4. Brownlee, M. The pathobiology of diabetes: A unified mechanism (Banting lecture). Diabetes 54: 1615-1625, 2005.
5. Buchanan, T.A. (How) can we prevent type II diabetes? Diabetes 56: 1502-1507, 2007.
6. Cheng, C. and D.W. Zochodne. Sensory neurons with activated, caspase-3 survive long-term experimental diabetes. Diabetes 52: 2363-2371, 2003.
7. Cheng, J.T., C.C. Huang, I.M. Liu, T.F. Tzeng and C.J. Chang. Novel mechanism f, or plasma glucose-lowering action for metformin in streptozotocin-induced diabetic rats. Diabetes 55: 819-825, 2006.
8. Clark, R.J., P.M. McDonough, E. Swanson, S.U. Trost, M. Suzuki, M. Fukuda and W.H. Dillmann. Diabetes and the accompanying hyperglycemia impair cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation. J. Biol. Chem. 278: 44230-44237, 2003.
9. Cnop, M.N., N. Welsh, J. Jean-Christope, A. Jorns, S. Lenzen and D. Eizirk. Mechanisms of β-cell death in type I and.type II diabetes. Diabetes 54(Suppl. 2): S97-S107, 2005.
10. Coppey, L.J., J.S. Gellett, E.P. Davidson, I.A. Dunlap, D.D. Lund and M.A. Yorek. Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes 50: 1927-1937, 2001.
11. Davies, K.J.A. Oxidative stress, antioxidant defenses. and damage removal, repair, and replacement systems. IUBMB Life 50: 279-289. 2000.
12. Du, X.L., D. Edelstein, L. Rossetti, I.G. Fantus. H. Goldberg. F. Ziyadeh. J. Wu and M. Brownlee. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor- 1 expression by increasing Sp1 glycosylation. Proc. Natl. Acad. Sci. USA 97: 12222-12226. 2000.
13. Eizirik, D.L. and T.A, Mandrup-Poulsen. Choice of death: The signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44: 2115-2133, 2001.
14. Evans, J.L.. B.A. Maddux and I.D. Goldfine. Antioxidants in diabetic complications and insulin resistance. In: Raz et al. (eds.) Diabeles: From Research to Diagnosis and Treatment. Martin Dunitz. London, 2003, pp. 479-496.
15. Festa, A., K. Williams, R. D'Agostino, L.E. Wagenknecht and S.M. Haffner. The natural course of β-cell function in non-diabetic and diabetic individuals: The insulin resistance atherosclerosis study. Diabetes 55: 1114-1120, 2006.
16. Finkel, T. Oxidants, oxidative stress and the biology of aging. Nature 408: 239-248, 2000.
17. Gao, Z.H., K.X. Huang and H.B. Xu. Protective effects of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY-5Y cells. Pharmacol. Res. 43: 174-178, 2001.
18. Garofano, A., P. Czernichow and B. Bréant. Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period. Diabetologia 42: 711-718, 1999.
19. Garofano, A., P. Czernichow and B. Bréant. Impaired beta-cell regeneration in perinatally malnourished rats: A study with STZ. FASEB J. 14: 2611-2617, 2000.
20. Gershell, L. Type II diabetes market. Nat. Rev. Drug Discov. 4: 367-368, 2005.
21. Grundy, S. Drug therapy of the metabolic syndrome: Minimizing the emerging crisis in polypharmacy. Nat. Rev. Drug Discov. 5: 295-309, 2006.
22. Guven, A., O. Yavuz, M. Cam, F. Ercan, N. Bukan, C. Comunuglu and F. Gokce. Effects of melatonin in streptozotocin-induced diabetic liver injury in rats. Acta Histochem. 108: 85-93, 2006.
23. Halliwell, B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18: 685-716, 2001
24. Hannon-Fletcher, M.P.A., M.J. O'Kane, K.W. Moles, C. Weatherup, C.R. Barnett and Y.A. Barnett Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects. Mutat. Res. 460: 53-60, 2000.
25. Hay, K.X., V.Y. Waisundara, Z. Yong, M.Y. Han and D.J. Huang. CdSe nanocrystals as hydroperoxide scavengers: A new approach to highly sensitive quantification of lipid hydroperoxides. Small 3: 290-20, 2007.
26. Ho, J.H., D.O. Kim, J.C. Soo, H.S. Dong and Y.L. Chang. Potent inhibitory effect of flavonoids from Scutellaria baicalensis on amyloid β protein-induced neurotoxicity. J. Agric. Food Chem. 52: 4128-4132, 2004.
27. Hoeldtke, R.D., K.D. Bryner, D.R. McNeill, G.R. Hobbs, J.E. Riggs, S.S. Warehime, I. Christie, G. Ganser and K. Van Dyke. Nitrosative stress, uric acid, and peripheral nerve function in early type I diabetes. Diabetes 51: 2817-2825, 2002.
28. Hovind, P., L. Tarnow, K. Rossing, P. Rossing, S. Eising. N. Larsen, C. Binder and H.H. Parving. Decreasing incidence of severe diabetic microangiopathy in type I diabetes. Diabetes Care 26, 1258-1264, 2003.
29. Huang, D.J., B.X. Ou, M. Hampsch-Woodill, J.A. Flanagan and R.L. Prior. High-throughput assay of Oxygen Radical Absorbance Capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J. Agric. Food Chem. 50: 4437-4444. 2002.
