-
1
-
-
29944443554
-
The UMD TP53 database and website: update and revisions
-
Hamroun D., et al. The UMD TP53 database and website: update and revisions. Hum. Mutat. 27 (2006) 14-20
-
(2006)
Hum. Mutat.
, vol.27
, pp. 14-20
-
-
Hamroun, D.1
-
2
-
-
57049114832
-
The genetics of the p53 pathway, apoptosis and cancer therapy
-
Vazquez A., et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat. Rev. Drug Discov. 7 (2008) 979-987
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 979-987
-
-
Vazquez, A.1
-
3
-
-
65349103899
-
Blinded by the light: the growing complexity of p53
-
Vousden K.H., and Prives C. Blinded by the light: the growing complexity of p53. Cell 137 (2009) 413-431
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
4
-
-
37549048249
-
The BCL-2 protein family: opposing activities that mediate cell death
-
Youle R.J., and Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 (2008) 47-59
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
5
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
6
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
-
Caelles C., et al. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370 (1994) 220-223
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles, C.1
-
7
-
-
0029092356
-
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
-
Haupt Y., et al. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9 (1995) 2170-2183
-
(1995)
Genes Dev.
, vol.9
, pp. 2170-2183
-
-
Haupt, Y.1
-
8
-
-
0028034199
-
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
-
Wagner A.J., et al. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev. 8 (1994) 2817-2830
-
(1994)
Genes Dev.
, vol.8
, pp. 2817-2830
-
-
Wagner, A.J.1
-
9
-
-
0041330430
-
p53's believe it or not: lessons on transcription-independent death
-
Chipuk J.E., and Green D.R. p53's believe it or not: lessons on transcription-independent death. J. Clin. Immunol. 23 (2003) 355-361
-
(2003)
J. Clin. Immunol.
, vol.23
, pp. 355-361
-
-
Chipuk, J.E.1
Green, D.R.2
-
10
-
-
27544486327
-
Transcription-independent pro-apoptotic functions of p53
-
Moll U.M., et al. Transcription-independent pro-apoptotic functions of p53. Curr. Opin. Cell Biol. 17 (2005) 631-636
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 631-636
-
-
Moll, U.M.1
-
11
-
-
0032500793
-
Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis
-
Bennett M., et al. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Science 282 (1998) 290-293
-
(1998)
Science
, vol.282
, pp. 290-293
-
-
Bennett, M.1
-
12
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk J.E., et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 (2004) 1010-1014
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
-
13
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu J.I., et al. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 6 (2004) 443-450
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
-
14
-
-
0037349289
-
p53 has a direct apoptogenic role at the mitochondria
-
Mihara M., et al. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 11 (2003) 577-590
-
(2003)
Mol. Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
-
15
-
-
65949083750
-
Cytoplasmic functions of the tumour suppressor p53
-
Green D.R., and Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature 458 (2009) 1127-1130
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
17
-
-
0037372005
-
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
-
Dumont P., et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 33 (2003) 357-365
-
(2003)
Nat. Genet.
, vol.33
, pp. 357-365
-
-
Dumont, P.1
-
18
-
-
0034717014
-
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
-
Marchenko N.D., et al. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J. Biol. Chem 275 (2000) 16202-16212
-
(2000)
J. Biol. Chem
, vol.275
, pp. 16202-16212
-
-
Marchenko, N.D.1
-
19
-
-
0035910385
-
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells
-
Sansome C., et al. Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett 488 (2001) 110-115
-
(2001)
FEBS Lett
, vol.488
, pp. 110-115
-
-
Sansome, C.1
-
20
-
-
33748551920
-
Neural precursor cells possess multiple p53-dependent apoptotic pathways
-
Akhtar R.S., et al. Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell. Death Differ. 13 (2006) 1727-1739
-
(2006)
Cell. Death Differ.
