Potent inhibition of store-operated Ca2+ influx and superoxide production in HL60 cells and polymorphonuclear neutrophils by the pyrazole derivative BTP2

Journal of Leukocyte Biology

Volumn 81, Issue 4, 2007, Pages 1054-1064

  Steinckwich, Natacha ^a   Frippiat, Jean Pol ^a   Stasia, Marie José ^b   Erard, Marie ^c,d   Boxio, Rachel ^a,e   Tankosic, Christiane ^a   Doignon, Isabelle ^d,e   Nüße, Oliver ^d,e  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIV GRENOBLE ALPES   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e INSERM   (France)

Author keywords

Bacterial killing; Calcium channel inhibitor; Human cells; Phagocytosis; Signal transduction

Indexed keywords

3,5 BISTRIFLUOROMETHYL PYRAZOLE; N (4 [3,5 BIS(TRIFLUOROMETHYL) 1H PYRAZOL 1YL]PHENYL) 4 METHYL 1,2,3 THIADIAZOLE 5 CARBOXAMIDE; PYRAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL FUNCTION; DOWN REGULATION; GRANULOCYTE; HUMAN; HUMAN CELL; INCUBATION TIME; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANILIDES; BLOOD BACTERICIDAL ACTIVITY; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; NADP; NEUTROPHILS; SUPEROXIDES; THIADIAZOLES;

BACTERIA (MICROORGANISMS);

EID: 33947660516     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0406248     Document Type: Article

References (32)

1. Lewis, R. S. (2001) Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19, 497-521.
2. Djuric, S. W., BaMaung, N. Y., Basha, A., Liu, H., Luly, J. R., Madar, D. J., Sciotti, R. J., Tu, N. P., Wagenaar, F. L., Wiedeman, P. E., et al. (2000) 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J. Med. Chem. 43, 2975-2981.
3. Trevillyan, J. M., Chiou, X. G., Chen, Y. W., Ballaron, S. J., Sheets, M. P., Smith, M. L., Wiedeman, P. E., Warrior, U., Wilkins, J., Gubbins, E. J., et al. (2001) Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds. J. Biol. Chem. 276, 48118-48126.
4. 2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J. Biol. Chem. 279, 12427-12437.
5. Parekh, A. B., Putney Jr., J. W. (2005) Store-operated calcium channels. Physiol. Rev. 85, 757-810.
6. 2+ influx and cytokine production by facilitating TRPM4 channel activity. Mol. Pharmacol. 69, 1413-1420.
7. Nilius, B., Voets, T. (2005) TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch. 451, 1-10.
8. He, L. P., Hewavitharana, T., Soboloff, J., Spassova, M. A., Gill, D. L. (2005) A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J. Biol. Chem. 280, 10997-11006.
9. Schwarz, E. C., Wissenbach, U., Niemeyer, B. A., Strauss, B., Philipp, S. E., Flockerzi, V., Hoth, M. (2006) TRPV6 potentiates calcium-dependent cell proliferation. Cell Calcium 39, 163-173.
10. 2+ influx channels in leukocytes: a therapeutic target? Trends Pharmacol. Sci. 23, 63-70.
11. Itagaki, K., Kannan, K. B., Singh, B. B., Hauser, C. J. (2004) Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. J. Immunol. 172, 601-607.
12. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
13. Demaurex, N., Monod, A., Lew, D. P., Krause, K. H. (1994) Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils. Biochem. J. 297, 595-601.
14. 2+ influx and stimulation of exocytosis in HL-60 granulocytes. J. Biol. Chem. 272, 28360-28367.
15. Boxio, R., Bossenmeyer-Pourie, C., Steinckwich, N., Dournon, C., Nusse, O. (2004) Mouse bone marrow contains large numbers of functionally competent neutrophils. J. Leukoc. Biol. 75, 604-611.
16. 2+ controls time not space. J. Cell Sci. 116, 2857-2865.
17. Dacheux, D., Attree, I., Schneider, C., Toussaint, B. (1999) Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system. Infect. Immun. 67, 6164-6167.
18. Mandeville, J. T., Maxfield, F. R. (1996) Calcium and signal transduction in granulocytes. Curr. Opin. Hematol. 3, 63-70.
19. Whyte, M. K., Meagher, L. C., MacDermot, J., Haslett, C. (1993) Impairment of function in aging neutrophils is associated with apoptosis. J. Immunol. 150, 5124-5134.
20. Birsan, T., Dambrin, C., Marsh, K. C., Jacobsen, W., Djuric, S. W., Mollison, K. W., Christians, U., Carter, G. W., Morris, R. E. (2004) Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT. Transpl. Int. 17, 145-150.
21. Itagaki, K., Kannan, K. B., Livingston, D. H., Deitch, E. A., Fekete, Z., Hauser, C. J. (2002) Store-operated calcium entry in human neutrophils reflects multiple contributions from independently regulated pathways. J. Immunol. 168, 4063-4069.
22. Itagaki, K., Kannan, K. B., Hauser, C. J. (2005) Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. J. Leukoc. Biol. 77, 181-189.
23. 2+ concentrations are essential and synergize with a kinetically distinct second signal. Biochem. J. 322, 709-718.
24. Hallett, M. B., Davies, E. V., Campbell, A. K. (1990) Oxidase activation in individual neutrophils is dependent on the onset and magnitude of the Ca2+ signal. Cell Calcium 11, 655-663.
25. Lew, P. D., Wollheim, C. B., Waldvogel, F. A., Pozzan, T. (1984) Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils. J. Cell Biol. 99, 1212-1220.
26. 2+ concentration and relation with respiratory burst activation. J. Biol. Chem. 266, 23152-23156.
27. 2+ sources in the superoxide production of human neutrophil granulocytes. Free Radic. Biol. Med. 26, 1092-1099.
28. Han, H., Stessin, A., Roberts, J., Hess, K., Gautam, N., Kamenetsky, M., Lou, O., Hyde, E., Nathan, N., Muller, W. A., Buck, J., Levin, L. L., Nathan, C. (2005) Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J. Exp. Med. 202, 353-361.
29. 2+-independent phagocytosis in human neutrophils. Nature 315, 509-511.
30. Dahlgren, C., Karlsson, A. (1999) Respiratory burst in human neutrophils. J. Immunol. Methods 232, 3-14.
31. 2+ stores during phagocytosis in human neutrophils. Science 265, 1439-1441.
32. 2+ during phagolysosome formation? Cell Calcium 27, 353-362.