-
2
-
-
34548694962
-
Innate recognition of viruses
-
Pichlmair A., and Reis e Sousa C. Innate recognition of viruses. Immunity 27 (2007) 370-383
-
(2007)
Immunity
, vol.27
, pp. 370-383
-
-
Pichlmair, A.1
Reis e Sousa, C.2
-
4
-
-
34548031870
-
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
-
Fernandes-Alnemri T., Wu J., Yu J.W., Datta P., Miller B., Jankowski W., Rosenberg S., Zhang J., and Alnemri E.S. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14 (2007) 1590-1604
-
(2007)
Cell Death Differ
, vol.14
, pp. 1590-1604
-
-
Fernandes-Alnemri, T.1
Wu, J.2
Yu, J.W.3
Datta, P.4
Miller, B.5
Jankowski, W.6
Rosenberg, S.7
Zhang, J.8
Alnemri, E.S.9
-
5
-
-
33749576792
-
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
-
Fink S.L., and Cookson B.T. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 8 (2006) 1812-1825
-
(2006)
Cell Microbiol
, vol.8
, pp. 1812-1825
-
-
Fink, S.L.1
Cookson, B.T.2
-
6
-
-
34548386663
-
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC
-
Willingham S.B., Bergstralh D.T., O'Connor W., Morrison A.C., Taxman D.J., Duncan J.A., Barnoy S., Venkatesan M.M., Flavell R.A., Deshmukh M., et al. Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe 2 (2007) 147-159
-
(2007)
Cell Host Microbe
, vol.2
, pp. 147-159
-
-
Willingham, S.B.1
Bergstralh, D.T.2
O'Connor, W.3
Morrison, A.C.4
Taxman, D.J.5
Duncan, J.A.6
Barnoy, S.7
Venkatesan, M.M.8
Flavell, R.A.9
Deshmukh, M.10
-
7
-
-
40449140937
-
The NLR gene family: a standard nomenclature
-
Ting J.P., Lovering R.C., Alnemri E.S., Bertin J., Boss J.M., Davis B.K., Flavell R.A., Girardin S.E., Godzik A., Harton J.A., et al. The NLR gene family: a standard nomenclature. Immunity 28 (2008) 285-287
-
(2008)
Immunity
, vol.28
, pp. 285-287
-
-
Ting, J.P.1
Lovering, R.C.2
Alnemri, E.S.3
Bertin, J.4
Boss, J.M.5
Davis, B.K.6
Flavell, R.A.7
Girardin, S.E.8
Godzik, A.9
Harton, J.A.10
-
8
-
-
0036671894
-
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon F., Burns K., and Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10 (2002) 417-426
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
9
-
-
47249089097
-
IL-1, IL-18, and IL-33 families of cytokines
-
Arend W.P., Palmer G., and Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223 (2008) 20-38
-
(2008)
Immunol Rev
, vol.223
, pp. 20-38
-
-
Arend, W.P.1
Palmer, G.2
Gabay, C.3
-
10
-
-
67049158193
-
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
-
This study argues that pro-IL-33 is active and that cleavage by casapse-1 results in loss of function.
-
Cayrol C., and Girard J.P. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1. Proc Natl Acad Sci USA 106 (2009) 9021-9026. This study argues that pro-IL-33 is active and that cleavage by casapse-1 results in loss of function.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9021-9026
-
-
Cayrol, C.1
Girard, J.P.2
-
11
-
-
68249137289
-
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
-
This study also argues that pro-IL-33 is active, but that cleavage by non-caspase-1 caspases results in loss of function.
-
Luthi A.U., Cullen S.P., McNeela E.A., Duriez P.J., Afonina I.S., Sheridan C., Brumatti G., Taylor R.C., Kersse K., Vandenabeele P., et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 31 (2009) 84-98. This study also argues that pro-IL-33 is active, but that cleavage by non-caspase-1 caspases results in loss of function.
-
(2009)
Immunity
, vol.31
, pp. 84-98
-
-
Luthi, A.U.1
Cullen, S.P.2
McNeela, E.A.3
Duriez, P.J.4
Afonina, I.S.5
Sheridan, C.6
Brumatti, G.7
Taylor, R.C.8
Kersse, K.9
Vandenabeele, P.10
-
12
-
-
39749084641
-
Active caspase-1 is a regulator of unconventional protein secretion
-
Using mass spectrometry-based iTRAQ, this study identifies numerous secreted but leaderless products from keratinocytes that require casapse-1.
