Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes

Journal of Hepatology

Volumn 34, Issue 6, 2001, Pages 946-954

  Hammond, Christine L ^a   Lee, Thomas K ^a   Ballatori, Nazzareno ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEME OXYGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ION CHANNEL; ORGANIC COMPOUND; STRESS ACTIVATED PROTEIN KINASE; THIOL GROUP; TRANSCRIPTION FACTOR AP 1;

BIOSYNTHESIS; CELL DEATH; DNA BINDING; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; MEMBRANE TRANSPORT; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; OXIDATION REDUCTION REACTION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; THYROID GLAND;

ANIMALS; APOPTOSIS; CASPASES; GENE EXPRESSION REGULATION; GLUTATHIONE; HEME OXYGENASE (DECYCLIZING); HOMEOSTASIS; HUMANS; ION CHANNELS; LIVER; MEMBRANE TRANSPORT PROTEINS; METALS; NF-KAPPA B; OXIDATION-REDUCTION; SULFHYDRYL COMPOUNDS; THYROID GLAND; TRANSCRIPTION FACTOR AP-1;

EID: 0034955787     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00037-X     Document Type: Review

References (123)

1. Glutathione
2. New developments in glutathione metabolism and their potential application in therapy
3. Endogenous glutathione conjugates: Occurrence and biological functions
4. Importance and regulation of hepatic glutathione
5. The physiological consequences of glutathione variations
6. Hepatic glutathione homeostasis in the rat: Efflux accounts for glutathione turnover
7. Intrabiliary glutathione hydrolysis. A source of glutamate in bile
8. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents
9. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver
10. Relation between biliary glutathione excretion and bile acid-independent bile flow
11. Glutathione as a primary osmotic driving force in hepatic bile formation
12. ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver
13. Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver
14. Glutathione and related γ-glutamyl compounds: Biosynthesis and utilization
15. Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process
16. Biological disulfides: The third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange
17. Glutathione metabolism and its role in hepatotoxicity
18. The glutathione status of cells
19. L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin
20. The role of glutathione and glutathione transferases in chemical carcinogenesis
21. The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis
22. The isoenzymes of glutathione transferase
23. The glutathione S-transferases: A group of multifunctional detoxification proteins
24. Reactivity of glutathione in model systems for glutathione S-transferases and related enzymes
25. Glutathione mercaptides as transport forms of metals
26. Molecular mechanisms of hepatic metal transport
27. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells
28. Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells
29. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes
30. Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells
31. Apoptosis or necrosis: Intracellular levels of glutathione influence mode of cell death
32. Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells
33. Glutathione depletion and neuronal cell death: The role of reactive oxygen intermediates and mitochondrial function
34. GSH extrusion and the mitochondrial pathway of apoptotic signaling
35. Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion
36. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death
37. Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols
38. ASTRO research fellowship: The role of BCL-2 and glutathione in an antioxidant pathway to prevent radiation-induced apoptosis
39. BCL-2 and glutathione: Alterations in cellular redox state that regulate apoptosis sensitivity
40. Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation
41. Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state
42. Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux
43. Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle
44. Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal
45. Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels
46. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols
47. Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death
48. Rescue of cells from apoptosis by inhibition of active GSH extrusion
49. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody
50. Specific efflux of glutathione from the basolateral membrane domain in polarized MDCK cells during ricin-induced apoptosis
51. Glutathione levels determine apoptosis in macrophages
52. CD95-Mediated murine hepatic apoptosis requires an intact glutathione status
53. Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice
54. Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
55. A comparative study of apoptosis and necrosis in HepG2 cells: Oxidant-induced caspase inactivation leads to necrosis
56. Redox regulation of the caspases during apoptosis
57. Regulation of gene expression by reactive oxygen
58. Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells: Implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2
59. Redox regulation of nuclear factor kappa B: Therapeutic potential for attenuating inflammatory responses
60. Control of apoptosis by Rel/NF-kappaB transcription factors
61. Is NF-kappaB the sensor of oxidative stress?
62. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal
63. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus
64. The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine
65. Optimal NF kappa B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals
66. Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of extracellular cysteine supply
67. Redox signals and NF-kappaB activation in T cells
68. The role of Jun, Fos and the AP-1 complex in cellproliferation and transformation
69. Antioxidant and redox regulation of gene transcription
70. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
71. Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells
72. Heterogeneity in c-jun gene expression in normal and malignant cells exposed to either ionizing radiation or hydrogen peroxide
73. Heme oxygenase-1 gene expression by a glutathione depletor, phorone, mediated through AP-1 activation in rats
74. 2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
75. Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells
76. Induction of heine oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts
77. Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heine oxygenase gene
78. Induction of heine oxygenase: A general response to oxidant stress in cultured mammalian cells
79. Thyroid-specific gene expression is differentially influenced by intracellular glutathione level in FRTL-5 cells
80. Influence of the cellular redox state on NF-kappaB-regulated gene expression
81. The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
82. N-Terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65
83. Redox regulation of fos and jun DNA-binding activity in vitro
84. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
85. Expression cloning of a rat liver Na(+)-independent organic anion transporter
86. Functional characterization of the basolateral rat liver organic anion transporting polypeptide
87. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
88. Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells
89. Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
90. ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins
91. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
92. ATP-dependent GSH and glutathione S-conjugate transport in skate liver: Role of an Mrp functional homologue
93. Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione
94. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
95. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
96. ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): No inhibition by intracellular glutathione depletion
97. Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation
98. Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance- associated protein
99. ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene
100. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
101. Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
102. ATPase activity of purified multidrug resistance-associated protein
103. Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles
104. The effect of glutathione on the ATPase activity of MRP1 in its natural membranes
105. Non-equivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1
106. Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1
107. The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
108. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
109. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates
110. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
111. Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia
112. Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR - ) rats with conjugated hyperbilirubinemia
113. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat
114. Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione
115. Redox control of ion channel activity in vascular endothelial cells by glutathione
116. Glutathione modulates the N-methyl-D-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells
117. Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors
118. Glutathione and signal transduction in the mammalian CNS
119. Redox modulatory site of the NMDA receptor-channel complex: Regulation by oxidized glutathione
120. 2+ release mechanism
121. + efflux system of Escherichia coli that cause constitutive activation
122. Glutathione and the gated potassium channels of Escherichia coli
123. The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli