메뉴 건너뛰기




Volumn 4, Issue 4, 2009, Pages 243-250

Flavonoids and brain health: Multiple effects underpinned by common mechanisms

Author keywords

Brain; Cognitive performance; Flavonoid; Memory; Neurodegeneration; Neuroinflammation; Signalling

Indexed keywords

BACALEIN; CAFFEIC ACID; CATECHIN; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVANONE DERIVATIVE; FLAVONOID; GENISTEIN; GINKGO BILOBA EXTRACT; HESPERETIN; IBUPROFEN; MITOGEN ACTIVATED PROTEIN KINASE; NARINGENIN; NEUROTOXIN; PELARGONIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; QUERCETIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WOGONIN;

EID: 71949107443     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-009-0136-3     Document Type: Review
Times cited : (264)

References (82)
  • 1
    • 0036886141 scopus 로고    scopus 로고
    • (Physio)logical circuits: The intellectual origins of the Mcculloch-Pitts neural networks
    • DOI 10.1002/jhbs.1094
    • TH Abraham 2002 (Physio)logical circuits: the intellectual origins of the McCulloch-Pitts neural networks J Hist Behav Sci 38 3 25 10.1002/jhbs.1094 11835218 (Pubitemid 41417652)
    • (2002) Journal of the History of the Behavioral Sciences , vol.38 , Issue.1 , pp. 3-25
    • Abraham, T.H.1
  • 2
    • 0037245729 scopus 로고    scopus 로고
    • Integrating mind and brain: Warren S. McCulloch, cerebral localization, and experimental epistemology
    • DOI 10.1016/S0160-9327(03)00017-6
    • TH Abraham 2003 Integrating mind and brain: Warren S. McCulloch, cerebral localization, and experimental epistemology Endeavour 27 32 36 10.1016/S0160-9327(03)00017-6 12642144 (Pubitemid 36405533)
    • (2003) Endeavour , vol.27 , Issue.1 , pp. 32-36
    • Abraham, T.H.1
  • 3
    • 34547925606 scopus 로고    scopus 로고
    • Role of lipids in brain injury and diseases
    • DOI 10.2217/17460875.2.4.403
    • RM Adibhatla JF Hatcher 2007 Role of lipids in brain injury and diseases Future Lipidol 2 403 422 10.2217/17460875.2.4.403 1:CAS:528:DC%2BD2sXosVShurg%3D 18176634 (Pubitemid 47250149)
    • (2007) Future Lipidology , vol.2 , Issue.4 , pp. 403-422
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 4
    • 0037455718 scopus 로고    scopus 로고
    • Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate
    • DOI 10.1038/sj.onc.1206206
    • F Afaq VM Adhami N Ahmad H Mukhtar 2003 Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate Oncogene 22 1035 1044 10.1038/sj.onc.1206206 1:CAS:528:DC%2BD3sXht1Gktrk%3D 12592390 (Pubitemid 36313147)
    • (2003) Oncogene , vol.22 , Issue.7 , pp. 1035-1044
    • Afaq, F.1    Adhami, V.M.2    Ahmad, N.3    Mukhtar, H.4
  • 5
    • 0037361388 scopus 로고    scopus 로고
    • Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
    • DOI 10.1016/S1471-4914(03)00020-0
    • A Barzilai E Melamed 2003 Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease Trends Mol Med 9 126 132 10.1016/S1471-4914(03)00020-0 1:CAS:528:DC%2BD3sXit1yqurk%3D 12657434 (Pubitemid 36433894)
    • (2003) Trends in Molecular Medicine , vol.9 , Issue.3 , pp. 126-132
    • Barzilai, A.1    Melamed, E.2
  • 6
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • 1:CAS:528:DyaK1cXht12jtbo%3D 9464988
    • NR Bhat P Zhang JC Lee EL Hogan 1998 Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures J Neurosci 18 1633 1641 1:CAS:528:DyaK1cXht12jtbo%3D 9464988
    • (1998) J Neurosci , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 7
    • 0037119464 scopus 로고    scopus 로고
    • P38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells: Roles of nuclear factors, nuclear factor κB, cAMP response element-binding protein, CCAAT/enhancer-binding protein-β, and activating transcription factor-2
    • DOI 10.1074/jbc.M204994200
    • NR Bhat DL Feinstein Q Shen AN Bhat 2002 p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2 J Biol Chem 277 29584 29592 10.1074/jbc.M204994200 1:CAS:528: DC%2BD38XmsVKitLo%3D 12048217 (Pubitemid 41079247)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.33 , pp. 29584-29592
    • Bhat, N.R.1    Feinstein, D.L.2    Shen, Q.3    Bhat, A.N.4
  • 8
    • 0034637089 scopus 로고    scopus 로고
    • Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro
    • DOI 10.1016/S0304-3940(00)01294-5, PII S0304394000012945
    • D Casper U Yaparpalvi N Rempel P Werner 2000 Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro Neurosci Lett 289 201 204 10.1016/S0304-3940(00)01294-5 1:CAS:528:DC%2BD3cXmtVCqurw%3D 10961664 (Pubitemid 30657973)
    • (2000) Neuroscience Letters , vol.289 , Issue.3 , pp. 201-204
    • Casper, D.1    Yaparpalvi, U.2    Rempel, N.3    Werner, P.4
  • 9
    • 26444594915 scopus 로고    scopus 로고
    • Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
    • DOI 10.1016/j.ejphar.2005.08.005, PII S0014299905007880
    • JC Chen FM Ho LC Pei-Dawn CP Chen KC Jeng HB Hsu ST Lee TW Wen WW Lin 2005 Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia Eur J Pharmacol 521 9 20 10.1016/j.ejphar.2005.08.005 1:CAS:528:DC%2BD2MXhtFWnur7N 16171798 (Pubitemid 41427784)
