Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor

Journal of Clinical Investigation

Volumn 103, Issue 7, 1999, Pages 945-952

  Wallukat, Gerd ^a   Homuth, Volker ^a   Fischer, Thorsten ^b   Lindschau, Carsten ^a   Horstkamp, Björn ^c   Jüpner, Axel ^e   Baur, Evi ^a   Nissen, Eberhard ^c   Vetter, Klaus ^d   Neichel, Dajana ^a   Dudenhausen, Joachim W ^c   Haller, Hermann ^a   Luft, Friedrich C ^a,f  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^d VIVANTES KLINIKUM NEUKÖLLN   (Germany)

^e HELIOS KLINIKUM BERLIN BUCH   (Germany)

^f FRANZ VOLHARD CLINIC   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; AUTOANTIBODY;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; BINDING SITE; ESSENTIAL HYPERTENSION; NONHUMAN; PREECLAMPSIA; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STIMULUS SECRETION COUPLING; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE;

EID: 0032924922     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI4106     Document Type: Article

References (43)

1. Lindheimer, M.D. 1993. Hypertension in pregnancy. Hypertension. 22:127-137.
2. Gant, N.F., Daley, G.L., Chand, S., Whalley, P.J., and MacDonald, P.C. 1973. A study of angiotensin II pressor response throughout primigravid pregnancy. J. Clin. Invest. 52:2683-2689.
3. Baker, P.N., Kilby, M.D., and Pipkin, F.B. 1992. The effect of angiotensin II on platelet intracellular free calcium concentration in human pregnancy. J. Hypertens. 10:55-60.
4. Haller, H., Oeney, T., Hauck, U., Distler, A., and Philipp, T. 1989. Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic women. Am. J. Hypertens. 2:238-243.
5. Pipkin, F.B. 1988. The renin-angiotensin system in normal and hypertensive pregnancies. In Handbook of hypertension. Vol. 10. P.C. Rubin, editor. Elsevier Science Publishers. Amsterdam, the Netherlands. 118-151.
6. Hanssens, M., Keirse, M., Spitz, B., and Van Assche, F.A. 1991. Angiotensin II levels in hypertensive and normotensive pregnancies. Br. J. Obstet. Gynaecol. 98:155-161.
7. Hannsens, M., Keirse, M., Spitz, B., and Van Assche, F.A. 1991. Measurement of individual plasma angiotensins in normal pregnancy and pregnancy-induced hypertension. J. Clin. Endocrinol. Metab. 73:489-494.
8. Luther, H.-P., Homuth, V., and Wallukat, G. 1996. α1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension. 29:678-682.
9. Wallukat, G., and Wollenberger, A. 1987. Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic β-adrenoceptor function in cultured rat heart myocytes. Biomed. Biochim. Acta. 78:634-639.
10. Haller, H., et al. 1998. Integrin-induced PKC α and ε translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ. Res. 82:157-165.
11. Kyle, P.M., Buckley, D., Kissane, J., de-Swiet, M., and Redman, C.W. 1995. The angiotensin sensitivity test and low-dose aspirin are ineffective methods to predict and prevent hypertensive disorders in nulliparous pregnancy. Am. J. Obstet. Gynecol. 173:865-872.
12. Sowers, J.R., et al. 1993. Expression of renin and angiotensinogen genes in preeclamptic and normal human placental tissue. Clin. Exp. Hypertens. B. 12:163-171.
13. Brar, H.S., et al. 1987. Increased fetoplacental active renin production in pregnancy-induced hypertension. Am. J. Obstet Gynecol. 157:363-367.
14. Roberts, J.M., and Redman, C.W.G. 1993. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 341:1446-1451.
15. Chesley, L.C. 1980. Hypertension in pregnancy: definitions, familial factor, and remote prognosis. Kidney Int. 18:234-250.
16. Cooper, D.W., Hill, J.A., Chesley, L.C., and Bryans, C.I. 1988. Genetic control of susceptibility to eclampsia and miscarriages. Br. J. Obstet. Gynaecol. 95:644-653.
17. Ward, K., et al. A molecular variant of angiotensinogen associated with preeclampsia. Nat. Genet. 4:59-61.
18. Inoue, I., et al. 1995. A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system. J. Biol. Chem. 270:11430-11436.
