Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis

Journal of Cell Science

Volumn 122, Issue 24, 2009, Pages 4481-4491

  Janssen, Katja ^a,b   Horn, Sibylle ^a,b   Niemann, Mathis T ^a,b   Daniel, Peter T ^c   Schulze Osthoff, Klaus ^a,b   Fischer, Ute ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Autophagy; Bak; Bax; ER stress; Ire1; Multidrug resistance; Necrosis; PARP; SERCA; UPR

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CASPASE; CYTOCHROME C; ETOPOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAK; PROTEIN BAX; THAPSIGARGIN; CALCIUM; ENZYME INHIBITOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME RELEASE; MITOCHONDRIAL PERMEABILITY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENDOPLASMIC RETICULUM; FIBROBLAST; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; MOUSE MUTANT; NECROSIS; NEOPLASM; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

MURINAE;

ANIMALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROMES C; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NECROSIS; NEOPLASMS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; THAPSIGARGIN;

EID: 71449090735     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.055772     Document Type: Article

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