Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization

Journal of Immunology

Volumn 180, Issue 9, 2008, Pages 5826-5832

  Watanabe, Hideki ^a,e   Gehrke, Samuel ^a   Contassot, Emmanuel ^a,c   Roques, Stéphanie ^a   Tschopp, Jürg ^b   Friedmann, Peter S ^d   French, Lars E ^c   Gaide, Olivier ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^e Maruho Company Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; BENZENE; CROSS REACTING ANTIGEN; CYTOKINE; DINITROTHIOCYANOBENZENE; EPITOPE; UNCLASSIFIED DRUG; 2,4 DINITROPHENYL THIOCYANATE; 2,4-DINITROTHIOCYANATOBENZENE; ANTIGEN; IL6 PROTEIN, HUMAN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 2; INTERLEUKIN 6; NITROBENZENE DERIVATIVE;

ADAPTIVE IMMUNITY; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; INFLAMMASOME; INNATE IMMUNITY; LYMPH NODE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SENSITIZATION; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; ANIMAL; CROSS REACTION; DRUG EFFECT; IMMUNOLOGY; INFLAMMATION; MOUSE;

ANIMALS; ANTIGENS; CASPASE 1; CROSS REACTIONS; DINITROBENZENES; DINITROFLUOROBENZENE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-2; INTERLEUKIN-6; MICE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 44449165058     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.9.5826     Document Type: Article

References (44)