-
Keller M., Ruegg A., Werner S., and Beer H.D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 132 (2008) 818-831. Using mass spectrometry-based iTRAQ, this study identifies numerous secreted but leaderless products from keratinocytes that require casapse-1.
-
(2008)
Cell
, vol.132
, pp. 818-831
-
-
Keller, M.1
Ruegg, A.2
Werner, S.3
Beer, H.D.4
-
13
-
-
58149287750
-
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
-
Using LC-MS/MS, this proteomics screen identified cleavage products of caspase-1 in macrophage cell lysates, with a particular focus on caspase-7.
-
Lamkanfi M., Kanneganti T.D., Van Damme P., Vanden Berghe T., Vanoverberghe I., Vandekerckhove J., Vandenabeele P., Gevaert K., and Nunez G. Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics 7 (2008) 2350-2363. Using LC-MS/MS, this proteomics screen identified cleavage products of caspase-1 in macrophage cell lysates, with a particular focus on caspase-7.
-
(2008)
Mol Cell Proteomics
, vol.7
, pp. 2350-2363
-
-
Lamkanfi, M.1
Kanneganti, T.D.2
Van Damme, P.3
Vanden Berghe, T.4
Vanoverberghe, I.5
Vandekerckhove, J.6
Vandenabeele, P.7
Gevaert, K.8
Nunez, G.9
-
14
-
-
33846024748
-
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
-
Amer A., Franchi L., Kanneganti T.D., Body-Malapel M., Ozoren N., Brady G., Meshinchi S., Jagirdar R., Gewirtz A., Akira S., et al. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 281 (2006) 35217-35223
-
(2006)
J Biol Chem
, vol.281
, pp. 35217-35223
-
-
Amer, A.1
Franchi, L.2
Kanneganti, T.D.3
Body-Malapel, M.4
Ozoren, N.5
Brady, G.6
Meshinchi, S.7
Jagirdar, R.8
Gewirtz, A.9
Akira, S.10
-
15
-
-
31744441475
-
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden E.D., and Dietrich W.F. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38 (2006) 240-244
-
(2006)
Nat Genet
, vol.38
, pp. 240-244
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
16
-
-
36248940773
-
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
-
Franchi L., Stoolman J., Kanneganti T.D., Verma A., Ramphal R., and Nunez G. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol 37 (2007) 3030-3039
-
(2007)
Eur J Immunol
, vol.37
, pp. 3030-3039
-
-
Franchi, L.1
Stoolman, J.2
Kanneganti, T.D.3
Verma, A.4
Ramphal, R.5
Nunez, G.6
-
17
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
-
Miao E.A., Alpuche-Aranda C.M., Dors M., Clark A.E., Bader M.W., Miller S.I., and Aderem A. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7 (2006) 569-575
-
(2006)
Nat Immunol
, vol.7
, pp. 569-575
-
-
Miao, E.A.1
Alpuche-Aranda, C.M.2
Dors, M.3
Clark, A.E.4
Bader, M.W.5
Miller, S.I.6
Aderem, A.7
-
18
-
-
62449101446
-
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages
-
Nour A.M., Yeung Y.G., Santambrogio L., Boyden E.D., Stanley E.R., and Brojatsch J. Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect Immun 77 (2009) 1262-1271
-
(2009)
Infect Immun
, vol.77
, pp. 1262-1271
-
-
Nour, A.M.1
Yeung, Y.G.2
Santambrogio, L.3
Boyden, E.D.4
Stanley, E.R.5
Brojatsch, J.6
-
19
-
-
32944462834
-
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
-
Kanneganti T.D., Ozoren N., Body-Malapel M., Amer A., Park J.H., Franchi L., Whitfield J., Barchet W., Colonna M., Vandenabeele P., et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440 (2006) 233-236
-
(2006)
Nature
, vol.440
, pp. 233-236
-
-
Kanneganti, T.D.1
Ozoren, N.2
Body-Malapel, M.3
Amer, A.4
Park, J.H.5
Franchi, L.6
Whitfield, J.7
Barchet, W.8
Colonna, M.9
Vandenabeele, P.10
-
20
