Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

Journal of Experimental Medicine

Volumn 188, Issue 5, 1998, Pages 979-984

  Ferrari, Davide ^a   Stepczynska, Ania ^a   Los, Marek ^a   Wesselborg, Sebastian ^a   Schulze Osthoff, Klaus ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Anticancer drugs; Apoptosis; ATP; CD95 (APO 1 Fas); Cytochrome c

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 8; CYCLOHEXIMIDE; DOXORUBICIN; FAS ANTIGEN; MITOMYCIN C; PROTEASE ACTIVATING FACTOR 1; STAUROSPORINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ADENOSINE TRIPHOSPHATE; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; MITOCHONDRIA; PROTEINS; STAUROSPORINE;

EID: 0032494108     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.5.979     Document Type: Article

References (34)

1. Cohen, G.M. 1997. Caspases: the executioners of apoptosis. Biochem. J. 326:1-16.
2. Nicholson, D.N., and N.A. Thornberry. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22:299-306.
3. Schulze-Osthoff, K., D. Ferrari, M. Los, S. Wesselborg, and M.E. Peter. 1998. Apoptosis signaling by death receptors. Eur. J. Biochem. 254:439-459.
4. Krammer, P.H., J. Dhein, H. Walczak, I. Behrmann, S. Mariani, B. Matiba, M. Fath, P.T. Daniel, E. Knipping, M.O. Westendorp, et al. 1994. The role of APO-1-mediated apoptosis in the immune system. Immunol. Rev. 142:175-191.
5. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
6. Kischkel, F.C., S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P.H. Krammer, and M.E. Peter. 1995. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBOJ. 14:5579-5588.
7. Muzio, M., A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, et al. 1996. FLICE, a novel FADD-homologous ICE/ CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell. 85:817-827.
8. Boldin, M.P., T.M. Goncharov, Y.V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/ FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 85:803-815.
9. Srinivasula, S.M., M. Ahmad, T. Fernandes-Alnemri, G. Litwack, and E.S. Alnemri. 1996. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ ICE-hke cysteine proteases. Proc. Natl. Acad. Sci. USA. 93: 14486-14491.
10. Kluck, R.M., E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 275:1132-1136.
11. Yang, J., X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones, and X. Wang. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 275:1129-1132.
12. Zou, H., W.J. Henzel, X. Liu, A. Lutschg, and X. Wang. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependem activation of caspase-3. Cell. 90:405-413.
13. Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479-489.
14. Pan, G., K. O'Rourke, and V.M. Dixit. 1998. Caspase-9, Bel-XL, and Apaf-1 form a ternary complex. J. Biol. Chem. 273:5841-5845.
15. Liu, X., C.N. Kim, J. Yang, R. Jemmerson, and X. Wang. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86:147-157.
16. Hofmann, K., P. Bucher, and J. Tschopp. 1997. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22:155-156.
17. Krippner, A., A. Matsuno-Yagi, R.A. Gottlieb, and B.M. Babior. 1996. Loss of function of cytochrome c in Jurkat cells undergoing Fas-mediated apoptosis. J. Biol. Chem. 271: 21629-21636.
18. Adachi, S., A.R. Cross, B.M. Babior, and R.A. Gottlieb. 1997. Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J. Biol. Chem. 272:21878-21882.
19. L as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis. Proc. Natl. Acad. Sci. USA. 94:6939-6942.
20. Friesen, C., I. Herr, P.H. Krammer, and K.M. Debatin. 1996. Involvement of the CD95 (APO-I/FAS) receptor/ ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2:574-577.
21. Müller, M., S. Strand, H. Hug, E.M. Heinemann, H. Walczak, W.J. Hofmann, W. Stremmel, P.H. Krammer, and P.R. Galle. 1997. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of Wild-type p53. J. Clin. Invest. 99:403-413.
22. Eischen, C.M., T.J. Kottke, L.M. Martins, G.S. Basi, J.S. Tung, W.C. Earnshaw, P.J. Leibson, and S.H. Kaufmann. 1997. Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions. Blood. 90:935-943.
23. Gamen, S., A. Anel, P. Lasierra, M.A. Alava, M.J. Martinez-Lorenzo, A. Pineiro, and J. Naval. 1997. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS Lett. 417:360-364.
24. Yeh, W.C., J.L. Pompa, M.E. McCurrach, H.B. Shu, A.J. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, K. Mitchell, et al. 1998. FADD: essential for embryo development and signaling from some, but not all, inducers ot apoptosis. Science. 279:1954-1958.
25. Leist, M., B. Single, A.F. Castoldi, S. Kuhnle, and P. Nicotera. 1997. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med. 185:1481-1486.
26. Eguchi, Y., S. Shimizu, and Y. Tsujimoto. 1997. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 57:1835-1840.
27. Nicoletti, I., G. Migliorati, M.C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139:271-279.
28. Medema, J.P., C. Scaffidi, F.C. Kischkel, A. Shevchenko, M. Mann, P.M. Krammer, and M.E. Peter. 1997. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16:2794-2804.
29. Scaffidi, C., J.P. Medema, P.H. Krammer, and M.E. Peter. 1997. FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J. Biol. Chem. 272:26953-26958.
30. Richter, C., M. Schweizer, A. Cossarizza, and C. Franceschi. 1996. Control of apoptosis by ATP level. FEBS Lett. 378: 107-110.
31. Tewari, M., L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit. 1995. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:801-809.
32. Kass, G.E.N., J.E. Eriksson, M. Weis, S. Orrenius, and S.C. Chow. 1996. Chromatin condensation during apoptosis requires ATP. Biochem. J. 318:749-752.
33. Kroemer, G. 1997. Mitochondrial control of apoptosis. Immunol. Today. 18:44-51.
34. Scaffidi, C., S. Fulda, A. Srinivasan, C. Friesen, F. Li, K.J. Tomaselli, K.-M. Debatin, P.H. Krammer, and M.E. Peter. 1998. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1675-1687.