메뉴 건너뛰기




Volumn 21, Issue 2, 2009, Pages 539-548

Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal squamous cell carcinoma

Author keywords

Epidermal growth factor receptor; Laryngeal carcinoma; Proinflammatory regulatory cytokines; Signal transducer and activator of transcription 3 factor

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; STAT3 PROTEIN, HUMAN;

EID: 62849087103     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000255     Document Type: Article
Times cited : (4)

References (52)
  • 1
    • 33749055594 scopus 로고    scopus 로고
    • Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
    • Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr and Gutkind JS: Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia 8: 733-746, 2006.
    • (2006) Neoplasia , vol.8 , pp. 733-746
    • Squarize, C.H.1    Castilho, R.M.2    Sriuranpong, V.3    Pinto Jr, D.S.4    Gutkind, J.S.5
  • 2
    • 33745328509 scopus 로고    scopus 로고
    • HIFing the brakes: Therapeutic opportunities for treatment of human malignancies
    • Garcia JA: HIFing the brakes: therapeutic opportunities for treatment of human malignancies. Sci STKE 337: 25, 2006.
    • (2006) Sci STKE , vol.337 , pp. 25
    • Garcia, J.A.1
  • 3
    • 33748422072 scopus 로고    scopus 로고
    • Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line
    • Kuwahara I, Lillehoj EP, Lu W, Singh IS, Isohama Y, Miyata T and Kim KC: Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line. Am J Physiol Lung Cell Mol Physiol 291: L407-L416, 2006.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Kuwahara, I.1    Lillehoj, E.P.2    Lu, W.3    Singh, I.S.4    Isohama, Y.5    Miyata, T.6    Kim, K.C.7
  • 4
    • 33745183542 scopus 로고    scopus 로고
    • Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas
    • Suzuki S, Igarashi S, Hanawa M, Matsubara H, Ooi A and Dobashi Y: Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas. Mod Pathol 19: 986-998, 2006.
    • (2006) Mod Pathol , vol.19 , pp. 986-998
    • Suzuki, S.1    Igarashi, S.2    Hanawa, M.3    Matsubara, H.4    Ooi, A.5    Dobashi, Y.6
  • 5
    • 24944479590 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial
    • Bentzen SM, Atasoy BM, Daley FM, et al: Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J Clin Oncol 23: 5560-5567, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 5560-5567
    • Bentzen, S.M.1    Atasoy, B.M.2    Daley, F.M.3
  • 6
    • 0036024855 scopus 로고    scopus 로고
    • STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo
    • Kijima T, Niwa H, Steinman RA, et al: STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ 13: 355-362, 2002.
    • (2002) Cell Growth Differ , vol.13 , pp. 355-362
    • Kijima, T.1    Niwa, H.2    Steinman, R.A.3
  • 8
    • 24944467002 scopus 로고    scopus 로고
    • Predicting the future from trials of the past: Epidermal growth factor receptor expression and outcome of fractionated radiation therapy trials
    • Dicker AP and Rodeck U: Predicting the future from trials of the past: epidermal growth factor receptor expression and outcome of fractionated radiation therapy trials. J Clin Oncol 23: 5437-5439, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 5437-5439
    • Dicker, A.P.1    Rodeck, U.2
  • 10
    • 0028955388 scopus 로고    scopus 로고
    • Salomon DS, Brandt R, Ciardiello, Ciardiello F and Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995.
    • Salomon DS, Brandt R, Ciardiello, Ciardiello F and Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995.
  • 11
    • 39749085844 scopus 로고    scopus 로고
    • TACE/ADAM-17: A component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer
    • Merchant NB, Voskresensky I, Rogers CM, et al: TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res 14: 1182-1191, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 1182-1191
    • Merchant, N.B.1    Voskresensky, I.2    Rogers, C.M.3
  • 12
    • 37849046940 scopus 로고    scopus 로고
    • ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis
    • Révillion F, Lhotellier V, Hornez L, Bonneterre J and Peyrat JP: ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis. Ann Oncol 19: 73-80, 2008.
    • (2008) Ann Oncol , vol.19 , pp. 73-80
    • Révillion, F.1    Lhotellier, V.2    Hornez, L.3    Bonneterre, J.4    Peyrat, J.P.5
  • 13
    • 20244389231 scopus 로고    scopus 로고
    • Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
    • Lee JW, Soung YH, Kim SY, et al: Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res 11: 2879-2882, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 2879-2882
