메뉴 건너뛰기




Volumn 42, Issue 1, 2007, Pages 16-25

Inflammatory bowel disease: Past, present, and future

Author keywords

Crohn's disease; Inflammatory bowel diseases; Medical therapy; Pathogenesis; Ulcerative colitis

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CERTOLIZUMAB; CORTICOSTEROID; CYCLOSPORIN; DACLIZUMAB; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROCORTISONE; INTERLEUKIN 10; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; MLN 02; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CA2; NATALIZUMAB; NONSTEROID ANTIINFLAMMATORY AGENT; ORNIDAZOLE; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG; VISILIZUMAB;

EID: 33847632044     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-006-1995-7     Document Type: Review
Times cited : (202)

References (101)
  • 1
    • 0035034523 scopus 로고    scopus 로고
    • Historical origins of current IBD concepts
    • 11819757 1:STN:280:DC%2BD383gs1GrtQ%3D%3D
    • JB Kirsner 2001 Historical origins of current IBD concepts World J Gastroenterol 7 175-84 11819757 1:STN:280:DC%2BD383gs1GrtQ%3D%3D
    • (2001) World J Gastroenterol , vol.7 , pp. 175-184
    • Kirsner, J.B.1
  • 2
    • 0034183793 scopus 로고    scopus 로고
    • Regional ileitis: A pathologic and clinical entity. 1932
    • 10828911 1:STN:280:DC%2BD3c3ptFGlsw%3D%3D
    • BB Crohn L Ginzburg GD Oppenheimer 2000 Regional ileitis: A pathologic and clinical entity. 1932 Mt Sinai J Med 67 263-8 10828911 1:STN:280:DC%2BD3c3ptFGlsw%3D%3D
    • (2000) MT Sinai J Med , vol.67 , pp. 263-268
    • Crohn, B.B.1    Ginzburg, L.2    Oppenheimer, G.D.3
  • 3
    • 0000960795 scopus 로고
    • Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis
    • 14417801 1:STN:280:CC%2BC2s%2FkslM%3D
    • HE Lockhart-Mummery BC Morson 1960 Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis Gut 1 87-105 14417801 1:STN:280:CC%2BC2s%2FkslM%3D
    • (1960) Gut , vol.1 , pp. 87-105
    • Lockhart-Mummery, H.E.1    Morson, B.C.2
  • 4
    • 84920223116 scopus 로고
    • An experiment to determine the active therapeutic moiety of sulphasalazine
    • 72239 10.1016/S0140-6736(77)90831-5 1:STN:280:CSeD3s%2FkslI%3D
    • AK Azad Khan J Piris SC Truelove 1977 An experiment to determine the active therapeutic moiety of sulphasalazine Lancet 2 892-5 72239 10.1016/ S0140-6736(77)90831-5 1:STN:280:CSeD3s%2FkslI%3D
    • (1977) Lancet , vol.2 , pp. 892-895
    • Azad Khan, A.K.1    Piris, J.2    Truelove, S.C.3
  • 5
    • 0015348162 scopus 로고
    • The role of intestinal bacteria in the metabolism of salicylazosulfapyridine
    • 4402374 1:CAS:528:DyaE38Xks12qt7c%3D
    • MA Peppercorn P Goldman 1972 The role of intestinal bacteria in the metabolism of salicylazosulfapyridine J Pharmacol Exp Ther 181 555-62 4402374 1:CAS:528:DyaE38Xks12qt7c%3D
    • (1972) J Pharmacol Exp Ther , vol.181 , pp. 555-562
    • Peppercorn, M.A.1    Goldman, P.2
  • 6
    • 0016800127 scopus 로고
    • A controlled evaluation of intravenous adrenocorticotropic hormone and hydrocortisone in the treatment of acute colitis
    • 168121 1:STN:280:CSqB3cbotVI%3D
    • HP Kaplan B Portnoy HJ Binder T Amatruda H Spiro 1975 A controlled evaluation of intravenous adrenocorticotropic hormone and hydrocortisone in the treatment of acute colitis Gastroenterology 69 91-5 168121 1:STN:280:CSqB3cbotVI%3D
    • (1975) Gastroenterology , vol.69 , pp. 91-95
    • Kaplan, H.P.1    Portnoy, B.2    Binder, H.J.3    Amatruda, T.4    Spiro, H.5
  • 7
    • 0016157704 scopus 로고
    • Intensive intravenous regimen for severe attacks of ulcerative colitis
    • 4135487 10.1016/S0140-6736(74)90552-2 1:STN:280:CSuB2snotlM%3D
    • SC Truelove DP Jewell 1974 Intensive intravenous regimen for severe attacks of ulcerative colitis Lancet 1 1067-70 4135487 10.1016/ S0140-6736(74)90552-2 1:STN:280:CSuB2snotlM%3D
    • (1974) Lancet , vol.1 , pp. 1067-1070
    • Truelove, S.C.1    Jewell, D.P.2
  • 8
    • 0008690916 scopus 로고
    • Cortisone in ulcerative colitis; Final report on a therapeutic trial
    • SC Truelove LJ Witts 1955 Cortisone in ulcerative colitis; final report on a therapeutic trial BMJ 4947 1041-8
    • (1955) BMJ , vol.4947 , pp. 1041-1048
    • Truelove, S.C.1    Witts, L.J.2
  • 9
    • 0028267896 scopus 로고
    • Frequency of glucocorticoid resistance and dependency in Crohn's disease
    • 8150347 1:STN:280:ByuB3c%2Fms1c%3D
    • P Munkholm E Langholz M Davidsen V Binder 1994 Frequency of glucocorticoid resistance and dependency in Crohn's disease Gut 35 360-2 8150347 1:STN:280:ByuB3c%2Fms1c%3D
    • (1994) Gut , vol.35 , pp. 360-362
    • Munkholm, P.1    Langholz, E.2    Davidsen, M.3    Binder, V.4
  • 10
    • 0018888679 scopus 로고
    • Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study
    • 6102739 1:STN:280:Bi%2BC28rjs1U%3D
    • DH Present BI Korelitz N Wisch JL Glass DB Sachar BS Pasternack 1980 Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study N Engl J Med 302 981-7 6102739 1:STN:280:Bi%2BC28rjs1U%3D
    • (1980) N Engl J Med , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3    Glass, J.L.4    Sachar, D.B.5    Pasternack, B.S.6
  • 11
    • 0021969487 scopus 로고
    • Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease
    • 2856904 10.1007/BF01318372 1:STN:280:BiqD2snhtlM%3D
    • BI Korelitz DH Present 1985 Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease Dig Dis Sci 30 58-64 2856904 10.1007/ BF01318372 1:STN:280:BiqD2snhtlM%3D
    • (1985) Dig Dis Sci , vol.30 , pp. 58-64
    • Korelitz, B.I.1    Present, D.H.2
  • 12
    • 29244457275 scopus 로고    scopus 로고
    • Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis
    • 15972298 10.1136/gut.2005.068809 1:STN:280:DC%2BD2Mnmt1SrtQ%3D%3D
    • S Ardizzone G Maconi A Russo V Imbesi E Colombo G Bianchi Porro 2006 Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis Gut 55 47-53 15972298 10.1136/gut.2005.068809 1:STN:280:DC%2BD2Mnmt1SrtQ%3D%3D
    • (2006) Gut , vol.55 , pp. 47-53
    • Ardizzone, S.1    Maconi, G.2    Russo, A.3    Imbesi, V.4    Colombo, E.5    Bianchi Porro, G.6
  • 13
