5-S-cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

Journal of Neurochemistry

Volumn 81, Issue 1, 2002, Pages 122-129

  Spencer, Jeremy P E ^a   Whiteman, Matthew ^b   Jenner, Peter ^a   Halliwell, Barry ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

5 S cysteinyl dopamine; Caspase 3; DNA base modification; Neurodegenerative disease; Parkinson's disease

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 8 HYDROXYGUANINE; CASPASE 3; DOPAMINE DERIVATIVE; GLUTATHIONE; LEVODOPA; METHAMPHETAMINE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DNA MODIFICATION; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; CASPASE 3; CASPASES; CATECHOLAMINES; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE; CYSTEINYLDOPA; DNA; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INTRACELLULAR FLUID; LEVODOPA; METHAMPHETAMINE; NEURONS; PURINES; PYRIMIDINES; RATS; REACTIVE OXYGEN SPECIES;

ANIMALIA;

EID: 0036074531     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00808.x     Document Type: Article

References (37)

1. Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra
2. Reactions of oxyl radicals with DNA
3. The neuromelanin of the human substantia nigra
4. Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: Possible markers for and potential insights into the pathoetiology of Parkinson's disease
5. Cellular injury by oxidants
6. The pathobiology of Parkinson's disease: Biochemical aspects of dopamine neuron senescence
7. Monoamine oxidase, hydrogen peroxide and Parkinson's disease
8. Oxidative damage to DNA in mammalian chromatin
9. Reverse chemical mutagenesis: Identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA
10. Vitamin C deficiency facilitates 5-S-cysteinyldopamine formation in the guinea pig striatum
11. Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine dopa and dopac in the brains of eight mammalian species
12. The apparent autoxidation rate of catechols in dopamine-rich regions of human brains increases with the degree of depigmentation of substantia nigra
13. Oxidative stress: Free radical production in neural degeneration
14. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
15. Commentary. The measurement of oxidative damage to DNA by HPLC and GC/MS techniques
16. Measurement of oxidative DNA damage by gas chromatographymass spectrometry: Ethane thiol prevents artifactual generation of oxidised DNA bases
17. Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease
18. Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydrexy-2H-1,4-benzothiazine-3-carboxylic acid (DHBT-1): A putative nigral endotoxin of relevance to Parkinson's disease
19. Neuromelanin of the human substantia nigra: A mixedtype melanin
20. Parkinson's disease: A disorder due to glutathione deficiency?
21. Majer oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro
22. Transition metals, ferritin, glutathione and ascorbic acid in Parkinsonian brains
23. Detection of 5-S-cysteinyldopamine in human brain
24. Further insights into the influence of 1-cysteine on the oxidation chemistry of dopamine: Reaction pathways of potential relevance to Parkinson's disease
25. Influence of glutathione on the oxidation chemistry of 5-S-cysteinyldopamine: Potentially neuro-protective reactions of relevance to Parkinson's Disease
26. Oxidation of dopamine in the presence of cysteine: Characterisation of new toxic products
27. Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinson's disease
28. Oxidative DNA damage in human respiratory tract epithelial cells. Time course in relation to DNA strand breakage
29. Conjugates of catecholamines with cysteine and GSH in Parkinson's disease. Possible mechanisms of formation involving reactive oxygen species
30. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
31. Oxidation chemistry of dopamine. Possible insights into the age-dependent loss of dopaminergic nigrostriatal neurons
32. Effects of 1-cysteine on the oxidation chemistry of dopamine: New reaction pathways of potential relevance to idiopathic Parkinson's disease
33. Influence of glutathione on the oxidation chemistry of the catecholaminergic neurotransmitter dopamine
34. Reactions of cysteine and cysteinyl derivatives with dopamine-o-quinone and further insights into the oxidation chemistry of 5-S-cysteinyldopamine: Potential relevance to idiopathic Parkinson's disease
35. Bcl-2 inhibits death of central neural cells induced by multiple agents