Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8480-8488

  De Ruiter, N D ^a   Wolthuis, R M F ^a   Van Dam, H ^a   Burgering, B M T ^a   Bos, J L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PROTEIN C JUN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; HUMANS; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHOSPHORYLATION; PYRAZOLES; PYRIMIDINES; RAL GTP-BINDING PROTEINS; RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAS PROTEINS; SERINE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TRANSCRIPTION FACTORS;

EID: 0033762434     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8480-8488.2000     Document Type: Article

References (43)

1. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
2. All in the family? New insights and questions regarding interconnectivity of Ras, Rapl and Ral
3. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
4. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways
5. Insulin stimulation of gene expression mediated by p21ras activation
6. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
7. The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
8. Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Racl-dependent pathway
9. Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases
10. JNKl: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
11. Involvement of p21ras in activation of extracellular signal-regulated kinase 2
12. Evidence for a Ras/Ral signaling cascade
13. Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf
14. Multiple ras effector pathways contribute to G(1) cell cycle progression
15. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
16. Selective interaction of JNK protein kinase isoforms with transcription factors
17. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
18. c-jun is essential for normal mouse development and hepatogenesis
19. Cellular transformation and malignancy induced by ras require c-jun
20. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture
21. AP-1 function and regulation
22. Direct control of the Forkhead transcription factor AFX by protein kinase B
23. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
24. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts
25. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells
26. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
27. Regulation and function of the JNK subgroup of MAP kinases
28. Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral
29. The small GTPase RalA targets filamin to induce filopodia
30. Synergistic activation of c-fos promoter activity by Raf and Ral GDP dissociation stimulator
31. The small GTPase, Rapl, mediates CD31-induced integrin adhesion
32. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
33. The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway
34. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
35. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
36. Rab5 induces Rac-independent lamellipodia formation and cell migration
37. Regulation of JNK by Src during Drosophila development
38. ATF-2 is preferentially activated by stress-activated protein kinases to meiate c-jun induction in response to genotoxic agents
39. Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells
40. Multiple Ras functions can contribute to mammalian cell transformation
41. Ras caught in another affair: The exchange factors for Ral
42. Stimulation of gene induction and cell growth by the Ras effector Rlf
43. Ras-dependent activation of the small GTPase Ral