    • (2005) European Journal of Pharmacology , vol.521 , Issue.1-3 , pp. 9-20
    • Chen, J.-C.1    Ho, F.-M.2    Chao, P.-D.L.3    Chen, C.-P.4    Jeng, K.-C.G.5    Hsu, H.-B.6    Lee, S.-T.7    Wen, T.W.8    Lin, W.-W.9
  • 11
    • 33747878212 scopus 로고    scopus 로고
    • Fruit and Vegetable Juices and Alzheimer's Disease: The Kame Project
    • DOI 10.1016/j.amjmed.2006.03.045, PII S0002934306006772
    • Q Dai AR Borenstein Y Wu JC Jackson EB Larson 2006 Fruit and vegetable juices and Alzheimer's disease: the Kame Project Am J Med 119 751 759 10.1016/j.amjmed.2006.03.045 1:CAS:528:DC%2BD28Xptlyrs7Y%3D 16945610 (Pubitemid 44308471)
    • (2006) American Journal of Medicine , vol.119 , Issue.9 , pp. 751-759
    • Dai, Q.1    Borenstein, A.R.2    Wu, Y.3    Jackson, J.C.4    Larson, E.B.5
  • 12
    • 33750357163 scopus 로고    scopus 로고
    • Cocoa flavanols and brain perfusion
    • DOI 10.1097/00005344-200606001-00017, PII 0000534420060600100017
    • ND Fisher FA Sorond NK Hollenberg 2006 Cocoa flavanols and brain perfusion J Cardiovasc Pharmacol 47 Suppl 2 S210 S214 10.1097/00005344- 200606001-00017 1:CAS:528:DC%2BD28XmtVOktbg%3D 16794460 (Pubitemid 44620213)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.SUPPL. 2
    • Fisher, N.D.L.1    Sorond, F.A.2    Hollenberg, N.K.3
  • 13
    • 33750305274 scopus 로고    scopus 로고
    • The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people
    • DOI 10.1097/00005344-200606001-00018, PII 0000534420060600100018
    • ST Francis K Head PG Morris IA Macdonald 2006 The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people J Cardiovasc Pharmacol 47 Suppl 2 S215 S220 10.1097/00005344-200606001-00018 1:CAS:528:DC%2BD28XmtVOktbY%3D 16794461 (Pubitemid 44620214)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.SUPPL. 2
    • Francis, S.T.1    Head, K.2    Morris, P.G.3    Macdonald, I.A.4
  • 14
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • DOI 10.1126/science.287.5457.1433
    • FH Gage 2000 Mammalian neural stem cells Science 287 1433 1438 10.1126/science.287.5457.1433 1:CAS:528:DC%2BD3cXhsV2qtrg%3D 10688783 (Pubitemid 30127128)
    • (2000) Science , vol.287 , Issue.5457 , pp. 1433-1438
    • Gage, F.H.1
  • 15
    • 0036233802 scopus 로고    scopus 로고
    • Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits
    • 1:CAS:528:DC%2BD38XktFWqtbc%3D 11976192
    • RL Galli B Shukitt-Hale KA Youdim JA Joseph 2002 Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits Ann N Y Acad Sci 959 128 132 1:CAS:528:DC%2BD38XktFWqtbc%3D 11976192
    • (2002) Ann N y Acad Sci , vol.959 , pp. 128-132
    • Galli, R.L.1    Shukitt-Hale, B.2    Youdim, K.A.3    Joseph, J.A.4
  • 16
    • 33645519220 scopus 로고    scopus 로고
    • Long-term administration of green tea catechins improves spatial cognition learning ability in rats
    • 1:CAS:528:DC%2BD28XjtVOkt7Y%3D 16549472
    • AM Haque M Hashimoto M Katakura Y Tanabe Y Hara O Shido 2006 Long-term administration of green tea catechins improves spatial cognition learning ability in rats J Nutr 136 1043 1047 1:CAS:528:DC%2BD28XjtVOkt7Y%3D 16549472
    • (2006) J Nutr , vol.136 , pp. 1043-1047
    • Haque, A.M.1    Hashimoto, M.2    Katakura, M.3    Tanabe, Y.4    Hara, Y.5    Shido, O.6
  • 17
    • 0028330166 scopus 로고
    • Dendritic spines: Cellular specializations imparting both stability and flexibility to synaptic function
    • 10.1146/annurev.ne.17.030194.002013 1:STN:280:DyaK2c3ntVOitA%3D%3D 8210179
    • KM Harris SB Kater 1994 Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function Annu Rev Neurosci 17 341 371 10.1146/annurev.ne.17.030194.002013 1:STN:280:DyaK2c3ntVOitA%3D%3D 8210179
    • (1994) Annu Rev Neurosci , vol.17 , pp. 341-371
    • Harris, K.M.1    Kater, S.B.2
  • 18
    • 0028812293 scopus 로고
    • Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
    • 1:CAS:528:DyaK2MXjtFymtL8%3D 7830086
    • TG Hastings 1995 Enzymatic oxidation of dopamine: the role of prostaglandin H synthase J Neurochem 64 919 924 1:CAS:528:DyaK2MXjtFymtL8%3D 7830086
    • (1995) J Neurochem , vol.64 , pp. 919-924
    • Hastings, T.G.1
  • 19
    • 18844374851 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Parkinson's disease
    • DOI 10.1016/j.parkreldis.2004.10.013, PII S1353802005000362
    • EC Hirsch S Hunot A Hartmann 2005 Neuroinflammatory processes in Parkinson's disease Parkinsonism Relat Disord 11 Suppl 1 S9 S15 10.1016/j.parkreldis.2004.10.013 15885630 (Pubitemid 40693572)
    • (2005) Parkinsonism and Related Disorders , vol.11 , Issue.SUPPL. 1
    • Hirsch, E.C.1    Hunot, S.2    Hartmann, A.3
  • 20
    • 0033861887 scopus 로고    scopus 로고
    • Anti-apoptotic effect of quercetin: Intervention in the JNK- and ERK-mediated apoptotic pathways
    • DOI 10.1046/j.1523-1755.2000.00265.x
    • Y Ishikawa M Kitamura 2000 Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways Kidney Int 58 1078 1087 10.1046/j.1523-1755.2000.00265.x 1:CAS:528:DC%2BD3cXmsleiu7Y%3D 10972672 (Pubitemid 30678032)
    • (2000) Kidney International , vol.58 , Issue.3 , pp. 1078-1087
    • Ishikawa, Y.1    Kitamura, M.2
  • 21
  • 22
    • 85046909683 scopus 로고    scopus 로고
    • Cell death mechanisms in neurodegeneration
    • 10.1111/j.1582-4934.2001.tb00134.x 1:CAS:528:DC%2BD3MXjslKmsLc%3D 12067447
    • KA Jellinger 2001 Cell death mechanisms in neurodegeneration J Cell Mol Med 5 1 17 10.1111/j.1582-4934.2001.tb00134.x 1:CAS:528:DC%2BD3MXjslKmsLc%3D 12067447
    • (2001) J Cell Mol Med , vol.5 , pp. 1-17
    • Jellinger, K.A.1
  • 23
    • 0032189767 scopus 로고    scopus 로고
    • Long-term dietary strawberry, spinach, or vitamin e supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits
    • 1:CAS:528:DyaK1cXmtlequ7s%3D 9742171
    • JA Joseph B Shukitt-Hale NA Denisova RL Prior G Cao A Martin G Taglialatela PC Bickford 1998 Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits J Neurosci 18 8047 8055 1:CAS:528: DyaK1cXmtlequ7s%3D 9742171
    • (1998) J Neurosci , vol.18 , pp. 8047-8055
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Prior, R.L.4    Cao, G.5    Martin, A.6    Taglialatela, G.7    Bickford, P.C.8
  • 24
    • 0033568849 scopus 로고    scopus 로고
    • Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
    • 1:CAS:528:DyaK1MXlvFahu7c%3D 10479711
    • JA Joseph B Shukitt-Hale NA Denisova D Bielinski A Martin JJ McEwen PC Bickford 1999 Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation J Neurosci 19 8114 8121 1:CAS:528:DyaK1MXlvFahu7c%3D 10479711
    • (1999) J Neurosci , vol.19 , pp. 8114-8121
    • Joseph, J.A.1    Shukitt-Hale, B.2    Denisova, N.A.3    Bielinski, D.4    Martin, A.5    McEwen, J.J.6    Bickford, P.C.7
  • 25
    • 0037736704 scopus 로고    scopus 로고
    • Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    • DOI 10.1080/1028415031000111282
    • JA Joseph NA Denisova G Arendash M Gordon D Diamond B Shukitt-Hale D Morgan 2003 Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model Nutr Neurosci 6 153 162 10.1080/1028415031000111282 1:CAS:528:DC%2BD3sXktVGlt7s%3D 12793519 (Pubitemid 36656693)
    • (2003) Nutritional Neuroscience , vol.6 , Issue.3 , pp. 153-162
    • Joseph, J.A.1    Denisova, N.A.2    Arendash, G.3    Gordon, M.4    Diamond, D.5    Shukitt-Hale, B.6    Morgan, D.7
  • 26
    • 13844272542 scopus 로고    scopus 로고
    • Reversing the deleterious effects of aging on neuronal communication and behavior: Beneficial properties of fruit polyphenolic compounds
    • 1:CAS:528:DC%2BD2MXlvFKktA%3D%3D 15640496
    • JA Joseph B Shukitt-Hale G Casadesus 2005 Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds Am J Clin Nutr 81 313S 316S 1:CAS:528: DC%2BD2MXlvFKktA%3D%3D 15640496
    • (2005) Am J Clin Nutr , vol.81
    • Joseph, J.A.1    Shukitt-Hale, B.2    Casadesus, G.3
  • 27
    • 34249717693 scopus 로고    scopus 로고
    • Fruit polyphenols and their effects on neuronal signaling and behavior in senescence
    • DOI 10.1196/annals.1395.052, Biogerontology: Mechanisms and Interventions
    • JA Joseph B Shukitt-Hale FC Lau 2007 Fruit polyphenols and their effects on neuronal signaling and behavior in senescence Ann N Y Acad Sci 1100 470 485 10.1196/annals.1395.052 1:CAS:528:DC%2BD2sXlslOitbw%3D 17460212 (Pubitemid 47092686)
    • (2007) Annals of the New York Academy of Sciences , vol.1100 , pp. 470-485
    • Joseph, J.A.1    Shukitt-Hale, B.2    Lau, F.C.3
  • 28
    • 33846818982 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: Implications for neuroprotection
    • DOI 10.1111/j.1471-4159.2006.04265.x
    • L Kalfon MB Youdim SA Mandel 2007 Green tea polyphenol (-)-epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection J Neurochem 100 992 1002 10.1111/j.1471-4159.2006.04265.x 1:CAS:528: DC%2BD2sXisFGnu7w%3D 17156130 (Pubitemid 46213924)
    • (2007) Journal of Neurochemistry , vol.100 , Issue.4 , pp. 992-1002
    • Kalfon, L.1    Youdim, M.B.H.2    Mandel, S.A.3
  • 30
    • 0032862903 scopus 로고    scopus 로고
    • Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
    • 1:CAS:528:DyaK1MXmt1amurY%3D 10484327
    • H Kobuchi S Roy CK Sen HG Nguyen L Packer 1999 Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway Am J Physiol 277 C403 C411 1:CAS:528:DyaK1MXmt1amurY%3D 10484327
    • (1999) Am J Physiol , vol.277
    • Kobuchi, H.1    Roy, S.2    Sen, C.K.3    Nguyen, H.G.4    Packer, L.5
  • 31
    • 28444485358 scopus 로고    scopus 로고
    • Lipopolysaccharide and proinflammatory cytokines require different astrocyte states to induce nitric oxide production
    • DOI 10.1002/jnr.20671
    • N Kozuka R Itofusa Y Kudo M Morita 2005 Lipopolysaccharide and proinflammatory cytokines require different astrocyte states to induce nitric oxide production J Neurosci Res 82 717 728 10.1002/jnr.20671 1:CAS:528:DC%2BD2MXhtlekt7vP 16247808 (Pubitemid 41740471)
    • (2005) Journal of Neuroscience Research , vol.82 , Issue.5 , pp. 717-728
    • Kozuka, N.1    Itofusa, R.2    Kudo, Y.3    Morita, M.4
  • 33
    • 34147196050 scopus 로고    scopus 로고
    • Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia
    • DOI 10.1002/jnr.21205
    • FC Lau DF Bielinski JA Joseph 2007 Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide- activated BV2 microglia J Neurosci Res 85 1010 1017 10.1002/jnr.21205 1:CAS:528:DC%2BD2sXks1Ohtr8%3D 17265471 (Pubitemid 46580342)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.5 , pp. 1010-1017
    • Lau, F.C.1    Bielinski, D.F.2    Joseph, J.A.3
  • 34
    • 0034733810 scopus 로고    scopus 로고
    • Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
    • DOI 10.1016/S0304-3940(00)01159-9, PII S0304394000011599
    • S Lee S Suh S Kim 2000 Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils Neurosci Lett 287 191 194 10.1016/S0304-3940(00) 01159-9 1:CAS:528:DC%2BD3cXktV2qurc%3D 10863027 (Pubitemid 30339381)
    • (2000) Neuroscience Letters , vol.287 , Issue.3 , pp. 191-194
    • Lee, S.-R.1    Suh, S.-I.2    Kim, S.-P.3
  • 35
    • 1642553221 scopus 로고    scopus 로고
    • Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
    • 1:CAS:528:DC%2BD3sXot1Kit7k%3D 12897065
    • H Lee YO Kim H Kim SY Kim HS Noh SS Kang GJ Cho WS Choi K Suk 2003 Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia FASEB J 17 1943 1944 1:CAS:528: DC%2BD3sXot1Kit7k%3D 12897065
    • (2003) FASEB J , vol.17 , pp. 1943-1944
    • Lee, H.1    Kim, Y.O.2    Kim, H.3    Kim, S.Y.4    Noh, H.S.5    Kang, S.S.6    Cho, G.J.7    Choi, W.S.8    Suk, K.9
  • 36
    • 0034851553 scopus 로고    scopus 로고
    • Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
    • DOI 10.1046/j.1471-4159.2001.00490.x
    • Y Levites O Weinreb G Maor MB Youdim S Mandel 2001 Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced dopaminergic neurodegeneration J Neurochem 78 1073 1082 10.1046/j.1471-4159.2001.00490.x 1:CAS:528:DC%2BD3MXms12rs7w%3D 11553681 (Pubitemid 32823156)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.5 , pp. 1073-1082
    • Levites, Y.1    Weinreb, O.2    Maor, G.3    Youdim, M.B.H.4    Mandel, S.5
  • 37
    • 0036145435 scopus 로고    scopus 로고
    • Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures
    • DOI 10.1016/S0006-2952(01)00813-9, PII S0006295201008139
    • Y Levites MB Youdim G Maor S Mandel 2002 Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures Biochem Pharmacol 63 21 29 10.1016/S0006-2952(01)00813-9 1:CAS:528:DC%2BD3MXptFyltr0%3D 11754870 (Pubitemid 34075289)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.1 , pp. 21-29
    • Levites, Y.1    Youdim, M.B.H.2    Maor, G.3    Mandel, S.4
  • 38
    • 10644230076 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury
    • DOI 10.1002/jnr.20315
    • R Li YG Huang D Fang WD Le 2004 (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury J Neurosci Res 78 723 731 10.1002/jnr.20315 1:CAS:528:DC%2BD2cXhtVGlurrL 15478178 (Pubitemid 39657589)
    • (2004) Journal of Neuroscience Research , vol.78 , Issue.5 , pp. 723-731
    • Li, R.1    Huang, Y.-G.2    Fang, D.3    Le, W.-D.4
  • 39
    • 0037126035 scopus 로고    scopus 로고
    • Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
    • 10.1073/pnas.182425199 1:CAS:528:DC%2BD38XntlCksro%3D 12213959
    • Y Luo JV Smith V Paramasivam A Burdick KJ Curry JP Buford I Khan WJ Netzer H Xu P Butko 2002 Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761 Proc Natl Acad Sci USA 99 12197 12202 10.1073/pnas.182425199 1:CAS:528:DC%2BD38XntlCksro%3D 12213959
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12197-12202
    • Luo, Y.1    Smith, J.V.2    Paramasivam, V.3    Burdick, A.4    Curry, K.J.5    Buford, J.P.6    Khan, I.7    Netzer, W.J.8    Xu, H.9    Butko, P.10
  • 41
    • 3042667647 scopus 로고    scopus 로고
    • Catechin polyphenols: Neurodegeneration and neuroprotection in neurodegenerative diseases
    • DOI 10.1016/j.freeradbiomed.2004.04.012, PII S0891584904003168
    • S Mandel MB Youdim 2004 Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases Free Radic Biol Med 37 304 317 10.1016/j.freeradbiomed.2004.04.012 1:CAS:528:DC%2BD2cXltF2rsbY%3D 15223064 (Pubitemid 38833997)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.3 , pp. 304-317
    • Mandel, S.1    Youdim, M.B.H.2
  • 42
    • 20944444111 scopus 로고    scopus 로고
    • Multifunctional activities of green tea catechins in neuroprotection: Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
    • DOI 10.1159/000085385
    • SA Mandel Y vramovich-Tirosh L Reznichenko H Zheng O Weinreb T Amit MB Youdim 2005 Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway Neurosignals 14 46 60 10.1159/000085385 1:CAS:528:DC%2BD2MXlt1Smsr0%3D 15956814 (Pubitemid 40868983)
