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Volumn , Issue , 2008, Pages 175-190

Toxicogenomics in non-clinical safety studies: Models of animal and human tissues to assess target organ injury

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EID: 70350477701     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (1)

References (84)
  • 1
    • 0033771951 scopus 로고    scopus 로고
    • Concordance of the toxicity of pharmaceuticals in humans and in animals
    • Olson H, Betton G, Robinson D, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regulatory Toxicol Pharmacol 2000; 32: 56-67.
    • (2000) Regulatory Toxicol Pharmacol , vol.32 , pp. 56-67
    • Olson, H.1    Betton, G.2    Robinson, D.3
  • 2
    • 1642282158 scopus 로고    scopus 로고
    • First dose of potential new medicines to humans: How animals help
    • Greaves P, Williams A, Eve M. First dose of potential new medicines to humans: how animals help. Nat Rev Drug Discov 2004; 3: 226-236.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 226-236
    • Greaves, P.1    Williams, A.2    Eve, M.3
  • 3
    • 13444302921 scopus 로고    scopus 로고
    • Do preclinical testing strategies help predict human hepatotoxic potentials ?
    • Peters TS. Do preclinical testing strategies help predict human hepatotoxic potentials ? Toxicol Pathol 2005; 33: 146-154.
    • (2005) Toxicol Pathol , vol.33 , pp. 146-154
    • Peters, T.S.1
  • 4
    • 0242300158 scopus 로고    scopus 로고
    • Heterogeneity of toxicant response: Sources of human variability
    • Aldridge JE, Gibbon JA, Flaherty MM, et al. Heterogeneity of toxicant response: sources of human variability. Toxicol Sci 2003; 76: 3-20.
    • (2003) Toxicol Sci , vol.76 , pp. 3-20
    • Aldridge, J.E.1    Gibbon, J.A.2    Flaherty, M.M.3
  • 5
    • 0035092543 scopus 로고    scopus 로고
    • Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets-1960 to 1999
    • Fung M, Thornton A, Mybeck K, et al. Evaluation of the characteristics of safety withdrawal of prescription drugs from worldwide pharmaceutical markets-1960 to 1999. Drug Info J 2001; 35: 293-317.
    • (2001) Drug Info J , vol.35 , pp. 293-317
    • Fung, M.1    Thornton, A.2    Mybeck, K.3
  • 6
    • 36048939609 scopus 로고    scopus 로고
    • Mechanisms of cytochrome P450 substrate oxidation: MiniReview
    • Guengerich FP. Mechanisms of cytochrome P450 substrate oxidation: MiniReview. J Biochem Mol Toxicol 2007; 21: 163-168.
    • (2007) J Biochem Mol Toxicol , vol.21 , pp. 163-168
    • Guengerich, F.P.1
  • 7
    • 28144457622 scopus 로고    scopus 로고
    • Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data
    • Seed J, Carney EW, Corley RA, et al. Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit Rev Toxicol 2005; 35: 663-672.
    • (2005) Crit Rev Toxicol , vol.35 , pp. 663-672
    • Seed, J.1    Carney, E.W.2    Corley, R.A.3
  • 8
    • 33645010143 scopus 로고    scopus 로고
    • Application of pharmacogenomics in clinical pharmacology
    • Huang S-M, Goodsaid F, Rahman A, et al. Application of pharmacogenomics in clinical pharmacology. Toxicol Mechan Meth 2006; 16: 89-99.
    • (2006) Toxicol Mechan Meth , vol.16 , pp. 89-99
    • Huang, S.-M.1    Goodsaid, F.2    Rahman, A.3
  • 9
    • 38849109564 scopus 로고    scopus 로고
    • Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
    • Thum T, Borlak J. Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes. Arch Toxicol 2008; 82: 89-101.
    • (2008) Arch Toxicol , vol.82 , pp. 89-101
    • Thum, T.1    Borlak, J.2
  • 10
    • 32644441817 scopus 로고    scopus 로고
    • Cellular stress responses and molecular mechanisms of nephrotoxicity
    • Van de Water B, de Graauw M, Le Dévédec S, et al. Cellular stress responses and molecular mechanisms of nephrotoxicity. Toxicol Lett 2006; 162: 83-93.