1. Janeway, C. A., Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu. Rev. Immunol. 20: 197-216. (Pubitemid 34293424)
2. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511. (Pubitemid 38931765)
3. Martinon, F., and J. Tschopp. 2005. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26: 447-454. (Pubitemid 41008082)
4. Kligman, A. M. 1966. The identification of contact allergens by human assay: II. Factors influencing the induction and measurement of allergic contact dermatitis. J. Invest. Dermatol. 47: 375-392.
5. Allenby, C. F., and D. A. Basketter. 1993. An arm immersion model of compromised skin: II. Influence on minimal eliciting patch test concentrations of nickel. Contact Dermatitis 28: 129-133. (Pubitemid 23093357)
6. Cumberbatch, M., R. C. Scott, D. A. Basketter, E. W. Scholes, J. Hilton, R. J. Dearman, and I. Kimber. 1993. Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation. Toxicology 77: 181-191. (Pubitemid 23055724)
7. Grabbe, S., M. Steinert, K. Mahnke, A. Schwartz, T. A. Luger, and T. Schwarz. 1996. Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice: evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J. Clin. Invest. 98: 1158-1164. (Pubitemid 26299929)
8. Martinon, F., L. Agostini, E. Meylan, and J. Tschopp. 2004. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14: 1929-1934. (Pubitemid 39464816)
9. Sutterwala, F. S., Y. Ogura, M. Szczepanik, M. Lara-Tejero, G. S. Lichtenberger, E. P. Grant, J. Bertin, A. J. Coyle, J. E. Galan, P. W. Askenase, and R. A. Flavell. 2006. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24: 317-327.
10. Watanabe, H., O. Gaide, V. Petrilli, F. Martinon, E. Contassot, S. Roques, J. A. Kummer, J. Tschopp, and L. E. French. 2007. Activation of the IL-1β-processing inflammasome is involved in contact hypersensitivity. J. Invest. Dermatol. 127: 1956-1963. (Pubitemid 47075373)
11. Sommer, G., D. Parker, and J. L. Turk. 1975. Epicutaneous induction of hyporeactivity in contact sensitization: demonstration of suppressor cells induced by contact with 2,4-dinitrothiocyanatebenzene. Immunology 29: 517-525.
12. Parker, D., J. L. Turk, and R. J. Scheper. 1976. Central and peripheral action of suppressor cells in contact sensitivity in the guinea-pig. Immunology 30: 593-597.
13. Wei, L., K. M. Muller, J. H. Saurat, and C. Hauser. 1993. Lymphokine profiles in contact sensitivity induced by dinitrofluorobenzene and tolerance induced by dinitrothiocyanobenzene. Arch. Dermatol. Res. 284: 427-431. (Pubitemid 23085779)
14. Riemann, H., K. Loser, S. Beissert, M. Fujita, A. Schwarz, T. Schwarz, and S. Grabbe. 2005. IL-12 breaks dinitrothiocyanobenzene (DNTB)-mediated tolerance and converts the tolerogen DNTB into an immunogen. J. Immunol. 175: 5866-5874. (Pubitemid 41508071)
15. Zepter, K., A. Haffner, L. F. Soohoo, D. De Luca, H. P. Tang, P. Fisher, J. Chavinson, and C. A. Elmets. 1997. Induction of biologically active IL-1 β-converting enzyme and mature IL-1 β in human keratinocytes by inflammatory and immunologic stimuli. J. Immunol. 159: 6203-6208. (Pubitemid 127471561)
16. Godfrey, H. P., and H. Baer. 1971. The effect of physical and chemical properties of the sensitizing substance on the induction and elicitation of delayed contact sensitivity. J. Immunol. 106: 431-441.
17. Kimber, I., P. A. Botham, N. J. Rattray, and S. T. Walsh. 1986. Contact-sensitizing and tolerogenic properties of 2,4-dinitrothiocyanobenzene. Int. Arch. Allergy Appl. Immunol. 81: 258-264. (Pubitemid 16004197)
18. Dearman, R. J., M. Cumberbatch, J. Hilton, I. Fielding, D. A. Basketter, and I. Kimber. 1997. A re-appraisal of the skin-sensitizing activity of 2,4-dinitrothiocyanobenzene. Food Chem. Toxicol. 35: 261-269. (Pubitemid 27187460)
19. Shornick, L. P., P. De Togni, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R. W. Karr, T. A. Ferguson, and D. D. Chaplin. 1996. Mice deficient in IL-1β manifest impaired contact hypersensitivity to trinitrochlorobenzone. J. Exp. Med. 183: 1427-1436. (Pubitemid 26134286)
20. Antonopoulos, C., M. Cumberbatch, R. J. Dearman, R. J. Daniel, I. Kimber, and R. W. Groves. 2001. Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice. J. Immunol. 166: 3672-3677. (Pubitemid 32224888)
21. Wannamaker, W., R. Davies, M. Namchuk, J. Pollard, P. Ford, G. Ku, C. Decker, P. Charifson, P. Weber, U. A. Germann, et al. 2007. VX-765, an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1β and IL-18. J. Pharmacol. Exp. Ther. 321: 509-516.
22. Kondo, S., S. Pastore, H. Fujisawa, G. M. Shivji, R. C. McKenzie, C. A. Dinarello, and D. N. Sauder. 1995. Interleukin-1 receptor antagonist suppresses contact hypersensitivity. J. Invest. Dermatol. 105: 334-338.
23. Murphy, J. E., C. Robert, and T. S. Kupper. 2000. Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity. J. Invest. Dermatol. 114: 602-608. (Pubitemid 30415356)
24. Dinarello, C. A. 1998. Interleukin-1 β, interleukin-18, and the interleukin-1 β converting enzyme. Ann. NY Acad. Sci. 856: 1-11. (Pubitemid 28517331)
25. Dinarello, C. A. 2005. Blocking IL-1 in systemic inflammation. J. Exp. Med. 201: 1355-1359. (Pubitemid 40664079)
26. Bettelli, E., M. Oukka, and V. K. Kuchroo. 2007. TH-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8: 345-350. (Pubitemid 46745409)
27. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688. (Pubitemid 43867371)
28. Cumberbatch, M., K. Clelland, R. J. Dearman, and I. Kimber. 2005. Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses. J. Immunol. 175: 43-50. (Pubitemid 40884300)
29. Kissenpfennig, A., and B. Malissen. 2006. Langerhans cells: revisiting the paradigm using genetically engineered mice. Trends Immunol. 27: 132-139. (Pubitemid 43306807)
30. + regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J. Immunol. 171: 5760-5768.
31. Terheyden, P., A. K. Kortum, H. J. Schulze, B. Durani, R. Remling, C. Mauch, V. Junghans, D. Schadendorf, U. Beiteke, M. Junger, et al. 2007. Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group. J. Cancer Res. Clin. Oncol. 133: 437-444. (Pubitemid 46800664)
32. Garland, S. M., M. Hernandez-Avila, C. M. Wheeler, G. Perez, D. M. Harper, S. Leodolter, G. W. Tang, D. G. Ferris, M. Steben, J. Bryan, et al. 2007. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N. Engl. J. Med. 356: 1928-1943. (Pubitemid 46740303)
33. Garbe, C., and T. K. Eigentler. 2007. Diagnosis and treatment of cutaneous melanoma: state of the art 2006. Melonoma Res. 17: 117-127. (Pubitemid 46673905)
34. Kanzler, H., F. J. Barrat, E. M. Hessel, and R. L. Coffman. 2007. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 13: 552-559. (Pubitemid 46830615)
35. + effector T cells. J. Immunol. 176: 7278-7287.
36. Weinlich, G., M. Heine, H. Stossel, M. Zanella, P. Stoitzner, U. Ortner, J. Smolle, F. Koch, N. T. Sepp, G. Schuler, and N. Romani. 1998. Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells. J. Invest. Dermatol. 110: 441-448. (Pubitemid 28158664)
37. Cumberbatch, M., R. J. Dearman, C. Antonopoulos, R. W. Groves, and I. Kimber. 2001. Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-α- and IL-1β-dependent mechanism. Immunology 102: 323-330. (Pubitemid 32281160)
38. Bennett, C. L., M. Noordegraaf, C. A. Martina, and B. E. Clausen. 2007. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J. Immunol. 179: 6830-6835.
39. Bennett, C. L., E. van Rijn, S. Jung, K. Inaba, R. M. Steinman, M. L. Kapsenberg, and B. E. Clausen. 2005. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169: 569-576. (Pubitemid 41002850)
40. Kaplan, D. H., M. C. Jenison, S. Saeland, W. D. Shlomchik, and M. J. Shlomchik. 2005. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23: 611-620. (Pubitemid 41779483)
41. Kissenpfennig, A., S. Henri, B. Dubois, C. Laplace-Builhe, P. Perrin, N. Romani, C. H. Tripp, P. Douillard, L. Leserman, D. Kaiserlian, et al. 2005. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22: 643-654. (Pubitemid 40719199)
42. Hawkins, P. N., H. J. Lachmann, and M. F. McDermott. 2003. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N. Engl. J. Med. 348: 2583-2584. (Pubitemid 36706554)
43. Hoffman, H. M., S. Rosengren, D. L. Boyle, J. Y. Cho, J. Nayar, J. L. Mueller, J. P. Anderson, A. A. Wanderer, and G. S. Firestein. 2004. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364: 1779-1785. (Pubitemid 39488063)
44. Stack, J. H., K. Beaumont, P. D. Larsen, K. S. Straley, G. W. Henkel, J. C. Randle, and H. M. Hoffman. 2005. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J. Immunol. 175: 2630-2634. (Pubitemid 41113877)