    • (2005) NeuroSignals , vol.14 , Issue.1-2 , pp. 46-60
    • Mandel, S.A.1    Avramovich-Tirosh, Y.2    Reznichenko, L.3    Zheng, H.4    Weinreb, O.5    Amit, T.6    Youdim, M.B.H.7
  • 43
    • 54249143535 scopus 로고    scopus 로고
    • Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: Special reference to epigallocatechin gallate (EGCG)
    • 1:CAS:528:DC%2BD1cXht1Cmtr3O 18953110
    • SA Mandel T Amit L Kalfon L Reznichenko O Weinreb MB Youdim 2008 Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG) J Alzheimers Dis 15 211 222 1:CAS:528:DC%2BD1cXht1Cmtr3O 18953110
    • (2008) J Alzheimers Dis , vol.15 , pp. 211-222
    • Mandel, S.A.1    Amit, T.2    Kalfon, L.3    Reznichenko, L.4    Weinreb, O.5    Youdim, M.B.6
  • 44
    • 56049088324 scopus 로고    scopus 로고
    • Simultaneous manipulation of multiple brain targets by green tea catechins: A potential neuroprotective strategy for Alzheimer and Parkinson diseases
    • 10.1111/j.1755-5949.2008.00060.x 1:CAS:528:DC%2BD1MXks1SmtA%3D%3D 19040558
    • SA Mandel T Amit O Weinreb L Reznichenko MB Youdim 2008 Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases CNS Neurosci Ther 14 352 365 10.1111/j.1755-5949.2008.00060.x 1:CAS:528:DC%2BD1MXks1SmtA%3D%3D 19040558
    • (2008) CNS Neurosci Ther , vol.14 , pp. 352-365
    • Mandel, S.A.1    Amit, T.2    Weinreb, O.3    Reznichenko, L.4    Youdim, M.B.5
  • 45
    • 0037440375 scopus 로고    scopus 로고
    • Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: Role of Erk mitogen-activated protein kinase and NF-κB
    • DOI 10.1002/glia.10168
    • JS Marcus SL Karackattu MA Fleegal C Sumners 2003 Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB Glia 41 152 160 10.1002/glia.10168 12509805 (Pubitemid 36262192)
    • (2003) GLIA , vol.41 , Issue.2 , pp. 152-160
    • Marcus, J.S.1    Karackattu, S.L.2    Fleegal, M.A.3    Sumners, C.4
  • 46
    • 0025112578 scopus 로고
    • A logical calculus of the ideas immanent in nervous activity. 1943
    • 1:STN:280:DyaK3c3kt1WgtQ%3D%3D 2185863
    • WS McCulloch W Pitts 1990 A logical calculus of the ideas immanent in nervous activity. 1943 Bull Math Biol 52 99 115 1:STN:280:DyaK3c3kt1WgtQ%3D%3D 2185863
    • (1990) Bull Math Biol , vol.52 , pp. 99-115
    • McCulloch, W.S.1    Pitts, W.2
  • 47
    • 0042632879 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • DOI 10.1016/S0278-5846(03)00124-6
    • EG McGeer PL McGeer 2003 Inflammatory processes in Alzheimer's disease Prog Neuropsychopharmacol Biol Psychiatry 27 741 749 10.1016/S0278-5846(03) 00124-6 1:CAS:528:DC%2BD3sXmt1Kjt74%3D 12921904 (Pubitemid 36966754)
    • (2003) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.27 , Issue.5 , pp. 741-749
    • McGeer, E.G.1    McGeer, P.L.2
  • 49
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • DOI 10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3
    • TD Palmer AR Willhoite FH Gage 2000 Vascular niche for adult hippocampal neurogenesis J Comp Neurol 425 479 494 10.1002/1096-9861(20001002)425:4<479:: AID-CNE2>3.0.CO;2-3 1:STN:280:DC%2BD3cvlvVOmtw%3D%3D 10975875 (Pubitemid 30683570)
    • (2000) Journal of Comparative Neurology , vol.425 , Issue.4 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 51
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • DOI 10.1016/0891-5849(95)02227-9
    • CA Rice-Evans NJ Miller G Paganga 1996 Structure-antioxidant activity relationships of flavonoids and phenolic acids Free Radic Biol Med 20 933 956 10.1016/0891-5849(95)02227-9 1:CAS:528:DyaK28XjsVChu7g%3D 8743980 (Pubitemid 26157509)
    • (1996) Free Radical Biology and Medicine , vol.20 , Issue.7 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 53
    • 0035884625 scopus 로고    scopus 로고
    • Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3
    • DOI 10.1042/0264-6021:3580547
    • H Schroeter JPE Spencer C Rice-Evans RJ Williams 2001 Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3 Biochem J 358 547 557 10.1042/0264-6021:3580547 1:CAS:528:DC%2BD3MXntlShu7Y%3D 11535118 (Pubitemid 32896942)
    • (2001) Biochemical Journal , vol.358 , Issue.3 , pp. 547-557
    • Schroeter, H.1    Spencer, J.P.E.2    Rice-Evans, C.3    Williams, R.J.4
  • 55
    • 34249788691 scopus 로고    scopus 로고
    • (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons
    • DOI 10.1111/j.1471-4159.2006.04434.x
    • H Schroeter P Bahia JPE Spencer O Sheppard M Rattray C Rice-Evans RJ Williams 2007 (-)-Epicatechin stimulates ERK-dependent cyclic AMP response element activity and upregulates GLUR2 in cortical neurons J Neurochem 101 1596 1606 10.1111/j.1471-4159.2006.04434.x 1:CAS:528:DC%2BD2sXnvVantb8%3D 17298385 (Pubitemid 46848841)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.6 , pp. 1596-1606
    • Schroeter, H.1    Bahia, P.2    Spencer, J.P.E.3    Sheppard, O.4    Rattray, M.5    Cadenas, E.6    Rice-Evans, C.7    Williams, R.J.8
  • 56
    • 32944454490 scopus 로고    scopus 로고
    • Effects of Concord grape juice on cognitive and motor deficits in aging
    • DOI 10.1016/j.nut.2005.07.016, PII S0899900705002984
    • B Shukitt-Hale A Carey L Simon DA Mark JA Joseph 2006 Effects of Concord grape juice on cognitive and motor deficits in aging Nutrition 22 295 302 10.1016/j.nut.2005.07.016 1:CAS:528:DC%2BD28Xhslyltbk%3D 16412610 (Pubitemid 43261528)
    • (2006) Nutrition , vol.22 , Issue.3 , pp. 295-302
    • Shukitt-Hale, B.1    Carey, A.2    Simon, L.3    Mark, D.A.4    Joseph, J.A.5
  • 57
    • 80051832372 scopus 로고    scopus 로고
    • Berry fruit supplementation and the aging brain
    • DOI 10.1021/jf072505f
    • B Shukitt-Hale FC Lau JA Joseph 2008 Berry fruit supplementation and the aging brain J Agric Food Chem 56 636 641 10.1021/jf072505f 1:CAS:528: DC%2BD1cXptlyqsA%3D%3D 18211020 (Pubitemid 351300224)
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , Issue.3 , pp. 636-641
    • Shukitt-Hale, B.1    Lau, F.C.2    Joseph, J.A.3
  • 58
    • 38349008651 scopus 로고    scopus 로고
    • The interactions of flavonoids within neuronal signalling pathways
    • 10.1007/s12263-007-0056-z 1:CAS:528:DC%2BD1MXhtF2is7zI 18850181
    • JPE Spencer 2007 The interactions of flavonoids within neuronal signalling pathways Genes Nutr 2 257 273 10.1007/s12263-007-0056-z 1:CAS:528:DC%2BD1MXhtF2is7zI 18850181
    • (2007) Genes Nutr , vol.2 , pp. 257-273
    • Spencer, J.P.E.1
  • 59
    • 52049089562 scopus 로고    scopus 로고
    • Flavonoids: Modulators of brain function?
    • 18503736
    • JPE Spencer 2008 Flavonoids: modulators of brain function? Br J Nutr 99 E Suppl 1 ES60 ES77 18503736
    • (2008) Br J Nutr , vol.99 , Issue.E SUPPL 1
    • Spencer, J.P.E.1
  • 60
    • 42149124306 scopus 로고    scopus 로고
    • Food for thought: The role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
    • DOI 10.1017/S0029665108007088, PII S0029665108007088
    • JPE Spencer 2008 Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance Proc Nutr Soc 67 238 252 10.1017/S0029665108007088 1:CAS:528:DC%2BD1cXntVSnsLk%3D 18412998 (Pubitemid 351543406)
    • (2008) Proceedings of the Nutrition Society , vol.67 , Issue.2 , pp. 238-252
    • Spencer, J.P.E.1
  • 61
    • 63049125250 scopus 로고    scopus 로고
    • The impact of flavonoids on memory: Physiological and molecular considerations
    • 10.1039/b800422f 1:CAS:528:DC%2BD1MXjsFaju7w%3D 19421586
    • JPE Spencer 2009 The impact of flavonoids on memory: physiological and molecular considerations Chem Soc Rev 38 1152 1161 10.1039/b800422f 1:CAS:528:DC%2BD1MXjsFaju7w%3D 19421586
    • (2009) Chem Soc Rev , vol.38 , pp. 1152-1161
    • Spencer, J.P.E.1
  • 62
    • 0031722906 scopus 로고    scopus 로고
    • Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: Possible mechanisms of formation involving reactive oxygen species
    • 1:CAS:528:DyaK1cXntVSkt74%3D 9798937
    • JPE Spencer P Jenner SE Daniel AJ Lees DC Marsden B Halliwell 1998 Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species J Neurochem 71 2112 2122 1:CAS:528:DyaK1cXntVSkt74%3D 9798937
    • (1998) J Neurochem , vol.71 , pp. 2112-2122
    • Spencer, J.P.E.1    Jenner, P.2    Daniel, S.E.3    Lees, A.J.4    Marsden, D.C.5    Halliwell, B.6
  • 63
    • 0035500851 scopus 로고    scopus 로고
    • Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts
    • DOI 10.1016/S0891-5849(01)00704-3, PII S0891584901007043
    • JPE Spencer H Schroeter AJ Crossthwaithe G Kuhnle RJ Williams C Rice-Evans 2001 Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts Free Radic Biol Med 31 1139 1146 10.1016/S0891-5849(01)00704-3 1:CAS:528:DC%2BD3MXnslWqu7k%3D 11677047 (Pubitemid 33000135)
    • (2001) Free Radical Biology and Medicine , vol.31 , Issue.9 , pp. 1139-1146
    • Spencer J.P.E1    Schroeter, H.2    Crossthwaithe, A.J.3    Kuhnle, G.4    Williams, R.J.5    Rice-Evans, C.6
  • 64
    • 0035868353 scopus 로고    scopus 로고
    • Epicatechin and its in vivo metabolite, 3′-o-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation
    • DOI 10.1042/0264-6021:3540493
    • JPE Spencer H Schroeter G Kuhnle SK Srai RM Tyrrell U Hahn C Rice-Evans 2001 Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation Biochem J 354 493 500 10.1042/0264-6021:3540493 1:CAS:528:DC%2BD3MXisFaks7k%3D 11237853 (Pubitemid 32269712)
    • (2001) Biochemical Journal , vol.354 , Issue.3 , pp. 493-500
    • Spencer, J.P.E.1    Schroeter, H.2    Kuhnle, G.3    Srai, S.K.S.4    Tyrrell, R.M.5    Hahn, U.6    Rice-Evans, C.7
  • 65
    • 0036074531 scopus 로고    scopus 로고
    • 5-S-cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons
    • DOI 10.1046/j.1471-4159.2002.00808.x
    • JPE Spencer M Whiteman P Jenner B Halliwell 2002 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons J Neurochem 81 122 129 10.1046/j.1471-4159.2002.00808.x 1:CAS:528:DC%2BD38XivVensb8%3D 12067224 (Pubitemid 34808859)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.1 , pp. 122-129