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators
    • 7816064 10.1056/NEJM199502023320503 1:STN:280:ByqC3MrntFI%3D
    • BG Feagan J Rochon RN Fedorak EJ Irvine G Wild L Sutherland 1995 Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators N Engl J Med 332 292-7 7816064 10.1056/ NEJM199502023320503 1:STN:280:ByqC3MrntFI%3D
    • (1995) N Engl J Med , vol.332 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3    Irvine, E.J.4    Wild, G.5    Sutherland, L.6
  • 14
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators
    • 10833208 10.1056/NEJM200006013422202 1:CAS:528:DC%2BD3cXktF2gsr4%3D
    • BG Feagan RN Fedorak EJ Irvine G Wild L Sutherland AH Steinhart 2000 A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators N Engl J Med 342 1627-32 10833208 10.1056/NEJM200006013422202 1:CAS:528:DC%2BD3cXktF2gsr4%3D
    • (2000) N Engl J Med , vol.342 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3    Wild, G.4    Sutherland, L.5    Steinhart, A.H.6
  • 15
    • 0028292007 scopus 로고
    • Cyclosporine in severe ulcerative colitis refractory to steroid therapy
    • 8196726 10.1056/NEJM199406303302601 1:STN:280:ByuB2Mvps1I%3D
    • S Lichtiger DH Present A Kornbluth I Gelernt J Bauer G Galler 1994 Cyclosporine in severe ulcerative colitis refractory to steroid therapy N Engl J Med 330 1841-5 8196726 10.1056/NEJM199406303302601 1:STN:280:ByuB2Mvps1I%3D
    • (1994) N Engl J Med , vol.330 , pp. 1841-1845
    • Lichtiger, S.1    Present, D.H.2    Kornbluth, A.3    Gelernt, I.4    Bauer, J.5    Galler, G.6
  • 16
    • 1542619846 scopus 로고    scopus 로고
    • Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis
    • 15168804 10.1097/00054725-200403000-00002
    • J Arts G D'Haens M Zeegers G Van Assche M Hiele A D'Hoore 2004 Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis Inflamm Bowel Dis 10 73-8 15168804 10.1097/ 00054725-200403000-00002
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 73-78
    • Arts, J.1    D'Haens, G.2    Zeegers, M.3    Van Assche, G.4    Hiele, M.5    D'Hoore, A.6
  • 17
    • 10144252422 scopus 로고    scopus 로고
    • Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial
    • 8857860 10.1097/00000658-199610000-00014 1:STN:280:ByiD3M%2Fot1M%3D discussion 571-3
    • VW Fazio F Marchetti M Church JR Goldblum C Lavery TL Hull 1996 Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial Ann Surg 224 563-71 8857860 10.1097/ 00000658-199610000-00014 1:STN:280:ByiD3M%2Fot1M%3D discussion 571-3
    • (1996) Ann Surg , vol.224 , pp. 563-571
    • Fazio, V.W.1    Marchetti, F.2    Church, M.3    Goldblum, J.R.4    Lavery, C.5    Hull, T.L.6
  • 18
    • 0024307212 scopus 로고
    • Stapler stricturoplasty for Crohn's disease
    • 2814760 1:STN:280:By%2BD2cbmsVA%3D
    • AA Deutsch HS Stern 1989 Stapler stricturoplasty for Crohn's disease Surg Gynecol Obstet 169 458-60 2814760 1:STN:280:By%2BD2cbmsVA%3D
    • (1989) Surg Gynecol Obstet , vol.169 , pp. 458-460
    • Deutsch, A.A.1    Stern, H.S.2
  • 19
    • 0020568268 scopus 로고
    • Straight ileoanal anastomosis v ileal pouch-anal anastomosis after colectomy and mucosal proctectomy
    • 6847364 1:STN:280:BiyB3czjvFQ%3D
    • BM Taylor RW Beart Jr RR Dozois KA Kelly SF Phillips 1983 Straight ileoanal anastomosis v ileal pouch-anal anastomosis after colectomy and mucosal proctectomy Arch Surg 118 696-701 6847364 1:STN:280:BiyB3czjvFQ%3D
    • (1983) Arch Surg , vol.118 , pp. 696-701
    • Taylor, B.M.1    Beart, R.W.2    Dozois Jr., R.R.3    Kelly, K.A.4    Phillips, S.F.5
  • 20
    • 0027404560 scopus 로고
    • Familial empirical risks for inflammatory bowel disease: Differences between Jews and non-Jews
    • 8491401 1:STN:280:ByyB2MbkvFc%3D
    • H Yang C McElree MP Roth F Shanahan SR Targan JI Rotter 1993 Familial empirical risks for inflammatory bowel disease: Differences between Jews and non-Jews Gut 34 517-24 8491401 1:STN:280:ByyB2MbkvFc%3D
    • (1993) Gut , vol.34 , pp. 517-524
    • Yang, H.1    McElree, C.2    Roth, M.P.3    Shanahan, F.4    Targan, S.R.5    Rotter, J.I.6
  • 21
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
    • 3396969 1:STN:280:BieB1cvltFE%3D
    • C Tysk E Lindberg G Jarnerot B Floderus-Myrhed 1988 Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking Gut 29 990-6 3396969 1:STN:280:BieB1cvltFE%3D
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3    Floderus-Myrhed, B.4
  • 22
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • 12167685 10.1056/NEJMra020831 1:CAS:528:DC%2BD38XlvFKrt7s%3D
    • DK Podolsky 2002 Inflammatory bowel disease N Engl J Med 347 417-29 12167685 10.1056/NEJMra020831 1:CAS:528:DC%2BD38XlvFKrt7s%3D
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 23
    • 0036143845 scopus 로고    scopus 로고
    • Crohn's disease caused by Mycobacterium avium subspecies paratuberculosis: A public health tragedy whose resolution is long overdue
    • 11800469
    • J Hermon-Taylor T Bull 2002 Crohn's disease caused by Mycobacterium avium subspecies paratuberculosis: A public health tragedy whose resolution is long overdue J Med Microbiol 51 3-6 11800469
    • (2002) J Med Microbiol , vol.51 , pp. 3-6
    • Hermon-Taylor, J.1    Bull, T.2
  • 24
    • 0034902828 scopus 로고    scopus 로고
    • Effects of current cigarette smoking on clinical course of Crohn's disease and ulcerative colitis
    • 11508673 10.1023/A:1010609722315 1:STN:280:DC%2BD3MvmsVahtA%3D%3D
    • HS Odes A Fich S Reif A Halak A Lavy D Keter 2001 Effects of current cigarette smoking on clinical course of Crohn's disease and ulcerative colitis Dig Dis Sci 46 1717-21 11508673 10.1023/A:1010609722315 1:STN:280:DC%2BD3MvmsVahtA%3D%3D
    • (2001) Dig Dis Sci , vol.46 , pp. 1717-1721
    • Odes, H.S.1    Fich, A.2    Reif, S.3    Halak, A.4    Lavy, A.5    Keter, D.6
  • 25
    • 0023193899 scopus 로고
    • Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans
    • 3609658 1:STN:280:BiiB2sjitlU%3D
    • I Bjarnason G Zanelli T Smith P Prouse P Williams P Smethurst 1987 Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans Gastroenterology 93 480-9 3609658 1:STN:280:BiiB2sjitlU%3D
