Ibuprofen protects dopaminergic neurons against glutamate toxicity in vitro

Neuroscience Letters

Volumn 289, Issue 3, 2000, Pages 201-204

  Casper, Diana ^a   Yaparpalvi, Uma ^a   Rempel, Nicole ^b   Werner, Peter ^b,c  

^a Department of Neurological Surgery   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

Acetaminophen; Aspirin; Cell culture; Dopaminergic; Ibuprofen; Neurodegeneration; Neuroprotection; Non steroidal anti inflammatory drugs; Parkinson's disease

Indexed keywords

ACETYLSALICYLIC ACID; DOPAMINE; GLUTAMIC ACID; IBUPROFEN; PARACETAMOL;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; EMBRYO; MESENCEPHALON; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TOXICITY;

ACETAMINOPHEN; ANIMALS; ASPIRIN; CELL COUNT; CELLS, CULTURED; DOPAMINE; FETUS; GLUTAMIC ACID; IBUPROFEN; MESENCEPHALON; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PARKINSON DISEASE; RATS;

EID: 0034637089     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01294-5     Document Type: Article

References (21)

1. Aubin H., Curet O., Deffois A., Carter C. Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice. J. Neurochem. 71:1998;1635-1642.
2. Bezzi P., Carmignoto G., Pasti L., Vesce S., Rossi D., Rizzini B.L., Pozzan T., Volterra A. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391:1998;281-285.
3. Bulera S.J., Birge R.B., Cohen S.D., Khairallah E.A. Identification of the mouse liver 44-kDa acetaminophen-binding protein as a subunit of glutamine synthetase. Toxicol. Appl. Pharmacol. 134:1995;313-320.
4. Casper D., Blum M. Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in culture. J. Neurochem. 65:1995;1016-1026.
5. Casper D., Lekhraj R., Yaparpalvi U.S., Pidel A., Jaggernauth W.A., Werner P., Tribius S., Del Rowe J., LaSala P. Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. J. Neurol.-Oncol. 46:2000;215-229.
6. Casper D., Mytilineou C., Blum M. EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary culture. J. Neurosci. Res. 30:1991;372-381.
7. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
8. γ agonists. J. Neurosci. 20:2000;558-567.
9. Driscoll B.F., Deibler G.E., Law M.J., Crane A.M. Damage to neurons in culture following medium change: role of glutamine and extracellular generation of glutamate. J. Neurochem. 61:1993;1795-1800.
10. Ferger B., Teismann P., Earl C.D., Kuschinsky K., Oertel W.H. Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice. Nauyn-Schmiedeberg's Arch. Pharmacol. 360:1999;256-261.
11. Greenberg S.G., Davies P., Schein J.D., Binder L.I. Hydrofluoric acid-treated τPHF proteins display the same biochemical properties as normal τ J. Biol. Chem. 267:1992;564-569.
12. Grilli M., Pizzi M., Memo M., Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science. 274:1996;1383-1385.
13. Halmes N.C., Hinson J.A., Martin B.M., Pumford N.R. Glutamate dehydrogenase covalently binds to a reactive metabolite of acetaminophen. Chem. Res. Toxicol. 9:1996;541-546.
14. Honer W.G., Bassett A.S., Falkai P., Beach T.G., Lapointe J.S. A case study of temporal lobe development in familial schizophrenia. Psychol. Med. 26:1996;191-195.
15. Hornykiewicz O. Dopamine (3-hydroxytyramine) and brain function. Pharmacol. Rev. 18:1966;244-253.
16. Hunot S., Brugg B., Ricard D., Michel P.P., Muriel M.-P., Ruberg M., Faucheux B.A., Agid Y., Hirsch E.C. Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson's disease. Proc. Natl. Acad. Sci. USA. 94:1997;7531-7536.
17. Kaltschmidt C., Kaltschmidt B., Baeuerle P.A. Brain synapses contain inducible forms of the transcription factor NF-κB. Mech. Dev. 43:1993;135-147.
18. Kaltschmidt C., Kaltschmidt B., Baeuerle P.A. Stimulation of ionotropic glutamate receptors activates transcription factor NF-κB in primary neurons. Proc. Natl. Acad. Sci. USA. 92:1995;9618-9622.
19. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. 21:1995;195-218.
20. Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. Exp. Neurol. 144:1997;339-349.
21. Vane J.R., Bakhle Y.S., Botting R.M. Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38:1998;97-120.