Vascular and cellular calcium in normal and hypertensive pregnancy

Current Clinical Pharmacology

Volumn 4, Issue 3, 2009, Pages 172-190

  Adamova, Zuzana ^a   Ozkan, Sifa ^a   Khalil, Raouf A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Calcium; Endothelium; Hypertension; Preeclampsia; Pregnancy; Smooth muscle

Indexed keywords

CALCIUM; CALCIUM ION; PARATHYROID HORMONE; PLACEBO; VITAMIN D;

CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM SIGNALING; CLINICAL TRIAL; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; ERYTHROCYTE; EXTRACELLULAR CALCIUM; EXTRACELLULAR MATRIX; HUMAN; IMMUNOCOMPETENT CELL; MATERNAL HYPERTENSION; MATERNAL NUTRITION; NONHUMAN; PATIENT COMPLIANCE; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REGULATORY MECHANISM; REVIEW; RISK REDUCTION; THROMBOCYTE; VASCULAR SMOOTH MUSCLE; VITAMIN BLOOD LEVEL;

BLOOD COAGULATION; BLOOD PLATELETS; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CALCIUM, DIETARY; ENDOTHELIUM, VASCULAR; ERYTHROCYTES; EXTRACELLULAR MATRIX; FEMALE; HEMODYNAMICS; HUMANS; HYPERTENSION, PREGNANCY-INDUCED; IMMUNE SYSTEM; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MUSCLE, SMOOTH, VASCULAR; PREGNANCY; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATION; VITAMIN D;

EID: 70549098238     PISSN: 15748847     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488409789375320     Document Type: Review

References (213)

1. Baylis C. The determinants of renal hemodynamics in pregnancy. Am J Kidney Dis 1987; 9: 260-264
2. Sowers JR, Zemel MB, Walsh MF, et al. Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance. Am J Hypertens 1990; 3(1): 16-22.
3. Duvekot JJ, Peeters LL. Renal hemodynamics and volume homeostasis in pregnancy. Obstet Gynecol Surv 1994; 49(12): 830-839
4. Deng A, Engels K, Baylis C. Impact of nitric oxide deficiency on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat. Kidney Int 1996; 50(4): 1132-1138 (Pubitemid 26342802)
5. Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997; 272(2): R441-63.
6. Alexander BT, Miller MT, Kassab S, et al. Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats. Hypertension 1999; 33(1): 435-439 (Pubitemid 29065698)
7. Nelson SH, Steinsland OS, Wang Y, Yallampalli C, Dong YL, Sanchez JM. Increased nitric oxide synthase activity and expression in the human uterine artery during pregnancy. Circ Res 2000; 87(5): 406-411 (Pubitemid 30688991)
8. Abram SR, Alexander BT, Bennett WA, Granger JP. Role of neuronal nitric oxide synthase in mediating renal hemodynamic changes during pregnancy. Am J Physiol Regul Integr Comp Physiol 2001; 281(5): R1390-3.
9. Davidge ST, McLaughlin MK. Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat. Am J Obstet Gynecol 1992; 167(6): 1691-1698
10. Khalil RA, Crews JK, Novak J, Kassab S, Granger JP. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension 1998; 31(5): 1065-1069 (Pubitemid 28191498)
11. Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol 2002; 283(1): R29-45.
12. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation 2002; 9(3): 147-160
13. Gilbert JS, Ryan MJ, LaMarca BB, Sedeek M, Murphy SR, Granger JP. Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction. Am J Physiol Heart Circ Physiol 2008; 294(2): H541-50.
14. MacKay AP, Berg CJ, Atrash HK. Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol 2001; 97(4): 533-538
15. Ramos JG, Brietzke E, Martins-Costa SH, Vettorazzi-Stuczynski J, Barros E, Carvalho C. Reported calcium intake is reduced in women with preeclampsia. Hypertens Pregnancy 2006; 25(3): 229-239 (Pubitemid 44655660)
16. Bronner YL, Hawkins AS, Holt ML, et al. Models for nutrition education to increase consumption of calcium and dairy products among African Americans. J Nutr 2006; 136(4): 1103-1106
17. Storey ML, Forshee RA, Anderson PA. Associations of adequate intake of calcium with diet, beverage consumption, and demographic characteristics among children and adolescents. J Am Coll Nutr 2004; 23(1): 18-33.
18. Harville EW, Schramm M, Watt-Morse M, Chantala K, Anderson JJ, Hertz-Picciotto I. Calcium intake during pregnancy among white and African-American pregnant women in the United States. J Am Coll Nutr 2004; 23(1): 43-50. (Pubitemid 38200833)
19. Thomas M, Weisman SM. Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am J Obstet Gynecol 2006; 194(4): 937-945
20. Bucher HC, Guyatt GH, Cook RJ, et al. Effect of calcium supplementation on pregnancy-induced hypertension and preeclampsia: a meta-analysis of randomized controlled trials. JAMA 1996; 275(14): 1113-1117 (Pubitemid 26106976)
21. Knight KB, Keith RE. Calcium supplementation on normotensive and hypertensive pregnant women. Am J Clin Nutr 1992; 55(4): 891-895
22. López-Jaramillo P, Delgado F, Jácome P, Terán E, Ruano C, Rivera J. Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers. Obstet Gynecol 1997; 90(2): 162-167 (Pubitemid 27318824)
23. Crowther CA, Hiller JE, Pridmore B, et al. Calcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study Group. Aust N Z J Obstet Gynaecol 1999; 39(1): 12-18 (Pubitemid 29108175)
24. Levine RJ, Esterlitz JR, Raymond EG, et al. Trial of Calcium for Preeclampsia Prevention (CPEP): rationale, design, and methods. Control Clin Trials 1996; 17(5): 442-469 (Pubitemid 26391665)
25. Sibai BM, Ewell M, Levine RJ, et al. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol 1997; 177(5): 1003-1010
26. Oken E, Ning Y, Rifas-Shiman SL, Rich-Edwards JW, Olsen SF, Gillman MW. Diet during pregnancy and risk of preeclampsia or gestational hypertension. Ann Epidemiol 2007; 17(9): 663-668 (Pubitemid 47277511)
27. Villar J, Abdel-Aleem H, Merialdi M, et al. World Health Organization Calcium Supplementation for the Prevention of Preeclampsia Trial Group. World Health Organization randomized trial of calcium supplementation among low calcium intake pregnant women. Am J Obstet Gynecol 2006; 194(3): 639-649
28. Hofmeyr GJ, Duley L, Atallah A. Dietary calcium supplementation for prevention of pre-eclampsia and related problems: a systematic review and commentary. BJOG 2007; 114(8): 933-943 (Pubitemid 47052743)
29. Levine RJ, Hauth JC, Curet LB, et al. Trial of calcium to prevent preeclampsia. N Engl J Med 1997; 337(2): 69-76.
30. Trumbo PR, Ellwood KC. Supplemental calcium and risk reduction of hypertension, pregnancy-induced hypertension, and preeclampsia: an evidence-based review by the US Food and Drug Administration. Nutr Rev 2007; 65(2): 78-87.
31. Prada JA, Tsang RC, Clark KE. Hypocalcemia and pregnancy-induced hypertension produced by low-calcium diet. Hypertension 1994; 23(6): 695-702.
32. Aiko A, Ito M, Okamura H, Araki H, Nishi K. Effect of a low calcium intake on the vascular sensitivity to angiotensin II in normotensive pregnant rats. Artery 1992; 19(4): 199-210. (Pubitemid 23074915)
33. Ezimokhai M, Osman N. Calcium supplementation is associated with endothelium dependent attenuation of vascular smooth muscle reactivity in normotensive pregnant and nonpregnant rats. Am J Hypertens 1998; 11(1 Pt 1): 88-96. (Pubitemid 28083157)
34. Fischer D, Schroer A, Lüdders D, et al. Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births. Clin Exp Obstet Gynecol 2007; 34(2): 80-84 (Pubitemid 47047546)
35. Pérez-López FR. Vitamin D: the secosteroid hormone and human reproduction. Gynecol Endocrinol 2007; 23(1): 13-24.
36. Allali F, El Aichaoui S, Khazani H, et al. High Prevalence of Hypovitaminosis D in Morocco: Relationship to Lifestyle, Physical Performance, Bone Markers, and Bone Mineral Density. Semin Arthritis Rheum. 2008 Mar 11. [Epub ahead of print].
37. Burnand B, Sloutskis D, Gianoli F, et al. Serum 25-hydroxyvitamin D: distribution and determinants in the Swiss population. Am J Clin Nutr 1992; 56(3): 537-542
38. Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V. Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2008; 87(1): 136-141
39. Sowers MR, Wallace RB, Lemke JH. The association of intakes of vitamin D and calcium with blood pressure among women. Am J Clin Nutr 1985; 42(1): 135-142 (Pubitemid 15028533)
40. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab 2001; 86(4): 1633-1637 (Pubitemid 32377290)
41. Halhali A, Díaz L, Avila E, Ariza AC, Garabédian M, Larrea F. Decreased fractional urinary calcium excretion and serum 1,25- dihydroxyvitamin D and IGF-I levels in preeclampsia. J Steroid Biochem Mol Biol 2007; 103(3-5): 803-806 (Pubitemid 46431189)
42. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110(2): 229-238
43. Cross NA, Hillman LS, Allen SH, Krause GF, Vieira NE. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr 1995; 61(3): 514-523
44. Ritchie LD, Fung EB, Halloran BP, et al. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr 1998; 67(4): 693-701.
45. Vargas Zapata CL, Donangelo CM, Woodhouse LR, Abrams SA, Spencer EM, King JC. Calcium homeostasis during pregnancy and lactation in Brazilian women with low calcium intakes: a longitudinal study. Am J Clin Nutr 2004; 80(2): 417-422
46. Seely EW, Wood RJ, Brown EM, Graves SW. Lower serum ionized calcium and abnormal calciotropic hormone levels in preeclampsia. J Clin Endocrinol Metab 1992; 74(6): 1436-1440
47. Whitehead M, Lane G, Young O, et al. Interrelations of calcium-regulating hormones during normal pregnancy. Br Med J (Clin Res Ed) 1981; 283(6283): 10-12 (Pubitemid 11048037)
48. Davis OK, Hawkins DS, Rubin LP, Posillico JT, Brown EM, Schiff I. Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab 1988; 67(4): 850-852 (Pubitemid 18238464)
49. Seki K, Makimura N, Mitsui C, Hirata J, Nagata I. Calcium-regulating hormones and osteocalcin levels during pregnancy: a longitudinal study. Am J Obstet Gynecol 1991; 164(5): 1248-1252
50. Gillette ME, Insogna KL, Lewis AM, Baran DT Influence of pregnancy on immunoreactive parathyroid hormone levels. Calcif Tissue Int 1982; 34(1): 9-12. (Pubitemid 12073832)
51. Saggese G, Baroncelli GI, Bertelloni S, Cipolloni C. Intact parathyroid hormone levels during pregnancy, in healthy term neonates and in hypocalcemic preterm infants. Acta Paediatr Scand 1991; 80(1): 36-41.
