Pharmacologic modulation of glycogen synthase kinase-3β promotes p53-dependent apoptosis through a direct bax-mediated mitochondrial pathway in colorectal cancer cells

Cancer Research

Volumn 65, Issue 19, 2005, Pages 9012-9020

  Tan, Jing ^a   Zhuang, Li ^a   Leong, Hui Sun ^a   Iyer, N Gopalakrishna ^a   Liu, Edison T ^a   Yu, Qiang ^a  

^a GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; ANTINEOPLASTIC AGENT; CASPASE 9; CELL PROTEIN; CYTOCHROME C; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; LY 2119301; PROTEIN BAX; PROTEIN P21; PROTEIN P53; PROTEIN PUMA; SERINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE; CELL NUCLEUS; COLORECTAL CANCER; CONTROLLED STUDY; DNA CONTENT; DNA MICROARRAY; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; WESTERN BLOTTING;

AMINOPHENOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; COLORECTAL NEOPLASMS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HCT116 CELLS; HUMANS; INDOLES; MALEIMIDES; MITOCHONDRIA; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 25444519182     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1226     Document Type: Article

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