, vol.13
, pp. 1727-1739
-
-
Akhtar, R.S.1
-
21
-
-
21444432928
-
Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
-
Arima Y., et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J. Biol. Chem. 280 (2005) 19166-19176
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19166-19176
-
-
Arima, Y.1
-
22
-
-
3242690522
-
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
-
Erster S., et al. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol. Cell. Biol. 24 (2004) 6728-6741
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6728-6741
-
-
Erster, S.1
-
23
-
-
33846086865
-
p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis
-
Geng Y., et al. p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis. J. Neuropathol. Exp. Neurol. 66 (2007) 66-74
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 66-74
-
-
Geng, Y.1
-
24
-
-
33746646758
-
Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
-
Kojima K., et al. Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108 (2006) 993-1000
-
(2006)
Blood
, vol.108
, pp. 993-1000
-
-
Kojima, K.1
-
25
-
-
4344566202
-
Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells
-
Mahyar-Roemer M., et al. Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells. Oncogene 23 (2004) 6226-6236
-
(2004)
Oncogene
, vol.23
, pp. 6226-6236
-
-
Mahyar-Roemer, M.1
-
26
-
-
33845994064
-
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition
-
Nair V.D., et al. p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J. Biol. Chem. 281 (2006) 39550-39560
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39550-39560
-
-
Nair, V.D.1
-
27
-
-
34247172579
-
Regulation of apoptosis and differentiation by p53 in human embryonic stem cells
-
Qin H., et al. Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J. Biol. Chem. 282 (2007) 5842-5852
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5842-5852
-
-
Qin, H.1
-
28
-
-
32544442894
-
Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress
-
Speidel D., et al. Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress. Oncogene 25 (2006) 940-953
-
(2006)
Oncogene
, vol.25
, pp. 940-953
-
-
Speidel, D.1
-
29
-
-
55749105875
-
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism
-
Steele A.J., et al. p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism. Blood 112 (2008) 3827-3834
-
(2008)
Blood
, vol.112
, pp. 3827-3834
-
-
Steele, A.J.1
-
30
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
-
Strom E., et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat. Chem. Biol. 2 (2006) 474-479
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 474-479
-
-
Strom, E.1
-
31
-
-
27744465454
-
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
-
Todorovicc V., et al. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J. Cell Biol. 171 (2005) 559-568
-
(2005)
J. Cell Biol.
, vol.171
, pp. 559-568
-
-
Todorovicc, V.1
-
32
-
-
67449150191
-
Redox-dependent translocation of p53 to mitochondria or nucleus in human melanocytes after UVA- and UVB-induced apoptosis
-
Waster P.K., and Ollinger K.M. Redox-dependent translocation of p53 to mitochondria or nucleus in human melanocytes after UVA- and UVB-induced apoptosis. J. Invest. Dermatol. 129 (2009) 1769-1781
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1769-1781
-
-
Waster, P.K.1
Ollinger, K.M.2
-
33
-
-
27644568226
-
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy
-
Kojima K., et al. MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy. Blood 106 (2005) 3150-3159
-
(2005)
Blood
, vol.106
, pp. 3150-3159
-
-
Kojima, K.1
-
34
-
-
27544461103
-
Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis
-
Nemajerova A., et al. Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis. FEBS Lett. 579 (2005) 6079-6083
-
(2005)
FEBS Lett.
, vol.579
, pp. 6079-6083
-
-
Nemajerova, A.1
-
35
-
-
18144382261
-
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
-
Zhao Y., et al. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 65 (2005) 3745-3750
-
(2005)
Cancer Res.
, vol.65
, pp. 3745-3750
-
-
Zhao, Y.1
-
36
-
-
33747056618
-
Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats
-
Endo H., et al. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J. Neurosci. 26 (2006) 7974-7983
-
(2006)
J. Neurosci.
, vol.26
, pp. 7974-7983
-
-
Endo, H.1
-
37
-
-
46749117587
-
p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity
-
Wolff S., et al. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res. 18 (2008) 733-744
-
(2008)
Cell Res.
, vol.18
, pp. 733-744
-
-
Wolff, S.1
-
38
-
-
33845640597
-
Teratogen-induced activation of p53 in early postimplantation mouse embryos
-
Hosako H., et al. Teratogen-induced activation of p53 in early postimplantation mouse embryos. Toxicol. Sci. 95 (2007) 257-269
-
(2007)
Toxicol. Sci.
, vol.95
, pp. 257-269
-
-
Hosako, H.1
-
39
-
-
27744449741
-
Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis
-
Essmann F., et al. Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J. Biol. Chem. 280 (2005) 37169-37177
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37169-37177
-
-
Essmann, F.1
-
40
-
-
51049086207
-
Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
-
Pietsch E.C., et al. Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J. Biol. Chem. 283 (2008) 21294-21304
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21294-21304
-
-
Pietsch, E.C.1
-
41
-
-
67749103995
-
Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
-
Sykes S.M., et al. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J. Biol. Chem. 284 (2009) 20197-20205
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20197-20205
-
-
Sykes, S.M.1
-
42
-
-
35748963522
-
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL
-
Sot B., et al. Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J. Biol. Chem. 282 (2007) 29193-29200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29193-29200
-
-
Sot, B.1
-
43
-
-
33646826684
-
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
-
Tomita Y., et al. WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. J. Biol. Chem. 281 (2006) 8600-8606
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8600-8606
-
-
Tomita, Y.1
-
44
-
-
0442323478
-
Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR
-
Petros A.M., et al. Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR. FEBS Lett. 559 (2004) 171-174
-
(2004)
FEBS Lett.