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 14
    • 13844321724 scopus 로고    scopus 로고
    • Chasing mutations in the epidermal growth factor in lung cancer
    • Dowell JE and Minna JD: Chasing mutations in the epidermal growth factor in lung cancer. N Engl J Med 352: 830-832, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 830-832
    • Dowell, J.E.1    Minna, J.D.2
  • 15
    • 14544284557 scopus 로고    scopus 로고
    • EGFR gene mutations: A call for global x global views of cancer
    • Sellers WR and Meyerson M: EGFR gene mutations: a call for global x global views of cancer. J Natl Cancer Inst 97: 326-328, 2005.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 326-328
    • Sellers, W.R.1    Meyerson, M.2
  • 16
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
    • Haura EB, Turkson J and Jove R: Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2: 315-324, 2005.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 17
    • 0037386568 scopus 로고    scopus 로고
    • Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
    • Leong PL, Andrews GA, Johnson DE, et al: Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci USA 100: 4138-4143, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4138-4143
    • Leong, P.L.1    Andrews, G.A.2    Johnson, D.E.3
  • 18
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M, Suzui M, Yasumatu R, et al: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62: 3351-3355, 2002.
    • (2002) Cancer Res , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3
  • 19
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Lesli K, et al: Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 117: 3846-3856, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Lesli, K.3
  • 20
    • 33644867711 scopus 로고    scopus 로고
    • Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/ or MEK in head and neck squamous cell carcinomas
    • Lee TL, Yeh J, Van Waes C and Chen Z: Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/ or MEK in head and neck squamous cell carcinomas. Mol Cancer Ther 5: 8-19, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 8-19
    • Lee, T.L.1    Yeh, J.2    Van Waes, C.3    Chen, Z.4
  • 21
    • 0038581774 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
    • Sriuranpong V, Par JI, Amornphimoltham P, Patel V, Nelki BD and Gutkind JS: Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res 63: 2948-2956, 2003.
    • (2003) Cancer Res , vol.63 , pp. 2948-2956
    • Sriuranpong, V.1    Par, J.I.2    Amornphimoltham, P.3    Patel, V.4    Nelki, B.D.5    Gutkind, J.S.6
  • 22
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T, Ishihar K and Hibi M: Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19: 2548-2556, 2000.
    • (2000) Oncogene , vol.19 , pp. 2548-2556
    • Hirano, T.1    Ishihar, K.2    Hibi, M.3
  • 23
    • 36849017497 scopus 로고    scopus 로고
    • IL-6 involvement in epithelial cancers
    • Schafer ZT and Brugge JS: IL-6 involvement in epithelial cancers. J Clin Invest 117: 3660-3663, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 3660-3663
    • Schafer, Z.T.1    Brugge, J.S.2
  • 24
    • 28544438023 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
    • Haura EB, Zhen Z, Son L, Cantor A and Bepler G: Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res 11: 8288-8294, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 8288-8294
    • Haura, E.B.1    Zhen, Z.2    Son, L.3    Cantor, A.4    Bepler, G.5
  • 25
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - new molecular targets come of age
    • Yu H and Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer 4: 97-105, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 26
    • 1842830790 scopus 로고    scopus 로고
    • STAT3 and MAPK in human lung cancer tissues and suppression of oncogenic growth by JAB and dominant negative STAT3
    • Seki Y, Suzuk N, Imaizumi M, Iwamoto T, Usami N, Ueda Y and Hamaguchi M: STAT3 and MAPK in human lung cancer tissues and suppression of oncogenic growth by JAB and dominant negative STAT3. Int J Oncol 24: 931-934, 2004.
    • (2004) Int J Oncol , vol.24 , pp. 931-934
    • Seki, Y.1    Suzuk, N.2    Imaizumi, M.3    Iwamoto, T.4    Usami, N.5    Ueda, Y.6    Hamaguchi, M.7
  • 27
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • Grandis JR, Drenning SD, Zeng Q, et al: Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci USA 97: 4227-4232, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4227-4232