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan S., Weiss D.S., Newton K., McBride J., O'Rourke K., Roose-Girma M., Lee W.P., Weinrauch Y., Monack D.M., and Dixit V.M. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440 (2006) 228-232
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
21
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon F., Petrilli V., Mayor A., Tardivel A., and Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006) 237-241
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
22
-
-
33644985564
-
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
-
Sutterwala F.S., Ogura Y., Szczepanik M., Lara-Tejero M., Lichtenberger G.S., Grant E.P., Bertin J., Coyle A.J., Galan J.E., Askenase P.W., et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24 (2006) 317-327
-
(2006)
Immunity
, vol.24
, pp. 317-327
-
-
Sutterwala, F.S.1
Ogura, Y.2
Szczepanik, M.3
Lara-Tejero, M.4
Lichtenberger, G.S.5
Grant, E.P.6
Bertin, J.7
Coyle, A.J.8
Galan, J.E.9
Askenase, P.W.10
-
23
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C., Petrilli V., Van Bruggen R., Steele C., Mossman B.T., and Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320 (2008) 674-677
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
24
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. While this study did not evaluate the in vivo effect of NLRP3-deficiency upon alum immunization, it did look at one potential mechanism of NLRP3 activation resulting from lysosomal disruption following alum phagocytosis.
-
Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., Fitzgerald K.A., and Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9 (2008) 847-856. One of seven papers describing the activation of the NLRP3 inflammasome by alum. While this study did not evaluate the in vivo effect of NLRP3-deficiency upon alum immunization, it did look at one potential mechanism of NLRP3 activation resulting from lysosomal disruption following alum phagocytosis.
-
(2008)
Nat Immunol
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
25
-
-
34548027736
-
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
-
Petrilli V., Papin S., Dostert C., Mayor A., Martinon F., and Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14 (2007) 1583-1589
-
(2007)
Cell Death Differ
, vol.14
, pp. 1583-1589
-
-
Petrilli, V.1
Papin, S.2
Dostert, C.3
Mayor, A.4
Martinon, F.5
Tschopp, J.6
-
26
-
-
70249138036
-
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
An important study clarifying the role of 'signal 1' in licensing of the inflammasome by multiple NF-κB activators.
-
Bauernfeind F.G., Horvath G., Stutz A., Alnemri E.S., MacDonald K., Speert D., Fernandes-Alnemri T., Wu J., Monks B.G., Fitzgerald K.A., et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183 (2009) 787-791. An important study clarifying the role of 'signal 1' in licensing of the inflammasome by multiple NF-κB activators.
-
(2009)
J Immunol
, vol.183
, pp. 787-791
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
Alnemri, E.S.4
MacDonald, K.5
Speert, D.6
Fernandes-Alnemri, T.7
Wu, J.8
Monks, B.G.9
Fitzgerald, K.A.10
-
27
-
-
70249110860
-
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
-
This paper also maintains that 'signal 1' can come from numerous stimuli including cytokines and IL-1beta.
-
Franchi L., Eigenbrod T., and Nunez G. Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183 (2009) 792-796. This paper also maintains that 'signal 1' can come from numerous stimuli including cytokines and IL-1beta.
-
(2009)
J Immunol
, vol.183
, pp. 792-796
-
-
Franchi, L.1
Eigenbrod, T.2
Nunez, G.3
-
28
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi K.S., Chamaillard M., Ogura Y., Henegariu O., Inohara N., Nunez G., and Flavell R.A. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 (2005) 731-734
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
Henegariu, O.4
Inohara, N.5
Nunez, G.6
Flavell, R.A.7
-
29
-
-
34247254780
-
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity
-
Fritz J.H., Le Bourhis L., Sellge G., Magalhaes J.G., Fsihi H., Kufer T.A., Collins C., Viala J., Ferrero R.L., Girardin S.E., et al. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26 (2007) 445-459
-
(2007)
Immunity
, vol.26
, pp. 445-459
-
-
Fritz, J.H.1
Le Bourhis, L.2
Sellge, G.3
Magalhaes, J.G.4
Fsihi, H.5
Kufer, T.A.6
Collins, C.7
Viala, J.8
Ferrero, R.L.9
Girardin, S.E.10
-
30
-
-
44449165058
-
Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization
-
Watanabe H., Gehrke S., Contassot E., Roques S., Tschopp J., Friedmann P.S., French L.E., and Gaide O. Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol 180 (2008) 5826-5832
-
(2008)
J Immunol
, vol.180
, pp. 5826-5832
-
-
Watanabe, H.1
Gehrke, S.2
Contassot, E.3
Roques, S.4
Tschopp, J.5
Friedmann, P.S.6
French, L.E.7
Gaide, O.8
-
31
-
-
69949175486
-
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors
-
Babelova A., Moreth K., Tsalastra-Greul W., Zeng-Brouwers J., Eickelberg O., Young M.F., Bruckner P., Pfeilschifter J., Schaefer R.M., Grone H.J., et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284 (2009) 24035-24048
-
(2009)
J Biol Chem
, vol.284
, pp. 24035-24048
-
-
Babelova, A.1
Moreth, K.2
Tsalastra-Greul, W.3
Zeng-Brouwers, J.4
Eickelberg, O.5
Young, M.F.6
Bruckner, P.7
Pfeilschifter, J.8
Schaefer, R.M.9
Grone, H.J.10
-
32
-
-
73949118676
-
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
-
Iyer S., Pulskensc W., Sadler J., Butter L., Teske G., Ulland T., Eisenbarth S., Florquin S., Flavell R., Leemans J., et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. PNAS 106 (2009) 20388-20393
-
(2009)
PNAS
, vol.106
, pp. 20388-20393
-
-
Iyer, S.1
Pulskensc, W.2
Sadler, J.3
Butter, L.4
Teske, G.5
Ulland, T.6
Eisenbarth, S.7
Florquin, S.8
Flavell, R.9
Leemans, J.10
-
33
-
-
68149170478
-
Cutting edge: necrosis activates the NLRP3 inflammasome
-
Li H., Ambade A., and Re F. Cutting edge: necrosis activates the NLRP3 inflammasome. J Immunol 183 (2009) 1528-1532
-
(2009)
J Immunol
, vol.183
, pp. 1528-1532
-
-
Li, H.1
Ambade, A.2
Re, F.3
-
34
-
-
67649831360
-
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury
-
Yamasaki K., Muto J., Taylor K.R., Cogen A.L., Audish D., Bertin J., Grant E.P., Coyle A.J., Misaghi A., Hoffman H.M., et al. NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem 284 (2009) 12762-12771
-
(2009)
J Biol Chem
, vol.284
, pp. 12762-12771
-
-
Yamasaki, K.1
Muto, J.2
Taylor, K.R.3
Cogen, A.L.4
Audish, D.5
Bertin, J.6
Grant, E.P.7
Coyle, A.J.8
Misaghi, A.9
Hoffman, H.M.10
-
35
-
-
70350569295
-
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
-
A thorough study of the adjuvant effect of chemotherapeutic-treated tumor cells. This paper argues that ATP released by dying cells, acting through P2x7R and HMGB1, activates the NLRP3 inflammasome thereby initiating adaptive anti-tumor immunity.
-
Ghiringhelli F., Apetoh L., Tesniere A., Aymeric L., Ma Y., Ortiz C., Vermaelen K., Panaretakis T., Mignot G., Ullrich E., et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 15 (2009) 1170-1178. A thorough study of the adjuvant effect of chemotherapeutic-treated tumor cells. This paper argues that ATP released by dying cells, acting through P2x7R and HMGB1, activates the NLRP3 inflammasome thereby initiating adaptive anti-tumor immunity.
-
(2009)
Nat Med
, vol.15
, pp. 1170-1178
-
-
Ghiringhelli, F.1
Apetoh, L.2
Tesniere, A.3
Aymeric, L.4
Ma, Y.5
Ortiz, C.6
Vermaelen, K.7
Panaretakis, T.8
Mignot, G.9
Ullrich, E.10
-
36
-
-
0141998606
-
Molecular identification of a danger signal that alerts the immune system to dying cells
-
Shi Y., Evans J.E., and Rock K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425 (2003) 516-521
-
(2003)
Nature
, vol.425
, pp. 516-521
-
-
Shi, Y.1
Evans, J.E.2
Rock, K.L.3
-
37
-
-
45749111446
-
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. Our study found a reduced T and B cell response in vivo in an OVA/alum asthma model.
