Development of a toxicogenomics in vitro assay for the efficient characterization of compounds

Pharmacogenomics

Volumn 7, Issue 2, 2006, Pages 177-186

  Yang, Yi ^a   Abel, Stephen J ^a   Ciurlionis, Rita ^a   Waring, Jeffrey F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Aryl hydrocarbon receptor; Blomarker; Gene expression profiling; Microarrays; Peroxisome proliferation; Primary rat hepatocytes; Toxicity classification; Toxicogenomics

Indexed keywords

3 METHYLCHOLANTHRENE; AROCLOR; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; BEZAFIBRATE; CHLORPHENIRAMINE; CLOFIBRATE; FENOPROFEN; INDOMETACIN; OMEPRAZOLE; PENICILLIN G; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; RNA; SPECTINOMYCIN; TROGLITAZONE; DRUG; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL CELL; ARTICLE; ASSAY; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CYTOTOXICITY; DRUG CLASSIFICATION; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LIVER CELL; MICROARRAY ANALYSIS; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TOXICOGENETICS; VALIDATION PROCESS; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DNA MICROARRAY; DRUG ANTAGONISM; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY;

ANIMALIA;

ANIMALS; DATA INTERPRETATION, STATISTICAL; GENE EXPRESSION; HEPATOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEROXISOME PROLIFERATORS; PHARMACEUTICAL PREPARATIONS; PPAR ALPHA; RATS; RECEPTORS, ARYL HYDROCARBON; RNA; TOXICOGENETICS;

EID: 33645970724     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.7.2.177     Document Type: Article

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