30. Inzucchi, S.E. Oral antihyperglycemic therapy for type 2 diabetes. J. Am. Med. Assoc. 287: 360-372, 2002.
31. Kahn, S.E.. R.L. Hull and K.M. Utszchneider Mechanisms linking obesity to insulin resistance and type II diabetes. Nature 444: 840-846. 2006.
32. Ketsawatskul. U. M. Whiteman and B. Halliwell. A re-evaluaiion of the peroxynitrite scavenging activity of some dietary phenolics. Biochem. Biophys. Res. Commun. 279: 692-699. 2000.
33. Ko, K.M., D.H.F. Mak, P.Y. Chiu and M.K.T. Poon. Pharmacological basis of yang-invigoration in Chinese medicine. Trends. Pharm. Sci. 25: 3-6. 2004.
34. Koya, D.. M. Haneda, H. Nakagawa. K. Isshiki, H. Sato. S. Maeda. T. Sugimoto, H. Yasuda. A. Kashiwagi, D.K. Ways, G.L. King and R. Kikkawa. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice - a rodent model for type II diabetes. FASEB J. 14: 439-447, 2000.
35. Lee, J.M. and J.D. Peuler. A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontaneously hypertensive rats. Life Sci. 69: 1085-1092, 2001.
36. Nordwall, M., M. Bojestig, H.J. Arnqvist and J. Ludvigsson. Declining incidence of severe retinopathy and persisting decrease of nephropathy in an unselected population of type I diabetes: The Linköping diabetes complications study. Diabetologia 46: 1266-1272, 2004.
37. Obrosova, I.G., J.G. Mabley, Z. Zsengeller, T. Charniauskaya, O.I. Abatan, J.T. Groves and C. Szabo. Roles for nitrosative stress in diabetic neuropathy: Evidence from studies with a peroxynitrite decomposition catalyst. FASEB J. 20: 1-21, 2004.
38. Onaran, I., G.S. Guven, S.B. Ozdas, G. Kanigur, and S. Vehid. Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress. Mutat. Res. 611: 1-8. 2006.
39. Ou, BX, D.J. Huang, M. Hampsch-Woodill and J. Flanagan. When east meets west: The relationship. between when east Teets west: the relationship between yin-yang and antioxidation-oxidation. FASEB J. 17: 127-129, 2003.
40. Packer, L. Oxidative stress and antioxidants: The antioxidant network, alpha-lipoic acid and diabetes. In: Packer et al. (eds.) Antioxidants in Diabetes Managment. Marcel Dekker, New York, 2000, 1-16.
41. Reddy, S. The preventive polypill - much promise, insufficient evidence. N. Engl. J. Med. 356: 212, 2007.
42. Rhodes, C. Type II diabetes: A matter of β-cell life or death? Science 307: 380-384, 2005.
43. Schinella, G.R., H.A. Tournier, J.M. Prieto, P. Mordujovich de Buschiazzo and J.L. Rios. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 70: 1023-1033, 2002.
44. Sheetz. M. and G. King. Molecular understanding of hyperglycemia's adverse effects for diabetes complications. J. Am. Med. Assoc. 288: 2579-2588, 2007.
45. Soriano, F.G., L. Virag, P. Jagtap, E. Szabo. J.G. Mabley, L. Liaudet, A. Marton, D.G. Hoyt, G.K.M. Kanneganti, A. Salzman, G.J. Southan and C. Szabo. Diabetic endothelial dysfunction: The role of poly (ADP-ribose) polymers activation. Nat. Med. 7: 108-113, 2001.
46. Suckow, M.A., C.L. Franklin and S.H. Weisbroth. The Laboratorv Rat Elsevier Inc., Burlington, MA, 2006, pp. 132-133.
47. Tang, S.Y., M. Whiteman, Z.F. Peng, A. Jenner, E.L. Yong and B. Halliwell. Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional Chinese medicines. Free Radic. Biol. Med. 36: 1575-1587, 2004.
48. Taylor. M.D. Causation of diabetes type II - the Gordian knot unravels. N. Engl. J. Med. 350: 639-641, 2003.
49. The Diabetes Control and Complication Trial (DCTT)/Epidemiology of Diabetes Interventions and Complications Researh Group. Retinopathy and nephropathy in patients with type I diabetes four years after a trial of intensive therapy. N. Engl. J. Med. 342: 381-389. 2000.
50. The Diabetes Control and Complication Trial Research Group (DCTT)/ Epidemiology of Diabetes Interventions and Complications Research Group. Long-term defects of diabetes and its treatment on cognitive function. N. Engl. J Med. 356: 1842-1852, 2007.
51. Tuomilehto, J. and N. Wareham. Glucose lowering and diabetes prevention - are they the same? Lancet 368: 1218-1219, 2006.
52. Uusitupa, M., V. Lindi, A. Louheranta, T. Salopuro, J. Lindstrom and J. Tuomilehto. Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish diabetes prevention study. Diabetes 52: 2532-2538, 2003.
53. Zhao, Y.L., H.L. Li, Z.H. Gao, Y.F. Gong and H.B. Xu. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-hydrogen peroxide-induced liver injury. Eur. J. Pharmacol. 536: 192-199, 2006.