Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia

European Journal of Pharmacology

Volumn 521, Issue 1-3, 2005, Pages 9-20

  Chen, Jui Ching ^a   Ho, Feng Ming ^b   Chao, Pei Dawn Lee ^c   Chen, Chih Ping ^b   Jeng, Kee Ching G ^d   Hsu, Hsiu Bao ^c   Lee, Sho Tone ^e   Wen, Tung Wu ^a   Lin, Wan Wan ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAO YUAN GENERAL HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Heme oxygenase 1; Inducible nitric oxide synthase; Microglia; Nuclear factor B; Quercetin; Signal transducer and activator of transcription 1

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; BACTERIUM LIPOPOLYSACCHARIDE; GAMMA INTERFERON; HEME OXYGENASE 1; HEMIN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN TYROSINE KINASE; QUERCETIN; QUERCETIN 3' SULFATE; QUERCETIN DERIVATIVE; STAT1 PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME KINETICS; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; INFLAMMATORY DISEASE; MICROGLIA; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMIDES; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BUTADIENES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HEMIN; I-KAPPA B KINASE; IMMUNOBLOTTING; INTERFERON REGULATORY FACTOR-1; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LUCIFERASES; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PHOSPHORYLATION; PYRIDINES; QUERCETIN; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 26444594915     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.08.005     Document Type: Article

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