Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 276, Issue 2 45-2, 1999, Pages

  Crews, Janice K ^a   Novak, Jacqueline ^a   Granger, Joey P ^a   Khalil, Raouf A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Arterial pressure; Calcium; Contraction; Nitric oxide; Peripheral vascular resistance

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; CALCIUM; ENZYME INHIBITOR; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE; POTASSIUM CHLORIDE; VASOCONSTRICTOR AGENT;

ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; FEMALE; MATERNAL HYPERTENSION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; ANIMAL; BREEDING; DRUG ANTAGONISM; IN VITRO STUDY; METABOLISM; PREGNANCY; SPRAGUE DAWLEY RAT; STIMULATION;

ANIMALS; CALCIUM; ENZYME INHIBITORS; FEMALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; POTASSIUM CHLORIDE; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL; VASOCONSTRICTOR AGENTS;

EID: 0033023939     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.276.2.r530     Document Type: Article

References (29)

1. Ahokas, R. A., B. M. Mercer, and B. M. Sibai. Enhanced endothelium-derived relaxing factor activity in pregnant, spontaneously hypertensive rats. Am. J. Obstet. Gynecol. 165: 801-807, 1991.
2. Andrea, J. E., and M. P. Walsh. Protein kinase C of smooth muscle. Hypertension 20: 585-595, 1992.
3. Baylis, C., and K. Engels. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat. Clin. Exp. Hypertens. B11: 117-129, 1992.
4. Baylis, C., T. Suto, and K. Conrad. Importance of nitric oxide in control of systemic and renal hemodynamics during normal pregnancy: studies in the rat and implications for preeclampsia. Hypertens. Pregnancy. 15: 147-169, 1996.
5. Berridge, M. J., and R. Irvine. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312: 315-321, 1984.
6. Cabrera, C., and D. Bohr. The role of nitric oxide in the central control of blood pressure. Biochem. Biophys. Res. Commun. 206: 77-81, 1995.
7. Davidge, S. T., and M. K. McLaughlin. Endogenous modulation of the blunted adrenergic responses in resistance-sized mesenteric arteries from the pregnant rat. Am. J. Obstet. Gynecol. 167: 1691-1697, 1992.
8. DeFeo, T. T., and K. G. Morgan. Calcium-force relationships as detected with aequorin in two different vascular smooth muscles of the ferret. J. Physiol. (Lond.) 369: 269-282, 1985.
9. Duvekott, J. J., and L. L. Peeters. Renal hemodynamics and volume homeostasis in pregnancy. Obstet. Gynecol. Surv. 49: 830-839, 1994.
10. Edwards, D. L., C. P. Arora, D. T. Bui, and L. C. Castro.Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1. Am. J. Obstet. Gynecol. 175: 484-488, 1996.
11. Friedman, S. A., S. L. Lubarsky, R. A. Ahokas, A. Nova, and B. M. Sibai. Pre-eclampsia and related disorders: clinical aspects and relevance of endothelin and nitric oxide. Clin. Perinatol. 2: 343-355, 1995.
12. Khalil, R. A., J. K. Crews, J. Novak, S. Kassab, and J. P. Granger. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension 31: 1065-1069, 1998.
13. Khalil, R. A., and K. G. Morgan. Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret. J. Physiol. (Lond.) 455: 585-599, 1992.
14. Khalil, R. A., and C. van Breemen. Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J. Pharmacol. Exp. Ther. 244: 537-542, 1988.
15. Khalil, R. A., and C. van Breemen. Mechanisms of calcium mobilization and homeostasis in vascular smooth muscle and their relevance to hypertension. In: Hypertension: Pathophysiology, Diagnosis and Management (2nd ed. ), edited by J. H. Laragh and B. M. Brenner. New York: Raven, 1995, p. 523-540.
16. ω-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy induced refractoriness to vasopressor agents. Am. J. Obstet. Gynecol. 166: 1560-1567, 1992.
17. Molnar, M., T. Suto, T. Toth, and F. Hertelendy. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am. J. Obstet. Gynecol. 170: 1458-1466, 1994.
18. Morris, N. H., B. M. Eaton, and G. Dekker. Nitric oxide, the endothelium, pregnancy and pre-eclampsia. Br. J. Obstet. Gynaecol. 103: 4-15, 1996.
19. Nathan, L., J. Cuevas, and G. Chaudhuri. The role of nitric oxide in the altered vascular reactivity of pregnancy in the rat. Br. J. Pharmacol. 114: 955-960, 1995.
20. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614, 1992
21. Novak, J., K. Cockrell, S. Kassab, J. F. Reckelhoff, and J. P. Granger. Chronic nitric oxide synthesis inhibition during pregnancy increases thromboxane excretion in rats. FASEB J. 11: A78, 1997.
22. Parent, A., E. L. Schiffrin, and J. St-Louis. Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats. Am. J. Obstet. Gynecol. 163: 229-234, 1990.
23. Sladek, S. M., R. R. Magness, and K. P. Conrad. Nitric oxide and pregnancy. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R441-R463, 1997.
24. St-Louis, J., and B. Sicotte. Prostaglandin- or endothelium-mediated vasodilation is not involved in the blunted responses of blood vessels to vasoconstrictors in pregnant rats. Am. J. Obstet. Gynecol. 166: 684-692, 1992.
25. 2+ from intracellular storage sites in skinned single cells of porcine coronary artery. Biochem. Biophys. Res. Commun. 120: 481-485, 1984.
26. Sugiyama, T., M. Yoshizumi, F. Takaku, and Y. Yazaki. Abnormal calcium handling in vascular smooth muscle cells of spontaneously hypertensive rats. J. Hypertens. 8: 369-375, 1990.
27. Van Breemen, C., P. Aaronson, and R. Loutzenhiser. Na-Ca interactions in mammalian smooth muscle. Pharmacol. Rev. 30: 167-208, 1979.
28. 2+ release. Ann. NY Acad. Sci. 522: 60-73, 1988.
29. Williams, D. J., P. J. T. Vallance, G. H. Neild, J. A. D. Spencer, and F. J. Imms. Nitric oxide-mediated vasodilation in human pregnancy. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H748-H752, 1997.