    • (1987) Gastroenterology , vol.93 , pp. 480-489
    • Bjarnason, I.1    Zanelli, G.2    Smith, T.3    Prouse, P.4    Williams, P.5    Smethurst, P.6
  • 26
    • 0034944311 scopus 로고    scopus 로고
    • Appendectomy and subsequent risk of inflammatory bowel diseases
    • 11436010 10.1067/msy.2001.115362 1:STN:280:DC%2BD3Mvgs1yqtQ%3D%3D
    • M Frisch C Johansen L Mellemkjaer EA Engels G Gridley RJ Biggar 2001 Appendectomy and subsequent risk of inflammatory bowel diseases Surgery 130 36-43 11436010 10.1067/msy.2001.115362 1:STN:280:DC%2BD3Mvgs1yqtQ%3D%3D
    • (2001) Surgery , vol.130 , pp. 36-43
    • Frisch, M.1    Johansen, C.2    Mellemkjaer, L.3    Engels, E.A.4    Gridley, G.5    Biggar, R.J.6
  • 27
    • 0035087887 scopus 로고    scopus 로고
    • Smoking cessation and the course of Crohn's disease: An intervention study
    • 11266373 10.1053/gast.2001.23231 1:STN:280:DC%2BD3M7mvFOqtQ%3D%3D
    • J Cosnes L Beaugerie F Carbonnel JP Gendre 2001 Smoking cessation and the course of Crohn's disease: An intervention study Gastroenterology 120 1093-9 11266373 10.1053/gast.2001.23231 1:STN:280:DC%2BD3M7mvFOqtQ%3D%3D
    • (2001) Gastroenterology , vol.120 , pp. 1093-1099
    • Cosnes, J.1    Beaugerie, L.2    Carbonnel, F.3    Gendre, J.P.4
  • 28
    • 0024159566 scopus 로고
    • Effects of cigarette smoking on the clinical course of ulcerative colitis
    • 3247593 1:STN:280:BiaB2c7psVI%3D
    • EJ Boyko DR Perera TD Koepsell EM Keane TS Inui 1988 Effects of cigarette smoking on the clinical course of ulcerative colitis Scand J Gastroenterol 23 1147-52 3247593 1:STN:280:BiaB2c7psVI%3D
    • (1988) Scand J Gastroenterol , vol.23 , pp. 1147-1152
    • Boyko, E.J.1    Perera, D.R.2    Koepsell, T.D.3    Keane, E.M.4    Inui, T.S.5
  • 29
    • 0001213646 scopus 로고
    • Non-smoking: A feature of ulcerative colitis
    • 1:STN:280:Bi2C287ntlw%3D
    • AD Harries A Baird J Rhodes 1982 Non-smoking: A feature of ulcerative colitis BMJ Clin Res Ed 284 7061:STN:280:Bi2C287ntlw%3D
    • (1982) BMJ Clin Res Ed , vol.284 , pp. 706
    • Harries, A.D.1    Baird, A.2    Rhodes, J.3
  • 30
    • 0023212523 scopus 로고
    • Time relationships between cessation of smoking and onset of ulcerative colitis
    • 3622939 1:STN:280:BiiA3critVw%3D
    • RJ Motley J Rhodes GA Ford SP Wilkinson IM Chesner P Asquith 1987 Time relationships between cessation of smoking and onset of ulcerative colitis Digestion 37 125-7 3622939 1:STN:280:BiiA3critVw%3D
    • (1987) Digestion , vol.37 , pp. 125-127
    • Motley, R.J.1    Rhodes, J.2    Ford, G.A.3    Wilkinson, S.P.4    Chesner, I.M.5    Asquith, P.6
  • 32
    • 29144489192 scopus 로고    scopus 로고
    • Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway
    • 16365149 10.1084/jem.20051047 1:CAS:528:DC%2BD2MXhtlCjsrjL
    • RA Hegazi KN Rao A Mayle AR Sepulveda LE Otterbein SE Plevy 2005 Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway J Exp Med 202 1703-13 16365149 10.1084/jem.20051047 1:CAS:528:DC%2BD2MXhtlCjsrjL
    • (2005) J Exp Med , vol.202 , pp. 1703-1713
    • Hegazi, R.A.1    Rao, K.N.2    Mayle, A.3    Sepulveda, A.R.4    Otterbein, L.E.5    Plevy, S.E.6
  • 33
    • 0345802756 scopus 로고    scopus 로고
    • Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease
    • 14653831 10.1046/j.1365-2036.2003.01793.x 1:CAS:528:DC%2BD2cXmt1SgtA%3D%3D
    • C Dejaco M Harrer T Waldhoer W Miehsler H Vogelsang W Reinisch 2003 Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease Aliment Pharmacol Ther 18 1113-20 14653831 10.1046/ j.1365-2036.2003.01793.x 1:CAS:528:DC%2BD2cXmt1SgtA%3D%3D
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 1113-1120
    • Dejaco, C.1    Harrer, M.2    Waldhoer, T.3    Miehsler, W.4    Vogelsang, H.5    Reinisch, W.6
  • 34
    • 2442493240 scopus 로고    scopus 로고
    • The role of antibiotics in the management of Crohn's disease
    • 15290930 10.1097/00054725-200405000-00022
    • GE Wild 2004 The role of antibiotics in the management of Crohn's disease Inflamm Bowel Dis 10 321-3 15290930 10.1097/ 00054725-200405000-00022
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 321-323
    • Wild, G.E.1
  • 35
    • 0029079279 scopus 로고
    • Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection
    • 7768364 10.1016/0016-5085(95)90121-3 1:STN:280:ByqB1crpslA%3D
    • P Rutgeerts M Hiele K Geboes M Peeters F Penninckx R Aerts 1995 Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection Gastroenterology 108 1617-21 7768364 10.1016/0016-5085(95)90121-3 1:STN:280:ByqB1crpslA%3D
    • (1995) Gastroenterology , vol.108 , pp. 1617-1621
    • Rutgeerts, P.1    Hiele, M.2    Geboes, K.3    Peeters, M.4    Penninckx, F.5    Aerts, R.6
  • 36
    • 20244388832 scopus 로고    scopus 로고
    • Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: A randomized, double-blind, placebo-controlled trial
    • 15825069 10.1053/j.gastro.2005.01.010 1:CAS:528:DC%2BD2MXjvV2qtrk%3D
    • P Rutgeerts G Van Assche S Vermeire G D'Haens F Baert M Noman 2005 Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial Gastroenterology 128 856-61 15825069 10.1053/j.gastro.2005.01.010 1:CAS:528:DC%2BD2MXjvV2qtrk%3D
    • (2005) Gastroenterology , vol.128 , pp. 856-861
    • Rutgeerts, P.1    Van, G.2    Assche Vermeire, S.3    D'Haens, G.4    Baert, F.5    Noman, M.6
  • 37
    • 0025887076 scopus 로고
    • Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
    • 1681159 10.1016/0140-6736(91)90663-A 1:STN:280:By2D3Mnns1U%3D
    • P Rutgeerts K Goboes M Peeters M Hiele F Penninckx R Aerts 1991 Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum Lancet 338 771-4 1681159 10.1016/0140-6736(91)90663-A 1:STN:280:By2D3Mnns1U%3D
    • (1991) Lancet , vol.338 , pp. 771-774
    • Rutgeerts, P.1    Goboes, K.2    Peeters, M.3    Hiele, M.4    Penninckx, F.5    Aerts, R.6
  • 38
    • 20444447446 scopus 로고    scopus 로고
    • Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: Cytokine production and endoscopic and histological findings
    • 15905706 10.1097/01.MIB.0000161307.58327.96