    • Grandis, J.R.1    Drenning, S.D.2    Zeng, Q.3
  • 28
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth in vitro
    • Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS and Tweardy DJ: Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth in vitro. J Clin Invest 102: 1385-1392, 1998.
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3    Zhou, M.Y.4    Zeng, Q.5    Pitt, A.S.6    Tweardy, D.J.7
  • 29
    • 34447312247 scopus 로고    scopus 로고
    • Erlotinib (OSI-774)-induced inhibition of transitional cell carcinoma of bladder cell line growth is enhanced by interferon-alpha
    • Yang JL, Qu XJ, Hayes VM, Brenner PC, Russell PJ and Goldstein D: Erlotinib (OSI-774)-induced inhibition of transitional cell carcinoma of bladder cell line growth is enhanced by interferon-alpha. BJU Int 6: 1539-1545, 2007.
    • (2007) BJU Int , vol.6 , pp. 1539-1545
    • Yang, J.L.1    Qu, X.J.2    Hayes, V.M.3    Brenner, P.C.4    Russell, P.J.5    Goldstein, D.6
  • 30
    • 22544441630 scopus 로고    scopus 로고
    • ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma
    • Teraishi F, Kagawa S, Watanabe T, et al: ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma. FEBS Lett 579: 4069-4075, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 4069-4075
    • Teraishi, F.1    Kagawa, S.2    Watanabe, T.3
  • 31
    • 0035116907 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy
    • Hambek M, Solbach C, Schnuerch HG, et al: Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy. Cancer Res 61: 1045-1049, 2001.
    • (2001) Cancer Res , vol.61 , pp. 1045-1049
    • Hambek, M.1    Solbach, C.2    Schnuerch, H.G.3
  • 32
    • 0033611564 scopus 로고    scopus 로고
    • Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: Potential interaction with epidermal growth factor receptor
    • Perez M, Haschke B and Donato NJ: Differential expression and translocation of protein tyrosine phosphatase 1B-related proteins in ME-180 tumor cells expressing apoptotic sensitivity and resistance to tumor necrosis factor: potential interaction with epidermal growth factor receptor. Oncogene18: 967-978, 1999.
    • (1999) Oncogene18 , pp. 967-978
    • Perez, M.1    Haschke, B.2    Donato, N.J.3
  • 33
    • 0031740997 scopus 로고    scopus 로고
    • Activation of EGF receptor family members suppresses the cytotoxic effects of tumor necrosis factor-alpha
    • Hoffmann M, Schmidt M and Wels W: Activation of EGF receptor family members suppresses the cytotoxic effects of tumor necrosis factor-alpha. Cancer Immunol Immunother 47: 167-175, 1998.
    • (1998) Cancer Immunol Immunother , vol.47 , pp. 167-175
    • Hoffmann, M.1    Schmidt, M.2    Wels, W.3
  • 34
    • 19944366232 scopus 로고    scopus 로고
    • Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib
    • Ueno Y, Sakurai H, Matsuo M, Choo MK, Koizumi K and Saiki I: Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib. Br J Cancer 92: 1690-1695, 2005.
    • (2005) Br J Cancer , vol.92 , pp. 1690-1695
    • Ueno, Y.1    Sakurai, H.2    Matsuo, M.3    Choo, M.K.4    Koizumi, K.5    Saiki, I.6
  • 35
    • 29344450601 scopus 로고    scopus 로고
    • Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib
    • Ando K, Ohmori T, Inoue F, et al: Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib. Clin Cancer Res 11: 8872-8879, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 8872-8879
    • Ando, K.1    Ohmori, T.2    Inoue, F.3
  • 36
    • 0029925153 scopus 로고    scopus 로고
    • Activation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor correlates with loss of cytotoxic activity
    • Perez M and Donato NJ: Activation of epidermal growth factor receptor tyrosine phosphorylation by tumor necrosis factor correlates with loss of cytotoxic activity. J Interferon Cytokine Res 16: 307-314, 1996.
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 307-314
    • Perez, M.1    Donato, N.J.2
  • 37
    • 33846817495 scopus 로고    scopus 로고
    • Targeting TACE-dependent EGFR ligand shedding in breast cancer
    • Kenny PA and Bissell MJ: Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 117: 337-345, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 337-345
    • Kenny, P.A.1    Bissell, M.J.2
  • 38
    • 34548189041 scopus 로고    scopus 로고
    • Three-dimensional extracellular matrix culture models of EGFR signalling and drug response
    • Kenny PA: Three-dimensional extracellular matrix culture models of EGFR signalling and drug response. Biochem Soc Trans 35: 665-668, 2007.
    • (2007) Biochem Soc Trans , vol.35 , pp. 665-668
    • Kenny, P.A.1
  • 39
    • 33646468634 scopus 로고    scopus 로고
    • Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
    • Zhang Q, Thomas SM, Lui VW, et al: Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci USA 103: 6901-6906, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6901-6906
    • Zhang, Q.1    Thomas, S.M.2    Lui, V.W.3
  • 40
    • 33751280992 scopus 로고    scopus 로고
    • Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression
    • Wehbe H, Henson R, Meng F, Mize-Berg J and Patel T: Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res 66: 10517-10524, 2006.
    • (2006) Cancer Res , vol.66 , pp. 10517-10524
    • Wehbe, H.1    Henson, R.2    Meng, F.3    Mize-Berg, J.4    Patel, T.5
  • 42
    • 0036605053 scopus 로고    scopus 로고
    • Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines
    • Bancroft CC, Chen Z, Yeh J, et al: Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. Int J Cancer 99: 538-548, 2002.
    • (2002) Int J Cancer , vol.99 , pp. 538-548
    • Bancroft, C.C.1    Chen, Z.2    Yeh, J.3
  • 43
    • 33744726186 scopus 로고    scopus 로고
    • Sobin LH and Wittekind C eds, 6th edition. Wiley J & Sons, Hoboken, NJ
    • Sobin LH and Wittekind C (eds): TNM Classification of Malignant Tumours, 6th edition. Wiley J & Sons, Hoboken, NJ, 2002.
    • (2002) TNM Classification of Malignant Tumours
  • 44
    • 33845532991 scopus 로고    scopus 로고
    • Characterization of the expression and activation of the epidermal growth factor receptor in squamous cell carcinoma of the skin
    • Fogarty GB, Conus NM, Chu J and McArthur G: Characterization of the expression and activation of the epidermal growth factor receptor in squamous cell carcinoma of the skin. Br J Dermatol 156: 92-98, 2007.
    • (2007) Br J Dermatol , vol.156 , pp. 92-98
    • Fogarty, G.B.1    Conus, N.M.2    Chu, J.3    McArthur, G.4
  • 45
    • 34249909820 scopus 로고    scopus 로고
    • The prognostic significance of epidermal growth factor receptor expression in clear-cell renal cell carcinoma: A call for standardized methods for immunohistochemical evaluation
    • Cohen D, Lane B, Jin T, et al: The prognostic significance of epidermal growth factor receptor expression in clear-cell renal cell carcinoma: a call for standardized methods for immunohistochemical evaluation. Clin Genitourin Cancer 5: 264-270, 2007.
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 264-270
    • Cohen, D.1    Lane, B.2    Jin, T.3
  • 46
    • 0037938816 scopus 로고    scopus 로고
    • SOCS3 negatively regulates IL-6 signaling in vivo
    • Croker BA, Krebs DL, Zhang JG, et al: SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol 4: 507-509, 2003.
    • (2003) Nat Immunol , vol.4 , pp. 507-509
    • Croker, B.A.1    Krebs, D.L.2    Zhang, J.G.3
  • 47
    • 34548549283 scopus 로고    scopus 로고
    • Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer
    • Berishaj M, Gao SP, Ahmed S, et al: Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Breast Cancer Res 9: R32, 2007.
    • (2007) Breast Cancer Res , vol.9
    • Berishaj, M.1    Gao, S.P.2    Ahmed, S.3
  • 48
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
    • Kotha A, Sekharam M, Cilenti L, et al: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5: 621-629, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3
  • 49
    • 33645067376 scopus 로고    scopus 로고
    • Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3
    • Leslie K, Lang C, Devgan G, et al: Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res 66: 2544-2552, 2006.
    • (2006) Cancer Res , vol.66 , pp. 2544-2552
    • Leslie, K.1    Lang, C.2    Devgan, G.3
  • 50
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: Discovery of a pleiotropic cytokine
    • Kishimoto T: Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther 8: S2, 2006.
    • (2006) Arthritis Res Ther , vol.8
    • Kishimoto, T.1
  • 51
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE and Stark GR: Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 21: 1396-1408, 2007.
    • (2007) Genes Dev , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 52
    • 33947414063 scopus 로고    scopus 로고
    • Significance of interleukin-6 (IL-6) in breast cancer
    • Knüpfer H and Preiss R: Significance of interleukin-6 (IL-6) in breast cancer. Breast Cancer Res Treat 102: 129-135, 2007.
    • (2007) Breast Cancer Res Treat , vol.102 , pp. 129-135
    • Knüpfer, H.1    Preiss, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.