Glutathione depletion and neuronal cell death: The role of reactive oxygen intermediates and mitochondrial function

Brain Research

Volumn 826, Issue 1, 1999, Pages 53-62

  Wullner U ^b   Seyfried, J ^a   Groscurth, P ^c   Beinroth, S ^a   Winter, S ^a   Gleichmann, M ^a   Heneka, M ^b   Loschmann P A ^a   Schulz, J B ^a   Weller, M ^a   Klockgether, T ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Apoptosis; Cerebellar granule neuron; Glutathione; L Buthionine sulfoximine; Mitochondria; Reactive oxygen intermediate

Indexed keywords

BUTHIONINE SULFOXIMINE; ETACRYNIC ACID; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CEREBELLUM; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; GLUTATHIONE METABOLISM; GRANULE CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIMETABOLITES; APOPTOSIS; BISBENZIMIDE; BUTHIONINE SULFOXIMINE; CEREBELLUM; CYCLOHEXIMIDE; DNA FRAGMENTATION; FLUORESCENT DYES; GLUTATHIONE; MICROSCOPY, ELECTRON; MITOCHONDRIA; NEURONS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 0344603640     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01228-7     Document Type: Article

References (26)

1. Ankacrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
2. Baker M.A., Cerniglia G.J., Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large samples. Anal. Biochem. 190:1990;360-365.
3. Beaver J.P., Waring P. A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes. Eur. J. Cell Biol. 68:1995;47-54.
4. Bojes H.K., Datta K., Xu J., Chin A., Simonian P., Nunez G., Kehrer J.P. Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Biochem. J. 325:1997;315-319.
5. Dobbelsteen D.J., Nobel C.S.I., Schlegel J., Cotgreave I.A., Orrenius S., Slaters A.F.G. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J. Biol. Chem. 271:1996;15420-15427.
6. Garcia R.C., Colell A., Morales A., Kaplowitz N., Fernandez C.J.C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa-B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48:1995;825-834.
7. Garcia R.C., Morales A., Colell A., Rodes J., Yi J.R., Kaplowitz N., Fernandez C.J.C. Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes. J. Biol. Chem. 270:1995;15946-15949.
8. Han S.K., Mytillineou C., Cohen G. L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J. Neurochem. 66:1996;501-510.
9. Heales S.J.R., Bolanos J.P., Clark J.B. Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity. Neurochem. Res. 21:1996;35-39.
10. Huang J., Philbert M.A. Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells. Brain Res. 680:1995;16-22.
11. Huang J., Philbert M.A. Cellular responses of cultured cerebellar astrocytes to ethacrynic acid-induced perturbation of subcellular glutathione homeostasis. Brain Res. 711:1996;184-192.
12. Jenner P. Oxidative damage in neurodegenerative disease. The Lancet. 344:1994;796-798.
13. Kane D.J., Sarafia T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ord T., Bredesen D.E. Bcl-2 inhibition of neuronal death: decreased generation of reactive oxygen species. Science. 262:1993;1274-1277.
14. Langeveld C.H., Jongenelen A.M., Schepens E., Stoof J.C., Bast A., Drukarch B. Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development. Neurosci. Lett. 192:1995;13-16.
15. Lomaestro B.M., Malone M. Glutathione in health and disease: pharmacotherapeutic issues. Annals of Pharmacotherapy. 29:1995;1263-1273.
16. Macho A., Hirsch T., Marzo I., Marchetti P., Dallaporta B., Susin S.A., Zamzami M., Kroemer G. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J. Immunol. 158:1997;4612-4619.
17. A. Meister, M. Andersson, Glutathione, Annu. Rev. Biochem. (1983) 711-760.
18. Nicoletti F., Wroblewski J.T., Novelli A., Alho H., Guidotti A.C.E. The activation of inositol phospholipid metabolism as a signal transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J. Neurosci. 67:1986;1905-1911.
19. Oyama Y., Hayashi A., Ueha T., Maekawa K. Characterization of 2′7′-dichlorofluorescinfluorescence in dissociated mammalian brain neurons: estimation on intracellular content of hydrogen peroxide. Brain Res. 635:1994;113-117.
20. Reed D.J. Glutathione: toxicological implications. Annu. Rev. Pharmacol. Toxicol. 30:1990;603-631.
21. Reed D.J., Savage M.K. Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status. Biochim. Biophys. Acta. 1271:1995;43-50.
22. Sato N., Iwata S., Nakamura K., Hori T., Mori K., Yodoi J. Thiol-mediated redox regulation of apoptosis: possible roles of cellular thiols other than glutathione in T cell apoptosis. J. Immunol. 154:1995;3194-3203.
23. Wüllner U., Löschmann P.-A., Schulz J.B., Schmid A., Dringen R., Eblen F., Turski L., Klockgether T. Glutathione depletion potentiates MPTP and MPP+ toxicity in nigral dopaminergic neurones. Neuroreport. 7:1996;921-923.
24. Wüllner U., Weller M., Groscurth P., Löschmann P.-A., Schulz J.B., Müller I., Klockgether T. Evidence for an active type of cell death with ultrastructural features distinct from apoptosis: the effects of 3-acetylpyridine toxicity. Neuroscience. 81:1997;721-734.
25. Zeevalk G.D., Bernard L.P., Albers D.S., Mirochnitchenko O., Nicklas W.J., Sonsalla P.K. Energy stress induced dopamine loss in glutathione peroxidase overexpressing transgenic mice and in glutathione depleted mesencephalic cultures. J. Neurochem. 68:1997;426-429.
26. Zheng X.X., Shoffner J.M., Voljavec A.S., Wallace D.C. Evaluation of procedures for assaying oxidativephosphorylation enzyme activities in mitochondrial myopathy muscle biopsies. Biochim. Biophys. Acta. 1019:1990;1-10.