, vol.559
, pp. 171-174
-
-
Petros, A.M.1
-
45
-
-
25444519182
-
Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells
-
Tan J., et al. Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. Cancer Res. 65 (2005) 9012-9020
-
(2005)
Cancer Res.
, vol.65
, pp. 9012-9020
-
-
Tan, J.1
-
46
-
-
0034649498
-
Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis
-
Raffo A.J., et al. Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis. Oncogene 19 (2000) 6216-6228
-
(2000)
Oncogene
, vol.19
, pp. 6216-6228
-
-
Raffo, A.J.1
-
47
-
-
0344925540
-
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
-
Chipuk J.E., et al. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4 (2003) 371-381
-
(2003)
Cancer Cell
, vol.4
, pp. 371-381
-
-
Chipuk, J.E.1
-
48
-
-
33845193134
-
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis
-
Jiang P., et al. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol. Cell. Biol. 26 (2006) 9071-9082
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9071-9082
-
-
Jiang, P.1
-
49
-
-
32344453486
-
The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl
-
Xu H., et al. The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl. Biochem. Biophys. Res. Commun. 341 (2006) 938-944
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.341
, pp. 938-944
-
-
Xu, H.1
-
50
-
-
33745017872
-
Bcl2's flexible loop domain regulates p53 binding and survival
-
Deng X., et al. Bcl2's flexible loop domain regulates p53 binding and survival. Mol. Cell. Biol. 26 (2006) 4421-4434
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 4421-4434
-
-
Deng, X.1
-
51
-
-
57449084714
-
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
-
Fletcher J.I., et al. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 18081-18087
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 18081-18087
-
-
Fletcher, J.I.1
-
52
-
-
0037380598
-
Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells
-
Jiang M., and Milner J. Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells. Genes Dev. 17 (2003) 832-837
-
(2003)
Genes Dev.
, vol.17
, pp. 832-837
-
-
Jiang, M.1
Milner, J.2
-
53
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
Chipuk J.E., et al. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309 (2005) 1732-1735
-
(2005)
Science
, vol.309
, pp. 1732-1735
-
-
Chipuk, J.E.1
-
54
-
-
33749845328
-
Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo
-
Palacios G., and Moll U.M. Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo. Oncogene 25 (2006) 6133-6139
-
(2006)
Oncogene
, vol.25
, pp. 6133-6139
-
-
Palacios, G.1
Moll, U.M.2
-
55
-
-
27544490654
-
Mitochondrially targeted p53 has tumor suppressor activities in vivo
-
Talos F., et al. Mitochondrially targeted p53 has tumor suppressor activities in vivo. Cancer Res. 65 (2005) 9971-9981
-
(2005)
Cancer Res.
, vol.65
, pp. 9971-9981
-
-
Talos, F.1
-
56
-
-
63849157457
-
Tickets for p53 journey among organelles
-
Ferecatu I., et al. Tickets for p53 journey among organelles. Front. Biosci. 14 (2009) 4214-4228
-
(2009)
Front. Biosci.
, vol.14
, pp. 4214-4228
-
-
Ferecatu, I.1
-
57
-
-
33745163907
-
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a
-
You H., et al. Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9051-9056
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 9051-9056
-
-
You, H.1
-
58
-
-
0348134742
-
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
-
Li M., et al. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302 (2003) 1972-1975
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
-
59
-
-
33646794425
-
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
-
Marine J.C., et al. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 13 (2006) 927-934
-
(2006)
Cell Death Differ.
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
-
60
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko N.D., et al. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J. 26 (2007) 923-934
-
(2007)
EMBO J.
, vol.26
, pp. 923-934
-
-
Marchenko, N.D.1
-
61
-
-
67650239851
-
Nucleophosmin blocks mitochondrial localization of p53 and apoptosis
-
Dhar S.K., and St Clair D.K. Nucleophosmin blocks mitochondrial localization of p53 and apoptosis. J. Biol. Chem. 284 (2009) 16409-16418
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16409-16418
-
-
Dhar, S.K.1
St Clair, D.K.2
-
62
-
-
36849049137
-
The tetramerization domain of p53 is required for efficient BAK oligomerization
-
Pietsch E.C., et al. The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biol. Ther. 6 (2007) 1576-1583
-
(2007)
Cancer Biol. Ther.
