메뉴 건너뛰기




Volumn 42, Issue 1, 1998, Pages 191-203

Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

Author keywords

Antioxidants; GSH; Oxidative stress; Radiobiology

Indexed keywords

GLUTATHIONE;

EID: 0031712812     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(98)00185-0     Document Type: Article
Times cited : (93)

References (63)
  • 2
    • 0018263443 scopus 로고
    • The biology of oxygen radicals
    • Fridovich, I. The biology of oxygen radicals. Science 201: 875-880; 1978.
    • (1978) Science , vol.201 , pp. 875-880
    • Fridovich, I.1
  • 3
    • 0024504551 scopus 로고
    • Superoxide dismutase amplifies organismal sensitivity to ionizing radiation
    • Scott, M. D.; Meshnick, S. R;. Eaton, J. W. Superoxide dismutase amplifies organismal sensitivity to ionizing radiation. J. Biol. Chem. 264:2498-2501;1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 2498-2501
    • Scott, M.D.1    Meshnick, S.R.2    Eaton, J.W.3
  • 4
    • 0027394553 scopus 로고
    • Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation
    • Hirose, K.; Longo, D. L.; Oppenheim, J. J.; Matsushima, K. Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation. FASEB J. 7:361-368; 1993.
    • (1993) FASEB J. , vol.7 , pp. 361-368
    • Hirose, K.1    Longo, D.L.2    Oppenheim, J.J.3    Matsushima, K.4
  • 11
    • 0000048543 scopus 로고
    • Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: A possible model for mammalian cell protection
    • Moore, W.; Anderson, M. E.; Meister, A.; Murata, K.; Kimura, A. Increased capacity for glutathione synthesis enhances resistance to radiation in Escherichia coli: A possible model for mammalian cell protection. Proc. Natl. Acad. Sci. USA 86:1461-1464; 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1461-1464
    • Moore, W.1    Anderson, M.E.2    Meister, A.3    Murata, K.4    Kimura, A.5
  • 12
    • 0029820524 scopus 로고    scopus 로고
    • The other human genome: Mitochondrial DNA and disease
    • John, D. R. The other human genome: Mitochondrial DNA and disease. Nat. Med. 2:1065-1068; 1996.
    • (1996) Nat. Med. , vol.2 , pp. 1065-1068
    • John, D.R.1
  • 14
    • 0019978703 scopus 로고
    • Replication of animal mitochondrial DNA
    • Clayton, D. A. Replication of animal mitochondrial DNA. Cell 28:693-705; 1982.
    • (1982) Cell , vol.28 , pp. 693-705
    • Clayton, D.A.1
  • 15
    • 0021118509 scopus 로고
    • Transcription of the mammalian mitochondrial gen
    • Clayton, D. A. Transcription of the mammalian mitochondrial gen. Annu. Rev. Biochem. 53:573-594; 1984.
    • (1984) Annu. Rev. Biochem. , vol.53 , pp. 573-594
    • Clayton, D.A.1
  • 16
    • 0024460992 scopus 로고
    • Endogenous oxidative DNA damage, aging and cancer
    • Ames, B. Endogenous oxidative DNA damage, aging and cancer. Free Radic. Res. Commun. 7:121-128; 1989.
    • (1989) Free Radic. Res. Commun. , vol.7 , pp. 121-128
    • Ames, B.1
  • 17
    • 0026743031 scopus 로고
    • Reactive oxygen and DNA damage in mitochondria
    • Richter, C. Reactive oxygen and DNA damage in mitochondria. Mutat. Res. 275:249-255; 1992.
    • (1992) Mutat. Res. , vol.275 , pp. 249-255
    • Richter, C.1
  • 18
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace, C. Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science 256:628-632; 1992.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, C.1
  • 19
    • 0025302401 scopus 로고
    • Role of GSH in the radiation response of mammalian cells in vitro and in vivo
    • Bump, E. A.; Brown, J. M. Role of GSH in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47:117-136; 1990.