    • (2006) Toxicol Lett , vol.162 , pp. 83-93
    • Van de Water, B.1    de Graauw, M.2    Le Dévédec, S.3
  • 11
    • 34548127553 scopus 로고    scopus 로고
    • Mechanisms of drug-induced liver disease
    • Gunawan BK, Kaplowitz N. Mechanisms of drug-induced liver disease. Clin Liver Dis 2007; 11: 459-475.
    • (2007) Clin Liver Dis , vol.11 , pp. 459-475
    • Gunawan, B.K.1    Kaplowitz, N.2
  • 12
    • 15444362827 scopus 로고    scopus 로고
    • In vitro methods to study chemically-induced hepatotoxicity: A literature review
    • Farkas D, Tannenbaum SR. In vitro methods to study chemically-induced hepatotoxicity: a literature review. Curr Drug Metab 2005; 6: 111-125.
    • (2005) Curr Drug Metab , vol.6 , pp. 111-125
    • Farkas, D.1    Tannenbaum, S.R.2
  • 13
    • 33747107838 scopus 로고    scopus 로고
    • Precision-cut organ slices to investigate target organ injury
    • Vickers AE, Fisher R. Precision-cut organ slices to investigate target organ injury. Expert Opin Drug Metab Toxicol 2005; 1: 687-699.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 687-699
    • Vickers, A.E.1    Fisher, R.2
  • 14
    • 33845503291 scopus 로고    scopus 로고
    • Cross-species comparative toxicogenomics as an aid to safety assessment
    • Mattes WB. Cross-species comparative toxicogenomics as an aid to safety assessment. Expert Opin Drug Metab Toxicol 2006; 2: 859-874.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 859-874
    • Mattes, W.B.1
  • 15
    • 13444263949 scopus 로고    scopus 로고
    • New insights into functional aspects of liver morphology
    • Malarkey DE, Johnson K, Ryan L, et al. New insights into functional aspects of liver morphology. Toxicol Pathol 2005; 33: 27-34.
    • (2005) Toxicol Pathol , vol.33 , pp. 27-34
    • Malarkey, D.E.1    Johnson, K.2    Ryan, L.3
  • 16
    • 0034892257 scopus 로고    scopus 로고
    • Functional heterogeneity in liver and lung macrophages
    • Laskin DL, Weinberger B, Laskin JD. Functional heterogeneity in liver and lung macrophages. J Leukocyte Biol 2001; 70: 163-170.
    • (2001) J Leukocyte Biol , vol.70 , pp. 163-170
    • Laskin, D.L.1    Weinberger, B.2    Laskin, J.D.3
  • 17
    • 33847262105 scopus 로고    scopus 로고
    • Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    • Roberts RA, Ganey PE, Ju C, et al. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 2007; 96: 2-15.
    • (2007) Toxicol Sci , vol.96 , pp. 2-15
    • Roberts, R.A.1    Ganey, P.E.2    Ju, C.3
  • 19
    • 0037484174 scopus 로고    scopus 로고
    • Modeling tissue-specific signaling and organ function in three dimensions
    • Schmeichel KL, Bissell MJ. Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci 2003; 116: 2377-2388.
    • (2003) J Cell Sci , vol.116 , pp. 2377-2388
    • Schmeichel, K.L.1    Bissell, M.J.2
  • 20
    • 0142128826 scopus 로고    scopus 로고
    • Gene expression analysis reveals chemical-specific profiles
    • Hamadeh HK, Bushel PR, Jayadev S, et al. Gene expression analysis reveals chemical-specific profiles. Toxicol Sci 2002; 67: 219-231.
    • (2002) Toxicol Sci , vol.67 , pp. 219-231
    • Hamadeh, H.K.1    Bushel, P.R.2    Jayadev, S.3
  • 21
    • 2142639373 scopus 로고    scopus 로고
    • Gene expression profiling reveals multiple toxicity end points induced by hepatotoxicants
    • Huang Q, Jin X, Gaillard ET, et al. Gene expression profiling reveals multiple toxicity end points induced by hepatotoxicants. Mut Res 2004; 549: 147-167.
    • (2004) Mut Res , vol.549 , pp. 147-167
    • Huang, Q.1    Jin, X.2    Gaillard, E.T.3
  • 22
    • 4444360916 scopus 로고    scopus 로고
    • Discriminating different classes of toxicants by transcript profiling
    • Steiner G, Suter L, Boess F, et al. Discriminating different classes of toxicants by transcript profiling. Environ Health Perspect 2004; 112: 1236-1248.