, vol.6
, pp. 1576-1583
-
-
Pietsch, E.C.1
-
63
-
-
0029049828
-
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
-
Moll U.M., et al. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 4407-4411
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 4407-4411
-
-
Moll, U.M.1
-
64
-
-
0030048389
-
Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage
-
Moll U.M., et al. Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol. Cell. Biol. 16 (1996) 1126-1137
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1126-1137
-
-
Moll, U.M.1
-
65
-
-
0026694826
-
Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion
-
Moll U.M., et al. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 7262-7266
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 7262-7266
-
-
Moll, U.M.1
-
66
-
-
0028843480
-
Functional inactivation but not structural mutation of p53 causes liver cancer
-
Ueda H., et al. Functional inactivation but not structural mutation of p53 causes liver cancer. Nat. Genet. 9 (1995) 41-47
-
(1995)
Nat. Genet.
, vol.9
, pp. 41-47
-
-
Ueda, H.1
-
67
-
-
68549101500
-
Mitochondrial localization of the low level p53 protein in proliferative cells
-
Ferecatu I., et al. Mitochondrial localization of the low level p53 protein in proliferative cells. Biochem. Biophys. Res. Commun. 387 (2009) 772-777
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.387
, pp. 772-777
-
-
Ferecatu, I.1
-
68
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E., et al. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 10 (2008) 676-687
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
-
69
-
-
53649086181
-
Mutant p53 protein localized in the cytoplasm inhibits autophagy
-
Morselli E., et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 7 (2008) 3056-3061
-
(2008)
Cell Cycle
, vol.7
, pp. 3056-3061
-
-
Morselli, E.1
-
70
-
-
13544256594
-
The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria
-
Nemajerova A., et al. The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria. Cell Death Differ. 12 (2005) 197-200
-
(2005)
Cell Death Differ.
, vol.12
, pp. 197-200
-
-
Nemajerova, A.1
-
71
-
-
46349083468
-
Resistance of mitochondrial p53 to dominant inhibition
-
Heyne K., et al. Resistance of mitochondrial p53 to dominant inhibition. Mol. Cancer 7 (2008) 54
-
(2008)
Mol. Cancer
, vol.7
, pp. 54
-
-
Heyne, K.1
-
72
-
-
58849089256
-
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
-
Deng X., et al. Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. Blood 113 (2009) 422-428
-
(2009)
Blood
, vol.113
, pp. 422-428
-
-
Deng, X.1
-
73
-
-
0037385609
-
Ku70 suppresses the apoptotic translocation of Bax to mitochondria
-
Sawada M., et al. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat. Cell. Biol. 5 (2003) 320-329
-
(2003)
Nat. Cell. Biol.
, vol.5
, pp. 320-329
-
-
Sawada, M.1
-
74
-
-
66449099052
-
p53 Acetylation is crucial for its transcription-independent proapoptotic functions
-
Yamaguchi H., et al. p53 Acetylation is crucial for its transcription-independent proapoptotic functions. J. Biol. Chem. 284 (2009) 11171-11183
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 11171-11183
-
-
Yamaguchi, H.1
-
75
-
-
36849074245
-
Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis and antagonizes the proapoptotic actions of p53 at mitochondria
-
Leu J.I., and George D.L. Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev. 21 (2007) 3095-3109
-
(2007)
Genes Dev.
, vol.21
, pp. 3095-3109
-
-
Leu, J.I.1
George, D.L.2
-
76
-
-
1642633791
-
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
-
Ohtsuka T., et al. ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat. Cell Biol. 6 (2004) 121-128
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 121-128
-
-
Ohtsuka, T.1
-
77
-
-
26944445883
-
Clusterin inhibits apoptosis by interacting with activated Bax
-
Zhang H., et al. Clusterin inhibits apoptosis by interacting with activated Bax. Nat. Cell Biol. 7 (2005) 909-915
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 909-915
-
-
Zhang, H.1
-
78
-
-
0038485614
-
Humanin peptide suppresses apoptosis by interfering with Bax activation
-
Guo B., et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 423 (2003) 456-461
-
(2003)
Nature
, vol.423
, pp. 456-461
-
-
Guo, B.1
-
79
-
-
37048999377
-
Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis
-
Li N., et al. Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res. 67 (2007) 11176-11185
-
(2007)
Cancer Res.
, vol.67
, pp. 11176-11185
-
-
Li, N.1
-
80
-
-
39549110602
-
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
-
Johnson T.M., et al. Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 1215-1220
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 1215-1220
-
-
Johnson, T.M.1
-
81
-
-
44049092395
-
The dark side of a tumor suppressor: anti-apoptotic p53
-
Janicke R.U., et al. The dark side of a tumor suppressor: anti-apoptotic p53. Cell Death Differ. 15 (2008) 959-976
-
(2008)
Cell Death Differ.
