A toxicogenomic approach revealed hepatic gene expression changes mechanistically linked to drug-induced hemolytic anemia

Toxicological Sciences

Volumn 95, Issue 2, 2007, Pages 474-484

  Rokushima, Masatomo ^a   Omi, Kazuo ^a   Araki, Akiko ^a   Kyokawa, Yoshimasa ^a   Furukawa, Naoko ^a   Itoh, Fumio ^a   Imura, Kae ^a   Takeuchi, Kumiko ^a   Okada, Manabu ^a   Kato, Ikuo ^a   Ishizaki, Jun ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Biomarker; Hemolytic anemia; Liver; Microarray; Toxicogenomics

Indexed keywords

AMINOLEVULINIC ACID SYNTHASE 2; BETA GLO; BILIRUBIN; BIOLOGICAL MARKER; ERYTHROID ASSOCIATED FACTOR; GALAPTIN; HEME OXYGENASE 1; HEMOGLOBIN; PHENACETIN; PHENYLHYDRAZINE; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD CHEMISTRY; CONTROLLED STUDY; ERYTHROCYTE COUNT; FEMALE; GENE EXPRESSION PROFILING; HEME SYNTHESIS; HEMOGLOBIN SYNTHESIS; HEMOLYTIC ANEMIA; HISTOPATHOLOGY; KUPFFER CELL; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANEMIA, HEMOLYTIC; ANIMALS; BILIRUBIN; DOWN-REGULATION; ERYTHROCYTE COUNT; ERYTHROCYTES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKERS; LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACEUTICAL PREPARATIONS; PHENACETIN; PHENYLHYDRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 33846475105     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl152     Document Type: Article

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