    • (2004) Environ Health Perspect , vol.112 , pp. 1236-1248
    • Steiner, G.1    Suter, L.2    Boess, F.3
  • 23
    • 2942750426 scopus 로고    scopus 로고
    • Bromobenzene-induced hepatotoxicity at the transcriptome level
    • Heijne WH, Slitt AL, van Bladeren PJ, et al. Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicol Sci 2004; 79: 411-422.
    • (2004) Toxicol Sci , vol.79 , pp. 411-422
    • Heijne, W.H.1    Slitt, A.L.2    van Bladeren, P.J.3
  • 24
    • 22244464275 scopus 로고    scopus 로고
    • Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis
    • Heijne WH, Lamers RJ, van Bladeren PJ, et al. Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis. Toxicol Pathol 2005; 33: 425-433.
    • (2005) Toxicol Pathol , vol.33 , pp. 425-433
    • Heijne, W.H.1    Lamers, R.J.2    van Bladeren, P.J.3
  • 25
    • 19644386887 scopus 로고    scopus 로고
    • Assessment of hepatotoxic liabilities by transcript profiling
    • Ruepp S, Boess F, Suter L, et al. Assessment of hepatotoxic liabilities by transcript profiling. Toxicol Appl Pharmacol 2005; 207: 161-170.
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 161-170
    • Ruepp, S.1    Boess, F.2    Suter, L.3
  • 26
    • 34547855849 scopus 로고    scopus 로고
    • Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses
    • Beyer RP, Fry RC, Lasarev MR, et al. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 2007; 99: 326-337.
    • (2007) Toxicol Sci , vol.99 , pp. 326-337
    • Beyer, R.P.1    Fry, R.C.2    Lasarev, M.R.3
  • 27
    • 34548616496 scopus 로고    scopus 로고
    • Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
    • Lum PY, He YD, Slatter JG, et al. Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia. Genomics 2007; 90: 464-473.
    • (2007) Genomics , vol.90 , pp. 464-473
    • Lum, P.Y.1    He, Y.D.2    Slatter, J.G.3
  • 28
    • 34247096610 scopus 로고    scopus 로고
    • Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue
    • Auman JT, Chou J, Gerrish K, et al. Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. Environ Health Perspect 2007; 115: 572-578.
    • (2007) Environ Health Perspect , vol.115 , pp. 572-578
    • Auman, J.T.1    Chou, J.2    Gerrish, K.3
  • 29
    • 34547914464 scopus 로고    scopus 로고
    • Acute hepatotoxicity: A predictive model based on focused illumina microarrays
    • Zideck N, Hellmann J, Kramer P-J, et al. Acute hepatotoxicity: a predictive model based on focused illumina microarrays. Toxicol Sci 2007; 99: 289-302.
    • (2007) Toxicol Sci , vol.99 , pp. 289-302
    • Zideck, N.1    Hellmann, J.2    Kramer, P.-J.3
  • 30
    • 10744233751 scopus 로고    scopus 로고
    • Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes
    • De Longueville F, Atienzar FA, Marcq L, et al. Use of a low-density microarray for studying gene expression patterns induced by hepatotoxicants on primary cultures of rat hepatocytes. Toxicol Sci 2003; 75: 378-392.
    • (2003) Toxicol Sci , vol.75 , pp. 378-392
    • De Longueville, F.1    Atienzar, F.A.2    Marcq, L.3
  • 31
    • 18844397275 scopus 로고    scopus 로고
    • A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeozycholic acid
    • Castro RE, Solá S, Ma X, et al. A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeozycholic acid. J Hepatol 2005; 42: 897-906.
    • (2005) J Hepatol , vol.42 , pp. 897-906
    • Castro, R.E.1    Solá, S.2    Ma, X.3
  • 32
    • 0034518116 scopus 로고    scopus 로고
    • Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells
    • Burczynski ME, McMillian M, Ciervo J, et al. Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol Sci 2000; 58: 399-415.
    • (2000) Toxicol Sci , vol.58 , pp. 399-415
    • Burczynski, M.E.1    McMillian, M.2    Ciervo, J.3
  • 33
    • 0034825987 scopus 로고    scopus 로고
    • The use of genomics technology to investigate gene expression changes in cultured human liver cells
    • Harries HM, Fletcher ST, Duggan CM, et al. The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro 2001; 15: 399-405.
    • (2001) Toxicol In Vitro , vol.15 , pp. 399-405
    • Harries, H.M.1    Fletcher, S.T.2    Duggan, C.M.3
  • 34
    • 13644258653 scopus 로고    scopus 로고
    • A toxicogenomic approach to drug-induced phospholipidosis: Analysis of its induction mechanism and establishment of a novel in vitro screening system
    • Sawada H, Takami K, Asahi S. A toxicogenomic approach to drug-induced phospholipidosis:analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci 2005; 83: 282-292.
    • (2005) Toxicol Sci , vol.83 , pp. 282-292
    • Sawada, H.1    Takami, K.2    Asahi, S.3
  • 35
    • 85057446174 scopus 로고    scopus 로고
    • The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbil-Chaloin S, Drocourt L, et al. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochem Biophys Acta 2003; 1619: 146-154.
    • (2003) Biochem Biophys Acta , vol.1619 , pp. 146-154
    • Pascussi, J.M.1    Gerbil-Chaloin, S.2    Drocourt, L.3
  • 36
    • 4644364576 scopus 로고    scopus 로고
    • Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    • Hirano M, Maeda K, Shitara Y, et al. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Therap 2004; 311: 139-146.
    • (2004) J Pharmacol Exp Therap , vol.311 , pp. 139-146
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3
  • 37
    • 0034813961 scopus 로고    scopus 로고
    • Temporal gene expression analysis of monolayer cultured rat hepatocytes
    • Baker TK, Carfagna MA, Gao H, et al. Temporal gene expression analysis of monolayer cultured rat hepatocytes. Chem Res Toxicol 2001; 14: 1218-1231.
    • (2001) Chem Res Toxicol , vol.14 , pp. 1218-1231
    • Baker, T.K.1    Carfagna, M.A.2    Gao, H.3
  • 38
    • 33645821905 scopus 로고    scopus 로고
    • Gene expression in human hepatocytes is suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating
    • Richert L, Liguori MJ, Abadie C, et al. Gene expression in human hepatocytes is suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating. Drug Metab Disp 2006; 34: 870-879.
    • (2006) Drug Metab Disp , vol.34 , pp. 870-879
    • Richert, L.1    Liguori, M.J.2    Abadie, C.3
  • 39
    • 0038172423 scopus 로고    scopus 로고
    • Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: Possible implications for toxicogenomics use of in vitro systems
    • Boess F, Kamber M, Romer S, et al. Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems. Toxicol Sci 2003; 73: 386-402.
    • (2003) Toxicol Sci , vol.73 , pp. 386-402
    • Boess, F.1    Kamber, M.2    Romer, S.3
  • 40
    • 0242298624 scopus 로고    scopus 로고
    • Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status
    • Waring JF, Ciurlionis R, Jolly RA, et al. Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status. Toxicol In Vitro 2003; 17: 693-701.
    • (2003) Toxicol In Vitro , vol.17 , pp. 693-701
    • Waring, J.F.1    Ciurlionis, R.2    Jolly, R.A.3
  • 41
    • 30744469621 scopus 로고    scopus 로고
    • The state of the art in predictive toxicogenomics
    • Fielden MR, Kolaja KL. The state of the art in predictive toxicogenomics. Curr Opin Drug Discov Dev 2006; 9: 84-91.
    • (2006) Curr Opin Drug Discov Dev , vol.9 , pp. 84-91
    • Fielden, M.R.1    Kolaja, K.L.2
  • 42
    • 33644865721 scopus 로고    scopus 로고
    • In vivo hepatotoxicity study of rats in comparison with in vitro hepatoxicity screening system
    • Kikkawa R, Fujikawa M, Yamamoto T, et al. In vivo hepatotoxicity study of rats in comparison with in vitro hepatoxicity screening system. J Toxicol Sci 2006; 31: 23-34.
    • (2006) J Toxicol Sci , vol.31 , pp. 23-34
    • Kikkawa, R.1    Fujikawa, M.2    Yamamoto, T.3
  • 43
    • 33645970724 scopus 로고    scopus 로고
    • Development of a toxicogenomics in vitro assay for the efficient characterization of compounds
    • Yang Y, Abel SJ, Ciurlionis R, et al. Development of a toxicogenomics in vitro assay for the efficient characterization of compounds. Pharmacogenomics 2006; 7: 177-186.
    • (2006) Pharmacogenomics , vol.7 , pp. 177-186
    • Yang, Y.1    Abel, S.J.2    Ciurlionis, R.3
  • 44
    • 35648942198 scopus 로고    scopus 로고
    • An in vitro study on 5-HT 6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics
    • Boess F, Durr E, Schaub N, et al. An in vitro study on 5-HT 6 receptor antagonist induced hepatotoxicity based on biochemical assays and toxicogenomics. Toxicol In Vitro 2007; 7: 1276-1286.
    • (2007) Toxicol In Vitro , vol.7 , pp. 1276-1286
    • Boess, F.1    Durr, E.2    Schaub, N.3
  • 45
    • 34248562343 scopus 로고    scopus 로고
    • Evaluation of felbamate and other antiepileptic drug toxicity potential base on hepatic protein covalent binding and gene expression
    • Leone AM, Kao LM, McMillian MK, et al. Evaluation of felbamate and other antiepileptic drug toxicity potential base on hepatic protein covalent binding and gene expression. Chem Res Toxicol 2007; 20: 600-608.
    • (2007) Chem Res Toxicol , vol.20 , pp. 600-608
    • Leone, A.M.1    Kao, L.M.2    McMillian, M.K.3
  • 46
    • 33751572319 scopus 로고    scopus 로고
    • Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes
    • Hultin-Rosenberg L, Jagannathan S, Nilsson KC, et al. Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes. Xenobiotica 2006; 36: 1122-1139.
    • (2006) Xenobiotica , vol.36 , pp. 1122-1139
    • Hultin-Rosenberg, L.1    Jagannathan, S.2    Nilsson, K.C.3
  • 47
    • 2142764409 scopus 로고    scopus 로고
    • Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells
    • Harris AJ, Dial SL, Casciano DA. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mut Res 2004; 549: 79-99.
    • (2004) Mut Res , vol.549 , pp. 79-99
    • Harris, A.J.1    Dial, S.L.2    Casciano, D.A.3
  • 48
    • 11244334169 scopus 로고    scopus 로고
    • Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin
    • Liguori MJ, Anderson LM, Bukofzer S, et al. Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology 2005; 41: 177-186.
    • (2005) Hepatology , vol.41 , pp. 177-186
    • Liguori, M.J.1    Anderson, L.M.2    Bukofzer, S.3
  • 49
    • 0035863271 scopus 로고    scopus 로고
    • Induction of nuclear transcription factors, CYP monooxygenases and GSTA2 gene expression in Aroclor 1254 treated rat hepatocyte cultures
    • Borlak J, Thum T. Induction of nuclear transcription factors, CYP monooxygenases and GSTA2 gene expression in Aroclor 1254 treated rat hepatocyte cultures. Biochem Pharmacol 2001; 61: 145-153.
    • (2001) Biochem Pharmacol , vol.61 , pp. 145-153
    • Borlak, J.1    Thum, T.2
  • 50
    • 17944365806 scopus 로고    scopus 로고
    • Rat liver slices as a tool to study LPS-induced inflammatory response in the liver
    • Olinga P, Merema MT, de Jager MH, et al. Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. J Hepatology 2001; 35: 187-194.
    • (2001) J Hepatology , vol.35 , pp. 187-194
    • Olinga, P.1    Merema, M.T.2    de Jager, M.H.3
  • 51
    • 0041881584 scopus 로고    scopus 로고
    • Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression
    • Jessen BA, Mullins JS, de Peyster A, et al. Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression. Toxicol Sci 2003; 75: 208-222.
    • (2003) Toxicol Sci , vol.75 , pp. 208-222
    • Jessen, B.A.1    Mullins, J.S.2    de Peyster, A.3
  • 52
    • 10044232717 scopus 로고    scopus 로고
    • Organ slice viability extended for pathway characterization: An in vitro model to investigate fibrosis
    • Vickers AE, Saulnier M, Cruz E, et al. Organ slice viability extended for pathway characterization:an in vitro model to investigate fibrosis. Toxicol Sci 2004a; 82: 534-544.
    • (2004) Toxicol Sci , vol.82 , pp. 534-544
    • Vickers, A.E.1    Saulnier, M.2    Cruz, E.3
  • 53
    • 4544290091 scopus 로고    scopus 로고
    • Kidney slices of human and rat to characterize cisplatininduced injury on cellular pathways and morphology
    • Vickers AE, Rose K, Fisher R, et al. Kidney slices of human and rat to characterize cisplatininduced injury on cellular pathways and morphology. Toxicol Pathol 2004b; 32: 577-590.
    • (2004) Toxicol Pathol , vol.32 , pp. 577-590
    • Vickers, A.E.1    Rose, K.2    Fisher, R.3
  • 54
    • 33745984570 scopus 로고    scopus 로고
    • Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices
    • Vickers AE, Bentley P, Fisher RL. Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices. Toxicol In Vitro 2006; 20: 1173-1182.
    • (2006) Toxicol In Vitro , vol.20 , pp. 1173-1182
    • Vickers, A.E.1    Bentley, P.2    Fisher, R.L.3
  • 55
    • 33846419835 scopus 로고    scopus 로고
    • Analysis of bile acid-induced regulation of FXR target genes in human liver slices
    • Jung D, Elferink MGL, Stellaard F, et al. Analysis of bile acid-induced regulation of FXR target genes in human liver slices. Liver Int 2007; 1: 137-144.
    • (2007) Liver Int , vol.1 , pp. 137-144
    • Jung, D.1    Elferink, M.G.L.2    Stellaard, F.3
  • 56
    • 13444269608 scopus 로고    scopus 로고
    • Tissue repair: An important determinant of final outcome of toxicant-induced injury
    • Mehendale HM. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 2005; 33: 41-51.
    • (2005) Toxicol Pathol , vol.33 , pp. 41-51
    • Mehendale, H.M.1
  • 57
    • 18144395823 scopus 로고    scopus 로고
    • Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu
    • Van de Bovenkamp M, Groothuis GMM, Draaisma AL, et al. Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci 2005; 85: 632-638.
    • (2005) Toxicol Sci , vol.85 , pp. 632-638
    • Van de Bovenkamp, M.1    Groothuis, G.M.M.2    Draaisma, A.L.3
  • 58
    • 16344376900 scopus 로고    scopus 로고
    • Precision cut tissue slices of the liver as morphological tool for investigation of apoptosis
    • Kasper H-U, Dries V, Drebber U, et al. Precision cut tissue slices of the liver as morphological tool for investigation of apoptosis. In Vivo 2005; 19: 423-432.
    • (2005) In Vivo , vol.19 , pp. 423-432
    • Kasper, H.-U.1    Dries, V.2    Drebber, U.3
  • 59
    • 13844297246 scopus 로고    scopus 로고
    • PPAR gamma and hepatic stellate cells
    • Hazra S, Miyahara T, Rippe RA, et al. PPAR gamma and hepatic stellate cells. Comp Hepatol 2004; 3: S7.
    • (2004) Comp Hepatol , vol.3 , pp. S7
    • Hazra, S.1    Miyahara, T.2    Rippe, R.A.3
  • 60
    • 14244257340 scopus 로고    scopus 로고
    • Adipogenic transcriptional regulation of hepatic stellate cells
    • She H, Xiong S, Hazra S, et al. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem 2005; 280: 4959-4967.
    • (2005) J Biol Chem , vol.280 , pp. 4959-4967
    • She, H.1    Xiong, S.2    Hazra, S.3
  • 61
    • 0141519565 scopus 로고    scopus 로고
    • Inflammation and drug idiosyncrasy-Is there a connection?
    • Roth RA, Luyendyk JP, Maddox JF, et al. Inflammation and drug idiosyncrasy-Is there a connection? J Pharmacol Exp Therap 2003; 307: 1-8.
    • (2003) J Pharmacol Exp Therap , vol.307 , pp. 1-8
    • Roth, R.A.1    Luyendyk, J.P.2    Maddox, J.F.3
  • 62
    • 7444268462 scopus 로고    scopus 로고
    • Adverse hepatic drug reactions: Inflammatory episodes as consequence and contributor
    • Ganey PE, Luyendyk JP, Maddox JF, et al. Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor. Chem Biol Interact 2004; 150: 35-51.
    • (2004) Chem Biol Interact , vol.150 , pp. 35-51
    • Ganey, P.E.1    Luyendyk, J.P.2    Maddox, J.F.3
  • 63
    • 33845478161 scopus 로고    scopus 로고
    • Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions
    • Liguori MJ, Waring JF. Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions. Expert Opin Drug Metab Toxicol 2006; 2: 835-846.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 835-846
    • Liguori, M.J.1    Waring, J.F.2
  • 64
    • 33751183319 scopus 로고    scopus 로고
    • Modest inflammation enhances diclofenac hepatotoxicity in rats: Role of neutrophils and bacterial translocation
    • Deng X, Stachlewitz RF, Liguoro MJ, et al. Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation. J Pharmacol Exp Therap 2006; 319: 1191-1199.
    • (2006) J Pharmacol Exp Therap , vol.319 , pp. 1191-1199
    • Deng, X.1    Stachlewitz, R.F.2    Liguoro, M.J.3
  • 65
    • 33644781852 scopus 로고    scopus 로고
    • Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggest a role for proinflammatory chemokines and neutrophils
    • Waring JF, Liguori MJ, Luyendyk JP, et al. Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggest a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Therap 2006; 316: 1080-1087.
    • (2006) J Pharmacol Exp Therap , vol.316 , pp. 1080-1087
    • Waring, J.F.1    Liguori, M.J.2    Luyendyk, J.P.3
  • 66
    • 34547117370 scopus 로고    scopus 로고
    • Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine
    • Deng X, Luyendyk JP, Zou W, et al. Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine. J Pharmacol Exp Therap 2007; 322: 852-861.
    • (2007) J Pharmacol Exp Therap , vol.322 , pp. 852-861
    • Deng, X.1    Luyendyk, J.P.2    Zou, W.3
  • 67
    • 7044223146 scopus 로고    scopus 로고
    • LPS-induced down regulation of MRP2 and BSEP in human liver is due to a posttranscriptional process
    • Elferink MG, Olinga P, Draaisma AL, et al. LPS-induced down regulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol 2004; 287: G1008-G1016.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287 , pp. G1008-G1016
    • Elferink, M.G.1    Olinga, P.2    Draaisma, A.L.3
  • 68
    • 17744391290 scopus 로고    scopus 로고
    • Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
    • Zollner G, Fickert P, Zenz R, et al. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 2001; 33: 633-646.
    • (2001) Hepatology , vol.33 , pp. 633-646
    • Zollner, G.1    Fickert, P.2    Zenz, R.3
  • 69
    • 33747834655 scopus 로고    scopus 로고
    • Role of innate immunity in acetaminophen-induced hepatotoxicity
    • Liu Z-X, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2006; 2: 493-503.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 493-503
    • Liu, Z.-X.1    Kaplowitz, N.2
  • 70
    • 0034779861 scopus 로고    scopus 로고
    • Assessment of cisplatin-induced nephrotoxicity by microarray technology
    • Huang Q, Dunn RT 2nd, Jayadev S, et al. Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicol Sci 2001; 63: 196-207.
    • (2001) Toxicol Sci , vol.63 , pp. 196-207
    • Huang, Q.1    Dunn, R.T.2    Jayadev, S.3
  • 71
    • 12144290763 scopus 로고    scopus 로고
    • Identification of putative gene-based markers of renal toxicity
    • Amin RP, Vickers AE, Sistare F, et al. Identification of putative gene-based markers of renal toxicity. Environ Health Perspect 2004; 112: 465-479.
    • (2004) Environ Health Perspect , vol.112 , pp. 465-479
    • Amin, R.P.1    Vickers, A.E.2    Sistare, F.3
  • 72
    • 22244444195 scopus 로고    scopus 로고
    • Preclinical drug safety analysis by chemogenomic profiling in the liver
    • Fielden MR, Pearson C, Brennan R, et al. Preclinical drug safety analysis by chemogenomic profiling in the liver. Am J Pharmacogenomics 2005; 5: 161-171.
    • (2005) Am J Pharmacogenomics , vol.5 , pp. 161-171
    • Fielden, M.R.1    Pearson, C.2    Brennan, R.3
  • 73
    • 20944440313 scopus 로고    scopus 로고
    • Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers
    • Thukral SK, Nordone PJ, Hu R, et al. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Toxicol Pathol 2005; 33: 343-355.
    • (2005) Toxicol Pathol , vol.33 , pp. 343-355
    • Thukral, S.K.1    Nordone, P.J.2    Hu, R.3
  • 74
    • 12144286400 scopus 로고    scopus 로고
    • Identification of platform-independent gene expression markers of cisplatin nephrotoxicity
    • Thompson KL, Afshari CA, Amin R, et al. Identification of platform-independent gene expression markers of cisplatin nephrotoxicity. Environ Health Perspect 2004; 112: 488-494.
    • (2004) Environ Health Perspect , vol.112 , pp. 488-494
    • Thompson, K.L.1    Afshari, C.A.2    Amin, R.3
  • 75
    • 35348845226 scopus 로고    scopus 로고
    • Activation and involvement of p53 in cisplatin-induced nephrotoxicity
    • Wei Q, Dong G, Yang T, et al. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol 2007; 293: 1282-1291.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. 1282-1291
    • Wei, Q.1    Dong, G.2    Yang, T.3
  • 76
    • 34848815678 scopus 로고    scopus 로고
    • Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin
    • Yano T, Itoh Y, Matsuo M, et al. Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin. Apoptosis 2007; 12: 1901-1909.
    • (2007) Apoptosis , vol.12 , pp. 1901-1909
    • Yano, T.1    Itoh, Y.2    Matsuo, M.3
  • 77
    • 34250765336 scopus 로고    scopus 로고
    • Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin IL-1β, IL-18, IL-6, and neutrophil infiltration in the kidney
    • Faubel S, Lewis EC, Rezmikov L, et al. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin IL-1β, IL-18, IL-6, and neutrophil infiltration in the kidney. J Pharmacol Exp Therap 2007; 322: 8-15.
    • (2007) J Pharmacol Exp Therap , vol.322 , pp. 8-15
    • Faubel, S.1    Lewis, E.C.2    Rezmikov, L.3
  • 78
    • 34547918307 scopus 로고    scopus 로고
    • Cisplatin, gentamicin and p -aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys
    • Peyrou M, Hanna PE, Cribb AE. Cisplatin, gentamicin and p -aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci 2007; 99: 346-353.
    • (2007) Toxicol Sci , vol.99 , pp. 346-353
    • Peyrou, M.1    Hanna, P.E.2    Cribb, A.E.3
  • 79
    • 36949014801 scopus 로고    scopus 로고
    • Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    • Zhou Y, Vaidya VS, Brown RP, et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 2008; 101: 159-170.
    • (2008) Toxicol Sci , vol.101 , pp. 159-170
    • Zhou, Y.1    Vaidya, V.S.2    Brown, R.P.3
  • 80
    • 0028670643 scopus 로고
    • Serum α-glutathione S -transferases: A sensitive marker of hepatocellular damage associated with acute liver allograft rejection
    • Trull AK, Facey SP, Rees GW, et al. Serum α-glutathione S -transferases: a sensitive marker of hepatocellular damage associated with acute liver allograft rejection. Transplantation 1994; 58: 1345-1351.
    • (1994) Transplantation , vol.58 , pp. 1345-1351
    • Trull, A.K.1    Facey, S.P.2    Rees, G.W.3
  • 81
    • 0031657398 scopus 로고    scopus 로고
    • Changes in human liver and kidney slice function related to potential side-effects in the presence of biotransformation of four cyclosporine derivatives-CSA, IMM, OG, PSC
    • Vickers AE, Alegret M, Jimenez RM, et al. Changes in human liver and kidney slice function related to potential side-effects in the presence of biotransformation of four cyclosporine derivatives-CSA, IMM, OG, PSC. In Vitro Mol Toxicol 1998; 11: 119-132.
    • (1998) In Vitro Mol Toxicol , vol.11 , pp. 119-132
    • Vickers, A.E.1    Alegret, M.2    Jimenez, R.M.3
  • 82
    • 33846475105 scopus 로고    scopus 로고
    • A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia
    • Rokushima M, Omi K, Araki A, et al. A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia. Toxicol Sci 2007; 95: 474-484.
    • (2007) Toxicol Sci , vol.95 , pp. 474-484
    • Rokushima, M.1    Omi, K.2    Araki, A.3
  • 83
    • 85057447223 scopus 로고    scopus 로고
    • Evaluating drug-induced hemolysis effects using whole bloodliver slice co-culture model
    • Sinclair JR, Way W, Vickers AE. Evaluating drug-induced hemolysis effects using whole bloodliver slice co-culture model. The Toxicologist 2007; 249.
    • (2007) The Toxicologist , pp. 249
    • Sinclair, J.R.1    Way, W.2    Vickers, A.E.3
  • 84
    • 85057451612 scopus 로고    scopus 로고
    • Human in vitro hemolysis model to assess drug-induced hemolytic effects
    • Vickers AE, Fisher RL, Sinclair JR, et al. Human in vitro hemolysis model to assess drug-induced hemolytic effects. The Toxicologist 2008; 102: 2083.
    • (2008) The Toxicologist , vol.102 , pp. 2083
    • Vickers, A.E.1    Fisher, R.L.2    Sinclair, J.R.3


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