    • Spencer, J.P.E.1    Whiteman, M.2    Jenner, P.3    Halliwell, B.4
  • 66
    • 0041816456 scopus 로고    scopus 로고
    • Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability
    • DOI 10.1074/jbc.M305063200
    • JPE Spencer C Rice-Evans RJ Williams 2003 Modulation of pro-survival Akt/PKB and ERK1/2 signalling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability J Biol Chem 278 34783 34793 10.1074/jbc.M305063200 1:CAS:528:DC%2BD3sXntVWqsL0%3D 12826665 (Pubitemid 37102237)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.37 , pp. 34783-34793
    • Spencer, J.P.E.1    Rice-Evans, C.2    Williams, R.J.3
  • 67
    • 18944393305 scopus 로고    scopus 로고
    • Nature, nurture and neurology: Gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw
    • DOI 10.1111/j.1742-4658.2005.04677.x
    • TL Spires AJ Hannan 2005 Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw FEBS J 272 2347 2361 10.1111/j.1742-4658.2005.04677.x 1:CAS:528:DC%2BD2MXksFyrsb0%3D 15885086 (Pubitemid 40705057)
    • (2005) FEBS Journal , vol.272 , Issue.10 , pp. 2347-2361
    • Spires, T.L.1    Hannan, A.J.2
  • 68
    • 0033593225 scopus 로고    scopus 로고
    • Activation of stress signaling pathways by the end product of lipid peroxidation: 4-Hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    • DOI 10.1074/jbc.274.4.2234
    • K Uchida M Shiraishi Y Naito Y Torii Y Nakamura T Osawa 1999 Activation of stress signaling pathways by the end product of lipid peroxidation. 4-Hydroxy-2-nonenal is a potential inducer of intracellular peroxide production J Biol Chem 274 2234 2242 10.1074/jbc.274.4.2234 1:CAS:528:DyaK1MXovVGlsg%3D%3D 9890986 (Pubitemid 29061378)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.4 , pp. 2234-2242
    • Uchida, K.1    Shiraishi, M.2    Naito, Y.3    Torii, Y.4    Nakamura, Y.5    Osawa, T.6
  • 69
    • 3242700558 scopus 로고    scopus 로고
    • Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)
    • DOI 10.1016/j.exger.2004.03.033, PII S0531556504001378
    • K Unno F Takabayashi T Kishido N Oku 2004 Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10) Exp Gerontol 39 1027 1034 10.1016/j.exger.2004.03.033 1:CAS:528:DC%2BD2cXltl2gurs%3D 15236762 (Pubitemid 38952883)
    • (2004) Experimental Gerontology , vol.39 , Issue.7 , pp. 1027-1034
    • Unno, K.1    Takabayashi, F.2    Kishido, T.3    Oku, N.4
  • 70
    • 62349089860 scopus 로고    scopus 로고
    • The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
    • 10.1016/j.abb.2009.01.016 1:CAS:528:DC%2BD1MXjsFWrt7w%3D 19467635
    • K VafeiAdou D Vauzour HY Lee A Rodriguez-Mateos RJ Williams JP Spencer 2009 The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury Arch Biochem Biophys 484 100 109 10.1016/j.abb.2009.01.016 1:CAS:528:DC%2BD1MXjsFWrt7w%3D 19467635
    • (2009) Arch Biochem Biophys , vol.484 , pp. 100-109
    • Vafeiadou, K.1    Vauzour, D.2    Lee, H.Y.3    Rodriguez-Mateos, A.4    Williams, R.J.5    Spencer, J.P.6
  • 71
    • 35448949428 scopus 로고    scopus 로고
    • Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
    • DOI 10.1111/j.1471-4159.2007.04841.x
    • D Vauzour K VafeiAdou C Rice-Evans RJ Williams JPE Spencer 2007 Activation of pro-survival Akt and ERK1/2 signaling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons J Neurochem 103 1355 1367 10.1111/j.1471-4159.2007.04841.x 1:CAS:528:DC%2BD2sXhtl2jurvE 17961201 (Pubitemid 47631805)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.4 , pp. 1355-1367
    • Vauzour, D.1    Vafeiadou, K.2    Rice-Evans, C.3    Williams, R.J.4    Spencer, J.P.E.5
  • 72
    • 34548250927 scopus 로고    scopus 로고
    • Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
    • DOI 10.1016/j.bbrc.2007.07.153, PII S0006291X07016518
    • D Vauzour K VafeiAdou JP Spencer 2007 Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols Biochem Biophys Res Commun 362 340 346 10.1016/j.bbrc.2007.07.153 1:CAS:528:DC%2BD2sXpvFKnu74%3D 17716620 (Pubitemid 47332414)
    • (2007) Biochemical and Biophysical Research Communications , vol.362 , Issue.2 , pp. 340-346
    • Vauzour, D.1    Vafeiadou, K.2    Spencer, J.P.E.3
  • 73
    • 48049106637 scopus 로고    scopus 로고
    • Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's disease and protection by polyphenols
    • 10.1016/j.abb.2008.03.011 1:CAS:528:DC%2BD1cXpsVGjsLY%3D 18394421
    • D Vauzour G Ravaioli K VafeiAadou A Rodriguez-Mateos C Angeloni JP Spencer 2008 Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols Arch Biochem Biophys 476 145 151 10.1016/j.abb.2008. 03.011 1:CAS:528:DC%2BD1cXpsVGjsLY%3D 18394421
    • (2008) Arch Biochem Biophys , vol.476 , pp. 145-151
    • Vauzour, D.1    Ravaioli, G.2    Vafeiaadou, K.3    Rodriguez-Mateos, A.4    Angeloni, C.5    Spencer, J.P.6
  • 74
    • 70450223158 scopus 로고    scopus 로고