19. Almon, R.R., Andrew, C.G., and Appel, J.H. 1974. Serum globulin in myasthenia gravis: inhibition of α-bungarotoxin binding to acetylcholine receptors. Science. 186:55-57.
20. Kishihara, M., et al. 1979. Interaction between thyroid-stimulating immunoglobulins and thyrotropin receptors in fat cell membranes. J. Clin. Endocrinol. Metab. 49:706-711.
21. Krook, A., Soos, M.A., Kumar, S., Siddle, K., and O'Rahilly, S. 1996. Functional activation of mutant human insulin receptor by monoclonal antibody. Lancet. 347:1586-1590.
22. Magnusson, Y., Wallukat, G., Waagstein, F., Hjalmarson, A., and Hoebeke, J. 1994. Autoimmunity in idiopathic dilated cardiomyopathy: characterization of antibodies against the β1-adrenoceptor with positive chronotropic effect. Circulation. 89:2760-2767.
23. Fu, M.L., et al. 1994, Functional autoimmune epitope on α1-adrenergic receptors in patients with malignant hypertension. Lancet. 334:1660-1663.
24. Fu, M.L., Herlitz, H., Wallukat, G., and Hjalmarson, A. 1996. Non-desensitized positive chronotropic effect of anti-angiotensin II receptor autoantibodies in patients with malignant hypertension. Circulation. 94:4046a. (Abstr.)
25. Dörffel, W.V., et al. 1997. Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation. 95:1994-1997.
26. Müller, J., et al. 1997. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 96:542-549.
27. Inoue, Y., Nakamura, N., and Inagami, T. 1997. A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism. J. Hypertens. 15:703-714.
28. Hebert, T.E., et al. 1996. A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J. Biol. Chem. 271:16384-16392.
29. Elies, R., et al. 1998. Immunochemical and functional characterization of an agonist-like monoclonal antibody against the MS acetylcholine receptor. Eur. J. Biochem. 251:659-666.
30. Sadoshima, J., Xu, Y., Slayter, M.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:977-984.
31. Taylor, R.N. 1997. Review: immunobiology of preeclampsia. Am. J. Reprod. Immunol. 37:79-86.
32. Kupferminc, M.J., Peaceman, A.M., Wigton, T.R., Rehnberg, K.A., and Socol, M.L. 1994. Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia. Am. J. Obstet. Gynecol. 170:1752-1757.
33. Hara, N., Fujii, T., Okai, T., and Taketani, Y. 1995. Histochemical demonstration of interleukin-2 in decidua cells of patients with preeclampsia. Am. J. Reprod. Immunol. 34:44-51.
34. Vinatier, D., and Monnier, C. 1995. Preeclampsia: physiology and immunological aspects. Eur. J. Obstet. Gynecol. Reprod. Biol. 61:85-97.
35. Magann, E.F., et al. 1994. Postpartum corticosteroids: accelerated recovety from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am. J. Obstet. Gynecol. 171:1154-1158.
36. Roberts, J.M., Taylor, R.N., and Goldfien, A. 1991. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am. J. Hypertens. 4:700-708.
37. Haller, H., et al. 1998. Endothelial cell permeability and protein kinase C in preeclampsia. Lancet. 351:945-949.
38. Plante, G.E., Chakir, M., Ettaouil, K., Lehoux, S., and Sirois, P. 1996. Consequences of alteration in capillary permeability. Can. J. Physiol. Pharmacol. 74:824-833.
39. Dekker, G.A., Robillard, P.Y., and Hulsey, T.C. 1998. Immune maladaptation in the etiology of preeclampsia: a review of corroborative epidemiologic studies. Obstet. Gynecol. Surv. 53:377-382.
40. Zhou, Y., et al. 1998. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. J. Clin. Invest. 99:2139-2151.
41. Zhou, Y., Damsky, C.H., and Fisher, S.J. 1997. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. J. Clin. Invest. 99:2152-2164.
42. Iruela-Arispe, M.L. 1997. Normal placentation: a tale that requires an epithelial-to-endothelial conversion [comment]. J. Clin. Invest. 99:2057-2058.
43. Otani, A., Takagi, H., Suzuma, K., and Honda, Y. 1998. Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cells. Circ. Res. 82:619-628.