Ral GTPases contribute to regulation of cyclin D1 through activation of NF-κB

Molecular and Cellular Biology

Volumn 20, Issue 21, 2000, Pages 8084-8092

  Henry, D O ^a   Moskalenko, S A ^a   Kaur, K J ^a   Fu, M ^a   Pestell, R G ^a   Camonis, J H ^a   White, M A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYCLIN D1; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOLIPASE D; PROTEIN RAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMAL; BLOTTING, WESTERN; CARRIER PROTEINS; CELL SURVIVAL; CYCLIN D1; ENZYME ACTIVATION; FIBROBLASTS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; LUCIFERASE; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICROSCOPY, FLUORESCENCE; NERVE TISSUE PROTEINS; NF-KAPPA B; PHOSPHOLIPASE D; PLASMIDS; PROMOTER REGIONS (GENETICS); RAL GTP-BINDING PROTEINS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0033781565     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.21.8084-8092.2000     Document Type: Article

References (64)

1. Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha
2. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism
3. NF-κB: Ten years after
4. Activate NF-kappa B or die?
5. The NF-kappa B and I kappa B proteins: New discoveries and insights
6. Effector recognition by the small GTP-binding proteins Ras and Ral
7. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
8. Coupling of a signal response domain in IκBα- to multiple pathways for NF-κB activation
9. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases
10. The ras superfamily proteins
11. The ral gene: A new ras related gene isolated by the use of a synthetic probe
12. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
13. New developments in phospholipase
14. Evidence for a Ras/Ral signaling cascade
15. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
16. Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells
17. Stimulation of NFκB activity by multiple signaling pathways requires PAK1
18. Multiple ras effector pathways contribute to G(1) cell cycle progression
19. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth
20. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
21. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
22. 1-to-S-phase transition
23. Involvement of Ral GTPase in v-Src-induced phospholipase D activation
24. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
25. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
26. Signal transduction from multiple Ras effectors
27. Cell cycle targets of Ras/Raf signalling
28. Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA
29. Antisense-fos RNA causes partial reversion of the transformed phenotypes induced by the c-Ha-ras oncogene
30. Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells
31. pp60(v-src) Induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells
32. An in vitro transcription analysis of early responses of the human immunodeficiency virus type 1 long terminal repeat to different transcriptional activators
33. 1 progression in NIH 3T3 cells
34. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts
35. Functional association between Arf and RalA in active phospholipase D complex
36. RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1
37. Ras effectors
38. RalGDS functions in Ras- and cAMP-mediated growth stimulation
39. Regulated migration of epidermal growth factor receptor from caveolae
40. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
41. Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways
42. The small GTPase RalA targets filamin to induce filopodia
43. Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator
44. A putative effector of Ral has homology to Rho/Rac GTPase activating proteins
45. Production of high-titer helper-free retroviruses by transient transfection
46. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
47. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation
48. The Ras branch of small GTPases: Ras family members don't fall far from the tree
49. Reduced skin tumor development in cyclin D1-deficient mice high-lights the oncogenic ras pathway in vivo
50. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
51. Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer
52. Cancer cell cycles
53. Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent
54. Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation
55. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
56. Increasing complexity of the Ras signaling pathway
57. Angiotensin II activation of cyclin D1-dependent kinase activity
58. Multiple Ras functions can contribute to mammalian cell transformation
59. A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
60. Ras caught in another affair: The exchange factors for Ral
61. Stimulation of gene induction and cell growth by the Ras effector Rlf
62. Ras-dependent activation of the small GTPase Ral
63. Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth