Xenobiotic-sensing nuclear receptors CAR and PXR as drug targets in cholestatic liver disease

Current Drug Targets

Volumn 10, Issue 11, 2009, Pages 1156-1163

  Kakizaki, Satoru ^a   Takizawa, Daichi ^a   Tojima, Hiroki ^a   Yamazaki, Yuichi ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cholestatic liver disease; Constitutive androstane receptor; Nuclear receptor; Pregnane X receptor

Indexed keywords

6 ETHYLCHENODEOXYCHOLIC ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID DERIVATIVE; CHINESE DRUG; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A11; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; FARNESOID X RECEPTOR; GLUCURONOSYLTRANSFERASE 1A1; LITHOCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; PREGNANE X RECEPTOR; RIFAMPICIN; SULFATASE; SULFATASE 2A1; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; YIN ZHI HUANG; CELL RECEPTOR; STEROID RECEPTOR; XENOBIOTIC AGENT;

BILE ACID METABOLISM; BILE ACID SYNTHESIS; CHOLESTASIS; CONJUGATION; CRIGLER NAJJAR SYNDROME; DRUG DETOXIFICATION; DRUG ELIMINATION; DRUG TARGETING; ENZYME INDUCTION; ENZYME REGULATION; GILBERT DISEASE; GLUCURONIDATION; HUMAN; HYDROXYLATION; INTRAHEPATIC CHOLESTASIS; LIVER METABOLISM; METABOLIC REGULATION; NEWBORN JAUNDICE; NONHUMAN; OBSTRUCTIVE JAUNDICE; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRURITUS; REVIEW; SULFATION; TRANSACTIVATION; URINARY EXCRETION; CHOLESTASIS, INTRAHEPATIC; METABOLISM;

BILE ACIDS AND SALTS; CHOLESTASIS, INTRAHEPATIC; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; XENOBIOTICS;

EID: 70450182200     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945009789735174     Document Type: Review

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