    • (1990) Pharmacol. Ther. , vol.47 , pp. 117-136
    • Bump, E.A.1    Brown, J.M.2
  • 20
    • 0029318917 scopus 로고
    • Radiation mutagenesis: The initial DNA lesions responsible
    • Ward, J. F. Radiation mutagenesis: The initial DNA lesions responsible. Radiat. Res. 142:362-368; 1995.
    • (1995) Radiat. Res. , vol.142 , pp. 362-368
    • Ward, J.F.1
  • 22
    • 0020521199 scopus 로고
    • The role of thiols in cellular response to radiation and drugs
    • Biaglow, J. E.; Varnes, M. E.; Clark, E. P.; Epp, E. P. The role of thiols in cellular response to radiation and drugs. Radiat. Res. 95:437-455; 1983.
    • (1983) Radiat. Res. , vol.95 , pp. 437-455
    • Biaglow, J.E.1    Varnes, M.E.2    Clark, E.P.3    Epp, E.P.4
  • 23
    • 0023032151 scopus 로고
    • The role of glutathione in aerobic radioresponse. Sensitization and recovery in the absence of intracellular glutathione
    • Clark, E. P.; Epp, E. P.; Morse-Gaudio, M.; Biaglow, J. E. The role of glutathione in aerobic radioresponse. Sensitization and recovery in the absence of intracellular glutathione. Radiat. Res. 108:238-250; 1986.
    • (1986) Radiat. Res. , vol.108 , pp. 238-250
    • Clark, E.P.1    Epp, E.P.2    Morse-Gaudio, M.3    Biaglow, J.E.4
  • 24
    • 0022470759 scopus 로고
    • The influence of cellular glutathione content on cell survival following photodynamic treatment in vitro
    • Miller, A. C.; Henderson, B. W. The influence of cellular glutathione content on cell survival following photodynamic treatment in vitro. Radiat. Res. 107:83-94; 1986.
    • (1986) Radiat. Res. , vol.107 , pp. 83-94
    • Miller, A.C.1    Henderson, B.W.2
  • 25
    • 0020050042 scopus 로고
    • Radiosensitization of hypoxic tumor cells by depletion of intracellular GSH
    • Bump, E. A.; Yu N.Y.; Brown, J. M. Radiosensitization of hypoxic tumor cells by depletion of intracellular GSH. Science 217:544-545; 1982.
    • (1982) Science , vol.217 , pp. 544-545
    • Bump, E.A.1    Yu, N.Y.2    Brown, J.M.3
  • 26
    • 0021242456 scopus 로고
    • The role of glutathione and DNA strand break repair in determining the shoulder of the radiation survival curve
    • Evans, J. W.; Taylor, Y. C.; Brown, J. M. The role of glutathione and DNA strand break repair in determining the shoulder of the radiation survival curve. Br. J. Cancer. 49(Suppl. VI):49-53; 1984.
    • (1984) Br. J. Cancer. , vol.49 , Issue.6 SUPPL. , pp. 49-53
    • Evans, J.W.1    Taylor, Y.C.2    Brown, J.M.3
  • 27
    • 0026564310 scopus 로고
    • Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles
    • García-Ruiz, C.; Fernández-Checa, J. C.; Kaplowitz, N. Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J. Biol. Chem. 267:22256-22264; 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22256-22264
    • García-Ruiz, C.1    Fernández-Checa, J.C.2    Kaplowitz, N.3
  • 28
    • 4243681979 scopus 로고
    • Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes
    • García-Ruiz, C.; Colell, A.; Marí, M.; Morales, A.; Fernández-Checa, J. C. Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology 22:201-210; 1995.
    • (1995) Hepatology , vol.22 , pp. 201-210
    • García-Ruiz, C.1    Colell, A.2    Marí, M.3    Morales, A.4    Fernández-Checa, J.C.5
  • 29
    • 0024604102 scopus 로고
    • Effect of chronic ethanol feeding on rat hepatocyte glutathione: Relationship of cytosolic glutathione to efflux and mitochondrial sequestration
    • Fernández-Checa, J. C.; Ookhtens, M.; Kaplowitz, N. Effect of chronic ethanol feeding on rat hepatocyte glutathione: Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J. Clin. Invest. 83:1247-1252; 1989.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1247-1252
    • Fernández-Checa, J.C.1    Ookhtens, M.2    Kaplowitz, N.3
  • 30
    • 0028229899 scopus 로고
    • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
    • García-Ruiz, C.; Morales, A.; Ballesta, A.; Rodes, J.; Kaplowitz, N.; Fernández-Checa, J. C. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J. Clin. Invest. 94:193-201; 1994.
    • (1994) J. Clin. Invest. , vol.94 , pp. 193-201
    • García-Ruiz, C.1    Morales, A.2    Ballesta, A.3    Rodes, J.4    Kaplowitz, N.5    Fernández-Checa, J.C.6
  • 31
    • 0028788763 scopus 로고
    • Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: Studies with isolated mitochondria and rat hepatocytes
    • García-Ruiz, C.; Colell, A.; Morales, A.; Kaplowitz, N.; Fernández-Checa, J. C. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: Studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48:825-834; 1995.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 825-834
    • García-Ruiz, C.1    Colell, A.2    Morales, A.3    Kaplowitz, N.4    Fernández-Checa, J.C.5
  • 32
    • 0023079953 scopus 로고
    • High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives
    • Fariss, M. W.; Reed, D. J. High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives. Methods Enzymol. 143:101-109; 1987.
    • (1987) Methods Enzymol. , vol.143 , pp. 101-109
    • Fariss, M.W.1    Reed, D.J.2
  • 34
    • 0021027358 scopus 로고
    • Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay
    • Cathcart, R.; Schwiers, E.; Ames, B. N. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem. 134:111-116; 1983.
    • (1983) Anal. Biochem. , vol.134 , pp. 111-116
    • Cathcart, R.1    Schwiers, E.2    Ames, B.N.3
  • 35
    • 0026742372 scopus 로고
    • A simple model of radiation action in cells based on a repair saturation mechanism
    • Sánchez-Reyes, A. A simple model of radiation action in cells based on a repair saturation mechanism. Radiat. Res. 130: 139-147; 1992.
    • (1992) Radiat. Res. , vol.130 , pp. 139-147
    • Sánchez-Reyes, A.1
  • 36
    • 0023612470 scopus 로고
    • Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes
    • Sellins, K. S.; Cohen, J. J. Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J. Immunol. 139:3199-3206; 1987.
    • (1987) J. Immunol. , vol.139 , pp. 3199-3206
    • Sellins, K.S.1    Cohen, J.J.2
  • 37
    • 0025316845 scopus 로고
    • Fine mapping of DNA damage and repair in specific genomic segments
    • Goram, H. L.; Valles-Ayoub, Y.; Braun, J. Fine mapping of DNA damage and repair in specific genomic segments. Nuclei Acid Res. 18:3823-3829, 1990.
    • (1990) Nuclei Acid Res. , vol.18 , pp. 3823-3829
    • Goram, H.L.1    Valles-Ayoub, Y.2    Braun, J.3
  • 38
    • 0026708608 scopus 로고
    • Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay
    • Kalinowski, D. P.; Illenye, S.; Van Houten, B. Analysis of DNA damage and repair in murine leukemia L1210 cells using a quantitative polymerase chain reaction assay. Nuclei Acid Res. 20:3845-3494, 1992.
    • (1992) Nuclei Acid Res. , vol.20 , pp. 3845-13494
    • Kalinowski, D.P.1    Illenye, S.2    Van Houten, B.3
  • 39
    • 0032079268 scopus 로고    scopus 로고
    • Transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase by ionizing radiation
    • Morales, A.; Miranda, M.; Sánchez-Reyes, A.; Colell, A.; Biete, A.; Fernández-Checa, J. C. Transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase by ionizing radiation. FEBS Lett. 427:15-20, 1998.
    • (1998) FEBS Lett. , vol.427 , pp. 15-20
    • Morales, A.1    Miranda, M.2    Sánchez-Reyes, A.3    Colell, A.4    Biete, A.5    Fernández-Checa, J.C.6
  • 40
    • 0020615123 scopus 로고
    • Depletion in vitro of mitochondrial GSH in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and BCNU
    • Meredith, M; Reed, D. J. Depletion in vitro of mitochondrial GSH in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and BCNU. Biochem. Pharmacol. 32:1383-1388; 1988.
