Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-α-induced hypertension in pregnant rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 282, Issue 2 51-2, 2002, Pages

  Davis, Justin R ^a   Giardina, Jena B ^a   Green, Gachavis M ^a   Alexander, Barbara T ^a   Granger, Joey P ^a   Khalil, Raouf A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Nitric oxide; Pregnancy

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME INHIBITION; FEMALE; MATERNAL HYPERTENSION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE; STRESS; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

EID: 0036081551     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00270.2001     Document Type: Article

References (47)

1. Enhanced endothelium-derived relaxing factor activity in pregnant, spontaneously hypertensive rats
2. Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide
3. Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats
4. Importance of nitric oxide in control of systemic and renal hemodynamics during normal pregnancy: Studies in the rat and implications for preeclampsia
5. An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice
6. Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1
7. Animal models of pre-eclampsia: Do they exist?
8. Placental cytokines and the pathogenesis of preeclampsia
9. Identification of increased nitric oxide biosynthesis during pregnancy in rats
10. Circulating levels of immunoreactive cytokines in women with preeclampsia
11. Plasma levels, urinary excretion, and metabolic production of cGMP during gestation in rats
12. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat
13. 2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats
14. Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat
15. Renal hemodynamics and volume homeostasis in pregnancy
16. A role for brain angiotensin II in experimental pregnancy-induced hypertension in laboratory rats
17. Long-term nitric oxide blockade in the pregnant rat: Effects on blood pressure and plasma levels of endothelin-1
18. A new animal model for human preeclampsia: Ultra-low-dose endotoxin infusion in pregnant rats
19. Preeclampsia and related disorders. Clinical aspects and relevance of endothelin and nitric oxide
20. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
21. Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet
22. Long-term elevation of plasma TNF-α increases arterial pressure and reduces kidney function in pregnant rats
23. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: A mechanism for endothelial dysfunction?
24. Relationship between cyclic guanosine 3′,5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: Effects of methylene blue and methemoglobin
25. The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-α]-quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate
26. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein
27. The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation
28. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats
29. Tumor necrosis factor-α is elevated in plasma and amniotic fluid of patients with severe preeclampsia
30. Increased peripheral resistance during reduced uterine perfusion pressure hypertension in pregnant rabbits
31. Transcriptional regulation of the endothelin-1 gene by TNF-α
32. G-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents
33. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation
34. The discovery of nitric oxide as the endogenous nitrovasodilator
35. Nitric oxide, the endothelium, pregnancy and pre-eclampsia
36. The role of nitric oxide in the altered vascular reactivity of pregnancy in the rat
37. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
38. Role of the endothelium in adrenergic responses of mesenteric artery rings of pregnant rats
39. Cytokines and endothelial cell biology
40. Evidence for the presence of an unusual nitric oxide- and citrulline-producing enzyme in rat kidney
41. Nitric oxide and pregnancy
42. Vascular biology. Old-timer makes a comeback
43. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia
44. Administration of tumor necrosis factor-α in vivo depresses endothelium-dependent relaxation
45. Induction of calcium-dependent nitric oxide synthases by sex hormones
46. Nitric oxide-mediated vasodilation in human pregnancy
47. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life