    • T Yamamoto M Nakahigashi S Umegae T Kitagawa K Matsumoto 2005 Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: Cytokine production and endoscopic and histological findings Inflamm Bowel Dis 11 580-8 15905706 10.1097/01.MIB.0000161307.58327.96
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 580-588
    • Yamamoto, T.1    Nakahigashi, M.2    Umegae, S.3    Kitagawa, T.4    Matsumoto, K.5
  • 39
    • 0038185270 scopus 로고    scopus 로고
    • Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial
    • [see comment 12730861 10.1016/S0016-5085(03)00171-9
    • P Gionchetti F Rizzello U Helwig A Venturi KM Lammers P Brigidi 2003 Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial [see comment Gastroenterology 124 1202-9 12730861 10.1016/S0016-5085(03)00171-9
    • (2003) Gastroenterology , vol.124 , pp. 1202-1209
    • Gionchetti, P.1    Rizzello, F.2    Helwig, U.3    Venturi, A.4    Lammers, K.M.5    Brigidi, P.6
  • 40
    • 0033860601 scopus 로고    scopus 로고
    • Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
    • 10930365 10.1053/gast.2000.9370 1:STN:280:DC%2BD3cvgtl2ltw%3D%3D
    • P Gionchetti F Rizzello A Venturi P Brigidi D Matteuzzi G Bazzocchi 2000 Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial Gastroenterology 119 305-9 10930365 10.1053/gast.2000.9370 1:STN:280:DC%2BD3cvgtl2ltw%3D%3D
    • (2000) Gastroenterology , vol.119 , pp. 305-309
    • Gionchetti, P.1    Rizzello, F.2    Venturi, A.3    Brigidi, P.4    Matteuzzi, D.5    Bazzocchi, G.6
  • 41
    • 2442495410 scopus 로고    scopus 로고
    • Probiotics and the management of inflammatory bowel disease
    • 15290926 10.1097/00054725-200405000-00018
    • RN Fedorak KL Madsen 2004 Probiotics and the management of inflammatory bowel disease Inflamm Bowel Dis 10 286-99 15290926 10.1097/ 00054725-200405000-00018
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 286-2399
    • Fedorak, R.N.1    Madsen, K.L.2
  • 42
    • 33748192909 scopus 로고    scopus 로고
    • Probiotics in the treatment of inflammatory bowel disease
    • 16633133 10.1097/00004836-200603000-00019
    • KP Rioux RN Fedorak 2006 Probiotics in the treatment of inflammatory bowel disease J Clin Gastroenterol 40 260-3 16633133 10.1097/ 00004836-200603000-00019
    • (2006) J Clin Gastroenterol , vol.40 , pp. 260-263
    • Rioux, K.P.1    Fedorak, R.N.2
  • 43
    • 0029993786 scopus 로고    scopus 로고
    • Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
    • 8625991 1:CAS:528:DyaK28XisVKlurY%3D
    • R Duchmann E Schmitt P Knolle KH Meyer zum Buschenfelde M Neurath 1996 Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12 Eur J Immunol 26 934-8 8625991 1:CAS:528:DyaK28XisVKlurY%3D
    • (1996) Eur J Immunol , vol.26 , pp. 934-938
    • Duchmann, R.1    Schmitt, E.2    Knolle, P.3    Meyer zum Buschenfelde, K.H.4    Neurath, M.5
  • 44
    • 0038687617 scopus 로고    scopus 로고
    • Experimental models of inflammatory bowel disease
    • A Stadnicki RW Colman 2003 Experimental models of inflammatory bowel disease Arch Immunol Ther Exp 51 149-55
    • (2003) Arch Immunol Ther Exp , vol.51 , pp. 149-155
    • Stadnicki, A.1    Colman, R.W.2
  • 45
    • 11144266571 scopus 로고    scopus 로고
    • Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype
    • 15571586 10.1111/j.1572-0241.2004.40417.x
    • ID Arnott CJ Landers EJ Nimmo HE Drummond BK Smith SR Targan 2004 Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype Am J Gastroenterol 99 2376-84 15571586 10.1111/j.1572-0241.2004.40417.x
    • (2004) Am J Gastroenterol , vol.99 , pp. 2376-2384
    • Arnott, I.D.1    Landers, C.J.2    Nimmo, E.J.3    Drummond, H.E.4    Smith, B.K.5    Targan, S.R.6
  • 46
    • 0036726184 scopus 로고    scopus 로고
    • Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens
    • 12198693 10.1053/gast.2002.35379 1:CAS:528:DC%2BD38Xntl2mtbk%3D
    • CJ Landers O Cohavy R Misra H Yang YC Lin J Braun 2002 Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens Gastroenterology 123 689-99 12198693 10.1053/gast.2002.35379 1:CAS:528:DC%2BD38Xntl2mtbk%3D
    • (2002) Gastroenterology , vol.123 , pp. 689-699
    • Landers, C.J.1    Cohavy, O.2    Misra, R.3    Yang, H.4    Lin, Y.C.5    Braun, J.6
  • 47
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • 15124021 10.1172/JCI200420295 1:CAS:528:DC%2BD2cXjvVOqs78%3D
    • MJ Lodes Y Cong CO Elson R Mohamath CJ Landers SR Targan 2004 Bacterial flagellin is a dominant antigen in Crohn disease J Clin Invest 113 1296-306 15124021 10.1172/JCI200420295 1:CAS:528:DC%2BD2cXjvVOqs78%3D
    • (2004) J Clin Invest , vol.113 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3    Mohamath, R.4    Landers, C.J.5    Targan, S.R.6
  • 48
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • 14762777 10.1053/j.gastro.2003.11.015 1:CAS:528:DC%2BD2cXhvV2rsbg%3D
    • WS Mow EA Vasiliauskas YC Lin PR Fleshner KA Papadakis KD Taylor 2004 Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease Gastroenterology 126 414-24 14762777 10.1053/j.gastro.2003.11.015 1:CAS:528:DC%2BD2cXhvV2rsbg%3D
    • (2004) Gastroenterology , vol.126 , pp. 414-424
    • Mow, W.S.1    Vasiliauskas, E.A.2    Lin, Y.C.3    Fleshner, P.R.4    Papadakis, K.A.5    Taylor, K.D.6
  • 49
    • 0037371185 scopus 로고    scopus 로고
    • Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment
    • 12584218 10.1136/gut.52.3.370 1:STN:280:DC%2BD3s%2FntlCgtg%3D%3D
    • LA Dieleman MS Goerres A Arends D Sprengers C Torrice F Hoentjen 2003 Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment Gut 52 370-6 12584218 10.1136/ gut.52.3.370 1:STN:280:DC%2BD3s%2FntlCgtg%3D%3D
    • (2003) Gut , vol.52 , pp. 370-376
    • Dieleman, L.A.1    Goerres, M.S.2    Arends, A.3    Sprengers, D.4    Torrice, C.5    Hoentjen, F.6
  • 50
    • 17144383927 scopus 로고    scopus 로고
    • Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    • 15825073 10.1053/j.gastro.2005.02.009 1:CAS:528:DC%2BD2MXjvV2qt78%3D
    • SC Kim SL Tonkonogy CA Albright J Tsang EJ Balish J Braun 2005 Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria Gastroenterology 128 891-906 15825073 10.1053/j.gastro.2005.02.009 1:CAS:528:DC%2BD2MXjvV2qt78%3D
    • (2005) Gastroenterology , vol.128 , pp. 891-906
    • Kim, S.C.1    Tonkonogy, S.L.2    Albright, C.A.3    Tsang, J.4    Balish, E.J.5    Braun, J.6
  • 51
    • 0034991524 scopus 로고    scopus 로고
    • Review article: The genetics of inflammatory bowel disease
    • 11380312 10.1046/j.1365-2036.2001.00981.x 1:CAS:528:DC%2BD3MXks1Kisbg%3D
    • T Ahmad J Satsangi D McGovern M Bunce DP Jewell 2001 Review article: The genetics of inflammatory bowel disease Aliment Pharmacol Ther 15 731-48 11380312 10.1046/j.1365-2036.2001.00981.x 1:CAS:528:DC%2BD3MXks1Kisbg%3D
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 731-748
    • Ahmad, T.1    Satsangi, J.2    McGovern, D.3    Bunce, M.4    Jewell, D.P.5
  • 52
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • 11425413 10.1016/S0140-6736(00)05063-7 1:CAS:528:DC%2BD3MXks1OisLk%3D
    • J Hampe A Cuthbert PJ Croucher MM Mirza S Mascheretti S Fisher 2001 Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations Lancet 357 1925-8 11425413 10.1016/ S0140-6736(00)05063-7 1:CAS:528:DC%2BD3MXks1OisLk%3D
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3    Mirza, M.M.4    Mascheretti, S.5    Fisher, S.6
  • 53
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • 11385576 10.1038/35079107 1:CAS:528:DC%2BD3MXksVShtLY%3D
    • JP Hugot M Chamaillard H Zouali S Lesage JP Cezard J Belaiche 2001 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 599-603 11385576 10.1038/35079107 1:CAS:528:DC%2BD3MXksVShtLY%3D
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cezard, J.P.5    Belaiche, J.6
  • 54
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • 11385577 10.1038/35079114 1:CAS:528:DC%2BD3MXksVShur8%3D
    • Y Ogura DK Bonen N Inohara DL Nicolae FF Chen R Ramos 2001 A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 603-6 11385577 10.1038/35079114 1:CAS:528:DC%2BD3MXksVShur8%3D
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 55
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • 12514169 10.1074/jbc.C200673200 1:CAS:528:DC%2BD3sXht1aqsro%3D
    • N Inohara Y Ogura A Fontalba O Gutierrez F Pons J Crespo 2003 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease J Biol Chem 278 5509-12 12514169 10.1074/jbc.C200673200 1:CAS:528:DC%2BD3sXht1aqsro%3D
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3    Gutierrez, O.4    Pons, F.5    Crespo, J.6
  • 56
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • 15692052 10.1126/science.1103685 1:CAS:528:DC%2BD2MXpt1WqtA%3D%3D
    • S Maeda LC Hsu H Liu LA Bankston M Iimura MF Kagnoff 2005 Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing Science 307 734-8 15692052 10.1126/science.1103685 1:CAS:528:DC%2BD2MXpt1WqtA%3D%3D
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1    Hsu, L.C.2    Liu, H.3    Bankston, L.A.4    Iimura, M.5    Kagnoff, M.F.6
  • 57
    • 0345303939 scopus 로고    scopus 로고
    • Lessons from Nod2 studies: Towards a link between Crohn's disease and bacterial sensing
    • 14644139 10.1016/j.it.2003.10.007 1:CAS:528:DC%2BD3sXptlyhsr4%3D
    • SE Girardin JP Hugot PJ Sansonetti 2003 Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing Trends Immunol 24 652-8 14644139 10.1016/j.it.2003.10.007 1:CAS:528:DC%2BD3sXptlyhsr4%3D
    • (2003) Trends Immunol , vol.24 , pp. 652-658
    • Girardin, S.E.1    Hugot, J.P.2    Sansonetti, P.J.3
  • 58
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • 15220916 10.1038/ni1092 1:CAS:528:DC%2BD2cXmtVCgtL8%3D
    • T Watanabe A Kitani PJ Murray W Strober 2004 NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses Nat Immunol 5 800-8 15220916 10.1038/ni1092 1:CAS:528:DC%2BD2cXmtVCgtL8%3D
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 59
    • 3242662009 scopus 로고    scopus 로고
    • Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease
    • 15236195 10.1053/j.gastro.2004.01.028 1:CAS:528:DC%2BD2cXmsVShsLw%3D
    • J Bilsborough JL Viney 2004 Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease Gastroenterology 127 300-9 15236195 10.1053/j.gastro.2004.01.028 1:CAS:528:DC%2BD2cXmsVShsLw%3D
    • (2004) Gastroenterology , vol.127 , pp. 300-309
    • Bilsborough, J.1    Viney, J.L.2
  • 60
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • 15653504 10.1126/science.1102901 1:CAS:528:DC%2BD2MXisVKltQ%3D%3D
    • JH Niess S Brand X Gu L Landsman S Jung BA McCormick 2005 CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance Science 307 254-8 15653504 10.1126/science.1102901 1:CAS:528:DC%2BD2MXisVKltQ%3D%3D
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3    Landsman, L.4    Jung, S.5    McCormick, B.A.6
  • 61
    • 33644822758 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling
    • 16326999 10.1203/01.pdr.0000195101.74184.e3 1:CAS:528:DC%2BD2MXhtlert7zF
    • TC Savidge PG Newman WH Pan MQ Weng HN Shi BA McCormick 2006 Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling Pediatr Res 59 89-95 16326999 10.1203/ 01.pdr.0000195101.74184.e3 1:CAS:528:DC%2BD2MXhtlert7zF
    • (2006) Pediatr Res , vol.59 , pp. 89-95
    • Savidge, T.C.1    Newman, P.G.2    Pan, W.H.3    Weng, M.Q.4    Shi, H.N.5    McCormick, B.A.6
  • 62
    • 29644443359 scopus 로고    scopus 로고
    • Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium
    • 16369019 10.1128/IAI.74.1.625-631.2006 1:CAS:528:DC%2BD28XitlKrug%3D%3D
    • P Tyrer AR Foxwell AW Cripps MA Apicella JM Kyd 2006 Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium Infect Immun 74 625-31 16369019 10.1128/IAI.74.1.625-631.2006 1:CAS:528:DC%2BD28XitlKrug%3D%3D
    • (2006) Infect Immun , vol.74 , pp. 625-631
    • Tyrer, P.1    Foxwell, A.R.2    Cripps, A.W.3    Apicella, M.A.4    Kyd, J.M.5
  • 63
    • 0034125228 scopus 로고    scopus 로고
    • Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease
    • 10877227 10.1023/A:1005541700805 1:STN:280:DC%2BD3czjtlOhsg%3D%3D
    • JR Korzenik BK Dieckgraefe 2000 Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease Dig Dis Sci 45 1121-9 10877227 10.1023/A:1005541700805 1:STN:280:DC%2BD3czjtlOhsg%3D%3D
    • (2000) Dig Dis Sci , vol.45 , pp. 1121-1129
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 64
    • 14644404938 scopus 로고    scopus 로고
    • An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
    • 15709989 10.1111/j.1365-2036.2005.02287.x 1:CAS:528:DC%2BD2MXisFCrsbo%3D
    • JR Korzenik BK Dieckgraefe 2005 An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease Aliment Pharmacol Ther 21 391-400 15709989 10.1111/ j.1365-2036.2005.02287.x 1:CAS:528:DC%2BD2MXisFCrsbo%3D
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 391-400
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 65
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • [see comment] 12433518 10.1016/S0140-6736(02)11437-1
    • BK Dieckgraefe JR Korzenik 2002 Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor [see comment] Lancet 360 1478-80 12433518 10.1016/S0140-6736(02)11437-1
    • (2002) Lancet , vol.360 , pp. 1478-1480
    • Dieckgraefe, B.K.1    Korzenik, J.R.2
  • 66
    • 19444363154 scopus 로고    scopus 로고
    • Sargramostim in Crohn's Disease Study G. Sargramostim for active Crohn's disease
    • 15917384 10.1056/NEJMoa041109 1:CAS:528:DC%2BD2MXksFOlsro%3D
    • JR Korzenik BK Dieckgraefe JF Valentine DF Hausman MJ Gilbert 2005 Sargramostim in Crohn's Disease Study G. Sargramostim for active Crohn's disease N Engl J Med 352 2193-201 15917384 10.1056/NEJMoa041109 1:CAS:528:DC%2BD2MXksFOlsro%3D
    • (2005) N Engl J Med , vol.352 , pp. 2193-2201
    • Korzenik, J.R.1    Dieckgraefe, B.K.2    Valentine, J.F.3    Hausman, D.F.4    Gilbert, M.J.5
  • 67
    • 33847642965 scopus 로고    scopus 로고
    • accessed on 10 December
    • http://www.schering.de/scripts/en/50_media/2006/pi/Q3/ 060731_Leukine.php?n=mep accessed on 10 December 2006
    • (2006)
  • 68
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • 8820272 10.1016/0167-5699(96)80606-2 1:CAS:528:DyaK28XhsVensLo%3D
    • TR Mosmann S Sad 1996 The expanding universe of T-cell subsets: Th1, Th2 and more Immunol Today 17 138-46 8820272 10.1016/0167-5699(96)80606-2 1:CAS:528:DyaK28XhsVensLo%3D
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 69
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • 8757634 1:CAS:528:DyaK28XksFKhtLY%3D
    • IJ Fuss M Neurath M Boirivant JS Klein C de la Motte SA Strong 1996 Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5 J Immunol 157 1261-70 8757634 1:CAS:528:DyaK28XksFKhtLY%3D
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    de la Motte, C.5    Strong, S.A.6
  • 70
    • 0027231774 scopus 로고
    • Tumour-necrosis-factor antibody treatment in Crohn's disease
    • 8101267 10.1016/0140-6736(93)91375-V 1:STN:280:ByyA38zmtlE%3D
    • B Derkx J Taminiau S Radema A Stronkhorst C Wortel G Tytgat 1993 Tumour-necrosis-factor antibody treatment in Crohn's disease Lancet 342 173-4 8101267 10.1016/0140-6736(93)91375-V 1:STN:280:ByyA38zmtlE%3D
    • (1993) Lancet , vol.342 , pp. 173-174
    • Derkx, B.1    Taminiau, J.2    Radema, S.3    Stronkhorst, A.4    Wortel, C.5    Tytgat, G.6
  • 71
    • 0029050742 scopus 로고
    • Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
    • 7797011 10.1016/0016-5085(95)90277-5 1:STN:280:ByqA3MjltlQ%3D
    • HM van Dullemen SJ Van Deventer DW Hommes HA Bijl J Jansen GN Tytgat 1995 Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2) Gastroenterology 109 129-35 7797011 10.1016/0016-5085(95)90277-5 1:STN:280:ByqA3MjltlQ%3D
    • (1995) Gastroenterology , vol.109 , pp. 129-135
    • van Dullemen, H.M.1    Van, S.J.2    Deventer Hommes, D.W.3    Bijl, H.A.4    Jansen, J.5    Tytgat, G.N.6
  • 72
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group
    • 9321530 10.1056/NEJM199710093371502 1:CAS:528:DyaK2sXmvVKjsrs%3D
    • SR Targan SB Hanauer SJ van Deventer L Mayer DH Present T Braakman 1997 A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group N Engl J Med 337 1029-35 9321530 10.1056/NEJM199710093371502 1:CAS:528:DyaK2sXmvVKjsrs%3D
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van, S.J.3    Deventer Mayer, L.4    Present, D.H.5    Braakman, T.6
  • 73
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial
    • 12047962 10.1016/S0140-6736(02)08512-4 1:CAS:528:DC%2BD38Xkt1Gru70%3D
    • SB Hanauer BG Feagan GR Lichtenstein LF Mayer S Schreiber JF Colombel 2002 Maintenance infliximab for Crohn's disease: The ACCENT I randomised trial Lancet 359 1541-9 12047962 10.1016/S0140-6736(02)08512-4 1:CAS:528:DC%2BD38Xkt1Gru70%3D
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3    Mayer, L.F.4    Schreiber, S.5    Colombel, J.F.6
  • 74
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • 14985485 10.1056/NEJMoa030815 1:CAS:528:DC%2BD2cXhsFyitLo%3D
    • BE Sands FH Anderson CN Bernstein WY Chey BG Feagan RN Fedorak 2004 Infliximab maintenance therapy for fistulizing Crohn's disease N Engl J Med 350 876-85 14985485 10.1056/NEJMoa030815 1:CAS:528:DC%2BD2cXhsFyitLo%3D
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, B.E.1    Anderson, F.H.2    Bernstein, C.N.3    Chey, W.Y.4    Feagan, B.G.5    Fedorak, R.N.6
  • 75
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
    • 16472588 10.1053/j.gastro.2005.11.030 1:CAS:528:DC%2BD28Xit1alu7o%3D quiz 591
    • SB Hanauer WJ Sandborn P Rutgeerts RN Fedorak M Lukas D MacIntosh 2006 Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial Gastroenterology 130 323-33 16472588 10.1053/j.gastro.2005.11.030 1:CAS:528:DC%2BD28Xit1alu7o%3D quiz 591
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3    Fedorak, R.N.4    Lukas, M.5    MacIntosh, D.6
  • 76
    • 24144483087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
    • 16143120 10.1053/j.gastro.2005.06.064 1:CAS:528:DC%2BD2MXhtV2isrrK
    • S Schreiber P Rutgeerts RN Fedorak M Khaliq-Kareemi MA Kamm M Boivin 2005 A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease Gastroenterology 129 807-18 16143120 10.1053/j.gastro.2005.06.064 1:CAS:528:DC%2BD2MXhtV2isrrK
    • (2005) Gastroenterology , vol.129 , pp. 807-818