    • (1988) Biochem. Pharmacol. , vol.32 , pp. 1383-1388
    • Meredith, M.1    Reed, D.J.2
  • 42
    • 0029077798 scopus 로고
    • Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells
    • Park, M. S. Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells. J. Biol. Chem. 270: 15467-15470; 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15467-15470
    • Park, M.S.1
  • 43
    • 0023138272 scopus 로고
    • Effects of gamma-radiation on isolated liver mitochondria
    • Erickson, G. A.; Koppenol, W. H. Effects of gamma-radiation on isolated liver mitochondria. Int. J. Radiat. Biol. 51:147-155, 1987.
    • (1987) Int. J. Radiat. Biol. , vol.51 , pp. 147-155
    • Erickson, G.A.1    Koppenol, W.H.2
  • 44
    • 0019944846 scopus 로고
    • Effect of body irradiation on rat liver mitochondria DNA and respiratory functions
    • Itoi, M. E.; de Rey, B. M.; Cabrini, R. L. Effect of body irradiation on rat liver mitochondria DNA and respiratory functions. Histochem. J. 14:205-213; 1982.
    • (1982) Histochem. J. , vol.14 , pp. 205-213
    • Itoi, M.E.1    De Rey, B.M.2    Cabrini, R.L.3
  • 45
    • 0021874179 scopus 로고
    • Radiation-induced damage to mitochondrial D-beta-hydroxybutyrate dehydrogenase and lipid peroxidation
    • Yukawa, O.; Miyahara, M.; Shiraishi, N.; Nakazawa, T. Radiation-induced damage to mitochondrial D-beta-hydroxybutyrate dehydrogenase and lipid peroxidation. Int. J. Radiat. Biol. 48:107-115; 1985.
    • (1985) Int. J. Radiat. Biol. , vol.48 , pp. 107-115
    • Yukawa, O.1    Miyahara, M.2    Shiraishi, N.3    Nakazawa, T.4
  • 46
    • 0025181435 scopus 로고
    • Effect of glutathione depletion on the cytotoxicity of xenobiotics and induction of single-strand DNA breaks by ionizing radiation in isolated round spermatids
    • Den Boer, P. J.; van Loon, A. A. W. M.; Mackenbach, P.; van der Schans, G. P.; Grootegoed, J. A. Effect of glutathione depletion on the cytotoxicity of xenobiotics and induction of single-strand DNA breaks by ionizing radiation in isolated round spermatids. J. Reprod. Fert. 88:259-269, 1990.
    • (1990) J. Reprod. Fert. , vol.88 , pp. 259-269
    • Den Boer, P.J.1    Van Loon, A.A.W.M.2    Mackenbach, P.3    Van Der Schans, G.P.4    Grootegoed, J.A.5
  • 47
    • 0023769597 scopus 로고
    • Subcellular localization of glutathione and thermal sensitivity
    • Freeman, M. L.; Meredith M. J. Subcellular localization of glutathione and thermal sensitivity. Radiat. Res. 115:461-471; 1988.
    • (1988) Radiat. Res. , vol.115 , pp. 461-471
    • Freeman, M.L.1    Meredith, M.J.2
  • 48
    • 0027310177 scopus 로고
    • Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione
    • Miller, A. C.; Gafner, J.; Clark, E. P.; Samid, D. Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione. Mol. Cell. Biol. 13:4416-4422; 1993.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4416-4422
    • Miller, A.C.1    Gafner, J.2    Clark, E.P.3    Samid, D.4
  • 49
    • 0023877990 scopus 로고
    • Toxic effects on acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells
    • Dethlefsen, L. A.; Lehman, C. M.; Biaglow, J. E.; Peck, V. M. Toxic effects on acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells. Radiat. Res. 114:215-224; 1988.