    • The neuroprotective potential of flavonoids: A multiplicity of effects
    • 10.1007/s12263-008-0091-4 1:CAS:528:DC%2BD1MXhtF2isLvM 18937002
    • D Vauzour K VafeiAdou A Rodriguez-Mateos C Rendeiro JP Spencer 2008 The neuroprotective potential of flavonoids: a multiplicity of effects Genes Nutr 3 115 126 10.1007/s12263-008-0091-4 1:CAS:528:DC%2BD1MXhtF2isLvM 18937002
    • (2008) Genes Nutr , vol.3 , pp. 115-126
    • Vauzour, D.1    Vafeiadou, K.2    Rodriguez-Mateos, A.3    Rendeiro, C.4    Spencer, J.P.5
  • 75
    • 0036094915 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E)
    • DOI 10.1159/000057616
    • L Wang K Matsushita I Araki M Takeda 2002 Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E) Nephron 91 142 147 10.1159/000057616 1:CAS:528:DC%2BD38XjvVGhtLc%3D 12021531 (Pubitemid 34522844)
    • (2002) Nephron , vol.91 , Issue.1 , pp. 142-147
    • Wang, L.1    Matsushita, K.2    Araki, I.3    Takeda, M.4
  • 76
    • 33745015824 scopus 로고    scopus 로고
    • The in vivo synaptic plasticity mechanism of EGb 761-induced enhancement of spatial learning and memory in aged rats
    • DOI 10.1038/sj.bjp.0706720, PII 0706720
    • Y Wang L Wang J Wu J Cai 2006 The in vivo synaptic plasticity mechanism of EGb 761-induced enhancement of spatial learning and memory in aged rats Br J Pharmacol 148 147 153 10.1038/sj.bjp.0706720 1:CAS:528:DC%2BD28XksFSgu78%3D 16547523 (Pubitemid 43873033)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.2 , pp. 147-153
    • Wang, Y.1    Wang, L.2    Wu, J.3    Cai, J.4
  • 77
    • 37849032997 scopus 로고    scopus 로고
    • Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
    • 10.1016/j.neuroimage.2007.09.045 17988892
    • Z Wang M Fernandez-Seara DC Alsop WC Liu JF Flax AA Benasich JA Detre 2008 Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI Neuroimage 39 973 978 10.1016/j.neuroimage.2007.09. 045 17988892
    • (2008) Neuroimage , vol.39 , pp. 973-978
    • Wang, Z.1    Fernandez-Seara, M.2    Alsop, D.C.3    Liu, W.C.4    Flax, J.F.5    Benasich, A.A.6    Detre, J.A.7
  • 78
    • 1542605222 scopus 로고    scopus 로고
    • Flavonoids: Antioxidants or signalling molecules?
    • DOI 10.1016/j.freeradbiomed.2004.01.001, PII S0891584904000334
    • RJ Williams JP Spencer C Rice-Evans 2004 Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36 838 849 10.1016/j.freeradbiomed. 2004.01.001 1:CAS:528:DC%2BD2cXitFeisbw%3D 15019969 (Pubitemid 38352901)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.7 , pp. 838-849
    • Williams, R.J.1    Spencer, J.P.E.2    Rice-Evans, C.3
  • 79
    • 46749094132 scopus 로고    scopus 로고
    • Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
    • 10.1016/j.freeradbiomed.2008.04.008 1:CAS:528:DC%2BD1cXntlSrsrw%3D 18457678
    • CM Williams MA El Mohsen D Vauzour C Rendeiro LT Butler JA Ellis M Whiteman JPE Spencer 2008 Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels Free Radic Biol Med 45 295 305 10.1016/j.freeradbiomed.2008.04.008 1:CAS:528:DC%2BD1cXntlSrsrw%3D 18457678
    • (2008) Free Radic Biol Med , vol.45 , pp. 295-305
    • Williams, C.M.1    El Mohsen, M.A.2    Vauzour, D.3    Rendeiro, C.4    Butler, L.T.5    Ellis, J.A.6    Whiteman, M.7    Spencer, J.P.E.8
  • 80
    • 7444253369 scopus 로고    scopus 로고
    • Flavonoids and the brain: Interactions at the blood-brain barrier and their physiological effects on the central nervous system
    • DOI 10.1016/j.freeradbiomed.2004.08.002, PII S0891584904006355
    • KA Youdim B Shukitt-Hale JA Joseph 2004 Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system Free Radic Biol Med 37 1683 1693 10.1016/j.freeradbiomed. 2004.08.002 1:CAS:528:DC%2BD2cXpsFWku7g%3D 15528027 (Pubitemid 39441053)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.11 , pp. 1683-1693
    • Youdim, K.A.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 81
    • 0038781698 scopus 로고    scopus 로고
    • Stroke: Molecular mechanisms and potential targets for treatment
    • DOI 10.2174/1566524033479717
    • Z Zheng JE Lee MA Yenari 2003 Stroke: molecular mechanisms and potential targets for treatment Curr Mol Med 3 361 372 10.2174/1566524033479717 1:CAS:528:DC%2BD3sXjvFGmtLY%3D 12776991 (Pubitemid 36621793)
    • (2003) Current Molecular Medicine , vol.3 , Issue.4 , pp. 361-372
    • Zheng, Z.1    Lee, J.E.2    Yenari, M.A.3
  • 82
    • 39149120805 scopus 로고    scopus 로고
    • Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
    • 10.1016/j.intimp.2007.12.012 1:CAS:528:DC%2BD1cXitVGhsL4%3D 18279803
    • LT Zheng J Ock BM Kwon K Suk 2008 Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity Int Immunopharmacol 8 484 494 10.1016/j.intimp.2007.12.012 1:CAS:528: DC%2BD1cXitVGhsL4%3D 18279803
    • (2008) Int Immunopharmacol , vol.8 , pp. 484-494
    • Zheng, L.T.1    Ock, J.2    Kwon, B.M.3    Suk, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.