-
Eisenbarth S.C., Colegio O.R., O'Connor W., Sutterwala F.S., and Flavell R.A. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453 (2008) 1122-1126. One of seven papers describing the activation of the NLRP3 inflammasome by alum. Our study found a reduced T and B cell response in vivo in an OVA/alum asthma model.
-
(2008)
Nature
, vol.453
, pp. 1122-1126
-
-
Eisenbarth, S.C.1
Colegio, O.R.2
O'Connor, W.3
Sutterwala, F.S.4
Flavell, R.A.5
-
38
-
-
50849112477
-
The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. This study failed to see a difference in antibody responses to antigens injected with alum in vivo in NLRP3-deficient mice.
-
Franchi L., and Nunez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 38 (2008) 2085-2089. One of seven papers describing the activation of the NLRP3 inflammasome by alum. This study failed to see a difference in antibody responses to antigens injected with alum in vivo in NLRP3-deficient mice.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2085-2089
-
-
Franchi, L.1
Nunez, G.2
-
39
-
-
56149119563
-
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. This study found reduced DC activation in NLRP3-deficient mice immunized with antigen in alum and did find reduced antigen-specific IgE but also found increased IgG2c.
-
Kool M., Petrilli V., De Smedt T., Rolaz A., Hammad H., van Nimwegen M., Bergen I.M., Castillo R., Lambrecht B.N., and Tschopp J. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 181 (2008) 3755-3759. One of seven papers describing the activation of the NLRP3 inflammasome by alum. This study found reduced DC activation in NLRP3-deficient mice immunized with antigen in alum and did find reduced antigen-specific IgE but also found increased IgG2c.
-
(2008)
J Immunol
, vol.181
, pp. 3755-3759
-
-
Kool, M.1
Petrilli, V.2
De Smedt, T.3
Rolaz, A.4
Hammad, H.5
van Nimwegen, M.6
Bergen, I.M.7
Castillo, R.8
Lambrecht, B.N.9
Tschopp, J.10
-
40
-
-
47849087075
-
Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. Using a tetanus toxoid-alum in vivo model, this group found reduced antigen-specific antibody production in NLRP3-deficient mice and also found that the adjuvants Quil A and chitosan also activate the NLRP3 inflammasome.
-
Li H., Willingham S.B., Ting J.P., and Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 181 (2008) 17-21. One of seven papers describing the activation of the NLRP3 inflammasome by alum. Using a tetanus toxoid-alum in vivo model, this group found reduced antigen-specific antibody production in NLRP3-deficient mice and also found that the adjuvants Quil A and chitosan also activate the NLRP3 inflammasome.
-
(2008)
J Immunol
, vol.181
, pp. 17-21
-
-
Li, H.1
Willingham, S.B.2
Ting, J.P.3
Re, F.4
-
41
-
-
70449713915
-
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. However, this group found no role for the NLRP3 inflammasome in the adaptive immune response in vivo to antigen in alum.
-
McKee A.S., Munks M.W., MacLeod M.K., Fleenor C.J., Van Rooijen N., Kappler J.W., and Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 183 (2009) 4403-4414. One of seven papers describing the activation of the NLRP3 inflammasome by alum. However, this group found no role for the NLRP3 inflammasome in the adaptive immune response in vivo to antigen in alum.
-
(2009)
J Immunol
, vol.183
, pp. 4403-4414
-
-
McKee, A.S.1
Munks, M.W.2
MacLeod, M.K.3
Fleenor, C.J.4
Van Rooijen, N.5
Kappler, J.W.6
Marrack, P.7
-
42
-
-
58849160540
-
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
-
One of seven papers describing the activation of the NLRP3 inflammasome by alum. While this paper mostly focused on the actions of microparticles in vivo, the authors did find in vitro NLRP3 activation by alum particles.