, vol.15
, pp. 959-976
-
-
Janicke, R.U.1
-
82
-
-
33745244111
-
Restoring p53-mediated apoptosis in cancer cells: new opportunities for cancer therapy
-
Yu Q. Restoring p53-mediated apoptosis in cancer cells: new opportunities for cancer therapy. Drug Resist. Updat. 9 (2006) 19-25
-
(2006)
Drug Resist. Updat.
, vol.9
, pp. 19-25
-
-
Yu, Q.1
-
83
-
-
0042763553
-
The complex interactions of p53 with target DNA: we learn as we go
-
Kim E., and Deppert W. The complex interactions of p53 with target DNA: we learn as we go. Biochem. Cell Biol. 81 (2003) 141-150
-
(2003)
Biochem. Cell Biol.
, vol.81
, pp. 141-150
-
-
Kim, E.1
Deppert, W.2
-
84
-
-
0036674617
-
Live or let die: the cell's response to p53
-
Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2 (2002) 594-604
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
85
-
-
54249096028
-
Caspases in apoptosis and beyond
-
Li J., and Yuan J. Caspases in apoptosis and beyond. Oncogene 27 (2008) 6194-6206
-
(2008)
Oncogene
, vol.27
, pp. 6194-6206
-
-
Li, J.1
Yuan, J.2
-
86
-
-
39749182234
-
Apoptosis: controlled demolition at the cellular level
-
Taylor R.C., et al. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9 (2008) 231-241
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 231-241
-
-
Taylor, R.C.1
-
87
-
-
0035957653
-
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
-
Wei M.C., et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 (2001) 727-730
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
-
88
-
-
0030780106
-
Movement of Bax from the cytosol to mitochondria during apoptosis
-
Wolter K.G., et al. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139 (1997) 1281-1292
-
(1997)
J. Cell Biol.
, vol.139
, pp. 1281-1292
-
-
Wolter, K.G.1
-
89
-
-
0034665461
-
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
-
Chao C., et al. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 19 (2000) 4967-4975
-
(2000)
EMBO J.
, vol.19
, pp. 4967-4975
-
-
Chao, C.1
-
90
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers J.R., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 (2003) 321-328
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
-
91
-
-
0033821977
-
A transactivation-deficient mouse model provides insights into Trp53 regulation and function
-
Jimenez G.S., et al. A transactivation-deficient mouse model provides insights into Trp53 regulation and function. Nat. Genet. 26 (2000) 37-43
-
(2000)
Nat. Genet.
, vol.26
, pp. 37-43
-
-
Jimenez, G.S.1
-
92
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A., et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 (2003) 1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
-
93
-
-
36048973184
-
Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons
-
Uo T., et al. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J. Neurosci. 27 (2007) 12198-12210
-
(2007)
J. Neurosci.
, vol.27
, pp. 12198-12210
-
-
Uo, T.1
-
94
-
-
62449278758
-
Targeting p53 for enhanced radio- and chemo-sensitivity
-
Lu C., and El-Deiry W.S. Targeting p53 for enhanced radio- and chemo-sensitivity. Apoptosis 14 (2009) 597-606
-
(2009)
Apoptosis
, vol.14
, pp. 597-606
-
-
Lu, C.1
El-Deiry, W.S.2
-
95
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
96
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
Issaeva N., et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat. Med. 10 (2004) 1321-1328
-
(2004)
Nat. Med.
, vol.10
, pp. 1321-1328
-
-
Issaeva, N.1
-
97
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev L.T. MDM2 inhibitors for cancer therapy. Trends Mol. Med. 13 (2007) 23-31
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
98
-
-
34047209861
-
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
-
Selivanova G., and Wiman K.G. Reactivation of mutant p53: molecular mechanisms and therapeutic potential. Oncogene 26 (2007) 2243-2254
-
(2007)
Oncogene
, vol.26
, pp. 2243-2254
-
-
Selivanova, G.1
Wiman, K.G.2
-
99
-
-
66749128074
-
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells
-
Vaseva A.V., et al. The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell Cycle 8 (2009) 1711-1719
-
(2009)
Cell Cycle
, vol.8
, pp. 1711-1719
-
-
Vaseva, A.V.1
-
100
-
-
46749115781
-
Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model
-
Palacios G., et al. Mitochondrially targeted wild-type p53 induces apoptosis in a solid human tumor xenograft model. Cell Cycle 7 (2008) 2584-2590
-
(2008)
Cell Cycle
, vol.7
, pp. 2584-2590
-
-
Palacios, G.1
|