Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation

Journal of Biological Chemistry

Volumn 283, Issue 44, 2008, Pages 30121-30128

  Fluhrer, Regina ^a   Fukumori, Akio ^a   Martin, Lucas ^a   Grammer, Gudula ^a   Haug Kröper, Martina ^a   Klier, Bärbel ^a   Winkler, Edith ^a   Kremmer, Elisabeth ^b   Condron, Margaret M ^c   Teplow, David B ^c   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ENZYME ACTIVITY; FUNCTIONS; GENE ENCODING; GLYCOPROTEINS; ORGANIC ACIDS; PLANTS (BOTANY); PROBABILITY DENSITY FUNCTION; SURFACE PLASMON RESONANCE;

ALZHEIMER DISEASES; AMYLOID PRECURSOR PROTEINS; ASPARTATE RESIDUES; ASPARTYL PROTEASES; CATALYTIC SUBUNITS; CLEAVAGE PRODUCTS; FUNCTIONAL SIMILARITIES; IN VITRO EXPERIMENTS; INCUBATION TIMES; INTRAMEMBRANE PROTEOLYSIS; MISSENSE MUTATIONS; MOLECULAR MECHANISMS; PRESENILINS; SECRETASE; SECRETASE COMPLEXES; SIGNAL PEPTIDES; TUMOR NECROSIS FACTORS;

CELL MEMBRANES;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ASPARTIC PROTEINASE; GAMMA SECRETASE; PRESENILIN 1; SIGNAL PEPTIDE; SIGNAL PEPTIDE PEPTIDASE LIKE 2B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ALZHEIMER DISEASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ASPARTIC ENDOPEPTIDASES; CATALYSIS; CELL LINE; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57649155865     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806092200     Document Type: Article

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