-
Sharp F.A., Ruane D., Claass B., Creagh E., Harris J., Malyala P., Singh M., O'Hagan D.T., Petrilli V., Tschopp J., et al. Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci USA 106 (2009) 870-875. One of seven papers describing the activation of the NLRP3 inflammasome by alum. While this paper mostly focused on the actions of microparticles in vivo, the authors did find in vitro NLRP3 activation by alum particles.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 870-875
-
-
Sharp, F.A.1
Ruane, D.2
Claass, B.3
Creagh, E.4
Harris, J.5
Malyala, P.6
Singh, M.7
O'Hagan, D.T.8
Petrilli, V.9
Tschopp, J.10
-
43
-
-
42249088234
-
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
-
A thorough study of DC activation following alum immunization in mice. This paper concludes that uric acid and the MyD88 pathway are crucial to the immunogenicity of alum and that the mediastinal LN rather than the spleen is the site of adaptive activation following i.p. immunization.
-
Kool M., Soullie T., van Nimwegen M., Willart M.A., Muskens F., Jung S., Hoogsteden H.C., Hammad H., and Lambrecht B.N. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 205 (2008) 869-882. A thorough study of DC activation following alum immunization in mice. This paper concludes that uric acid and the MyD88 pathway are crucial to the immunogenicity of alum and that the mediastinal LN rather than the spleen is the site of adaptive activation following i.p. immunization.
-
(2008)
J Exp Med
, vol.205
, pp. 869-882
-
-
Kool, M.1
Soullie, T.2
van Nimwegen, M.3
Willart, M.A.4
Muskens, F.5
Jung, S.6
Hoogsteden, H.C.7
Hammad, H.8
Lambrecht, B.N.9
-
44
-
-
63149126030
-
Towards an understanding of the adjuvant action of aluminium
-
Marrack P., McKee A.S., and Munks M.W. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol 9 (2009) 287-293
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 287-293
-
-
Marrack, P.1
McKee, A.S.2
Munks, M.W.3
-
45
-
-
67349272344
-
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
-
Demento S.L., Eisenbarth S.C., Foellmer H.G., Platt C., Caplan M.J., Mark Saltzman W., Mellman I., Ledizet M., Fikrig E., Flavell R.A., et al. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 27 (2009) 3013-3021
-
(2009)
Vaccine
, vol.27
, pp. 3013-3021
-
-
Demento, S.L.1
Eisenbarth, S.C.2
Foellmer, H.G.3
Platt, C.4
Caplan, M.J.5
Mark Saltzman, W.6
Mellman, I.7
Ledizet, M.8
Fikrig, E.9
Flavell, R.A.10
-
46
-
-
70349331255
-
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF
-
Kolly L., Karababa M., Joosten L.A., Narayan S., Salvi R., Petrilli V., Tschopp J., van den Berg W.B., So A.K., and Busso N. Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF. J Immunol 183 (2009) 4003-4012
-
(2009)
J Immunol
, vol.183
, pp. 4003-4012
-
-
Kolly, L.1
Karababa, M.2
Joosten, L.A.3
Narayan, S.4
Salvi, R.5
Petrilli, V.6
Tschopp, J.7
van den Berg, W.B.8
So, A.K.9
Busso, N.10
-
47
-
-
64049111768
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
-
Allen I.C., Scull M.A., Moore C.B., Holl E.K., McElvania-TeKippe E., Taxman D.J., Guthrie E.H., Pickles R.J., and Ting J.P. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30 (2009) 556-565
-
(2009)
Immunity
, vol.30
, pp. 556-565
-
-
Allen, I.C.1
Scull, M.A.2
Moore, C.B.3
Holl, E.K.4
McElvania-TeKippe, E.5
Taxman, D.J.6
Guthrie, E.H.7
Pickles, R.J.8
Ting, J.P.9
-
48
-
-
60549112774
-
Inflammasome recognition of influenza virus is essential for adaptive immune responses
-
Ichinohe T., Lee H.K., Ogura Y., Flavell R., and Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 206 (2009) 79-87
-
(2009)
J Exp Med
