Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

Nature

Volumn 427, Issue 6971, 2004, Pages 256-260

  Matheny, Sharon A ^a   Chen, Chiyuan ^a   Kortum, Robert L ^b   Razidlo, Gina L ^b   Lewis, Robert E ^b   White, Michael A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL IMPACT; ONCOLOGY; SENSITIVITY ANALYSIS;

SIGNAL TRANSDUCTION;

ENZYMES;

MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN; PROTEIN IMP; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

PROTEIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RATS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA;

EID: 1642471746     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02237     Document Type: Article

References (16)

1. Nguven, A. et al. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 22, 3035-3045 (2002).
2. Jensen, K., Shiels, C. & Freemont, P. S. PML protein isoforms and the RBCC/TRIM motif. Oncogene 20, 7223-7233 (2001).
3. Li, S. et al. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. J. Biol. Chem. 273, 6183-6189 (1998).
4. White, M. A. et al. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541 (1995).
5. Bruder, J. T., Heidecker, G. & Rapp, U. R. Serum-, TPA-, and Ras-induced expression from Ap-I/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6, 545-556 (1992).
6. Diaz, B. et al. Phosphorylation Raf-1 serine 338/serine 339 is an essential regulatory event for Ras-dependent activation and biological signalling. Mol. Cell. Biol. 17, 4509-4516 (1997).
7. Joazeiro, C. A. & Weissman, A. M. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102, 349-352 (2000).
8. Yeung, K. et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401, 173-177 (1999).
9. Muller, J. S. O., Copeland, T., Piwnica-Worms, H. & Morrison, D. K. C-TAKI regulates Ras signalling by phosphorylating the MAPK scaffold, KSRI. Mol. Cell 8, 983-993 (2001).
10. Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D. & Therrien, M. KSR is a scaffold required for activation of the ERK/MAPK module. Genes Dev. 16, 427-438 (2002).
11. Bremtan, J. A., Volle, D. J., Chaika, O. V. & Lewis, R. E. Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras. J. Biol. Chem. 277, 5369-5377 (2002).
12. Sundaram, M. & Han, M. The C. elegans KSR-I gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83, 889-901 (1995).
13. Stewart, S. et al. Kinase suppressor of Ras forms a multiprotein signalling complex and modulates MEK localization. Mol. Cell Biol. 19, 5523-5534 (1999).
14. Clements, J. C. et al. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. USA 97, 6499-6303 (2000).
15. Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
16. Chien, Y. & White, M. A. RAL GTPases are liuchpin modulators of human tumour-cell proliferation and survival. EMBO Rep. 4, 800-806 (2003).