    • (1988) Radiat. Res. , vol.114 , pp. 215-224
    • Dethlefsen, L.A.1    Lehman, C.M.2    Biaglow, J.E.3    Peck, V.M.4
  • 50
    • 0026661425 scopus 로고
    • Aerobic radioprotection of pBR322 by thiols: Effects of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals
    • Zheng, S.; Newton, G. L.; Ward, J. F.; Fahey, R. C. Aerobic radioprotection of pBR322 by thiols: Effects of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat. Res. 130:183-193; 1995.
    • (1995) Radiat. Res. , vol.130 , pp. 183-193
    • Zheng, S.1    Newton, G.L.2    Ward, J.F.3    Fahey, R.C.4
  • 53
    • 0025979356 scopus 로고
    • Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats
    • Fernández-Checa, J. C.; García-Ruiz, C.; Ookhtens, M.; Kaplowitz, N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. J. Clin. Invest. 87: 397-405; 1991.
    • (1991) J. Clin. Invest. , vol.87 , pp. 397-405
    • Fernández-Checa, J.C.1    García-Ruiz, C.2    Ookhtens, M.3    Kaplowitz, N.4
  • 54
    • 0023835721 scopus 로고
    • The ras oncogene increases the intrinsic resistance of NIH 3T3 cells to ionizing radiation
    • Sklar, M. D. The ras oncogene increases the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 239:645-647; 1988.
    • (1988) Science , vol.239 , pp. 645-647
    • Sklar, M.D.1
  • 55
    • 0029872210 scopus 로고    scopus 로고
    • Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: Involvement of reactive oxygen intermediates
    • Sánchez, A.; Alvarez, A. M.; Benito, M; Fabregat, I. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: Involvement of reactive oxygen intermediates. J. Biol. Chem. 271:7416-7422; 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7416-7422
    • Sánchez, A.1    Alvarez, A.M.2    Benito, M.3    Fabregat, I.4
  • 58
    • 0029000942 scopus 로고
    • Ceramide: A signal for apoptosis or mitogenesis?
    • Kolesnick, R.; Fuks, Z. Ceramide: A signal for apoptosis or mitogenesis? J. Exp. Med. 181:1949-1952; 1995.
    • (1995) J. Exp. Med. , vol.181 , pp. 1949-1952
    • Kolesnick, R.1    Fuks, Z.2
  • 59
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • García-Ruiz, C; Colell, A.; Marí, M.; Morales, A.; Fernández-Checa, J. C. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272:11369-11377; 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11369-11377
    • García-Ruiz, C.1    Colell, A.2    Marí, M.3    Morales, A.4    Fernández-Checa, J.C.5
  • 60
    • 0030960327 scopus 로고    scopus 로고
    • Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
    • Liu, B.; Hannun, Y. A. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J. Biol. Chem. 272:16281-16287, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16281-16287
    • Liu, B.1    Hannun, Y.A.2
  • 61
    • 0028296508 scopus 로고
    • Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria
    • Yen, T. C.; King, K. L.; Lee, H. C.; Yeh, S. W.; Wei, Y. H. Age-dependent increase of mitochondrial DNA deletions together with lipid peroxides and superoxide dismutase in human liver mitochondria. Free Rad. Biol. Med. 16:207-214; 1994.
    • (1994) Free Rad. Biol. Med. , vol.16 , pp. 207-214
    • Yen, T.C.1    King, K.L.2    Lee, H.C.3    Yeh, S.W.4    Wei, Y.H.5
  • 62
    • 0024996681 scopus 로고
    • The oxidative inactivation of mitochondrial electron transport chain components and ATPase
    • Zhang, Y.; Marcillat, O.; Giulivi, C.; Ernster, L.; Davies, K. L. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265:16330-16336; 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 16330-16336
    • Zhang, Y.1    Marcillat, O.2    Giulivi, C.3    Ernster, L.4    Davies, K.L.5
  • 63
    • 1842375100 scopus 로고    scopus 로고
    • Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
    • Quillet-Mary, A.; Jaffrezou, J. P.; Mansat, V.; Bordier, C.; Naval, J.; Laurent, G. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272:21288-21395; 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21288-21395
    • Quillet-Mary, A.1    Jaffrezou, J.P.2    Mansat, V.3    Bordier, C.4    Naval, J.5    Laurent, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.