, vol.206
, pp. 79-87
-
-
Ichinohe, T.1
Lee, H.K.2
Ogura, Y.3
Flavell, R.4
Iwasaki, A.5
-
49
-
-
64049096334
-
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
-
Thomas P.G., Dash P., Aldridge Jr. J.R., Ellebedy A.H., Reynolds C., Funk A.J., Martin W.J., Lamkanfi M., Webby R.J., Boyd K.L., et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30 (2009) 566-575
-
(2009)
Immunity
, vol.30
, pp. 566-575
-
-
Thomas, P.G.1
Dash, P.2
Aldridge Jr., J.R.3
Ellebedy, A.H.4
Reynolds, C.5
Funk, A.J.6
Martin, W.J.7
Lamkanfi, M.8
Webby, R.J.9
Boyd, K.L.10
-
50
-
-
33947497237
-
NALP1 in vitiligo-associated multiple autoimmune disease
-
Jin Y., Mailloux C.M., Gowan K., Riccardi S.L., LaBerge G., Bennett D.C., Fain P.R., and Spritz R.A. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med 356 (2007) 1216-1225
-
(2007)
N Engl J Med
, vol.356
, pp. 1216-1225
-
-
Jin, Y.1
Mailloux, C.M.2
Gowan, K.3
Riccardi, S.L.4
LaBerge, G.5
Bennett, D.C.6
Fain, P.R.7
Spritz, R.A.8
-
51
-
-
70449724715
-
Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma
-
e776
-
Hitomi Y., Ebisawa M., Tomikawa M., Imai T., Komata T., Hirota T., Harada M., Sakashita M., Suzuki Y., Shimojo N., et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol 124 (2009) 779-785 e776
-
(2009)
J Allergy Clin Immunol
, vol.124
, pp. 779-785
-
-
Hitomi, Y.1
Ebisawa, M.2
Tomikawa, M.3
Imai, T.4
Komata, T.5
Hirota, T.6
Harada, M.7
Sakashita, M.8
Suzuki, Y.9
Shimojo, N.10
-
52
-
-
66949115474
-
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
-
An elegant paper describing the characterization of a constitutively activate NLRP3 mutation to mimic a mouse model of CAPS. This study found no significant role for the adaptive immune system in the autoinflammatory disease process.
-
Brydges S.D., Mueller J.L., McGeough M.D., Pena C.A., Misaghi A., Gandhi C., Putnam C.D., Boyle D.L., Firestein G.S., Horner A.A., et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30 (2009) 875-887. An elegant paper describing the characterization of a constitutively activate NLRP3 mutation to mimic a mouse model of CAPS. This study found no significant role for the adaptive immune system in the autoinflammatory disease process.
-
(2009)
Immunity
, vol.30
, pp. 875-887
-
-
Brydges, S.D.1
Mueller, J.L.2
McGeough, M.D.3
Pena, C.A.4
Misaghi, A.5
Gandhi, C.6
Putnam, C.D.7
Boyle, D.L.8
Firestein, G.S.9
Horner, A.A.10
-
53
-
-
66949175347
-
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
-
An intriguing study also describing the characterization of a constitutively activate NLRP3 mutation to mimic a mouse model of CAPS. This study found increased Th17 cell populations, increased activation state of T cells and autoantibodies in the autoinflammatory model.
-
Meng G., Zhang F., Fuss I., Kitani A., and Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 30 (2009) 860-874. An intriguing study also describing the characterization of a constitutively activate NLRP3 mutation to mimic a mouse model of CAPS. This study found increased Th17 cell populations, increased activation state of T cells and autoantibodies in the autoinflammatory model.
-
(2009)
Immunity
, vol.30
, pp. 860-874
-
-
Meng, G.1
Zhang, F.2
Fuss, I.3
Kitani, A.4
Strober, W.5
-
54
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov I.I., Atarashi K., Manel N., Brodie E.L., Shima T., Karaoz U., Wei D., Goldfarb K.C., Santee C.A., Lynch S.V., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009)
-
(2009)
Cell
-
-
Ivanov, I.I.1
Atarashi, K.2
Manel, N.3
Brodie, E.L.4
Shima, T.5
Karaoz, U.6
Wei, D.7
Goldfarb, K.C.8
Santee, C.A.9
Lynch, S.V.10
|