Studies with IL-10(-/-) mice: An overview

Journal of Leukocyte Biology

Volumn 61, Issue 4, 1997, Pages 389-396

  Rennick, Donna M ^a   Fort, Madeline M ^a   Davidson, Natalie J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

aberrant cytokine production; enterocolitis; inflammatory bowel disease; interferon ; interleukin 10 therapy; interleukin 12; pathogenic Th1 response

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL MODEL; ENTERITIS; ENTEROCOLITIS; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 0030954018     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.61.4.389     Document Type: Review

References (49)

1. Kühn, R., Lohler, J., Rennick, D., Rajewsky, K., Müller, W. (1993) Interleukin-10 deficient mice develop chronic enterocolitis. Cell 75, 263-274.
2. + TH1-like responses. J. Clin. Invest. 98, 1010-1020.
3. Moore, K. W., O'Garra, A., de Waal Malefyt, R., Vieira, P., Mosmann, T. R. (1993) Interleukin-10. Annu. Rev. Immunol. 11, 165-190.
4. Podolsky, D. K. (1991) Inflammatory bowel disease I. N. Engl. J. Med. 325, 928-937.
5. Lewin, K. J., Riddell, R. H., Weinstein, W. M. (1992) Inflammatory bowel disease. In Gastrointestinal Pathology and Its Clinical Implications. New York: Igaku-Shoin, 812-989.
6. + T cells, but not B cells, mediate colitis in interleukin-10-deficient mice. J. Exp. Med. 184, 241-251.
7. Das, K. M., Dasgupta, A., Mandal, A., Geng, X. (1993) Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenic mechanism for ulcerative colitis. J. Immunol. 150, 2487-2493.
8. r 40 kD putative autoantigen in ulcerative colitis. Gut 34, 650-657.
9. Braegger, C. P., MacDonald, T. T. (1994) Immune mechanisms in chronic inflammatory bowel disease. Ann. Allergy 72, 135-141.
10. Brandtzaeg, P. (1995) Autoimmunity and ulcerative colitis: Can two enigmas make sense together? Gastroenterology 109, 307-322.
11. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., Horak, I. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75, 253-261.
12. Kitamura, D., Roes, J., Kühn, R., Rajewsky, K. (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature (London) 350, 423-426.
13. Brandtzaeg, P., Halstensen, T. S., Kett, K. (1992) Immunopathology of inflammatory bowel disease. In Inflammatory Bowel Disease (MacDermott, R. P., Stenson, W. F. eds.), New York: Elsevier, 95-136.
14. Schreiber, S., Raedler, A., Stenson, W. F., MacDermott, R. P. (1992) The role of the mucosal immune system in inflammatory bowel disease. Gastroenterol. Clin. North Am. 21, 451-502.
15. + T cells. Res. Immunol. 145, 332-337.
16. Powrie, F. (1995) T cells in inflammatory bowel disease: Protective and pathogenic roles. Immunity 3, 171-174.
17. Powrie, F., Leach, M. L. (1995) Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation. Therapeutic Immunol. 2, 115-123.
18. Rennick, D., Davidson, N., Berg, D. (1995) Interleukin-10 gene knock-out mice: A model of chronic inflammation. Clin. Immunol. Immunopathol. 76, S174-S178.
19. O'Garra, A., Murphy, K. (1996) Role of cytokines in development of Th1 and Th2 cells. Chem. Immunol. 63, 1-13.
20. Swain, S. L., Bradley, L. M., Croft, M. (1991) Helper T-cell subsets: Phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123, 115-144.
21. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
22. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90, 1088-1098.
23. Manetti, R., Parronchi, P., Guidizi, M. G., Piccinni, M. P., Maggi, E., Trinchieri, G., Romagnani, S. (1993) Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177, 1199-1204.
24. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5, 1119-1128.
25. Manetti, R., Gerosa, F. Giudizi, M. G. Biagiotti, R., Parronchi, P., Piccinni, M. P., Sampognaro, S., Maggi, E., Romagnani, S., Trinchieri, G. (1994) Interleukin-12 induces stable priming for interferon-γ production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179, 1273-1283.
26. Gerard, C., Bruyns, C., Marchant, A., Abramowicz, D., Vandenabeele, P., Delvaux, A., Fiers, W., Goldman, M., Velu, T. (1993) Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177, 547-550.