    • Schreiber, S.1    Rutgeerts, P.2    Fedorak, R.N.3    Khaliq-Kareemi, M.4    Kamm, M.A.5    Boivin, M.6
  • 77
    • 33846449387 scopus 로고    scopus 로고
    • Adalimumab induces and maintains clinical response and remission in patients with active Crohn's disease: Results of the CHARM trial
    • 10.1053/j.gastro.2006.06.098
    • JF Colombel WJ Sandborn P Rutgeerts R Enns SB Hanauer R Panaccione 2006 Adalimumab induces and maintains clinical response and remission in patients with active Crohn's disease: Results of the CHARM trial Gastroenterology 131 95010.1053/j.gastro.2006.06.098
    • (2006) Gastroenterology , vol.131 , pp. 950
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3    Enns, R.4    Hanauer, S.B.5    Panaccione, R.6
  • 78
    • 33748923591 scopus 로고    scopus 로고
    • Certolizumab pegol administered subcutaneously is effective and well tolerated in patients with active Crohn's disease: Results from a 26-week, placebo-controlled phase iii study (PRECiSE 1)
    • WJ Sandborn BG Feagan S Stoinov PJ Honiball P Rutgeerts JA McColm 2006 Certolizumab pegol administered subcutaneously is effective and well tolerated in patients with active Crohn's disease: Results from a 26-week, placebo-controlled phase iii study (PRECiSE 1) Gastroenterology 130 A107
    • (2006) Gastroenterology , vol.130
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3    Honiball, P.J.4    Rutgeerts, P.5    McColm, J.A.6
  • 79
    • 33746345358 scopus 로고    scopus 로고
    • Risks and benefits of infliximab for the treatment of Crohn's disease
    • 16843733 10.1016/j.cgh.2006.05.020 1:CAS:528:DC%2BD28XptFWmtrc%3D quiz 976
    • CA Siegel C Hur JR Korzenik GS Gazelle BE Sands 2006 Risks and benefits of infliximab for the treatment of Crohn's disease Clin Gastroenterol Hepatol 4 1017-24 16843733 10.1016/j.cgh.2006.05.020 1:CAS:528:DC%2BD28XptFWmtrc%3D quiz 976
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1017-1024
    • Siegel, C.A.1    Hur, C.2    Korzenik, J.R.3    Gazelle, G.S.4    Sands, B.E.5
  • 80
    • 0347991877 scopus 로고    scopus 로고
    • The safety profile of infliximab in patients with Crohn's disease: The Mayo clinic experience in 500 patients
    • 14699483 10.1053/j.gastro.2003.10.047 1:CAS:528:DC%2BD2cXhtFGnt7c%3D
    • JF Colombel EV Loftus Jr WJ Tremaine LJ Egan WS Harmsen CD Schleck 2004 The safety profile of infliximab in patients with Crohn's disease: The Mayo clinic experience in 500 patients Gastroenterology 126 19-31 14699483 10.1053/j.gastro.2003.10.047 1:CAS:528:DC%2BD2cXhtFGnt7c%3D
    • (2004) Gastroenterology , vol.126 , pp. 19-31
    • Colombel, J.F.1    Loftus, E.V.2    Tremaine Jr., W.J.3    Egan, L.J.4    Harmsen, W.S.5    Schleck, C.D.6
  • 81
    • 0034464148 scopus 로고    scopus 로고
    • Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group
    • 11113067 10.1053/gast.2000.20196 1:CAS:528:DC%2BD3MXhtlKgtA%3D%3D
    • S Schreiber RN Fedorak OH Nielsen G Wild CN Williams S Nikolaus 2000 Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's Disease IL-10 Cooperative Study Group Gastroenterology 119 1461-72 11113067 10.1053/gast.2000.20196 1:CAS:528:DC%2BD3MXhtlKgtA%3D%3D
    • (2000) Gastroenterology , vol.119 , pp. 1461-1472
    • Schreiber, S.1    Fedorak, R.N.2    Nielsen, O.H.3    Wild, G.4    Williams, C.N.5    Nikolaus, S.6
  • 82
    • 33750343050 scopus 로고    scopus 로고
    • Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: A randomised, double blind, placebo controlled, dose ranging trial
    • 16603634 10.1136/gut.2005.089854 1:CAS:528:DC%2BD28Xht1GkurvI
    • G Van Assche WJ Sandborn BG Feagan BA Salzberg D Silvers PS Monroe 2006 Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: A randomised, double blind, placebo controlled, dose ranging trial Gut 55 1568-74 16603634 10.1136/gut.2005.089854 1:CAS:528:DC%2BD28Xht1GkurvI
    • (2006) Gut , vol.55 , pp. 1568-1574
    • Van Assche, G.1    Sandborn, W.J.2    Feagan, B.G.3    Salzberg, B.A.4    Silvers, D.5    Monroe, P.S.6
  • 83
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • 15537905 10.1056/NEJMoa033402 1:CAS:528:DC%2BD2cXpslegs74%3D
    • PJ Mannon IJ Fuss L Mayer CO Elson WJ Sandborn D Present 2004 Anti-interleukin-12 antibody for active Crohn's disease N Engl J Med 351 2069-79 15537905 10.1056/NEJMoa033402 1:CAS:528:DC%2BD2cXpslegs74%3D
    • (2004) N Engl J Med , vol.351 , pp. 2069-2079
    • Mannon, P.J.1    Fuss, I.J.2    Mayer, L.3    Elson, C.O.4    Sandborn, W.J.5    Present, D.6
  • 84
    • 33845340501 scopus 로고    scopus 로고
    • A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
    • 17068223 10.1126/science.1135245 1:CAS:528:DC%2BD28Xht1CntrjF
    • RH Duerr KD Taylor SR Brant JD Rioux MS Silverberg MJ Daly 2006 A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene Science 314 1461-3 17068223 10.1126/science.1135245 1:CAS:528:DC%2BD28Xht1CntrjF
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6
  • 85
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-34
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 86
    • 0027237424 scopus 로고
    • Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    • 7687523 10.1016/0092-8674(93)90305-A 1:CAS:528:DyaK3sXltlOhtb0%3D
    • C Berlin EL Berg MJ Briskin DP Andrew PJ Kilshaw B Holzmann 1993 Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1 Cell 74 185-95 7687523 10.1016/0092-8674(93)90305-A 1:CAS:528:DyaK3sXltlOhtb0%3D
    • (1993) Cell , vol.74 , pp. 185-195
    • Berlin, C.1    Berg, E.L.2    Briskin, M.J.3    Andrew, D.P.4    Kilshaw, P.J.5    Holzmann, B.6
  • 87
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • 12510039 10.1056/NEJMoa020732 1:CAS:528:DC%2BD3sXhsVSltg%3D%3D
    • S Ghosh E Goldin FH Gordon HA Malchow J Rask-Madsen P Rutgeerts 2003 Natalizumab for active Crohn's disease N Engl J Med 348 24-32 12510039 10.1056/NEJMoa020732 1:CAS:528:DC%2BD3sXhsVSltg%3D%3D
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3    Malchow, H.A.4    Rask-Madsen, J.5    Rutgeerts, P.6
  • 88
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • 16267322 10.1056/NEJMoa043335 1:CAS:528:DC%2BD2MXhtF2rsbzF