52. Bourdeau A, Manganella G, Thil-Trubert CL, Sachs C, Cournot G. Bioactive parathyroid hormone in pregnant rats and fetuses. Am J Physiol 1990; 258(4 Pt 1): E549-54. (Pubitemid 20142333)
53. Gonen E, Sahin I, Ozbek M, Kovalak E, Yologlu S, Ates Y. Effects of pregnancy and lactation on bone mineral density, and their relation to the serum calcium, phosphorus, calcitonin and parathyroid hormone levels in rats. J Endocrinol Invest 2005; 28(4): 322-326 (Pubitemid 43162750)
54. Fukuoka H, Haruna M. Calcium and bone metabolism during pregnancy and lactation. Clin Calcium 2003; 13(11): 1425-1431
55. August P, Marcaccio B, Gertner JM, Druzin ML, Resnick LM, Laragh JH. Abnormal 1,25-dihydroxyvitamin D metabolism in preeclampsia. Am J Obstet Gynecol 1992; 166(4): 1295-1299
56. Sanchez-Ramos L, Jones DC, Cullen MT. Urinary calcium as an early marker for preeclampsia. Obstet Gynecol 1991; 77(5): 685-688
57. Szmidt-Adjidé V, Vendittelli F, David S, Brédent-Bangou J, Janky E. Calciuria and preeclampsia: a case-control study. Eur J Obstet Gynecol Reprod Biol 2006; 125(2): 193-198
58. Kisters K, Barenbrock M, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular, and plasma magnesium and calcium concentrations in preeclampsia. Am J Hypertens 2000; 13(7): 765-769 (Pubitemid 30604114)
59. Sukonpan K, Phupong V. Serum calcium and serum magnesium in normal and preeclamptic pregnancy. Arch Gynecol Obstet 2005; 273(1): 12-16 (Pubitemid 41571161)
60. Silver HM, Seebeck M, Carlson R. Comparison of total blood volume in normal, preeclamptic, and nonproteinuric gestational hypertensive pregnancy by simultaneous measurement of red blood cell and plasma volumes. Am J Obstet Gynecol 1998; 179(1): 87-93. (Pubitemid 28394478)
61. Ray J, Vasishta K, Kaur S, Majumdar S, Sawhney H. Calcium metabolism in pre-eclampsia. Int J Gynaecol Obstet 1999; 66(3): 245-250
62. Ceyhan T, Beyan C, Başer I, Kaptan K, Güngör S, Ifran A., The effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol 2006; 85(5): 320-322 (Pubitemid 43732655)
63. Sowers JR, Zemel MB, Bronsteen RA, et al. Erythrocyte cation metabolism in preeclampsia. Am J Obstet Gynecol 1989; 161(2): 441-445
64. Kosch M, Hausberg M, Louwen F, Barenbrock M, Rahn KH, Kisters K. Alterations of plasma calcium and intracellular and membrane calcium in erythrocytes of patients with pre-eclampsia. J Hum Hypertens 2000; 14(5): 333-336 (Pubitemid 30311516)
65. Lurie S, Frenkel E, Tuvbin Y, Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy. Gynecol Obstet Invest 1998; 45(4): 229-231 (Pubitemid 28241175)
66. Hojo M, Suthanthiran M, Helseth G, August P. Lymphocyte intracellular free calcium concentration is increased in preeclampsia. Am J Obstet Gynecol 1999; 180(5): 1209-1214 (Pubitemid 29259018)
67. Kilby MD, Broughton Pipkin F, Cockbill S, Heptinstall S, Symonds EM. A cross-sectional study of basal platelet intracellular free calcium concentration in normotensive and hypertensive primigravid pregnancies. Clin Sci (Lond) 1990; 78(1): 75-80. (Pubitemid 20030054)
68. Haller H, Ziegler EM, Homuth V, et al. Endothelial adhesion molecules and leukocyte integrins in preeclamptic patients. Hypertension 1997; 29(1): 291-296 (Pubitemid 27074058)
69. Bouchlariotou S, Liakopoulos V, Dovas S, et al. Nocturnal hypertension is associated with an exacerbation of the endothelial damage in preeclampsia. Am J Nephrol 2008; 28(3): 424-430
70. 2+ metabolism in normal vasular smooth muscle cells. J Am Soc Nephrol 2000; 11(7): 1188-1198
71. Pedersen EB, Johannesen P, Kristensen S, Rasmussen AB, Emmertsen K, Møller J, Lauritsen JG, Wohlert M. Calcium, parathyroid hormone and calcitonin in normal pregnancy and preeclampsia. Gynecol Obstet Invest 1984; 18(3): 156-164 (Pubitemid 14071893)
72. Richards SR, Nelson DM, Zuspan FP. Calcium levels in normal and hypertensive pregnant patients. Am J Obstet Gynecol 1984; 149(2): 168-171 (Pubitemid 14103910)
73. Ebose EJ, Campbell PI, Okorodudu AO. Electrolytes and pH changes in pre-eclamptic rats. Clin Chim Acta 2007; 384(1-2): 135-140
74. 2+ signaling contributes to pregnancy-enhanced vasodilation of rat uteroplacental arteries. Am J Physiol Heart Circ Physiol 2006; 290(5): H2124-35.
75. 2+]i signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am J Physiol Regul Integr Comp Physiol 2001; 280(1): R87-99.
76. Nardulli G, Proverbio F, Limongi FG, Marín R, Proverbio T. Preeclampsia and calcium adenosine triphosphatase activity of red blood cell ghosts. Am J Obstet Gynecol 1994; 171(5): 1361-1365 (Pubitemid 24365743)
77. Teppa-Garrán A, Proverbio T, Marín R, Proverbio F. Lipid peroxidation and active calcium transport in inside-out vesicles of red blood cells from preeclamptic women. Int J Biochem Cell Biol 2004; 36(5): 806-813 (Pubitemid 38299396)
78. 2+-ATPase protein from red blood cells is not modified in preeclampsia. Biochim Biophys Acta 2006; 1762(3): 381-385
79. ++-ATPase from human placenta. J Enzyme Inhib 2000; 15(2): 163-170
80. Carrera F, Casart YC, Proverbio T, Proverbio F, Marín R. Preeclampsia and calcium-ATPase activity of plasma membranes from human myometrium and placental trophoblast. Hypertens Pregnancy 2003; 22(3): 295-304. (Pubitemid 37288693)
81. Kaur G, Mishra S, Sehgal A, Prasad R. Alterations in lipid peroxidation and antioxidant status in pregnancy with preeclampsia. Mol Cell Biochem 2008; 333: 37-44.
82. Kilby MD, Broughton Pipkin F, Symonds EM. Platelet cytosolic calcium in human pregnancy complicated by essential hypertension. Am J Obstet Gynecol 1993; 169(1): 141-143 (Pubitemid 23223946)
83. Bar J.; Ben-Haroush A.; Lahav J.; Sullivan M. Interaction Between Platelets and Cytokines - A Possible Role in the Pathogenesis of Preeclampsia. Vasc Dis Prev 2004; 1(2), 101-107.
84. Janes SL, Kyle PM, Redman C, Goodall AH. Flow cytometric detection of activated platelets in pregnant women prior to the development of pre-eclampsia. Thromb Haemost 1995; 74(4): 1059-1063
85. Konijnenberg A, Stokkers EW, van der Post JA, et al. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol 1997; 176(2): 461-469 (Pubitemid 27107940)
86. Haller H, Oeney T, Hauck U, Distler A, Philipp T. Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic women. Am J Hypertens 1989; 2(4): 238-243 (Pubitemid 19087202)
87. Barr SM, Lees KR, Butters L, O'Donnell A, Rubin PC. Platelet intracellular free calcium concentration in normotensive and hypertensive pregnancies in the human. Clin Sci (Lond) 1989; 76(1): 67-71. (Pubitemid 19039093)
88. Zemel MB, Zemel PC, Berry S, et al. Altered platelet calcium metabolism as an early predictor of increased peripheral vascular resistance and preeclampsia in urban black women. N Engl J Med 1990; 323: 434-438 (Pubitemid 20231554)
89. van der Post JA, Konijnenberg A, Boer K, et al. Preeclampsia is not associated with altered platelet vasopressin binding and cytosolic Ca++ concentration. Am J Obstet Gynecol 1993; 169(5): 1169-1178 (Pubitemid 24001634)
90. Kyle PM, Jackson MC, Buckley DC, de Swiet M, Redman CW. Platelet intracellular free calcium response to arginine vasopressin is similar in preeclampsia and normal pregnancy. Am J Obstet Gynecol 1995; 172(2 Pt 1): 654-660
91. Sheu JR, Hsiao G, Shen MY, Lin WY, Tzeng CR. The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways. Clin Lab Haematol 2002; 24(2): 121-129 (Pubitemid 35013553)
92. Herrera JA, Arévalo-Herrera M, Shahabuddin AK, et al. Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytes. Am J Hypertens 2006; 19(4): 381-387
93. Torres PJ, Escolar G, Palacio M, Gratacós E, Alonso PL, Ordinas A. Platelet sensitivity to prostaglandin E1 inhibition is reduced in pre-eclampsia but not in nonproteinuric gestational hypertension. Br J Obstet Gynaecol 1996; 103(1): 19-24. (Pubitemid 26009920)
94. Hawkins T, Jones MP, Gallery ED. Secretion of prostanoids by platelets and monocytes in normal and hypertensive pregnancies. Am J Obstet Gynecol 1993; 168(2): 661-667
95. Teran E, Escudero C, Vivero S, Enriquez A, Calle A. Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia. Hypertens Pregnancy 2004; 23(3): 303-308 (Pubitemid 39552303)
96. von Dadelszen P, Hurst G, Redman CW. Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro. Hum Reprod 1999; 14(4): 919-924 (Pubitemid 29176466)
97. Luppi P, Tse H, Lain KY, Markovic N, Piganelli JD, DeLoia JA. Preeclampsia activates circulating immune cells with engagement of the NF-kappaB pathway. Am J Reprod Immunol 2006; 56(2): 135-144
98. Lee VM, Quinn PA, Jennings SC, Ng LL. Neutrophil activation and production of reactive oxygen species in pre-eclampsia. Hypertension 2003; 21(2): 395-402. (Pubitemid 36269712)
99. Aly AS, Khandelwal M, Zhao J, Mehmet AH, Sammel MD, Parry S. Neutrophils are stimulated by syncytiotrophoblast icrovillous membranes to generate superoxide radicals in women with preeclampsia. Am J Obstet Gynecol 2004; 190(1): 252-258 (Pubitemid 38156356)
100. Vaughan JE, Walsh SW. Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. Am J Obstet Gynecol 2005; 193(3): 830-835
101. Steinckwich N, Frippiat JP, Stasia MJ, et al. Potent inhibition of store-operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2. J Leukoc Biol 2007; 81(4): 1054-1064 (Pubitemid 46495654)
102. Giambelluca MS, Gende OA. Hydrogen peroxide activates calcium influx in human neutrophils. Mol Cell Biochem 2008; 309(1-2): 151-156
103. Gupta AK, Gebhardt S, Hillermann R, Holzgreve W, Hahn S. Analysis of plasma elastase levels in early and late onset preeclampsia. Arch Gynecol Obstet 2006; 273(4): 239-242 (Pubitemid 43004697)
104. von Dadelszen P, Wilkins T, Redman CW. Maternal peripheral blood leukocytes in normal and pre-eclamptic pregnancies. Br J Obstet Gynaecol 1999; 106(6): 576-581 (Pubitemid 29245590)
105. Schaff UY, Yamayoshi I, Tse T, Griffin D, Kibathi L, Simon SI. Calcium flux in neutrophils synchronizes beta2 integrin adhesive and signaling events that guide inflammatory recruitment. Ann Biomed Eng 2008; 36(4): 632-646
106. Shima E, Katsube M, Kato T, et al. Calcium channel blockers suppress cytokine-induced activation of human neutrophils. Am J Hypertens 2008; 21(1): 78-84.
107. Tintinger GR, Theron AJ, Potjo M, Anderson R. Reactive oxidants regulate membrane depolarization and store-operated uptake of calcium by formyl peptide-activated human neutrophils. Free Radic Biol Med 2007; 42(12): 1851-1857 (Pubitemid 46778806)
108. Wilczyński JR, Tchórzewski H, Gowacka E, et al. Cytokine secretion by decidual lymphocytes in transient hypertension of pregnancy and pre-eclampsia. Mediators Inflamm 2002; 11(2): 105-111 (Pubitemid 34526414)
109. Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 2001; 19: 497-521.
110. Tergaonkar V. NFkappaB pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell Biol 2006; 38(10): 1647-1653 (Pubitemid 43947652)
111. Chen BC, Wu WT, Ho FM, Lin WW. Inhibition of Interleukin-1-induced NF-κB Activation by Calcium/Calmodulin-dependent Protein Kinase Kinase Occurs through Akt Activation Associated with Interleukin-1 Receptor-associated Kinase Phosphorylation and Uncoupling of MyD88. J Biol Chem 2002; 277(27): 24169-24179
112. Hojo M, Suthanthiran M, Helseth G, August P. Lymphocyte intracellular free calcium concentration is increased in preeclampsia. Am J Obstet Gynecol. 1999;180(5):1209-1214 (Pubitemid 29259018)
113. Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 2001; 81(4): 1415-1459 (Pubitemid 32947776)
114. Lantoine F, Iouzalen L, Devynck MA, Millanvoye-Van Brussel E, David-Dufilho M. Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx. Biochem J 1998; 330 (Pt 2): 695-699 (Pubitemid 28111964)
115. Noris M, Todeschini M, Cassis P, et al. L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species. Hypertension 2004; 43(3): 614-622 (Pubitemid 38282437)
116. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci U S A 1994; 91(11): 5212-5216 (Pubitemid 24177823)
117. Anumba DOC, Robson SC, Boys RJ, Ford GA. Nitric oxide activity in the peripheral vasculature during normotensive and preeclamptic pregnancy. Am J Physiol Heart Circ Physiol 1999; 277(2): H848-H854. (Pubitemid 29416002)
118. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension 2001; 38(3 Pt 2): 718-722
119. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995; 102(1): 20-25
120. Davidge ST, Signorella AP, Hubel CA, Lykins DL, Roberts JM. Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide or prostacyclin. Hypertension 1996; 28(5): 758-764
121. Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab 1997; 82(5): 1582-1588 (Pubitemid 27200438)
122. Conrad KP, Miles TM, Benyo DF. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40(2): 102-111 (Pubitemid 28380065)
123. Lamarca BD, Ryan MJ, Gilbert JS, Murphy SR, Granger JP. Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia. Curr Hypertens Rep 2007; 9(6): 480-485
124. Conrad KP, Benyo DF. Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 1997; 37(3): 240-249
125. Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 2003; 361: 1511-1517 (Pubitemid 36566342)
126. Smárason AK, Sargent IL, Starkey PM, Redman CW. The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro. Br J Obstet Gynaecol 1993; 100(10): 943-949
127. Wimalasundera RC, Thom SA, Regan L, Hughes AD.Effects of vasoactive agents on intracellular calcium and force in myometrial and subcutaneous resistance arteries isolated from preeclamptic, pregnant, and nonpregnant woman. Am J Obstet Gynecol 2005; 192(2): 625-632 (Pubitemid 40215006)
128. Papazoglou D, Galazios G, Koukourakis MI, et al. Vascular endothelial growth factor gene polymorphisms and pre-eclampsia. Mol Hum Reprod 2004; 10(5): 321-324 (Pubitemid 38714362)
129. Shim JY, Jun JK, Jung BK, Kim SH, Won HS, Lee PR, Kim A. Vascular endothelial growth factor gene +936 C/T polymorphism is associated with preeclampsia in Korean women. Am J Obstet Gynecol 2007; 197(3): 271.e1-4 (Pubitemid 47361975)
130. Van der Zee R, Murohara T, Luo Z, et al. Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 1997; 95: 1030-1037 (Pubitemid 27091550)
131. Mukherjee S, Tessema M, Wandinger-Ness A. Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular function. Circ Res. 2006; 31; 98(6): 743-756 (Pubitemid 43755258)
132. Livingston JC, Chin R, Haddad B, McKinney ET, Ahokas R, Sibai BM. Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia. Am J Obstet Gynecol 2000; 183(6): 1554-1557 (Pubitemid 32061224)
133. Koga K, Osuga Y, Yoshino O, et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003; 88(5): 2348-2351 (Pubitemid 36549917)
134. Tsatsaris V, Goffin F, Munaut C, et al. Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences. J Clin Endocrinol Metab 2003; 88(11): 5555-5563 (Pubitemid 37452769)
135. Karumanchi SA, Epstein FH. Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia? Kidney Int 2007; 71(10): 959-961
136. Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci U S A 1993; 15; 90(22): 10705-10709 (Pubitemid 23347111)
137. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350(7): 672-683 (Pubitemid 38364626)
138. Bosio PM, Wheeler T, Anthony F, Conroy R, O'herlihy C, McKenna P. Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance. Am J Obstet Gynecol 2001; 184(2): 146-152 (Pubitemid 32141657)
139. Boccardo P, Soregaroli M, Aiello S, et al. Systemic and fetal-maternal nitric oxide synthesis in normal pregnancy and preeclampsia. Br J Obstet Gynaecol 1996; 103(9): 879-886 (Pubitemid 26297912)
140. Rowe J, Campbell S, Gallery ED. Nitric oxide production by decidual endothelial cells is not reduced in preeclampsia. Hypertens Pregnancy 2003; 22(1): 63-75.
141. Steinert JR, Wyatt AW, Poston L, Jacob R, Mann GE. Preeclampsia is associated with altered Ca2+ regulation and NO production in human fetal venous endothelial cells. FASEB J 2002; 16(7): 721-723
142. Taylor RN, Casal DC, Jones LA, Varma M, Martin JN Jr, Roberts JM. Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression. Am J Obstet Gynecol 1991; 165: 1705-1710
143. Taylor RN, Musci TJ, Rodgers GM, Roberts JM. Preeclamptic sera stimulate increased platelet-derived growth factor mRNA and protein expression by cultured human endothelial cells. Am J Reprod Immunol 1991; 25: 105-108
144. Baker PN, Davidge ST, Roberts JM. Plasma from women with preeclampsia increases endothelial cell nitric oxide production. Hypertension 1995; 26: 244-248
145. Baker PN, Davidge ST, Barankiewicz J, Roberts JM. Plasma of preeclamptic women stimulates and then inhibits endothelial prostacyclin. Hypertension 1996; 27(1): 56-61. (Pubitemid 26017681)
146. Davidge ST, Baker PN, Roberts JM. NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia. Am J Physiol 1995; 269: H1106-H1112.
147. Gallery ED, Rowe J, Campbell S, Hawkins T. Effect of serum on secretion of prostacyclin and endothelin-1 by decidual endothelial cells from normal and preeclamptic pregnancies. Am J Obstet Gynecol 1995; 173: 918-923
148. Saraswathi V, Wu G, Toborek M, Hennig B. Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling. J Lipid Res 2004; 45(5): 794-804. (Pubitemid 38552849)
149. Conrad KP, Davis AK. Nitric oxide synthase activity in placentae from women with pre-eclampsia. Placenta 1995; 16(8): 691-699 (Pubitemid 26033180)
150. Brennecke SP, Gude NM, Di Iulio JL, King RG. Reduction of placental
151. Mantovani A, Dejana E. Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today 1989; 10(11): 370-375 (Pubitemid 19242062)
152. Haller H, Hempel A, Homuth V, et al. Endothelial cell permeability and protein kinase C in preeclampsia. Lancet 1998; 351: 945-949 (Pubitemid 28138468)
153. Yallampalli C, Garfield RE. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 1993; 169(5): 1316-1320 (Pubitemid 24001657)
154. 2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am J Physiol 1999; 276(2): R530-8.
155. Alexander BT, Llinas MT, Kruckeberg WC, Granger JP. Larginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure. Hypertension 2004; 43: 832-836
156. Williams MA, Mahomed K, Farrand A, et al. Plasma tumor necrosis factor-alpha soluble receptor p55 (sTNFp55) concentrations in eclamptic, preeclamptic and normotensive pregnant Zimbabwean women. J Reprod Immunol 1998; 40(2): 159-173 (Pubitemid 28552976)
157. Stennett AK, Khalil RA. Neurovascular mechanisms of hypertension in pregnancy. Curr Neurovasc Res 2006; 3(2):131-148
158. Benyo DF, Smarason A, Redman CW, Sims C, Conrad KP. Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 2001; 86(6): 2505-2512 (Pubitemid 32545699)
159. Davis JR, Giardina JB, Green GM, Alexander BT, Granger JP, Khalil RA. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol 2002; 282(2): R390-9.
160. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension 2004; 43(2): 434-444
161. Giardina JB, Green GM, Cockrell KL, Granger JP, Khalil RA. TNF-alpha enhances contraction and inhibits endothelial NOcGMP relaxation in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol 2002; 283(1): R130-43.
162. Orshal JM, Khalil RA. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol 2004; 286(6): R1013-23.
163. Ramón de Berrazueta J. The role of calcium in the regulation of normal vascular tone and in arterial hypertension. Rev Esp Cardiol 1999; 52(3): 25-33.
164. Mizutani S, Tomoda Y. Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia. Am J Hypertens 1996; 9(6): 591-597 (Pubitemid 26228082)
165. Dechend R, Homuth V, Wallukat G, et al. AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation 2000; 101(20): 2382-2387
166. 2+ mobilization through angiotensin receptor activation. Circulation 2004; 110(12): 1612-1619
167. Jin L, Ying Z, Webb RC. Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004; 287(4): H1495-500. (Pubitemid 39313251)
168. Ebeigbe AB, Ezimokhai M, Aloamaka CP. Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644. Res Exp Med (Berl) 1987; 187(6): 461-468
169. 2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am J Physiol Heart Circ Physiol 2003; 284(1): H393-403.
170. Horowitz A, Menice CB, Laporte R, Morgan KG. Mechanisms of smooth muscle contraction. Physiol Rev 1996; 76(4): 967-1003.
171. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol 2005; 70(11): 1537-1547 (Pubitemid 41540347)
172. VanWijk MJ, Boer K, van der Meulen ET, Bleker OP, Spaan JA, VanBavel E. Resistance artery smooth muscle function in pregnancy and preeclampsia. Am J Obstet Gynecol 2002; 186(1): 148-154 (Pubitemid 34093756)
173. Wallukat G, Homuth V, Fischer T, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest. 1999;103:945-952 (Pubitemid 29169601)
174. Magness RR, Rosenfeld CR, Carr BR. Protein kinase C in uterine and systemic arteries during ovarian cycle and pregnancy. Am J Physiol 1991; 260(3): E464-70.
175. Kanashiro CA, Cockrell KL, Alexander BT, Granger JP, Khalil RA. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am J Physiol Regul Integr Comp Physiol 2000; 278(2): R295-303.
176. 2+- insensitive vascular protein kinase C during pregnancy and NOS inhibition. Hypertension 1999; 34(4 Pt 2): 924-930
177. Hu E. Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov 2006; 1(3): 249-263
178. Loirand G, Guérin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 2006; 98(3): 322-334 (Pubitemid 43755328)
179. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003; 83(4): 1325-1358
180. Uehata M, Ishizaki T, Satoh H, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997; 389(6654): 990-994 (Pubitemid 27485693)
181. Friel AM, Sexton DJ, O'reilly MW, Smith TJ, Morrison JJ. Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction. Reproduction 2006; 132(1): 169-176
182. Kataoka C, Egashira K, Inoue S, et al. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 2002; 39(2): 245-250 (Pubitemid 34165223)
183. Kyaw M, Yoshizumi M, Tsuchiya K, Izawa Y, Kanematsu Y, Tamaki T. Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases. Acta Pharmacol Sin 2004; 25(8): 977-985 (Pubitemid 39071099)
184. Khalil RA, Menice CB, Wang CL, Morgan KG. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res 1995; 76(6): 1101-1108
185. Adam LP, Gapinski CJ, Hathaway DR. Phosphorylation sequences in h-caldesmon from phorbol ester-stimulated canine aortas. FEBS Lett 1992; 302(3): 223-226
186. D'Angelo G, Graceffa P, Wang CA, Wrangle J, Adam LP. Mammal-specific, ERK-dependent, caldesmon phosphorylation in smooth muscle. Quantitation using novel anti-phosphopeptide antibodies. J Biol Chem 1999; 274(42): 30115-30121
187. Hedges JC, Oxhorn BC, Carty M, Adam LP, Yamboliev IA, Gerthoffer WT. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 2000; 278(4): C718-26. (Pubitemid 30211304)
188. Huang Y, Lu MQ, Li H, Xu C, Yi SH, Chen GH. Occurrence of cGMP/nitric oxide-sensitive store-operated calcium entry in fibroblasts and its effect on matrix metalloproteinase secretion. World J Gastroenterol 2006; 12(34): 5483-5489 (Pubitemid 44501806)
189. 2+- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. FEBS Lett 2005; 579(28): 6451-6458
190. Merchant SJ, Narumiya H, Zhang Y, Guilbert LJ, Davidge ST. The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2. Hypertens Pregnancy 2004; 23(1): 47-60. (Pubitemid 38445552)
191. Tayebjee MH, Karalis I, Nadar SK, Beevers DG, MacFadyen RJ, Lip GY. Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension. Am J Hypertens 2004; 17: 162A-163A.
192. Huisman MA, Timmer A, Zeinstra M, et al. Matrix-metalloproteinase activity in first trimester placental bed biopsies in further complicated and uncomplicated pregnancies. Placenta 2004; 25(4): 253-258 (Pubitemid 38514933)
193. Lockwood CJ, Oner C, Uz YH, et al. Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells. Biol Reprod 2008; 78(6): 1064-1072 (Pubitemid 351749303)
194. Qiao C, Wang CH, Shang T, Lin QD. Clinical significance of KiSS-1 and matrix metalloproteinase-9 expression in trophoblasts of women with preeclampsia and their relation to perinatal outcome of neonates. Zhonghua Fu Chan Ke Za Zhi 2005; 40(9): 585-590
195. Mahameed S, Goldman S, Gabarin D, Weiss A, Shalev E. The effect of serum from women with preeclampsia on JAR (trophoblast-like) cell line. J Soc Gynecol Investig 2005; 12(6): e45-50. (Pubitemid 41242387)
196. Galewska Z, Ba□kowski E, Romanowicz L, Jaworski S. Preeclampsia (EPH-gestosis)-induced decrease of MMP-s content in the umbilical cord artery. Clin Chim Acta 2003; 335(1-2): 109-115 (Pubitemid 37338315)
197. Gallery ED, Campbell S, Arkell J, Nguyen M, Jackson CJ. Preeclamptic decidual microvascular endothelial cells express lower levels of matrix metalloproteinase-1 than normals. Microvasc Res 1999; 57(3): 340-346 (Pubitemid 29393279)
198. Fernandez-Patron C, Stewart KG, Zhang Y, Koivunen E, Radomski MW, Davidge ST. Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. Circ Res 2000; 87(8): 670-676 (Pubitemid 30778314)
199. Davison JM, Homuth V, Jeyabalan A, et al. New aspects in the pathophysiology of preeclampsia. J Am Soc Nephrol 2004; 15(9): 2440-2448
200. Jeyabalan A, Novak J, Danielson LA, Kerchner LJ, Opett SL, Conrad KP. Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. Circ Res 2003; 93(12): 1249-1257 (Pubitemid 37543066)
201. Pustovrh MC, Jawerbaum A, White V, et al. The role of nitric oxide on matrix metalloproteinase 2 (MMP2) and MMP9 in placenta and fetus from diabetic rats. Reproduction 2007; 134(4): 605-613 (Pubitemid 47555054)
202. Narumiya H, Zhang Y, Fernandez-Patron C, Guilbert LJ, Davidge ST. Matrix metalloproteinase-2 is elevated in the plasma of women with preeclampsia. Hypertens Pregnancy 2001; 20: 185-194 (Pubitemid 33032126)
203. 2+ entry mechanisms of vascular contraction. J Vasc Surg 2004; 40(5): 1001-1010
204. + channels: relevance to varicose vein formation. J Vasc Surg 2007; 45(2): 373-380
205. Waitkus-Edwards KR, Martinez-Lemus LA, Wu X, et al. alpha(4)beta(1) Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction.Circ Res 2002; 90(4): 473-480
206. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol Rev 2001; 53(2): 245-282
207. Hamilton JR, Nguyen PB, Cocks TM. Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries. Circ Res1998; 82(12): 1306-1311
208. Walters BN, Redman CW. Treatment of severe pregnancy-associated hypertension with the calcium antagonist nifedipine. Br J Obstet Gynaecol 1984; 91(4): 330-336 (Pubitemid 14132439)
209. Papatsonis DN, Lok CA, Bos JM, Geijn HP, Dekker GA. Calcium channel blockers in the management of preterm labor and hypertension in pregnancy. Eur J Obstet Gynecol Reprod Biol 2001; 97(2): 122-140 (Pubitemid 32651682)
210. Brown MA, Buddle ML, Farrell T, Davis GK. Efficacy and safety of nifedipine tablets for the acute treatment of severe hypertension in pregnancy. Am J Obstet Gynecol 2002; 187(4): 1046-1050 (Pubitemid 35178409)
211. Elatrous S, Nouira S, Ouanes Besbes L, et al. Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol. Intensive Care Med 2002; 28(9): 1281-1286 (Pubitemid 35025047)
212. Fletcher H, Roberts G, Mullings A, Forrester T . An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia. J Obstet Gynaecol 1999; 19(3): 235-238 (Pubitemid 29271651)
213. Hanff LM, Vulto AG, Bartels PA, et al. Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients. J Hypertens 2005; 23(12): 2319-2326