27. Howard, M., Muchamuel, T., Andrade, S., Menon, S. (1993) Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177, 1205-1208.
28. Marchant, A., Bruyns, C., Vandenabeele, P., Durcarme, M., Gerard, C., Delvaux, A., De Groote, D., Abramowicz, D., Velu, T., Goldman, M. (1994) Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur. J. Immunol. 24, 1167-1171.
29. Standiford, T. J., Strieter, R. M., Lukacs, N. W., Kunkel, S. L. (1995) Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J. Immunol. 155, 2222-2229.
30. Van Der Poll, T., Marchant, A., Buurman, W. A., Berman, L., Keogh, C. V., Lazarus, D. D., Nguyen, L., Goldman, M., Moldawer, L. L., Lowry, S. F. (1995) Endogenous IL-10 protects mice from death during septic peritonitis. J. Immunol. 155, 5397-5401.
31. Florquin, S., Amraoui, Z., Abramowicz, D., Goldman, M. (1994) Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice. J. Immunol. 153, 2618-2623.
32. Berg, D. J., Kuhn, R., Rajewsky, K., Muller, W., Menon, S., Davidson, N., Grunig, G., Rennick, D. (1995) Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96, 2339-2347.
33. Mengozzi, M., Ghezzi, P. (1993) Cytokine down-regulation in endotoxin tolerance. Eur. Cytokine Netw. 4, 89-98.
34. Mengozzi, M., Fantuzzi, G., Sironi, M., Bianchi, M., Fratelli, M., Peri, G., Bernasconi, S., Ghezzi, P. (1993) Early down-regulation of TNF production by LPS tolerance in human monocytes: comparison with IL-1β, IL-6, and IL-8. Lymphokine Cytokine Res. 12, 231-236.
35. Randow, F., Syrbe, U., Meisel, C., Krausch, D., Zuckermann, H., Platzer, C., Volk, H-D. (1995) Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor β. J. Exp. Med. 181, 1887-1892.
36. Wilmer, J. L., Burleson, F. G., Kayama, F., Kanno, J., Luster, M. I. (1994) Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin. J. Invest. Dermatol. 102, 915-922.
37. Enk, A. H., Katz, S. I. (1992) Identification and induction of keratinocyte-derived IL-10. J. Immunol. 149, 92-95.
38. Ferguson, T. A., Philip, D., Griffith, T. S. (1994) Regulation of contact hypersensitivity by interleukin 10. J. Exp. Med. 179, 1597-1604.
39. Rivas, J. M., Ullrich, S. E. (1992) Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J. Immunol. 149, 3865-3871.
40. Berg, D. J., Leach, M. W., Kuhn, R., Rajewsky, K., Muller, W., Davidson, N. J., Rennick, D. (1995) Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J. Exp. Med. 182, 99-108.
41. Greenberger, M. J., Strieter, R. M., Kunkel, S. L., Danforth, J. M., Goodman, R. E., Standiford, T. J. (1995) Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J. Immunol. 155, 722-729.
42. Fernandes, D. M., Baldwin, C. L. (1995) Interleukin-10 downregulates protective immunity to Brucella abortus. Infect. Immun. 63, 1130-1133.
43. Romani, L., Puccetti, P., Mencacci, A., Cenci, E., Spaccapelo, R., Tonnetti, L., Grohmann, U., Bistoni, F. (1994) Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152, 3514-3521.
44. Reed, S. G., Brownell, C. E., Russo, D. M., Silva, J. S., Grabstein, K. H., Morrissey, P. J. (1994) IL-10 mediates susceptibility to Trypanosoma cruzi infection. J. Immunol. 153, 3135-3140.
45. Denis, M., Ghadirian, E. (1993) IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections. J. Immunol. 151, 5425-5430.
46. Arai, T., Hiromatsu, K., Nishimura, H., Kimura, Y., Kobayashi, N., Ishida, H., Nimura, Y., Yoshikai, Y. (1995) Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defense mechanism against murine Salmonella infection. Immunol. 85, 381-388.
47. Pie, S., Matsiota-Bernard, P., Truffa-Bachi, P., Nauciel, C. (1996) Gamma interferon and interleukin-10 gene expression in innately susceptible and resistant mice during the early phase of Salmonella typhimurium infection. Infect. Immun. 64, 849-854.
48. Wagner, R. D., Maroushek, N. M., Brown, J. F., Czuprynksi, C. J. (1994) Treatment with anti-interleukin-10 monoclonal antibody enhances early resistance to but impairs complete clearance of Listeria monocytogenes infection in mice. Infect. Immun. 62, 2345-2353.
49. + T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α. J. Immunol. 157, 798-805.