    • WJ Sandborn JF Colombel R Enns BG Feagan SB Hanauer IC Lawrance 2005 Natalizumab induction and maintenance therapy for Crohn's disease N Engl J Med 353 1912-25 16267322 10.1056/NEJMoa043335 1:CAS:528:DC%2BD2MXhtF2rsbzF
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3    Feagan, B.G.4    Hanauer, S.B.5    Lawrance, I.C.6
  • 89
    • 33748940026 scopus 로고    scopus 로고
    • Natalizumab induces sustained response and remission in patients with active Crohn's disease: Results from the Encore trial
    • S Targan B Feagan R Fedorak B Lashner R Panacionne D Present 2006 Natalizumab induces sustained response and remission in patients with active Crohn's disease: Results from the Encore trial Gastroenterology 130 A108
    • (2006) Gastroenterology , vol.130
    • Targan, S.1    Feagan, B.2    Fedorak, R.3    Lashner, B.4    Panacionne, R.5    Present, D.6
  • 90
    • 22844445587 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease
    • 15947080 10.1056/NEJMoa051586 1:CAS:528:DC%2BD2MXms1Kntrk%3D
    • G Van Assche M Van Ranst R Sciot B Dubois S Vermeire M Noman 2005 Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease N Engl J Med 353 362-8 15947080 10.1056/NEJMoa051586 1:CAS:528:DC%2BD2MXms1Kntrk%3D
    • (2005) N Engl J Med , vol.353 , pp. 362-368
    • Van Assche, G.1    Van Ranst, M.2    Sciot, R.3    Dubois, B.4    Vermeire, S.5    Noman, M.6
  • 91
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • 15958805 10.1056/NEJMoa042982 1:CAS:528:DC%2BD2MXltlaksb4%3D
    • BG Feagan GR Greenberg G Wild RN Fedorak P Pare JW McDonald 2005 Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin N Engl J Med 352 2499-507 15958805 10.1056/ NEJMoa042982 1:CAS:528:DC%2BD2MXltlaksb4%3D
    • (2005) N Engl J Med , vol.352 , pp. 2499-2507
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3    Fedorak, R.N.4    Pare, P.5    McDonald, J.W.6
  • 92
    • 0142157983 scopus 로고    scopus 로고
    • MLN-02 Crohn's disease
    • 10.1016/S0016-5085(03)80125-7
    • BG Feagan 2003 MLN-02 Crohn's disease Gastroenterology 124 A2510.1016/ S0016-5085(03)80125-7
    • (2003) Gastroenterology , vol.124
    • Feagan, B.G.1
  • 93
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • 7904900 10.1016/0092-8674(94)90332-8 1:CAS:528:DyaK2cXhs1Srtr8%3D
    • WE Paul RA Seder 1994 Lymphocyte responses and cytokines Cell 76 241-51 7904900 10.1016/0092-8674(94)90332-8 1:CAS:528:DyaK2cXhs1Srtr8%3D
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 94
    • 0028123444 scopus 로고
    • CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
    • 8270872 10.1084/jem.179.1.299 1:CAS:528:DyaK2cXnsFWlsw%3D%3D
    • RA Seder RN Germain PS Linsley WE Paul 1994 CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production J Exp Med 179 299-304 8270872 10.1084/jem.179.1.299 1:CAS:528:DyaK2cXnsFWlsw%3D%3D
    • (1994) J Exp Med , vol.179 , pp. 299-304
    • Seder, R.A.1    Germain, R.N.2    Linsley, P.S.3    Paul, W.E.4
  • 95
    • 23044476655 scopus 로고    scopus 로고
    • Update in medical therapy of ulcerative colitis: Newer concepts and therapies
    • [erratum appears in J Clin Gastroenterol 2005;39:843 16000921 10.1097/ 01.mcg.0000170735.43887.3a
    • S Katz 2005 Update in medical therapy of ulcerative colitis: Newer concepts and therapies [erratum appears in J Clin Gastroenterol 2005;39:843 J Clin Gastroenterol 39 557-69 16000921 10.1097/ 01.mcg.0000170735.43887.3a
    • (2005) J Clin Gastroenterol , vol.39 , pp. 557-569
    • Katz, S.1
  • 96
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition
    • 16162882 10.1056/NEJMoa050524 1:CAS:528:DC%2BD2MXhtVWhsbnI
    • MC Genovese JC Becker M Schiff M Luggen Y Sherrer J Kremer 2005 Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition N Engl J Med 353 1114-23 16162882 10.1056/NEJMoa050524 1:CAS:528:DC%2BD2MXhtVWhsbnI
    • (2005) N Engl J Med , vol.353 , pp. 1114-1123
    • Genovese, M.C.1    Becker, J.C.2    Schiff, M.3    Luggen, M.4    Sherrer, Y.5    Kremer, J.6
  • 97
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • 9338786 10.1038/39614 1:CAS:528:DyaK2sXmvVSgtb0%3D
    • H Groux A O'Garra M Bigler M Rouleau S Antonenko JE de Vries 1997 A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature 389 737-42 9338786 10.1038/39614 1:CAS:528:DyaK2sXmvVSgtb0%3D
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    de Vries, J.E.6
  • 98
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • 11722636 10.1034/j.1600-065X.2001.1820117.x 1:CAS:528:DC%2BD3MXpt1eisbo%3D
    • HL Weiner 2001 Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells Immunol Rev 182 207-14 11722636 10.1034/j.1600-065X.2001.1820117.x 1:CAS:528:DC%2BD3MXpt1eisbo%3D
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 99
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells
    • 12119349 10.1084/jem.20020642 1:CAS:528:DC%2BD38XlsV2ms7g%3D
    • D Dieckmann CH Bruett H Ploettner MB Lutz G Schuler 2002 Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells J Exp Med 196 247-53 12119349 10.1084/jem.20020642 1:CAS:528:DC%2BD38XlsV2ms7g%3D
    • (2002) J Exp Med , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 100
    • 0036892993 scopus 로고    scopus 로고
    • Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer
    • 12454845 10.1053/gast.2002.37066 1:CAS:528:DC%2BD38Xps1yktbo%3D
    • C Van Montfrans E Hooijberg MS Rodriguez Pena EC De Jong H Spits AA Te Velde 2002 Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer Gastroenterology 123 1877-88 12454845 10.1053/gast.2002.37066 1:CAS:528:DC%2BD38Xps1yktbo%3D
    • (2002) Gastroenterology , vol.123 , pp. 1877-1888
    • Van Montfrans, C.1    Hooijberg, E.2    Rodriguez Pena, M.S.3    De Jong, E.C.4    Spits, H.5    Te Velde, A.A.6
  • 101
    • 0037159530 scopus 로고    scopus 로고
    • Are 100 000 "SNPs" useless?
    • author reply 1509
    • Hurles M. Are 100 000 "SNPs" useless? Science 2002;298:1509; author reply 1509
    • (2002) Science , vol.298 , pp. 1509
    • Hurles, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.